DK0784974T3 - Fremstilling af xanthinderivater i fast dispersion - Google Patents
Fremstilling af xanthinderivater i fast dispersionInfo
- Publication number
- DK0784974T3 DK0784974T3 DK96916342T DK96916342T DK0784974T3 DK 0784974 T3 DK0784974 T3 DK 0784974T3 DK 96916342 T DK96916342 T DK 96916342T DK 96916342 T DK96916342 T DK 96916342T DK 0784974 T3 DK0784974 T3 DK 0784974T3
- Authority
- DK
- Denmark
- Prior art keywords
- solid dispersion
- preparation
- xanthine derivatives
- hxdrogen
- hxdroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19005895 | 1995-07-26 | ||
| PCT/JP1996/001555 WO1997004782A1 (fr) | 1995-07-26 | 1996-06-07 | Dispersion solide ou preparation a dispersion solide de derives xanthine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0784974T3 true DK0784974T3 (da) | 2003-09-01 |
Family
ID=16251650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96916342T DK0784974T3 (da) | 1995-07-26 | 1996-06-07 | Fremstilling af xanthinderivater i fast dispersion |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6254889B1 (es) |
| EP (1) | EP0784974B1 (es) |
| JP (1) | JP3938938B2 (es) |
| AT (1) | ATE240734T1 (es) |
| DE (1) | DE69628276T2 (es) |
| DK (1) | DK0784974T3 (es) |
| ES (1) | ES2199289T3 (es) |
| PT (1) | PT784974E (es) |
| WO (1) | WO1997004782A1 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| ATE400252T1 (de) * | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
| US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
| CA2396380C (en) * | 1999-12-23 | 2015-04-21 | David Hayes | Improved pharmaceutical compositions for poorly soluble drugs |
| CA2395331C (en) | 1999-12-23 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions providing enhanced drug concentrations |
| US20010053791A1 (en) * | 2000-03-16 | 2001-12-20 | Babcock Walter C. | Glycogen phosphorylase inhibitor |
| US7125565B2 (en) * | 2000-12-01 | 2006-10-24 | Kyowa Hakko Kogyo Co., Ltd. | Composition improved in the solubility or oral absorbability |
| WO2002062393A2 (en) * | 2001-02-02 | 2002-08-15 | Metagenics, Inc. | Coating for orally administered compositions |
| JP4310605B2 (ja) * | 2001-05-25 | 2009-08-12 | 大塚製薬株式会社 | 医薬用組成物 |
| DE60233874D1 (de) | 2001-06-22 | 2009-11-12 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren |
| CA2474838C (en) * | 2002-02-01 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
| EP1479300B1 (en) * | 2002-02-22 | 2009-10-21 | Ajinomoto Co., Inc. | Amino acid powder and process for producing the same |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| EP1932529A1 (en) | 2003-04-25 | 2008-06-18 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| RU2367442C2 (ru) * | 2003-04-25 | 2009-09-20 | Новокардия, Инк. | Способ нормализации мочеиспускания при нарушении функции почек |
| CA2525037C (en) * | 2003-05-09 | 2011-12-20 | Kyowa Hakko Kogyo Co., Ltd. | Microcrystals of (e)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methylxanthine |
| WO2005011635A2 (en) | 2003-08-04 | 2005-02-10 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
| JP2007532671A (ja) * | 2004-04-16 | 2007-11-15 | ノヴァカーディア，インク． | アデノシンａ１受容体アンタゴニストおよびアルドステロン阻害剤を含む併用療法 |
| US20080312587A1 (en) * | 2005-06-10 | 2008-12-18 | Gruenethal Gmbh | System for the Oral Administration of Solids to Persons Suffering from Dementia |
| US20100168140A1 (en) * | 2005-12-14 | 2010-07-01 | Kyowa Hakko Kogyo Co., Ltd. | Easily Absorbable Oral Preparations of Xanthine Derivatives |
| JP2007308480A (ja) * | 2006-04-20 | 2007-11-29 | Shin Etsu Chem Co Ltd | 腸溶性固体分散体を含んでなる固形製剤 |
| JP2009540003A (ja) * | 2006-06-16 | 2009-11-19 | ノヴァカーディア，インク． | Ａａ１ｒａの低頻度投与を含む腎機能の長期間にわたる改善 |
| US20090197900A1 (en) * | 2007-03-29 | 2009-08-06 | Howard Dittrich | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| GB0708258D0 (en) * | 2007-04-27 | 2007-06-06 | Katholleke Universiteit Leuven | New anti-viral nulceoside analogs |
| WO2008135855A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
| WO2008135828A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| WO2008149192A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
| US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
| HUE043897T2 (hu) | 2007-09-25 | 2019-09-30 | Solubest Ltd | Lipofil hatóanyagot tartalmazó készítmények és eljárás elõállításukra |
| WO2009073215A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| EP2240162A4 (en) | 2007-12-06 | 2013-10-09 | Bend Res Inc | NANOTE PARTICLES WITH A NON-IONIZABLE POLYMER AND AN AMIN-FUNCTIONALIZED METHACRYLATE COPOLYMER |
| JP2011513497A (ja) * | 2008-03-11 | 2011-04-28 | ドクター・レディーズ・ラボラトリーズ・リミテッド | レナリドミドの調製 |
| EP2863911A4 (en) | 2012-06-21 | 2016-07-13 | Mayne Pharma Int Pty Ltd | ITRACONAZOLE COMPOSITIONS AND METHOD OF DOSING AND METHOD OF USE THEREOF |
| TWI615157B (zh) * | 2013-02-06 | 2018-02-21 | 大塚製藥股份有限公司 | 包括不定形西洛他唑的固體分散劑 |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| WO2018005552A1 (en) | 2016-06-27 | 2018-01-04 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
| TWI780270B (zh) | 2017-11-28 | 2022-10-11 | 靜岡縣公立大學法人 | 固體分散體 |
| JP2021535112A (ja) | 2018-08-20 | 2021-12-16 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 補体ｄ因子の医学的障害の治療のための医薬化合物 |
| EP3866773A4 (en) | 2018-10-16 | 2022-10-26 | Georgia State University Research Foundation, Inc. | CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL CONDITIONS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US5286489A (en) * | 1985-08-26 | 1994-02-15 | The Procter & Gamble Company | Taste masking compositions |
| WO1988000051A1 (en) * | 1986-06-24 | 1988-01-14 | Racz Istvan | Proceeding for the production of pharmaceutical preparations of high gastric acid binding capacity, of retarded effect and of increased bioavailability |
| JP2521461B2 (ja) | 1987-03-10 | 1996-08-07 | エスエス製薬株式会社 | 持続性錠剤 |
| DE69020758T2 (de) * | 1989-03-10 | 1995-12-07 | Yamanouchi Pharma Co Ltd | Die Wirkstoffabgabe steuerndes Überzugsmaterial für lang wirksame Formulierungen. |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US5290782A (en) | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| AU1537292A (en) * | 1991-04-16 | 1992-11-17 | Nippon Shinyaku Co. Ltd. | Method of manufacturing solid dispersion |
-
1996
- 1996-06-07 WO PCT/JP1996/001555 patent/WO1997004782A1/ja active IP Right Grant
- 1996-06-07 US US08/809,651 patent/US6254889B1/en not_active Expired - Fee Related
- 1996-06-07 PT PT96916342T patent/PT784974E/pt unknown
- 1996-06-07 EP EP96916342A patent/EP0784974B1/en not_active Expired - Lifetime
- 1996-06-07 ES ES96916342T patent/ES2199289T3/es not_active Expired - Lifetime
- 1996-06-07 DK DK96916342T patent/DK0784974T3/da active
- 1996-06-07 JP JP50744297A patent/JP3938938B2/ja not_active Expired - Fee Related
- 1996-06-07 AT AT96916342T patent/ATE240734T1/de not_active IP Right Cessation
- 1996-06-07 DE DE69628276T patent/DE69628276T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2199289T3 (es) | 2004-02-16 |
| JP3938938B2 (ja) | 2007-06-27 |
| DE69628276D1 (de) | 2003-06-26 |
| WO1997004782A1 (fr) | 1997-02-13 |
| US6254889B1 (en) | 2001-07-03 |
| PT784974E (pt) | 2003-09-30 |
| EP0784974A1 (en) | 1997-07-23 |
| ATE240734T1 (de) | 2003-06-15 |
| EP0784974B1 (en) | 2003-05-21 |
| DE69628276T2 (de) | 2004-04-08 |
| EP0784974A4 (en) | 2000-09-27 |
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