DK0763037T3 - [a]-Annellerede pyrrolderivater og deres anvendelse i farmacien - Google Patents

[a]-Annellerede pyrrolderivater og deres anvendelse i farmacien

Info

Publication number
DK0763037T3
DK0763037T3 DK95921801T DK95921801T DK0763037T3 DK 0763037 T3 DK0763037 T3 DK 0763037T3 DK 95921801 T DK95921801 T DK 95921801T DK 95921801 T DK95921801 T DK 95921801T DK 0763037 T3 DK0763037 T3 DK 0763037T3
Authority
DK
Denmark
Prior art keywords
pct
annotated
pharmacy
pyrrole derivatives
sec
Prior art date
Application number
DK95921801T
Other languages
English (en)
Inventor
Stefan Laufer
Hans Guenther Striegel
Gerd Dannhardt
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Application granted granted Critical
Publication of DK0763037T3 publication Critical patent/DK0763037T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK95921801T 1994-06-01 1995-05-31 [a]-Annellerede pyrrolderivater og deres anvendelse i farmacien DK0763037T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4419247A DE4419247A1 (de) 1994-06-01 1994-06-01 Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
PCT/EP1995/002079 WO1995032972A1 (de) 1994-06-01 1995-05-31 [a]-ANNELIERTE PYRROLDERIVATE UND DEREN ANWENDUNG IN DER PHARMAZIE

Publications (1)

Publication Number Publication Date
DK0763037T3 true DK0763037T3 (da) 2002-03-04

Family

ID=6519585

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95921801T DK0763037T3 (da) 1994-06-01 1995-05-31 [a]-Annellerede pyrrolderivater og deres anvendelse i farmacien

Country Status (13)

Country Link
US (1) US5942535A (da)
EP (1) EP0763037B1 (da)
JP (1) JP3671303B2 (da)
KR (1) KR100378884B1 (da)
AT (1) ATE208777T1 (da)
AU (1) AU2673095A (da)
DE (2) DE4419247A1 (da)
DK (1) DK0763037T3 (da)
ES (1) ES2166823T3 (da)
FI (1) FI114099B (da)
NO (1) NO310076B1 (da)
PT (1) PT763037E (da)
WO (1) WO1995032972A1 (da)

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AU741754B2 (en) * 1997-09-12 2001-12-06 Merck Frosst Canada Ltd. 2-aminopyridines as inhibitors of cyclooxygenase-2
US6004950A (en) * 1997-09-12 1999-12-21 Merck Frosst Canada, Inc. 2-aminopyridines as inhibitors of cyclooxygenase-2
ES2291577T3 (es) * 1999-11-23 2008-03-01 Merckle Gmbh Derivados oxo e hidroxi de pirrolizinas antiinflamatorios y su aplicacion en farmacia.
DE10001166A1 (de) * 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
SK286608B6 (sk) * 2000-01-28 2009-02-05 Merckle Gmbh Spôsob prípravy kyseliny 6-(4-chlórfenyl)-2,2-dimetyl-7-fenyl- 2,3-dihydro-1H-pyrolizin-5-yl octovej
DE10004157A1 (de) * 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
KR20010108722A (ko) * 2000-05-31 2001-12-08 우진석 피롤리진 유도체가 부착된 신규의 올리고뉴클레오타이드화합물, 이의 제조방법, 이를 포함하는 조성물, 및 이를유전자 관련 질병의 치료, 진단 및 분석에 사용하는 방법
DE10141285A1 (de) 2001-08-23 2003-03-27 Merckle Gmbh Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
MXPA04001868A (es) 2001-08-30 2005-10-05 Merckle Gmbh Uso de compuestos de pirrol anillados en el tratamiento de la degeneracion del hueso sub-condrial o cartilago articular.
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CN1805938B (zh) * 2003-06-17 2010-06-16 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
JP4920409B2 (ja) 2003-06-17 2012-04-18 アリーナ ファーマシューティカルズ， インコーポレイテッド ３−ベンズアゼピンを調製する方法
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
EA201200954A1 (ru) 2004-12-21 2013-05-30 Арена Фармасьютикалз, Инк. Способ получения полугидрата гидрохлорида (r)-8-хлор-1-метил-2,3,4,5-тетрагидро-1н-3-бензазепина, фармацевтическая композиция на его основе и его применение
EA015012B1 (ru) * 2004-12-23 2011-04-29 Арена Фармасьютикалз, Инк. Композиция, содержащая фентермин и избирательный агонист рецептора 5ht, и ее применение
DE102005012971A1 (de) * 2005-03-21 2006-09-28 Merckle Gmbh Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
AU2006274197A1 (en) * 2005-07-26 2007-02-01 Merckle Gmbh Macrolide conjugates of pyrrolizine and indolizine compounds as inhibitors of 5-lipooxygenase and cyclooxygenase
US8168782B2 (en) 2006-04-03 2012-05-01 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto
US8299241B2 (en) * 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
WO2009111004A1 (en) * 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
SG10201506896RA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
SG10201506865WA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
CN107669687A (zh) 2010-09-01 2018-02-09 艾尼纳制药公司 用于体重控制的5‑ht2c激动剂的调节释放剂型
US9248133B2 (en) 2010-09-01 2016-02-02 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
AR088670A1 (es) 2012-10-09 2014-06-25 Arena Pharm Inc Metodo de control del peso
WO2015077905A1 (en) * 2013-11-29 2015-06-04 Merck Sharp & Dohme Corp. Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
EP3324959B1 (en) * 2015-07-17 2023-07-12 The Board Of Regents Of The University Of Oklahoma Licofelone derivatives and methods of use
KR101695566B1 (ko) 2015-09-24 2017-01-11 주식회사 지오엔씨 라미네이터용 히팅롤의 간극조절장치

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GB1461592A (en) * 1973-04-25 1977-01-13 Agfa Gevaert Specially sensitized direct positive silver halide emulsions
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US4536512A (en) * 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
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MA20003A1 (fr) * 1983-01-13 1984-10-01 Rhone Poulenc Sante Nouveaux derives de pyrrole orthocondense utiles pour la preparation de nouveaux produits et leurs preparation
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Also Published As

Publication number Publication date
EP0763037B1 (de) 2001-11-14
FI964773A (fi) 1997-01-27
JP3671303B2 (ja) 2005-07-13
ATE208777T1 (de) 2001-11-15
NO965095L (no) 1996-11-29
FI964773A0 (fi) 1996-11-29
AU2673095A (en) 1995-12-21
WO1995032972A1 (de) 1995-12-07
DE4419247A1 (de) 1995-12-07
KR100378884B1 (ko) 2003-08-06
FI114099B (fi) 2004-08-13
NO965095D0 (no) 1996-11-29
KR970703346A (ko) 1997-07-03
US5942535A (en) 1999-08-24
DE59509846D1 (de) 2001-12-20
EP0763037A1 (de) 1997-03-19
PT763037E (pt) 2002-05-31
JPH10506370A (ja) 1998-06-23
ES2166823T3 (es) 2002-05-01
NO310076B1 (no) 2001-05-14

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