ZA948669B - New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions - Google Patents
New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositionsInfo
- Publication number
- ZA948669B ZA948669B ZA948669A ZA948669A ZA948669B ZA 948669 B ZA948669 B ZA 948669B ZA 948669 A ZA948669 A ZA 948669A ZA 948669 A ZA948669 A ZA 948669A ZA 948669 B ZA948669 B ZA 948669B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparation
- pharmaceutical compositions
- carboxamide derivatives
- pyrazine carboxamide
- new pyrazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4337609A DE4337609A1 (de) | 1993-11-04 | 1993-11-04 | Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA948669B true ZA948669B (en) | 1995-07-04 |
Family
ID=6501757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA948669A ZA948669B (en) | 1993-11-04 | 1994-11-03 | New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0726899B1 (fr) |
| JP (1) | JPH09505035A (fr) |
| KR (1) | KR960705815A (fr) |
| CN (1) | CN1134151A (fr) |
| AT (1) | ATE188965T1 (fr) |
| AU (1) | AU690588B2 (fr) |
| CA (1) | CA2175837A1 (fr) |
| CO (1) | CO4290432A1 (fr) |
| DE (2) | DE4337609A1 (fr) |
| DK (1) | DK0726899T3 (fr) |
| ES (1) | ES2140565T3 (fr) |
| GR (1) | GR3033034T3 (fr) |
| NZ (1) | NZ274848A (fr) |
| PL (1) | PL314187A1 (fr) |
| PT (1) | PT726899E (fr) |
| WO (1) | WO1995012592A1 (fr) |
| ZA (1) | ZA948669B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19548812A1 (de) * | 1995-12-27 | 1997-07-03 | Hoechst Ag | Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation |
| DE19738604A1 (de) * | 1997-09-04 | 1999-03-11 | Hoechst Marion Roussel De Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe |
| WO2000075115A1 (fr) | 1999-06-03 | 2000-12-14 | Takeda Chemical Industries, Ltd. | Preparations s'administrant par voie nasale |
| US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
| JP2005530739A (ja) | 2002-04-19 | 2005-10-13 | セルラー ジェノミクス，インコーポレーテッド | イミダゾ［１，２−ａ］ピラジン−８−イルアミン、生成方法、および使用方法 |
| US7312341B2 (en) | 2002-09-09 | 2007-12-25 | Cgi Pharmaceuticals, Inc. | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof |
| WO2004072080A1 (fr) | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | 8-heteroaryle-6-phenyle-imidazo[1,2-a]pyrazines comme modulateurs de l'activite du complexe hsp90 |
| WO2005014599A1 (fr) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines et methodes d'inhibition de la tyrosine kinase de bruton par de tels composes |
| US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
| KR100802856B1 (ko) | 2003-07-02 | 2008-02-12 | 에프. 호프만-라 로슈 아게 | 아릴아민-치환된 퀴나졸린온 화합물 |
| WO2005019220A2 (fr) | 2003-08-11 | 2005-03-03 | Cellular Genomics Inc. | Imidazo[1,2-a]pyrazines substituees utilisees comme modulateurs de l'activite d'une kinase |
| AU2004276341B2 (en) | 2003-09-23 | 2011-04-14 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrrole derivatives as protein kinase inhibitors |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| JP5496915B2 (ja) | 2008-02-13 | 2014-05-21 | シージーアイ ファーマシューティカルズ，インコーポレーテッド | ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法 |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| US8440667B2 (en) | 2008-12-08 | 2013-05-14 | Gilead Connecticut, Inc. | Imidazopyrazine Syk inhibitors |
| PE20120058A1 (es) | 2008-12-08 | 2012-02-02 | Gilead Connecticut Inc | Derivados de imidazopirazina como inhibidores de syk |
| NZ602362A (en) | 2010-03-11 | 2014-11-28 | Gilead Connecticut Inc | Imidazopyridines syk inhibitors |
| ES2553387T3 (es) | 2010-09-13 | 2015-12-09 | Otsuka Pharmaceutical Co., Ltd. | Compuestos heterocíclicos para el tratamiento o la prevención de trastornos causados por neurotransmisión reducida de serotonina, norepinefrina o dopamina |
| MX2016001304A (es) | 2013-07-30 | 2016-04-07 | Gilead Connecticut Inc | Polimorfo de inhibidores de syk. |
| BR112016001678A2 (pt) | 2013-07-30 | 2017-09-19 | Gilead Connecticut Inc | Composição, método de fabricação de um comprimido, comprimido, forma de dosagem unitária, artigo de fabricação, e, uso de uma composição, de um comprimido ou de uma forma de dosagem unitária |
| CN103467392B (zh) * | 2013-10-09 | 2016-08-17 | 重庆工商大学 | 一种多卤代吡嗪甲酰胺衍生物及其盐类、制备方法和用途 |
| DK3076976T3 (da) | 2013-12-04 | 2020-12-07 | Kronos Bio Inc | Fremgangsmåder til behandling af cancer |
| UY35898A (es) | 2013-12-23 | 2015-07-31 | Gilead Sciences Inc | ?compuestos inhibidores de syk y composiciones que los comprenden?. |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| MA40075A (fr) | 2014-07-14 | 2016-01-21 | Gilead Sciences Inc | Combinaisons pour traiter des cancers |
| KR20220070056A (ko) | 2017-08-25 | 2022-05-27 | 길리애드 사이언시즈, 인코포레이티드 | Syk 억제제의 다형체 |
| US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE639386A (fr) * | 1962-10-30 | |||
| TW213903B (fr) * | 1991-08-16 | 1993-10-01 | Boehringer Ingelheim Kg |
-
1993
- 1993-11-04 DE DE4337609A patent/DE4337609A1/de not_active Withdrawn
-
1994
- 1994-10-31 PT PT94931018T patent/PT726899E/pt unknown
- 1994-10-31 EP EP94931018A patent/EP0726899B1/fr not_active Expired - Lifetime
- 1994-10-31 JP JP7513010A patent/JPH09505035A/ja active Pending
- 1994-10-31 WO PCT/EP1994/003580 patent/WO1995012592A1/fr active IP Right Grant
- 1994-10-31 PL PL94314187A patent/PL314187A1/xx unknown
- 1994-10-31 DE DE59409094T patent/DE59409094D1/de not_active Expired - Fee Related
- 1994-10-31 AU AU79936/94A patent/AU690588B2/en not_active Ceased
- 1994-10-31 AT AT94931018T patent/ATE188965T1/de not_active IP Right Cessation
- 1994-10-31 CA CA002175837A patent/CA2175837A1/fr not_active Abandoned
- 1994-10-31 NZ NZ274848A patent/NZ274848A/en unknown
- 1994-10-31 DK DK94931018T patent/DK0726899T3/da active
- 1994-10-31 ES ES94931018T patent/ES2140565T3/es not_active Expired - Lifetime
- 1994-10-31 CN CN94194016A patent/CN1134151A/zh active Pending
- 1994-11-02 CO CO94050173A patent/CO4290432A1/es unknown
- 1994-11-03 ZA ZA948669A patent/ZA948669B/xx unknown
-
1996
- 1996-05-03 KR KR1019960702301A patent/KR960705815A/ko not_active Application Discontinuation
-
2000
- 2000-03-22 GR GR20000400720T patent/GR3033034T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT726899E (pt) | 2000-04-28 |
| CA2175837A1 (fr) | 1995-05-11 |
| KR960705815A (ko) | 1996-11-08 |
| CO4290432A1 (es) | 1996-04-17 |
| AU7993694A (en) | 1995-05-23 |
| DK0726899T3 (da) | 2000-06-26 |
| JPH09505035A (ja) | 1997-05-20 |
| AU690588B2 (en) | 1998-04-30 |
| ES2140565T3 (es) | 2000-03-01 |
| EP0726899B1 (fr) | 2000-01-19 |
| ATE188965T1 (de) | 2000-02-15 |
| NZ274848A (en) | 1998-03-25 |
| EP0726899A1 (fr) | 1996-08-21 |
| DE59409094D1 (de) | 2000-02-24 |
| WO1995012592A1 (fr) | 1995-05-11 |
| GR3033034T3 (en) | 2000-08-31 |
| DE4337609A1 (de) | 1995-05-11 |
| CN1134151A (zh) | 1996-10-23 |
| PL314187A1 (en) | 1996-09-02 |
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