DK0734383T3 - Cykliske amidderivater som neurokinin-A-antagonister - Google Patents

Cykliske amidderivater som neurokinin-A-antagonister

Info

Publication number
DK0734383T3
DK0734383T3 DK95903415T DK95903415T DK0734383T3 DK 0734383 T3 DK0734383 T3 DK 0734383T3 DK 95903415 T DK95903415 T DK 95903415T DK 95903415 T DK95903415 T DK 95903415T DK 0734383 T3 DK0734383 T3 DK 0734383T3
Authority
DK
Denmark
Prior art keywords
neurokinin
antagonists
amide derivatives
cyclic amide
compounds
Prior art date
Application number
DK95903415T
Other languages
Danish (da)
English (en)
Inventor
Ashokkumar Bhikkappa Shenvi
Robert Toms Jacobs
Scott Carson Miller
Cyrus John Ohnmacht Jr
Chris Allan Veale
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939325654A external-priority patent/GB9325654D0/en
Priority claimed from GB9423248A external-priority patent/GB9423248D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0734383T3 publication Critical patent/DK0734383T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK95903415T 1993-12-15 1994-12-13 Cykliske amidderivater som neurokinin-A-antagonister DK0734383T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939325654A GB9325654D0 (en) 1993-12-15 1993-12-15 Cyclic amide derivatives
GB9423248A GB9423248D0 (en) 1994-11-17 1994-11-17 Cyclic amide derivatives
PCT/GB1994/002726 WO1995016682A1 (en) 1993-12-15 1994-12-13 Cyclic amide derivatives as neurokinin a antagonists

Publications (1)

Publication Number Publication Date
DK0734383T3 true DK0734383T3 (da) 2002-10-14

Family

ID=26304034

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95903415T DK0734383T3 (da) 1993-12-15 1994-12-13 Cykliske amidderivater som neurokinin-A-antagonister

Country Status (22)

Country Link
US (3) US5589489A (fi)
EP (1) EP0734383B1 (fi)
JP (1) JP3819934B2 (fi)
CN (1) CN1142822A (fi)
AT (1) ATE221064T1 (fi)
AU (1) AU690951B2 (fi)
BR (1) BR9408325A (fi)
CA (1) CA2176036A1 (fi)
CZ (1) CZ171796A3 (fi)
DE (1) DE69431069T2 (fi)
DK (1) DK0734383T3 (fi)
ES (1) ES2179094T3 (fi)
FI (1) FI962418A (fi)
HU (1) HUT76275A (fi)
IL (1) IL111970A (fi)
NO (1) NO962543L (fi)
NZ (1) NZ277291A (fi)
PL (1) PL315035A1 (fi)
PT (1) PT734383E (fi)
SG (1) SG52667A1 (fi)
SK (1) SK76396A3 (fi)
WO (1) WO1995016682A1 (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
GB9408872D0 (en) * 1994-05-03 1994-06-22 Zeneca Ltd Heterocyclic compounds
EP0709375B1 (en) * 1994-10-25 2005-05-18 AstraZeneca AB Therapeutic heterocycles
US5998444A (en) * 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9508786D0 (en) 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
GB9521781D0 (en) * 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
WO1998031364A1 (en) * 1997-01-21 1998-07-23 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6124319A (en) * 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6281248B1 (en) 2000-02-16 2001-08-28 Magda Abdel Fattah Ahmed Composition for treating asthma
US6846814B2 (en) 2000-04-06 2005-01-25 Astra Zeneca Ab Neurokinin antagonists for use as medicaments
US20050142495A1 (en) * 2003-10-09 2005-06-30 David Peter Van Heerden Methods of controlling multilayer foil ignition
US7441688B2 (en) * 2003-11-04 2008-10-28 Reactive Nanotechnologies Methods and device for controlling pressure in reactive multilayer joining and resulting product
US7121402B2 (en) * 2003-04-09 2006-10-17 Reactive Nano Technologies, Inc Container hermetically sealed with crushable material and reactive multilayer material
US20050136270A1 (en) * 2003-05-13 2005-06-23 Etienne Besnoin Method of controlling thermal waves in reactive multilayer joining and resulting product
ES2299561T3 (es) 2001-01-26 2008-06-01 Btg International Limited Analogo de bencilamina.
CN1968932A (zh) 2004-06-18 2007-05-23 惠氏公司 制备6－烷基－5－芳基磺酰基－二氢菲啶的方法
ES2595240T3 (es) 2012-07-09 2016-12-28 Lupin Limited Derivados de tetrahidroquinazolinona como inhibidores de PARP

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
JPH08511522A (ja) * 1993-06-07 1996-12-03 メルク エンド カンパニー インコーポレーテッド ニューロキニンアンタゴニストとしてのスピロ置換アザ環
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives

Also Published As

Publication number Publication date
BR9408325A (pt) 1997-08-19
SG52667A1 (en) 1998-09-28
ES2179094T3 (es) 2003-01-16
AU1247195A (en) 1995-07-03
IL111970A (en) 1999-03-12
SK76396A3 (en) 1996-12-04
NZ277291A (en) 1997-12-19
JPH09506608A (ja) 1997-06-30
WO1995016682A1 (en) 1995-06-22
CN1142822A (zh) 1997-02-12
HUT76275A (en) 1997-07-28
AU690951B2 (en) 1998-05-07
PL315035A1 (en) 1996-09-30
US5705505A (en) 1998-01-06
NO962543L (no) 1996-08-14
US5965576A (en) 1999-10-12
DE69431069D1 (de) 2002-08-29
PT734383E (pt) 2002-12-31
CA2176036A1 (en) 1995-06-22
CZ171796A3 (en) 1996-09-11
FI962418A0 (fi) 1996-06-11
EP0734383B1 (en) 2002-07-24
DE69431069T2 (de) 2003-05-08
US5589489A (en) 1996-12-31
HU9601568D0 (en) 1996-08-28
EP0734383A1 (en) 1996-10-02
NO962543D0 (no) 1996-06-14
ATE221064T1 (de) 2002-08-15
IL111970A0 (en) 1995-03-15
JP3819934B2 (ja) 2006-09-13
FI962418A (fi) 1996-06-11

Similar Documents

Publication Publication Date Title
DK0734383T3 (da) Cykliske amidderivater som neurokinin-A-antagonister
DK0726893T3 (da) Hidtil ukendte 4-piperidinyl-substituerede lactamer som neurokinon 2-receptor-antagonister til behandling af astma
CA2166800A1 (en) 4-substituted piperidine derivatives useful as neurokinin antagonists
NO20085078L (no) Nye forbindelser
NO982222L (no) 3-(4-Subst.-piperidinyl-1)-1-(3,4-diklorfenyl)propylkarbamater og -ureaer og derivater som neurokinin-antagonister
NO20052683L (no) Nye pyridopyrimidinonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
IL114894A (en) Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
NO20060146L (no) Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
DK0733051T3 (da) Bicykliske, heterocykliske forbindelser som neurokinin A-antagonister
NO973652D0 (no) 5-(4-subst.-piperidinyl-1)-3-aryl-pentansyre og derivater som tachykininreseptor-antagonist
PT992509E (pt) Novos derivados macrolidos