DK0642332T3 - Ophthalmiske præparater indeholdende cyclosporin - Google Patents

Ophthalmiske præparater indeholdende cyclosporin

Info

Publication number
DK0642332T3
DK0642332T3 DK93909919.8T DK93909919T DK0642332T3 DK 0642332 T3 DK0642332 T3 DK 0642332T3 DK 93909919 T DK93909919 T DK 93909919T DK 0642332 T3 DK0642332 T3 DK 0642332T3
Authority
DK
Denmark
Prior art keywords
preparations containing
ophthalmic preparations
containing cyclosporin
eye
cyclosporin
Prior art date
Application number
DK93909919.8T
Other languages
Danish (da)
English (en)
Inventor
Yoichi Kawashima
Mitsuaki Kuwano
Original Assignee
Sandoz Ltd
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929210226A external-priority patent/GB9210226D0/en
Priority claimed from GB929224367A external-priority patent/GB9224367D0/en
Application filed by Sandoz Ltd, Sandoz Ag filed Critical Sandoz Ltd
Application granted granted Critical
Publication of DK0642332T3 publication Critical patent/DK0642332T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK93909919.8T 1992-05-13 1993-05-07 Ophthalmiske præparater indeholdende cyclosporin DK0642332T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929210226A GB9210226D0 (en) 1992-05-13 1992-05-13 Pharmaceutical compositions
GB929224367A GB9224367D0 (en) 1992-11-20 1992-11-20 Organic compounds

Publications (1)

Publication Number Publication Date
DK0642332T3 true DK0642332T3 (da) 1997-06-16

Family

ID=26300871

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93909919.8T DK0642332T3 (da) 1992-05-13 1993-05-07 Ophthalmiske præparater indeholdende cyclosporin

Country Status (14)

Country Link
US (2) US5951971A (de)
EP (1) EP0642332B1 (de)
JP (2) JP3631490B2 (de)
KR (1) KR100344083B1 (de)
CN (1) CN1074932C (de)
AT (1) ATE147619T1 (de)
DE (1) DE69307505T2 (de)
DK (1) DK0642332T3 (de)
ES (1) ES2098739T3 (de)
GR (1) GR3022990T3 (de)
HK (1) HK1004520A1 (de)
SG (1) SG45449A1 (de)
TW (1) TW279801B (de)
WO (1) WO1993023010A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG45449A1 (en) * 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
EP0988046B1 (de) 1997-01-30 2004-09-15 Novartis AG Ölfreie pharmazeutische zusammensetzung welche cyclosporin enthält
MX9701946A (es) * 1997-03-14 1998-04-30 Arturo Jimenez Bayardo Solucion oftalmica transportadora.
AU777655B2 (en) 1999-06-03 2004-10-28 Maxim Pharmaceuticals, Inc. Ophthalmic histamine compositions and uses thereof
JP4880808B2 (ja) * 1999-11-15 2012-02-22 久光製薬株式会社 人工涙液型点眼剤組成物
ES2206363T3 (es) * 2000-04-07 2004-05-16 Laboratoire Medidom S.A. Formulaciones oftalmicas a base de ciclosporina, de acido hialuronico y de polisorbato.
ATE382057T1 (de) 2001-06-28 2008-01-15 Novo Nordisk As Stabile formulierung von modifiziertem glp-1
US20030165545A1 (en) * 2002-01-30 2003-09-04 Allergan, Inc. Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same
AU2003228126A1 (en) * 2003-05-02 2004-11-23 Arturo Jimenez Bayardo Method of preparing an aqueous solution of cyclosporin-a and resulting aqueous solution
PL1633391T3 (pl) 2003-06-03 2012-03-30 Novo Nordisk As Stabilizowane farmaceutycznie kompozycje peptydowe
JP4936884B2 (ja) 2003-06-03 2012-05-23 ノボ・ノルデイスク・エー/エス 安定化された薬学的ペプチド組成物
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
HUE038395T2 (hu) * 2003-11-20 2018-10-29 Novo Nordisk As Propilén-glikol tartalmú peptidkészítmények, amelyek elõállításra és injekciós eszközökben történõ alkalmazásra optimálisak
US7241674B2 (en) * 2004-05-13 2007-07-10 Taiwan Semiconductor Manufacturing Co., Ltd. Method of forming silicided gate structure
JP4965446B2 (ja) 2004-08-31 2012-07-04 ノヴォ ノルディスク アー/エス ペプチド、ポリペプチド及びタンパク質の安定化のためのトリス(ヒドロキシメチル)アミノメタンの使用
AU2005303777B2 (en) 2004-11-12 2010-12-16 Novo Nordisk A/S Stable formulations of insulinotropic peptides
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
JP2008535921A (ja) * 2005-04-12 2008-09-04 エラン・ファルマ・インターナショナル・リミテッド シクロスポリンを含むナノ粒子および放出調節された組成物
KR20080029974A (ko) * 2005-06-09 2008-04-03 산텐 세이야꾸 가부시키가이샤 로플루밀라스트 점안액
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
CA2625700A1 (en) * 2005-10-14 2007-04-26 Allergan, Inc. Prevention and treatment of drug-associated ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
EP1956906A4 (de) * 2005-11-09 2009-12-30 Combinatorx Inc Verfahren, zusammensetzungen und kits für die behandlung von medizinischen beschwerden
AU2016203191B2 (en) * 2006-07-25 2018-03-01 Allergan, Inc. Cyclosporin compositions
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
US20080146497A1 (en) * 2006-07-25 2008-06-19 Graham Richard S Cyclosporin Compositions
CN101896160A (zh) * 2006-10-17 2010-11-24 阿勒根公司 环胞菌素组合物
DE202007008971U1 (de) 2007-06-27 2008-11-06 Weber, Erhard, Dr. Abstandshalter aus Schaumstoff zur Füllung von Matratzenkernen, Polsterungen und Kissen
CA2710843A1 (en) * 2008-01-04 2009-07-16 Alcon Pharmaceuticals Ltd. Stable aqueous cyclosporin compositions
JP5288970B2 (ja) * 2008-09-26 2013-09-11 シスメックス株式会社 血液試料希釈用試薬を用いた平均赤血球容積の測定方法
WO2010127301A1 (en) * 2009-05-01 2010-11-04 Allergan, Inc. Method of treating allergic conjunctivitis with cyclosporin compositions
KR101690817B1 (ko) * 2009-06-30 2016-12-28 라이온 가부시키가이샤 안과용 조성물
US8492557B2 (en) 2010-09-16 2013-07-23 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol
CN103228283A (zh) * 2010-11-29 2013-07-31 千寿制药株式会社 含有二氟泼尼酯和托普霉素的水包油型乳状液组合物
US9018202B2 (en) 2010-12-03 2015-04-28 Allergan, Inc. Methods for treating diseases of the retina
DE102011108948A1 (de) * 2011-07-29 2013-01-31 Achim Göpferich Wässrige, kolloidale Lösungen von lipophilen Substanzen,insbesondere Arzneistofflösungen
EP2782569A1 (de) 2011-11-21 2014-10-01 Allergan, Inc. Pharmazeutische zusammensetzungen mit 4-[1-(2,3-dimethylphenyl-)ethyl-]3h-imidazolderivaten zur behandlung von netzhauterkrankungen
AU2012351948A1 (en) * 2011-12-16 2014-07-10 Allergan, Inc. Ophthalmic compositions comprising polyvinyl capralactam - polyvinyl acetate - polyethylene glycol graft copolymer
US20130197002A1 (en) 2012-01-30 2013-08-01 Allergan, Inc. Brimonidine for treating visual disorders mediated by central visual projections from the eye
FR2988297B1 (fr) * 2012-03-22 2014-03-28 Thea Lab Solution ophtalmique aqueuse a base de ciclosporine a sans conservateur
KR101211902B1 (ko) * 2012-04-30 2012-12-13 주식회사 휴온스 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물
FI2887923T3 (fi) * 2012-08-24 2023-06-30 Sun Pharmaceutical Ind Ltd Polyoksylilipidin tai polyoksylirasvahapon oftalminen formulaatio ja silmätilojen hoito
WO2014050301A1 (ja) * 2012-09-27 2014-04-03 千寿製薬株式会社 水性液剤
CN104812370B (zh) * 2012-11-19 2018-05-08 博士伦公司 包含2-氨基-3-(4-溴苯甲酰基)苯基乙酸的含水液体组合物
EA028008B1 (ru) * 2012-12-19 2017-09-29 Саркоуд Байосайенс Инк. Составы ингибитора lfa-1
BR112017001017A2 (pt) * 2014-07-18 2018-01-23 Allergan Inc composições em suspensão de ciclosporina a para injeção subconjuntival e periocular
WO2016013993A1 (en) 2014-07-25 2016-01-28 Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. Stable preservative free ophthalmic formulations of opioid antagonists
US20160346347A1 (en) * 2015-05-29 2016-12-01 Oculis ehf. Formation of cyclosporin a/cyclodextrin nanoparticles
KR101587385B1 (ko) * 2015-07-29 2016-01-21 국제약품공업주식회사 사이클로스포린 함유 무자극성의 안약조성물 및 편리한 제조방법
BR112018067946A8 (pt) 2016-02-29 2022-11-08 Sun Pharma Global Fze Formulações tópicas contendo ciclosporina e usos das mesmas
CN109689161A (zh) 2016-08-19 2019-04-26 阿克里维斯塔有限责任公司 诊断和治疗干眼综合症的方法以及用于治疗人眼的组合物
KR20190057338A (ko) * 2016-09-23 2019-05-28 노바리크 게엠베하 시클로스포린을 포함하는 안과 조성물
US11583496B2 (en) * 2016-10-12 2023-02-21 PS Therapy Inc. Drug vehicle compositions and methods of use thereof
CN114376961A (zh) 2017-08-18 2022-04-22 阿克里维斯塔有限责任公司 诊断和治疗干眼综合症的方法和用于治疗人类眼睛的组合物
TWI762706B (zh) 2017-08-24 2022-05-01 丹麥商諾佛 儂迪克股份有限公司 Glp-1組成物及其用途
US20220354869A1 (en) * 2019-07-01 2022-11-10 Oculis SA Method for stabilizing the ph of an aqueous composition comprising a drug
BR112022013795A2 (pt) 2020-02-18 2022-09-13 Novo Nordisk As Composição farmacêutica líquida, e, kit

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB616190A (en) 1945-11-06 1949-01-18 Procter & Gamble Improvements in application of low temperature inter-esterification or alcoholysis to glycerides
FR1274354A (fr) 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
GB1171125A (en) 1966-06-08 1969-11-19 Glaxo Lab Ltd Improvements in or relating to Injectable Preparations
US3947573A (en) * 1969-12-01 1976-03-30 Burton, Parsons And Company, Inc. Opthalmic solution
US3954967A (en) 1971-08-05 1976-05-04 Vanguard Chemical Company, Inc. Method of producing microcolloidal aqueous emulsions of unsaturated organic insecticidal compounds
US3813345A (en) 1971-08-05 1974-05-28 Vanguard Chem Co Inc Method of producing microcolloidal aqueous emulsions of unsaturated organic compounds
US4029817A (en) * 1973-09-24 1977-06-14 Allergan Pharmaceuticals Soft contact lens preserving solutions
US4073943A (en) 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4146499A (en) 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
JPS53107408A (en) 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
DE2907460A1 (de) 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
CH636013A5 (en) 1978-03-07 1983-05-13 Sandoz Ag More readily absorbable pharmaceutical composition
CH641356A5 (en) 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
NZ199915A (en) 1981-03-11 1985-07-12 Unilever Plc Treating edible oils to raise melting point thereof
FR2502951B1 (fr) 1981-04-06 1985-12-06 Sandoz Sa Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
AU558155B2 (en) 1982-02-01 1987-01-22 Sandoz Ltd. Treating multiple sclerosis with dihydro-cyclosporin d
DE3225706C2 (de) 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
DE3235612A1 (de) 1982-09-25 1984-03-29 Bayer Ag, 5090 Leverkusen Mikroemulsionen
DE3237814A1 (de) 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3315805A1 (de) 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Wirkstoffzubereitungen
JPS6061535A (ja) 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
FR2553661B1 (fr) 1983-10-19 1985-12-20 Rhone Poulenc Sante Nouvelles microemulsions pharmaceutiquement acceptables
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4794000A (en) 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
GB8903804D0 (en) 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
EP0170623B1 (de) 1984-08-02 1990-11-28 Sandoz Ag Pharmazeutische Anwendung von (NVA)2-Cyclosporine
CH662944A5 (it) 1984-10-18 1987-11-13 Pier Luigi Prof Dr Luisi Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
DE3444893A1 (de) 1984-12-08 1986-06-12 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von fettsaeuremethylestern
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
JPS61249918A (ja) 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
IL78929A0 (en) 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US5023271A (en) 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US4797272A (en) 1985-11-15 1989-01-10 Eli Lilly And Company Water-in-oil microemulsions for cosmetic uses
SE8601624D0 (sv) 1986-04-11 1986-04-11 Haessle Ab New pharmaceutical preparations
SE457693B (sv) 1986-07-01 1989-01-23 Drilletten Ab Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
EP0256856A3 (de) 1986-08-14 1989-01-11 Synthetic Blood Corporation Parenteral verabreichbares Mittel
DE3629386A1 (de) 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
DE3707711A1 (de) 1987-03-11 1988-09-22 Hoechst Ag Oel-in-wasser-emulsionen, verfahren zu deren herstellung und deren verwendung
CA1301642C (en) 1987-03-30 1992-05-26 Howard Bernard Dawson Chemical formulations
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
EP0296122B1 (de) * 1987-06-17 1993-09-29 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel
GB2206119B (en) 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
US4835002A (en) 1987-07-10 1989-05-30 Wolf Peter A Microemulsions of oil in water and alcohol
DE3851152T2 (de) 1987-09-03 1995-01-26 Univ Georgia Cyclosporin-augenmittel.
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5756450A (en) 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
HU205010B (en) 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
IL88076A (en) 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
US4914188A (en) 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
ES2033086T3 (es) 1988-01-29 1993-03-01 Sankyo Company Limited Un procedimiento para la preparacion de una composicion farmaceutica.
CH679119A5 (de) 1988-05-13 1991-12-31 Sandoz Ag
HU201567B (en) 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
KR900004323A (ko) 1988-09-29 1990-04-12 후쿠하라 요시하루 유화 조성물
FR2638089A1 (fr) 1988-10-26 1990-04-27 Sandoz Sa Nouvelles compositions ophtalmiques a base d'une cyclosporine
JPH0738771B2 (ja) 1989-01-17 1995-05-01 花王株式会社 液状食用油組成物
AU5157590A (en) 1989-02-06 1990-08-24 Abbott Laboratories Pharmaceutical compositions for oral administration
BE1003009A5 (fr) 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
US4996193A (en) 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
JP2785981B2 (ja) * 1989-11-20 1998-08-13 株式会社資生堂 乳化組成物
AU6785490A (en) 1989-12-18 1991-06-20 Kraft General Foods, Inc. Low-saturate edible oils and transesterification methods for production thereof
IL102236A0 (en) * 1991-06-27 1993-01-14 Ltt Inst Co Ltd Topical preparations containing cyclosporin
JP3065734B2 (ja) * 1991-08-27 2000-07-17 昭和電工株式会社 桂皮酸誘導体
FR2683225B1 (fr) 1991-10-31 1993-12-31 Gattefosse Sa Procede pour ameliorer une huile glycerolysee.
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
SG45449A1 (en) * 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions

Also Published As

Publication number Publication date
CN1084079A (zh) 1994-03-23
US6582718B2 (en) 2003-06-24
US5951971A (en) 1999-09-14
EP0642332A1 (de) 1995-03-15
KR100344083B1 (ko) 2002-11-23
ATE147619T1 (de) 1997-02-15
GR3022990T3 (en) 1997-07-30
DE69307505T2 (de) 1997-07-24
CN1074932C (zh) 2001-11-21
ES2098739T3 (es) 1997-05-01
WO1993023010A1 (en) 1993-11-25
JP2004346085A (ja) 2004-12-09
DE69307505D1 (de) 1997-02-27
KR950701515A (ko) 1995-04-28
HK1004520A1 (en) 1998-11-27
JP3631490B2 (ja) 2005-03-23
EP0642332B1 (de) 1997-01-15
TW279801B (de) 1996-07-01
SG45449A1 (en) 1998-01-16
US20020045601A1 (en) 2002-04-18
JPH07506579A (ja) 1995-07-20

Similar Documents

Publication Publication Date Title
DK0642332T3 (da) Ophthalmiske præparater indeholdende cyclosporin
NO955193L (no) Stabile, topiske retinoidpreparater
DE69620877D1 (de) Arzneimittelformulierungen für il-12
FI963424A0 (fi) Menetelmä terapeuttisesti aktiivisten tiofeenisulfonamidien valmistamiseksi
ES2097546T3 (es) Preparaciones cosmeticas desodorantes que contienen esteres di- o trigliceridos.
ATE202706T1 (de) Verwendung von 9-deoxyprostaglandinderivaten zur behandlung von glaukom
ITMI920074A1 (it) Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol
ES2175413T3 (es) Formulaciones de aerosol.
EP0573423A4 (en) Methods and preparations of stable, deodorized oils and pharmaceutical compositions thereof
ATE151640T1 (de) Verwendung von protease-inhibitoren als antiexudative, antiphlogistische und antimikrobielle mittel
DE69629989D1 (de) Präparate zur äusserlichen anwendung zur behandlung von dermatosen
KR100260061B1 (en) Vitamin e drop
MX9710252A (es) Utilizacion de al menos un peptido en una composicion cosmetica o para la preparacion de un medicamento.
ES2108422T3 (es) Combinaciones sinergicas de productos antisolares y composiciones cosmeticas y dermatologicas que las contienen.
WO2000018316A3 (en) Sustained release, and comfortable ophthalmic composition and method for ocular therapy
DK0445781T3 (da) Anti-glaucomapræparater indeholdende 3-arylcarbonyl-1-aminoalkyl-1H-indol
NO951989L (no) Anvendelse av amidoaminer i öyepreparater
UA74388C2 (uk) Фармацевтичні композиції тизоксаніду і нітазоксаніду
GB1537047A (en) Eye ointment
SE7705812L (sv) Farmaceutiska ogonberedningar med langsam utsondring, innehallande kollagener samt sett for framstellning derav
EP0820770A3 (de) Arzneimittel zur Behandlung von Neuropathien, das ein lipidlösliches Thiamin und ein Antioxidans enthält
IT1272274B (it) Composizioni erbicide.
WO1996025183A3 (en) Ophthalmic compositions including peptides and peptide derivatives and methods for using same
RU94032143A (ru) Композиция, содержащая препарат коагуляционного фактора viii, способ ее получения и применение поверхностно-активного вещества в качестве стабилизатора
NL7811788A (nl) Als reukstoffen toepasbare 3.5.5-trimethylhexaanzuur- esters alsmede de reukstofpreparaten daarvan.