DK0719343T3 - Adeno-associerede virale (AAV) liposomer og fremgangsmåde forbundet dermed - Google Patents
Adeno-associerede virale (AAV) liposomer og fremgangsmåde forbundet dermedInfo
- Publication number
- DK0719343T3 DK0719343T3 DK94927972T DK94927972T DK0719343T3 DK 0719343 T3 DK0719343 T3 DK 0719343T3 DK 94927972 T DK94927972 T DK 94927972T DK 94927972 T DK94927972 T DK 94927972T DK 0719343 T3 DK0719343 T3 DK 0719343T3
- Authority
- DK
- Denmark
- Prior art keywords
- aav
- adeno
- liposomes
- cells
- viral
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title abstract 2
- 239000000463 material Substances 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Medical Informatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12060593A | 1993-09-13 | 1993-09-13 | |
US08/305,221 US5834441A (en) | 1993-09-13 | 1994-09-12 | Adeno-associated viral (AAV) liposomes and methods related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0719343T3 true DK0719343T3 (da) | 2004-04-26 |
Family
ID=26818551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94927972T DK0719343T3 (da) | 1993-09-13 | 1994-09-13 | Adeno-associerede virale (AAV) liposomer og fremgangsmåde forbundet dermed |
Country Status (15)
Country | Link |
---|---|
US (3) | US5834441A (fr) |
EP (1) | EP0719343B1 (fr) |
JP (1) | JPH09505982A (fr) |
KR (1) | KR100421753B1 (fr) |
AT (1) | ATE257177T1 (fr) |
AU (1) | AU692470B2 (fr) |
CA (1) | CA2171318A1 (fr) |
DE (1) | DE69433462T2 (fr) |
DK (1) | DK0719343T3 (fr) |
ES (1) | ES2213149T3 (fr) |
FI (1) | FI961146A (fr) |
NO (1) | NO961010L (fr) |
PT (1) | PT719343E (fr) |
SG (1) | SG48099A1 (fr) |
WO (1) | WO1995007995A2 (fr) |
Families Citing this family (101)
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US6652850B1 (en) | 1993-09-13 | 2003-11-25 | Aventis Pharmaceuticals Inc. | Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity |
US6197553B1 (en) | 1994-07-15 | 2001-03-06 | Merck & Co., Inc. | Method for large scale plasmid purification |
JPH10503086A (ja) * | 1994-07-15 | 1998-03-24 | メルク エンド カンパニー インコーポレーテッド | 大規模プラスミド精製方法 |
US5856152A (en) * | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
US6342390B1 (en) * | 1994-11-23 | 2002-01-29 | The United States Of America As Represented By The Secretary Of Health And Human Services | Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy |
US5843742A (en) * | 1994-12-16 | 1998-12-01 | Avigen Incorporated | Adeno-associated derived vector systems for gene delivery and integration into target cells |
AR003122A1 (es) * | 1995-05-19 | 1998-07-08 | Merck & Co Inc | Un proceso para aislacion y purificacion de plasmidos en fermentadores de gran escala y el adn aislado y purificado obtenido mediante dicho proceso. |
AU6504596A (en) * | 1995-07-21 | 1997-02-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity |
US6086913A (en) * | 1995-11-01 | 2000-07-11 | University Of British Columbia | Liposomal delivery of AAV vectors |
US5952221A (en) * | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
DE19608751B4 (de) | 1996-03-06 | 2006-05-18 | Medigene Ag | Verwendung eines Adeno-assoziierten Virus-Vektors zur Steigerung der Immunogenität von Zellen |
US5866552A (en) * | 1996-09-06 | 1999-02-02 | The Trustees Of The University Of Pennsylvania | Method for expressing a gene in the absence of an immune response |
US6251677B1 (en) | 1997-08-25 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
US6759237B1 (en) * | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
ES2340230T3 (es) * | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
US6602705B1 (en) | 1998-12-31 | 2003-08-05 | Chiron Corporation | Expression of HIV polypeptides and production of virus-like particles |
US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
US6387368B1 (en) | 1999-02-08 | 2002-05-14 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
US6165754A (en) * | 1999-06-08 | 2000-12-26 | Cornell Research Foundation, Inc. | Method of expressing an exogenous nucleic acid |
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US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
EP2292772A1 (fr) | 2001-07-05 | 2011-03-09 | Novartis Vaccines and Diagnostics, Inc. | Vaccination VIH avec un ADN codant un polypeptide VIH et un polypeptide VIH |
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WO2007068784A1 (fr) | 2005-12-14 | 2007-06-21 | Licentia Ltd | Nouveau facteur neurotrophique et utilisations de celui-ci |
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US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
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US7582442B2 (en) * | 2004-03-16 | 2009-09-01 | The Regents Of The University Of Michigan | Methods and compositions for using aleveolar macrophage phospholipase A2 |
US7319015B2 (en) * | 2004-03-16 | 2008-01-15 | The Regents Of The University Of Michigan | Methods and compositions for using alveolar macrophage phospholipase A2 |
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AU2005287393A1 (en) * | 2004-06-18 | 2006-03-30 | The University Of Montana | AAV mediated gene delivery to cochlear cells |
US20090233986A1 (en) * | 2004-07-27 | 2009-09-17 | Mount Sinai School Of Medicine | Methods and compositions for using sax2 |
FI20050753A (fi) | 2004-09-03 | 2006-03-04 | Licentia Oy | Uudet peptidit |
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WO2006101629A2 (fr) | 2005-02-17 | 2006-09-28 | Vertex Pharmaceuticals Incorporated | Variant d'epissage d'une sous-unite alpha de proteine type iii de canal sodique |
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US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
US8859229B2 (en) * | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
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US20120040367A1 (en) | 2007-10-15 | 2012-02-16 | The University Of Queensland | Construct system and uses therefor |
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JP2011526916A (ja) | 2008-06-30 | 2011-10-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 全身性紅斑性狼瘡を同定および処置するための診断標的および治療標的としてのリソソームホスホリパーゼa2(lpla2)活性 |
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ES2625406T3 (es) | 2010-03-25 | 2017-07-19 | Oregon Health & Science University | Glicoproteínas de CMV y vectores recombinantes |
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EP2710037B1 (fr) | 2011-05-19 | 2019-07-31 | The Regents of The University of Michigan | Agents se liant à l'intégrine alpha-2 et leur utilisation pour inhiber la prolifération des cellules cancéreuses |
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WO2016168601A1 (fr) | 2015-04-17 | 2016-10-20 | Khalid Shah | Agents, systèmes et méthodes de traitement du cancer |
CN107708718B (zh) | 2015-04-22 | 2022-01-11 | 西达-赛奈医疗中心 | 用于治疗2型糖尿病的肠内递送的苦味寡肽 |
EP3294755B1 (fr) | 2015-05-13 | 2023-08-23 | The United States of America as represented by the Secretary of the Department of Health and Human Services | Methodes et compositions pour eliciter des reponses immune a base des constructs contenant des elements conservatives |
WO2016196366A1 (fr) | 2015-05-29 | 2016-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Extension de durée de vie réplicative dans des maladies de vieillissement prématuré à l'aide d'isoformes p53 |
WO2017004022A2 (fr) | 2015-06-29 | 2017-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Constructions de fusion de degron et procédés de régulation de la production de protéine |
EP3386593A4 (fr) | 2015-12-09 | 2019-07-24 | Admedus Vaccines Pty Ltd | Composition immunomodulatrice pour le traitement |
WO2018215936A1 (fr) | 2017-05-24 | 2018-11-29 | Novartis Ag | Protéines greffées d'anticorps-cytokine et procédés d'utilisation dans le traitement du cancer |
CN111363761A (zh) * | 2020-03-17 | 2020-07-03 | 苏州吉恒基因科技有限公司 | 利用阳离子多聚体dna复合物促进aav介导的基因表达方法 |
EP4419684A1 (fr) | 2021-10-21 | 2024-08-28 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Leurres de facteur de transcription générés par rétro-éléments |
EP4426832A1 (fr) | 2021-11-03 | 2024-09-11 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Édition précise du génome à l'aide de rétrons |
WO2023141602A2 (fr) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Rétrons modifiés et méthodes d'utilisation |
WO2023183589A1 (fr) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Édition génomique à fidélité de rt-adn et à rétrons |
WO2023183627A1 (fr) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Production d'adn transcrit inversé (adn-rt) au moyen d'une rétron transcriptase inverse à partir d'adn exogène |
WO2023183588A1 (fr) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Procédés d'évaluation de l'activité rétronique modifiée et leurs utilisations |
WO2024020346A2 (fr) | 2022-07-18 | 2024-01-25 | Renagade Therapeutics Management Inc. | Composants d'édition génique, systèmes et procédés d'utilisation |
WO2024044673A1 (fr) | 2022-08-24 | 2024-02-29 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Éditeurs de rétron à double coupe pour insertions et délétions génomiques |
WO2024044723A1 (fr) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Rétrons modifiés et méthodes d'utilisation |
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US4394448A (en) * | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
CA1203049A (fr) * | 1981-08-10 | 1986-04-08 | Ahti A. Koski | Preparation de peroxyde de zinc |
JPH0634727B2 (ja) * | 1984-08-17 | 1994-05-11 | 東レ株式会社 | ベクタ−および形質転換体 |
FR2583770B1 (fr) * | 1985-06-21 | 1988-08-19 | Transgene Sa | Expression de l'il-2 humaine dans les cellules de mammiferes par un poxvirus recombine |
CA1341303C (fr) * | 1985-06-28 | 2001-10-09 | Gary R. Landucci | Cellules effectrices activees par des lymphokines pour le traitement, par cytotoxicite cellulaire dependant des anticorps, du cancer et autres maladies |
US5139941A (en) * | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US4935372A (en) * | 1986-05-20 | 1990-06-19 | Dana Farber Cancer Institute | Art nucleotide segments, vectors, cell lines methods of preparation and use |
US5198344A (en) * | 1986-07-15 | 1993-03-30 | Massachusetts Institute Of Technology | DNA sequence that encodes the multidrug resistance gene |
US5250431A (en) * | 1988-06-13 | 1993-10-05 | Dana-Farber Cancer Institute, Inc. | Alteration of the interaction of a T-cell receptor with a proteintyrosine kinase |
WO1990010059A1 (fr) * | 1989-02-21 | 1990-09-07 | Terumo Corporation | Procede de generation de lymphocytes cd4 proliferatifs |
WO1990013629A1 (fr) * | 1989-05-11 | 1990-11-15 | The Public Health Research Institute Of The City Of New York, Inc. | Procede d'activation de cellules t |
DE69017769T2 (de) * | 1989-06-27 | 1995-07-13 | Smithkline Beecham Biologicals S.A., Rixensart | Verbindungen. |
US5126132A (en) * | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
US5436146A (en) * | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
US5188959A (en) * | 1989-09-28 | 1993-02-23 | Trustees Of Tufts College | Extracellular matrix protein adherent t cells |
US5252479A (en) * | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
EP0624192A1 (fr) * | 1992-01-22 | 1994-11-17 | New England Deaconess Hospital | Nouvelles tyrosine kinases de proteines |
US5587308A (en) * | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
-
1994
- 1994-09-12 US US08/305,221 patent/US5834441A/en not_active Expired - Fee Related
- 1994-09-13 DE DE1994633462 patent/DE69433462T2/de not_active Expired - Fee Related
- 1994-09-13 AU AU77175/94A patent/AU692470B2/en not_active Ceased
- 1994-09-13 CA CA002171318A patent/CA2171318A1/fr not_active Abandoned
- 1994-09-13 KR KR1019960701259A patent/KR100421753B1/ko not_active IP Right Cessation
- 1994-09-13 AT AT94927972T patent/ATE257177T1/de not_active IP Right Cessation
- 1994-09-13 PT PT94927972T patent/PT719343E/pt unknown
- 1994-09-13 EP EP94927972A patent/EP0719343B1/fr not_active Expired - Lifetime
- 1994-09-13 SG SG1996007027A patent/SG48099A1/en unknown
- 1994-09-13 JP JP7509211A patent/JPH09505982A/ja active Pending
- 1994-09-13 WO PCT/US1994/009774 patent/WO1995007995A2/fr active IP Right Grant
- 1994-09-13 DK DK94927972T patent/DK0719343T3/da active
- 1994-09-13 ES ES94927972T patent/ES2213149T3/es not_active Expired - Lifetime
-
1995
- 1995-06-02 US US08/458,342 patent/US5861171A/en not_active Expired - Fee Related
- 1995-06-06 US US08/471,603 patent/US5861314A/en not_active Expired - Fee Related
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1996
- 1996-03-12 NO NO961010A patent/NO961010L/no not_active Application Discontinuation
- 1996-03-12 FI FI961146A patent/FI961146A/fi not_active IP Right Cessation
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Publication number | Publication date |
---|---|
KR100421753B1 (ko) | 2004-07-01 |
EP0719343B1 (fr) | 2004-01-02 |
DE69433462T2 (de) | 2004-11-18 |
NO961010L (no) | 1996-05-07 |
KR960705055A (ko) | 1996-10-09 |
WO1995007995A3 (fr) | 1995-07-20 |
EP0719343A1 (fr) | 1996-07-03 |
FI961146A0 (fi) | 1996-03-12 |
AU692470B2 (en) | 1998-06-11 |
AU7717594A (en) | 1995-04-03 |
ES2213149T3 (es) | 2004-08-16 |
US5834441A (en) | 1998-11-10 |
US5861314A (en) | 1999-01-19 |
WO1995007995A2 (fr) | 1995-03-23 |
NO961010D0 (no) | 1996-03-12 |
US5861171A (en) | 1999-01-19 |
CA2171318A1 (fr) | 1995-03-23 |
DE69433462D1 (de) | 2004-02-05 |
ATE257177T1 (de) | 2004-01-15 |
FI961146A (fi) | 1996-05-10 |
JPH09505982A (ja) | 1997-06-17 |
PT719343E (pt) | 2004-05-31 |
SG48099A1 (en) | 1998-04-17 |
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