DK0746551T3 - Optisk rene 4-aryl-2-hydroxytetronsyrer - Google Patents

Optisk rene 4-aryl-2-hydroxytetronsyrer

Info

Publication number
DK0746551T3
DK0746551T3 DK95911075T DK95911075T DK0746551T3 DK 0746551 T3 DK0746551 T3 DK 0746551T3 DK 95911075 T DK95911075 T DK 95911075T DK 95911075 T DK95911075 T DK 95911075T DK 0746551 T3 DK0746551 T3 DK 0746551T3
Authority
DK
Denmark
Prior art keywords
optically pure
aryl
treatment
cyclooxygenase
hydroxytetronic acids
Prior art date
Application number
DK95911075T
Other languages
Danish (da)
English (en)
Inventor
Allen T Hopper
Donald T Witiak
Original Assignee
Univ Ohio State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/201,775 external-priority patent/US5399721A/en
Application filed by Univ Ohio State Res Found filed Critical Univ Ohio State Res Found
Application granted granted Critical
Publication of DK0746551T3 publication Critical patent/DK0746551T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK95911075T 1994-02-25 1995-02-22 Optisk rene 4-aryl-2-hydroxytetronsyrer DK0746551T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/201,775 US5399721A (en) 1990-01-12 1994-02-25 Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
US08/350,205 US5504108A (en) 1990-01-12 1994-12-05 Optically pure 4-aryl-2-hydroxytetronic acids
PCT/US1995/002183 WO1995023139A1 (en) 1994-02-25 1995-02-22 Optically pure 4-aryl-2-hydroxytetronic acids

Publications (1)

Publication Number Publication Date
DK0746551T3 true DK0746551T3 (da) 2003-01-06

Family

ID=26897085

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95911075T DK0746551T3 (da) 1994-02-25 1995-02-22 Optisk rene 4-aryl-2-hydroxytetronsyrer

Country Status (10)

Country Link
US (1) US5504108A (ja)
EP (1) EP0746551B1 (ja)
JP (1) JP3241735B2 (ja)
AT (1) ATE223395T1 (ja)
CA (1) CA2184068A1 (ja)
DE (1) DE69528044T2 (ja)
DK (1) DK0746551T3 (ja)
ES (1) ES2182890T3 (ja)
PT (1) PT746551E (ja)
WO (1) WO1995023139A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005000A (en) 1996-08-22 1999-12-21 Oxis International, Inc. 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor
DE69913390D1 (de) * 1999-12-29 2004-01-15 Oxis Isle Of Man Ltd Methode zur trennung von racemischen mischungen von 5-substituierten 4-hydroxy-2-furanonen
DK1303265T3 (da) 2000-07-20 2007-11-12 Lauras As Anvendelse af COX-2-inhibitorer, som immunostimulerende midler ved behandling af HIV eller AIDS
EP1449821B1 (en) * 2001-11-30 2012-05-09 Nippon Shokubai Co., Ltd. Optically active mandelic acid and its derivative, and method for crystallization thereof
WO2003053916A1 (en) * 2001-12-21 2003-07-03 Ortho-Mcneil Pharmaceutical, Inc. Process for preparing 2-(substituted phenyl) - 2 - hydroxy-ethyl carbamates
KR100945720B1 (ko) * 2001-12-21 2010-03-05 오르토-맥네일 파마슈티칼, 인코퍼레이티드 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법
NZ789295A (en) 2009-04-29 2024-02-23 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
GB2512863A (en) * 2013-04-09 2014-10-15 Pornthip Lattmann Medicinal applications of arylated hydroxy-tetronic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2830268B2 (ja) * 1989-01-21 1998-12-02 武田薬品工業株式会社 アスコルビン酸誘導体の製造法
US5095126A (en) * 1990-01-12 1992-03-10 Ohio State University Research Foundation Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids
US5071872A (en) * 1990-08-14 1991-12-10 The Ohio State University Research Foundation Method for improving interleukin-2 activity using aci-reductone compounds

Also Published As

Publication number Publication date
JP3241735B2 (ja) 2001-12-25
EP0746551B1 (en) 2002-09-04
PT746551E (pt) 2003-01-31
DE69528044D1 (de) 2002-10-10
ATE223395T1 (de) 2002-09-15
CA2184068A1 (en) 1995-08-31
DE69528044T2 (de) 2003-04-17
WO1995023139A1 (en) 1995-08-31
US5504108A (en) 1996-04-02
ES2182890T3 (es) 2003-03-16
EP0746551A1 (en) 1996-12-11
JPH10500663A (ja) 1998-01-20

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