DK0742218T3 - Pyrrolopyridazinderivat - Google Patents
PyrrolopyridazinderivatInfo
- Publication number
- DK0742218T3 DK0742218T3 DK95906477T DK95906477T DK0742218T3 DK 0742218 T3 DK0742218 T3 DK 0742218T3 DK 95906477 T DK95906477 T DK 95906477T DK 95906477 T DK95906477 T DK 95906477T DK 0742218 T3 DK0742218 T3 DK 0742218T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- alkyl group
- aryl
- halogeno
- cycloalkyl
- Prior art date
Links
- YTJAMOLQXDNLJC-UHFFFAOYSA-N N1N=CC=C2N=CC=C21 Chemical compound N1N=CC=C2N=CC=C21 YTJAMOLQXDNLJC-UHFFFAOYSA-N 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 1
- 241000590002 Helicobacter pylori Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000001156 gastric mucosa Anatomy 0.000 abstract 1
- 229940037467 helicobacter pylori Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP398894 | 1994-01-19 | ||
| PCT/JP1995/000038 WO1995019980A1 (fr) | 1994-01-19 | 1995-01-18 | Derive de pyrrolopyridazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0742218T3 true DK0742218T3 (da) | 2003-01-13 |
Family
ID=11572411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95906477T DK0742218T3 (da) | 1994-01-19 | 1995-01-18 | Pyrrolopyridazinderivat |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6063782A (cs) |
| EP (1) | EP0742218B1 (cs) |
| KR (1) | KR100361199B1 (cs) |
| CN (1) | CN1044811C (cs) |
| AT (1) | ATE229020T1 (cs) |
| AU (1) | AU680998B2 (cs) |
| CZ (1) | CZ283216B6 (cs) |
| DE (1) | DE69529056T2 (cs) |
| DK (1) | DK0742218T3 (cs) |
| ES (1) | ES2185693T3 (cs) |
| FI (1) | FI112488B (cs) |
| HU (1) | HU225920B1 (cs) |
| MX (1) | MX9602850A (cs) |
| NO (1) | NO307300B1 (cs) |
| NZ (1) | NZ278675A (cs) |
| PT (1) | PT742218E (cs) |
| RU (1) | RU2146257C1 (cs) |
| WO (1) | WO1995019980A1 (cs) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316429B1 (en) * | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| SE9704404D0 (sv) * | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
| DE19836698A1 (de) * | 1998-08-13 | 2000-02-17 | Bayer Ag | Verfahren zur Herstellung von fluorierten Benzylalkoholen und -aldehyden |
| KR100666514B1 (ko) * | 1999-05-21 | 2007-02-28 | 브리스톨-마이어즈 스퀴브 컴페니 | 키나제의 피롤로트리아진 저해제 |
| TWI287014B (en) | 1999-06-15 | 2007-09-21 | Sankyo Co | Optically active pyrrolopyridazine compound |
| PL358014A1 (en) * | 2000-02-10 | 2004-08-09 | Sankyo Company, Limited | Pyrrolopyridazine compound |
| FR2849025B1 (fr) * | 2002-12-20 | 2005-10-14 | Rhodia Chimie Sa | Esters d'allyle substitue par un groupe difluoromethylene, leur procede de synthese et leur utilisation |
| RU2186108C1 (ru) * | 2001-04-24 | 2002-07-27 | Институт органической химии им. Н.Д.Зелинского РАН | Необратимый ингибитор н,к - аденозинтрифосфатазы |
| JP2003119140A (ja) * | 2001-08-08 | 2003-04-23 | Sankyo Co Ltd | ピロロピリダジン化合物を含有する医薬 |
| MXPA04002942A (es) * | 2001-09-27 | 2004-06-21 | Monsanto Technology Llc | Composiciones fungicidas y su aplicacion en la agricultura. |
| WO2004029058A1 (ja) * | 2002-09-25 | 2004-04-08 | Sankyo Company, Limited | 血中ガストリン濃度上昇の抑制のための医薬組成物 |
| WO2004029057A1 (ja) * | 2002-09-25 | 2004-04-08 | Sankyo Company, Limited | 内臓痛の治療または予防のための医薬組成物 |
| PT1581535E (pt) * | 2003-01-09 | 2007-12-12 | Astellas Pharma Inc | Derivados de pirrolopiridazina |
| US7608625B2 (en) * | 2003-03-13 | 2009-10-27 | Eisai R & D Management Co., Ltd. | Method for treating bruxism and bruxism-related diseases |
| CN100564379C (zh) * | 2004-09-03 | 2009-12-02 | 株式会社柳韩洋行 | 吡咯并[3,2-c]吡啶衍生物及其制备方法 |
| EP1784402B1 (en) * | 2004-09-03 | 2011-08-03 | Yuhan Corporation | PYRROLO[3,2-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF |
| CN101010321B (zh) * | 2004-09-03 | 2011-10-26 | 株式会社柳韩洋行 | 吡咯并[3,2-b]吡啶衍生物及其制备方法 |
| KR101137168B1 (ko) * | 2005-03-09 | 2012-04-19 | 주식회사유한양행 | 피롤로［２,３-ｄ］피리다진 유도체 및 그의 제조방법 |
| ATE548369T1 (de) * | 2006-01-16 | 2012-03-15 | Ube Industries | Pyrrolopyridazinonverbindung als pde4 inhibitor |
| CN101003537A (zh) * | 2006-01-17 | 2007-07-25 | 上海恒瑞医药有限公司 | 吡咯并哒嗪类衍生物及其制备方法和用途 |
| BR112012018631A8 (pt) | 2010-01-28 | 2017-12-19 | President And Fellows Of Harvard Colege | composições e métodos para intensificação da atividade do proteassoma |
| HUE044867T2 (hu) * | 2011-05-12 | 2019-11-28 | Proteostasis Therapeutics Inc | Proteosztázis szabályzók |
| US9849135B2 (en) | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| EP3245189B1 (en) * | 2015-01-13 | 2020-07-22 | Vivreon Biosciences, LLC | Modulators of ca2+ release-activated ca2+ (crac) channels and pharmaceutical uses thereof. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8901430D0 (en) * | 1989-01-23 | 1989-03-15 | Smithkline Beckman Intercredit | Compounds |
| AU7754691A (en) * | 1990-04-27 | 1991-11-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel pyridazines |
| US5068332A (en) * | 1990-10-12 | 1991-11-26 | American Home Products Corporation | Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
| AU8712191A (en) * | 1990-10-15 | 1992-05-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New diazines |
| JPH07500329A (ja) * | 1991-10-25 | 1995-01-12 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | ピロロ−ピリダジン |
-
1995
- 1995-01-18 ES ES95906477T patent/ES2185693T3/es not_active Expired - Lifetime
- 1995-01-18 RU RU96116162A patent/RU2146257C1/ru not_active IP Right Cessation
- 1995-01-18 DK DK95906477T patent/DK0742218T3/da active
- 1995-01-18 KR KR1019960703911A patent/KR100361199B1/ko not_active Expired - Fee Related
- 1995-01-18 EP EP95906477A patent/EP0742218B1/en not_active Expired - Lifetime
- 1995-01-18 AT AT95906477T patent/ATE229020T1/de not_active IP Right Cessation
- 1995-01-18 DE DE69529056T patent/DE69529056T2/de not_active Expired - Fee Related
- 1995-01-18 WO PCT/JP1995/000038 patent/WO1995019980A1/ja active IP Right Grant
- 1995-01-18 HU HU9601967A patent/HU225920B1/hu not_active IP Right Cessation
- 1995-01-18 CZ CZ962084A patent/CZ283216B6/cs not_active IP Right Cessation
- 1995-01-18 PT PT95906477T patent/PT742218E/pt unknown
- 1995-01-18 CN CN95192061A patent/CN1044811C/zh not_active Expired - Fee Related
- 1995-01-18 NZ NZ278675A patent/NZ278675A/en unknown
- 1995-01-18 MX MX9602850A patent/MX9602850A/es not_active IP Right Cessation
- 1995-01-18 AU AU14657/95A patent/AU680998B2/en not_active Ceased
-
1996
- 1996-07-17 US US08/676,375 patent/US6063782A/en not_active Expired - Fee Related
- 1996-07-18 FI FI962892A patent/FI112488B/fi active
- 1996-07-18 NO NO962998A patent/NO307300B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2185693T3 (es) | 2003-05-01 |
| EP0742218B1 (en) | 2002-12-04 |
| CN1143964A (zh) | 1997-02-26 |
| WO1995019980A1 (fr) | 1995-07-27 |
| CZ208496A3 (en) | 1996-12-11 |
| NO962998L (no) | 1996-09-17 |
| DE69529056D1 (de) | 2003-01-16 |
| DE69529056T2 (de) | 2003-11-13 |
| KR100361199B1 (ko) | 2003-04-16 |
| EP0742218A4 (en) | 1997-07-09 |
| PT742218E (pt) | 2003-02-28 |
| FI112488B (fi) | 2003-12-15 |
| FI962892A7 (fi) | 1996-09-16 |
| CZ283216B6 (cs) | 1998-02-18 |
| FI962892A0 (fi) | 1996-07-18 |
| AU1465795A (en) | 1995-08-08 |
| NZ278675A (en) | 1997-07-27 |
| MX9602850A (es) | 1997-06-28 |
| NO307300B1 (no) | 2000-03-13 |
| HUT77998A (hu) | 1999-04-28 |
| RU2146257C1 (ru) | 2000-03-10 |
| ATE229020T1 (de) | 2002-12-15 |
| AU680998B2 (en) | 1997-08-14 |
| NO962998D0 (no) | 1996-07-18 |
| EP0742218A1 (en) | 1996-11-13 |
| US6063782A (en) | 2000-05-16 |
| HU225920B1 (en) | 2008-01-28 |
| HU9601967D0 (en) | 1996-09-30 |
| CN1044811C (zh) | 1999-08-25 |
| HK1015609A1 (en) | 1999-10-15 |
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