DE69528044D1 - Synthese von optisch reiner 4-aryl-2-hydroxytetronic - Google Patents

Synthese von optisch reiner 4-aryl-2-hydroxytetronic

Info

Publication number
DE69528044D1
DE69528044D1 DE69528044T DE69528044T DE69528044D1 DE 69528044 D1 DE69528044 D1 DE 69528044D1 DE 69528044 T DE69528044 T DE 69528044T DE 69528044 T DE69528044 T DE 69528044T DE 69528044 D1 DE69528044 D1 DE 69528044D1
Authority
DE
Germany
Prior art keywords
optically pure
aryl
synthesis
treatment
hydroxytetronic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528044T
Other languages
English (en)
Other versions
DE69528044T2 (de
Inventor
Allen T Hopper
T Witiak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State University Research Foundation
Original Assignee
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/201,775 external-priority patent/US5399721A/en
Application filed by Ohio State University Research Foundation filed Critical Ohio State University Research Foundation
Application granted granted Critical
Publication of DE69528044D1 publication Critical patent/DE69528044D1/de
Publication of DE69528044T2 publication Critical patent/DE69528044T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69528044T 1994-02-25 1995-02-22 Synthese von optisch reiner 4-aryl-2-hydroxytetronic Expired - Fee Related DE69528044T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/201,775 US5399721A (en) 1990-01-12 1994-02-25 Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
US08/350,205 US5504108A (en) 1990-01-12 1994-12-05 Optically pure 4-aryl-2-hydroxytetronic acids
PCT/US1995/002183 WO1995023139A1 (en) 1994-02-25 1995-02-22 Optically pure 4-aryl-2-hydroxytetronic acids

Publications (2)

Publication Number Publication Date
DE69528044D1 true DE69528044D1 (de) 2002-10-10
DE69528044T2 DE69528044T2 (de) 2003-04-17

Family

ID=26897085

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528044T Expired - Fee Related DE69528044T2 (de) 1994-02-25 1995-02-22 Synthese von optisch reiner 4-aryl-2-hydroxytetronic

Country Status (10)

Country Link
US (1) US5504108A (de)
EP (1) EP0746551B1 (de)
JP (1) JP3241735B2 (de)
AT (1) ATE223395T1 (de)
CA (1) CA2184068A1 (de)
DE (1) DE69528044T2 (de)
DK (1) DK0746551T3 (de)
ES (1) ES2182890T3 (de)
PT (1) PT746551E (de)
WO (1) WO1995023139A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005000A (en) 1996-08-22 1999-12-21 Oxis International, Inc. 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor
EP1246811B1 (de) * 1999-12-29 2003-12-03 OXIS Isle of Man, Limited Methode zur trennung von racemischen mischungen von 5-substituierten 4-hydroxy-2-furanonen
PT1303265E (pt) 2000-07-20 2007-10-09 Lauras As ''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida''
US20040242693A1 (en) * 2001-11-30 2004-12-02 Norimasa Okuda Optically active mandelic acid and its derivative, and method for crystallization thereof
KR100945720B1 (ko) * 2001-12-21 2010-03-05 오르토-맥네일 파마슈티칼, 인코퍼레이티드 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법
EP2248799B1 (de) * 2001-12-21 2015-05-20 SK Biopharmaceuticals Co., LTD Verfahren zur herstellung von 2-(substituierte phenyl)-2-hydroxy-ethyl-carbamate
EP2424521A4 (de) 2009-04-29 2015-03-04 Amarin Pharmaceuticals Ie Ltd Pharmazeutische zusammensetzungen mit epa und einem kardiovaskulären mittel sowie verwendungsverfahren dafür
GB2512863A (en) * 2013-04-09 2014-10-15 Pornthip Lattmann Medicinal applications of arylated hydroxy-tetronic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2830268B2 (ja) * 1989-01-21 1998-12-02 武田薬品工業株式会社 アスコルビン酸誘導体の製造法
US5095126A (en) * 1990-01-12 1992-03-10 Ohio State University Research Foundation Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids
US5071872A (en) * 1990-08-14 1991-12-10 The Ohio State University Research Foundation Method for improving interleukin-2 activity using aci-reductone compounds

Also Published As

Publication number Publication date
EP0746551A1 (de) 1996-12-11
ES2182890T3 (es) 2003-03-16
WO1995023139A1 (en) 1995-08-31
PT746551E (pt) 2003-01-31
DE69528044T2 (de) 2003-04-17
DK0746551T3 (da) 2003-01-06
JP3241735B2 (ja) 2001-12-25
US5504108A (en) 1996-04-02
EP0746551B1 (de) 2002-09-04
JPH10500663A (ja) 1998-01-20
ATE223395T1 (de) 2002-09-15
CA2184068A1 (en) 1995-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee