DK0742789T3 - Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse - Google Patents

Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse

Info

Publication number
DK0742789T3
DK0742789T3 DK95910923T DK95910923T DK0742789T3 DK 0742789 T3 DK0742789 T3 DK 0742789T3 DK 95910923 T DK95910923 T DK 95910923T DK 95910923 T DK95910923 T DK 95910923T DK 0742789 T3 DK0742789 T3 DK 0742789T3
Authority
DK
Denmark
Prior art keywords
group
chain
liposomes
methods
active compounds
Prior art date
Application number
DK95910923T
Other languages
Danish (da)
English (en)
Inventor
Andrew S Janoff
Imran Ahmad
Yong-Wei Pei
Eric Mayhew
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of DK0742789T3 publication Critical patent/DK0742789T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK95910923T 1994-02-02 1995-02-02 Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse DK0742789T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19029594A 1994-02-02 1994-02-02
PCT/US1995/001490 WO1995021175A1 (en) 1994-02-02 1995-02-02 Pharmaceutically active compounds and liposomes, and methods of use therof

Publications (1)

Publication Number Publication Date
DK0742789T3 true DK0742789T3 (da) 2000-11-13

Family

ID=22700754

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95910923T DK0742789T3 (da) 1994-02-02 1995-02-02 Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse

Country Status (14)

Country Link
US (3) US5631394A (pt)
EP (2) EP1008342A3 (pt)
JP (1) JPH09508900A (pt)
AT (1) ATE195944T1 (pt)
AU (1) AU691886B2 (pt)
CA (1) CA2182485A1 (pt)
DE (1) DE69518627T2 (pt)
DK (1) DK0742789T3 (pt)
ES (1) ES2149350T3 (pt)
FI (1) FI116620B (pt)
GR (1) GR3034521T3 (pt)
NO (1) NO314405B1 (pt)
PT (1) PT742789E (pt)
WO (1) WO1995021175A1 (pt)

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US7683044B2 (en) * 1999-03-25 2010-03-23 Center For Molecular Medicine And Immunology Sphingomyelin therapy of autoimmune disease
JP2002540172A (ja) * 1999-03-25 2002-11-26 センター・フォー・モレキュラー・メディシン・アンド・イムノロジー 腫瘍治療の増強のためのスフィンゴミエリン含有調製物
US7820718B1 (en) * 1999-04-07 2010-10-26 Roger Williams Hospital Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
TW502133B (en) 1999-06-10 2002-09-11 Wako Pure Chem Ind Ltd Resist composition, agent and method for reducing substrate dependence thereof
US6682545B1 (en) * 1999-10-06 2004-01-27 The Penn State Research Foundation System and device for preventing restenosis in body vessels
WO2001038295A1 (fr) * 1999-11-24 2001-05-31 Taisho Pharmaceutical Co.,Ltd. Derives de sphingosine
US6410597B1 (en) * 2000-02-25 2002-06-25 Virginia Commonwealth University Hydroxyalkyl amide analogs of ceramide
US6858383B2 (en) * 2000-12-22 2005-02-22 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
ATE555102T1 (de) 2001-07-16 2012-05-15 Genzyme Corp N-acylsphingosinglucosyltransferase-inhibitor
EP1287815A1 (en) * 2001-08-31 2003-03-05 Cosmoferm B.V. Use of a sphingoid base for inhibiting ceramidase activity
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
WO2004078677A2 (en) * 2003-03-07 2004-09-16 Celator Pharmaceuticals, Inc. Enhanced delivery of sphingolipids
EP1610763A2 (en) * 2003-03-31 2006-01-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer
KR20060015534A (ko) 2003-04-25 2006-02-17 더 펜 스테이트 리서치 파운데이션 성장 억제, 지질 유래된 생활성 화합물의 전신 전달을 위한방법 및 시스템
EP1638610B1 (en) 2003-06-18 2015-03-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingoid polyalkylamine conjugates for vaccination
US7906122B2 (en) 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
JP2008519840A (ja) * 2004-11-10 2008-06-12 ジェンザイム・コーポレイション 糖尿病の処置方法
WO2006051549A2 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combination therapy associating preferably a ceramide with a cytotoxic drug
JP4791082B2 (ja) * 2005-05-30 2011-10-12 株式会社クラレ リポソームおよびそれを含む皮膚外用剤
WO2007044748A2 (en) * 2005-10-11 2007-04-19 University Of Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
ES2546181T3 (es) 2006-05-09 2015-09-21 Genzyme Corporation Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
SI2087002T1 (sl) 2006-10-27 2014-11-28 Lpath, Inc. Sestavki in postopki za vezavo sfingozin-1-fosfata
US8614103B2 (en) 2006-10-27 2013-12-24 Lpath, Inc. Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
EP2167485B1 (en) 2007-05-31 2015-09-30 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
MX2010003603A (es) 2007-10-05 2010-06-02 Genzyme Corp Metodo para el tratamiento de enfermedades de riñon poliquisticas con derivados de ceramida.
WO2009132082A2 (en) * 2008-04-22 2009-10-29 Medical College Of Georgia Research Institute, Inc. Immunogenic compositions containing ceramide and methods of use thereof
CA2731685A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
MX2011003517A (es) * 2008-10-03 2011-05-25 Genzyme Corp Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol.
EP3133070B1 (en) 2009-11-27 2019-08-14 Genzyme Corporation Eliglustat (genz 112638) as inhibitor of glucosylceramide synthase for use in a method of treating fabry's or gaucher's disease, the method comprising adjusting the individual therapeutical dose to the p-450 metabolism of the patient
US9207232B2 (en) * 2011-08-15 2015-12-08 National University Corporation Chiba University Ceramide derivative and Golgi apparatus-labeling fluorescent probe using same
KR102423002B1 (ko) * 2021-02-17 2022-07-21 주식회사 엘씨에스바이오텍 신규 세라마이드, 그의 제조방법 및 그의 용도

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Also Published As

Publication number Publication date
AU691886B2 (en) 1998-05-28
JPH09508900A (ja) 1997-09-09
EP0742789A1 (en) 1996-11-20
FI963045A0 (fi) 1996-08-01
NO314405B1 (no) 2003-03-17
WO1995021175A1 (en) 1995-08-10
GR3034521T3 (en) 2000-12-29
US5677337A (en) 1997-10-14
NO963224L (no) 1996-09-27
ES2149350T3 (es) 2000-11-01
FI116620B (fi) 2006-01-13
FI963045A (fi) 1996-08-01
ATE195944T1 (de) 2000-09-15
US5631394A (en) 1997-05-20
EP1008342A3 (en) 2004-12-29
DE69518627T2 (de) 2001-01-11
EP1008342A2 (en) 2000-06-14
AU1871295A (en) 1995-08-21
EP0742789B1 (en) 2000-08-30
CA2182485A1 (en) 1995-08-10
NO963224D0 (no) 1996-08-01
US5681589A (en) 1997-10-28
PT742789E (pt) 2000-12-29
DE69518627D1 (de) 2000-10-05

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