DK0726899T3 - Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler - Google Patents

Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler

Info

Publication number
DK0726899T3
DK0726899T3 DK94931018T DK94931018T DK0726899T3 DK 0726899 T3 DK0726899 T3 DK 0726899T3 DK 94931018 T DK94931018 T DK 94931018T DK 94931018 T DK94931018 T DK 94931018T DK 0726899 T3 DK0726899 T3 DK 0726899T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
preparation
new
pyrazinecarboxamide derivatives
pyrazinecarboxamide
Prior art date
Application number
DK94931018T
Other languages
Danish (da)
English (en)
Inventor
Dietrich Arndts
Otto Roos
Georg Speck
Walter Lisel
Wolf-Dietrich Bechtel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0726899T3 publication Critical patent/DK0726899T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK94931018T 1993-11-04 1994-10-31 Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler DK0726899T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4337609A DE4337609A1 (de) 1993-11-04 1993-11-04 Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
PCT/EP1994/003580 WO1995012592A1 (fr) 1993-11-04 1994-10-31 Nouveaux derives de pyrazinecarboxamide, leur preparation et leur utilisation dans des medicaments

Publications (1)

Publication Number Publication Date
DK0726899T3 true DK0726899T3 (da) 2000-06-26

Family

ID=6501757

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94931018T DK0726899T3 (da) 1993-11-04 1994-10-31 Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler

Country Status (17)

Country Link
EP (1) EP0726899B1 (fr)
JP (1) JPH09505035A (fr)
KR (1) KR960705815A (fr)
CN (1) CN1134151A (fr)
AT (1) ATE188965T1 (fr)
AU (1) AU690588B2 (fr)
CA (1) CA2175837A1 (fr)
CO (1) CO4290432A1 (fr)
DE (2) DE4337609A1 (fr)
DK (1) DK0726899T3 (fr)
ES (1) ES2140565T3 (fr)
GR (1) GR3033034T3 (fr)
NZ (1) NZ274848A (fr)
PL (1) PL314187A1 (fr)
PT (1) PT726899E (fr)
WO (1) WO1995012592A1 (fr)
ZA (1) ZA948669B (fr)

Families Citing this family (28)

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Publication number Priority date Publication date Assignee Title
DE19548812A1 (de) * 1995-12-27 1997-07-03 Hoechst Ag Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation
DE19738604A1 (de) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe
CA2375702A1 (fr) 1999-06-03 2000-12-14 Takeda Chemical Industries, Ltd. Preparations s'administrant par voie nasale
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
KR20050008691A (ko) 2002-04-19 2005-01-21 셀룰러 지노믹스 아이엔씨 이미다조[1,2-ａ]피라진-8-일 아민, 그의 제조방법 및사용방법
WO2004022562A1 (fr) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-arykl-imidazo[1,2-a]pyrazin-8-ylamines, procede de preparation et procede d'utilisation correspondants
US7160885B2 (en) 2003-02-10 2007-01-09 Cgi Pharmaceuticals, Inc. Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
CN1845924A (zh) 2003-07-02 2006-10-11 弗·哈夫曼-拉罗切有限公司 芳基胺取代的喹唑啉酮化合物
WO2005019220A2 (fr) 2003-08-11 2005-03-03 Cellular Genomics Inc. Imidazo[1,2-a]pyrazines substituees utilisees comme modulateurs de l'activite d'une kinase
WO2005030776A1 (fr) 2003-09-23 2005-04-07 Vertex Pharmaceuticals Incorporated Derives de pyrazolopyrrole utilises en tant qu'inhibiteurs de proteines kinases
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
NZ587039A (en) 2008-02-13 2013-01-25 Gilead Connecticut Inc 6-aryl-imidazo[1, 2-a]pyrazine derivatives, method of making, and method of use thereof
SI2716157T1 (sl) 2008-12-08 2016-10-28 Gilead Connecticut, Inc., c/o Gilead Sciences, Inc. Imidazopirazinski Syk-inhibitorji
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
ES2744541T3 (es) 2008-12-08 2020-02-25 Gilead Connecticut Inc Inhibidores de imidazopirazina Syk
KR101717809B1 (ko) 2010-03-11 2017-03-17 질레드 코네티컷 인코포레이티드 이미다조피리딘 ｓｙｋ 억제제
KR101944552B1 (ko) 2010-09-13 2019-01-31 오쓰까 세이야꾸 가부시키가이샤 세로토닌, 노르에피네프린 또는 도파민의 감소된 신경전달에 의해 야기된 장애의 치료 또는 예방용 헤테로시클릭 화합물
TW201601728A (zh) 2013-07-30 2016-01-16 吉李德康乃狄克公司 脾酪胺酸激酶（ＳｙＫ）抑制劑之調合物
AU2014296308C1 (en) 2013-07-30 2018-09-13 Kronos Bio, Inc. Polymorph of Syk inhibitors
CN103467392B (zh) * 2013-10-09 2016-08-17 重庆工商大学 一种多卤代吡嗪甲酰胺衍生物及其盐类、制备方法和用途
MX2016007311A (es) 2013-12-04 2016-09-07 Gilead Sciences Inc Metodos para tratar canceres.
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
TWI662037B (zh) 2013-12-23 2019-06-11 美商基利科學股份有限公司 脾酪胺酸激酶抑制劑
BR112016028641A2 (pt) 2014-07-14 2017-08-22 Gilead Sciences Inc ?método para tratar câncer?
CN115028640A (zh) 2017-08-25 2022-09-09 吉利德科学公司 Syk抑制剂的多晶型物
EP3927708A1 (fr) 2019-02-22 2021-12-29 Kronos Bio, Inc. Formes solides de pyrazines condensées en tant qu'inhibiteur de syk

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (fr) * 1962-10-30
TW213903B (fr) * 1991-08-16 1993-10-01 Boehringer Ingelheim Kg

Also Published As

Publication number Publication date
DE59409094D1 (de) 2000-02-24
CA2175837A1 (fr) 1995-05-11
GR3033034T3 (en) 2000-08-31
JPH09505035A (ja) 1997-05-20
PT726899E (pt) 2000-04-28
NZ274848A (en) 1998-03-25
WO1995012592A1 (fr) 1995-05-11
ES2140565T3 (es) 2000-03-01
CO4290432A1 (es) 1996-04-17
KR960705815A (ko) 1996-11-08
CN1134151A (zh) 1996-10-23
ATE188965T1 (de) 2000-02-15
AU7993694A (en) 1995-05-23
DE4337609A1 (de) 1995-05-11
EP0726899A1 (fr) 1996-08-21
EP0726899B1 (fr) 2000-01-19
AU690588B2 (en) 1998-04-30
ZA948669B (en) 1995-07-04
PL314187A1 (en) 1996-09-02

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