DK0640128T3 - Vaccinesammensætninger indeholdende attenueret respiratorisk syncytialvirus - Google Patents

Vaccinesammensætninger indeholdende attenueret respiratorisk syncytialvirus

Info

Publication number
DK0640128T3
DK0640128T3 DK93912315T DK93912315T DK0640128T3 DK 0640128 T3 DK0640128 T3 DK 0640128T3 DK 93912315 T DK93912315 T DK 93912315T DK 93912315 T DK93912315 T DK 93912315T DK 0640128 T3 DK0640128 T3 DK 0640128T3
Authority
DK
Denmark
Prior art keywords
attenuated
virus
respiratory syncytial
syncytial virus
vaccine compositions
Prior art date
Application number
DK93912315T
Other languages
Danish (da)
English (en)
Inventor
Brian Robert Murphy
Robert Merritt Chanock
James Earl Crowe Jr
Mark Connors
Kuo-Hom Lee Hsu
Alan Robert Davis
Michael David Lubeck
Bernard Hugh Apt N- Selling
Original Assignee
American Home Prod
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod, Us Health filed Critical American Home Prod
Application granted granted Critical
Publication of DK0640128T3 publication Critical patent/DK0640128T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vertical, Hearth, Or Arc Furnaces (AREA)
DK93912315T 1992-04-21 1993-04-20 Vaccinesammensætninger indeholdende attenueret respiratorisk syncytialvirus DK0640128T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87274692A 1992-04-21 1992-04-21
US3994593A 1993-04-09 1993-04-09
PCT/US1993/003670 WO1993021310A1 (en) 1992-04-21 1993-04-20 Attenuated respiratory syncytial virus vaccine compositions

Publications (1)

Publication Number Publication Date
DK0640128T3 true DK0640128T3 (da) 1999-11-22

Family

ID=26716607

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912315T DK0640128T3 (da) 1992-04-21 1993-04-20 Vaccinesammensætninger indeholdende attenueret respiratorisk syncytialvirus

Country Status (18)

Country Link
US (3) US5922326A (de)
EP (1) EP0640128B1 (de)
JP (1) JP3883202B2 (de)
KR (1) KR100257171B1 (de)
AT (1) ATE181359T1 (de)
AU (1) AU683840B2 (de)
CA (1) CA2118509C (de)
DE (1) DE69325370T2 (de)
DK (1) DK0640128T3 (de)
ES (1) ES2132233T3 (de)
GR (1) GR3031208T3 (de)
HU (1) HU220189B (de)
IL (1) IL105456A (de)
MX (1) MX9302278A (de)
NZ (1) NZ252857A (de)
RU (1) RU2139729C1 (de)
UA (1) UA41315C2 (de)
WO (1) WO1993021310A1 (de)

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CN1103603C (zh) 1993-08-06 2003-03-26 康诺特实验室有限公司 灭活的呼吸合胞体病毒疫苗
US7223410B1 (en) 1994-08-05 2007-05-29 Sanofi Pasteur Limited Inactivated respiratory syncytial viral vaccines
US5716821A (en) * 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
WO1996010400A1 (en) * 1994-09-30 1996-04-11 The Uab Research Foundation Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
US6019980A (en) 1995-06-07 2000-02-01 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US6083925A (en) * 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US20050287540A1 (en) * 1995-09-27 2005-12-29 Murphy Brian R Production of attenuated negative stranded RNA virus vaccines from cloned nucleotide sequences
US6689367B1 (en) 1995-09-27 2004-02-10 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
US7485440B2 (en) 1995-09-27 2009-02-03 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
US7846455B2 (en) 1996-07-15 2010-12-07 The United States Of America As Represented By The Department Of Health And Human Services Attenuated chimeric respiratory syncytial virus
US6264957B1 (en) 1995-09-27 2001-07-24 The United States Of America As Represented By The Department Of Health And Human Services Product of infectious respiratory syncytial virus from cloned nucleotide sequences
EP0917592A4 (de) * 1996-04-04 2002-04-24 Univ Michigan Abgeschwaechter rsv
US6077514A (en) * 1996-04-04 2000-06-20 The Regents Of The University Of Michigan Attenuated respiratory syncytial virus
EP0936921B1 (de) * 1996-07-12 2003-03-19 Aventis Pasteur Limited Immunisierungsverfahren in zwei schritten gegen pyramyxoviridae-viren unter verwendung abgeschwächter viraler stämme und preparation von proteinuntereinheiten
US6699476B1 (en) 1996-07-15 2004-03-02 Peter L. Collins Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules
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US7951383B2 (en) 1997-05-23 2011-05-31 The United States Of America As Represented By The Department Of Health And Human Services Attenuated parainfluenza virus (PIV) vaccines
US7201907B1 (en) 1997-05-23 2007-04-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines
US6410023B1 (en) 1997-05-23 2002-06-25 United States Of America Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene
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FR2764903A1 (fr) * 1997-06-23 1998-12-24 Pasteur Institut Detection des infections par des paramyxovirus (virus respiratoire syncitial et virus parainfluenza) utilisant des polynucleotides codant de la proteine l
US20040005542A1 (en) 2001-06-22 2004-01-08 Krempl Christine D Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes
US7662397B2 (en) 1997-07-15 2010-02-16 The United States Of America As Represented By The Department Of Health And Human Services Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes
US6482414B1 (en) 1998-08-13 2002-11-19 The University Of Pittsburgh-Of The Commonwealth System Of Higher Education Cold-adapted equine influenza viruses
US6579528B1 (en) 1998-08-13 2003-06-17 The University Of Pittsburgh - Of The Commonwealth System Of Higher Education Cold-adapted equine influenza viruses
US6177082B1 (en) 1998-08-13 2001-01-23 The University Of Pittsburgh-Of The Commonwealth System Of Higher Education Cold-adapted equine influenza viruses
EP1690940A1 (de) 1999-04-13 2006-08-16 The Government of the United States of America as Represented by The Department of Health and Human Services Herstellung von attenuierten chimären respiratorischen Syncytialvirus-Impfstoffen aus klonierten Nukleotidsequenzen
WO2001004335A2 (en) * 1999-07-09 2001-01-18 The Government Of The United States Of America, As Represented By The Department Of Health And Humanservices Human-bovine chimeric respiratory syncytial virus vaccines
US7820182B2 (en) * 1999-07-09 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions
DE60125736D1 (de) 2000-04-03 2007-02-15 Univ Pittsburgh Zusammensetzungen, die kälteangepasste pferdeinfluenzaviren enthaltende, für die behandlung von bestehende virusinfektionen des atmungssystems
JP2005508927A (ja) * 2001-09-28 2005-04-07 ユニバーシティ オブ サウス フロリダ Ｒｓｖ遺伝子発現ワクチン
CN103540568A (zh) 2002-04-26 2014-01-29 米迪缪尼有限公司 制备流感病毒的多质粒系统
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US7687240B2 (en) * 2003-03-18 2010-03-30 Wyeth Holdings Corporation Process for increasing RSV surface glycoprotein yields using a mutant strain of RSV
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JP2011527581A (ja) * 2008-07-11 2011-11-04 メディミューン，エルエルシー インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
JP5818693B2 (ja) * 2009-02-12 2015-11-18 メディミューン，エルエルシー インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
GB201003630D0 (en) 2010-03-04 2010-04-21 Novartis Ag Avian rotavirus
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EP2836231B1 (de) 2012-04-13 2019-01-09 The United States of America, as represented by The Secretary, Department of Health and Human Services Genetisch stabiler attenuierter lebendimpfstoff gegen das respiratorische-synzytial-virus und seine herstellung
ES2762631T3 (es) * 2013-03-14 2020-05-25 Harvard College Composiciones a base de nanopartículas
CN113322264B (zh) 2013-03-14 2024-05-31 爱默蕾大学 具有沉默突变的重组rsv、其相关疫苗和方法
EP3368547A4 (de) 2015-10-29 2019-06-05 Emory University Chimäres rsv, immunogene zusammensetzungen und verfahren zur verwendung davon
RU2746280C1 (ru) * 2020-08-03 2021-04-12 Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) Штамм респираторно-синцитиального вируса RSV/Novosibirsk/66Hl/2018 для использования в диагностике респираторно-синцитиальной вирусной инфекции и исследования эффективности противовирусных препаратов in vitro

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Also Published As

Publication number Publication date
GR3031208T3 (en) 1999-12-31
AU683840B2 (en) 1997-11-27
WO1993021310A1 (en) 1993-10-28
MX9302278A (es) 1994-07-29
DE69325370T2 (de) 1999-10-14
CA2118509A1 (en) 1993-10-28
JPH07505891A (ja) 1995-06-29
NZ252857A (en) 1997-06-24
EP0640128B1 (de) 1999-06-16
RU94045898A (ru) 1996-09-20
HU9403023D0 (en) 1994-12-28
IL105456A0 (en) 1993-08-18
JP3883202B2 (ja) 2007-02-21
US6284254B1 (en) 2001-09-04
EP0640128A1 (de) 1995-03-01
AU4290793A (en) 1993-11-18
ES2132233T3 (es) 1999-08-16
CA2118509C (en) 2009-05-19
US5922326A (en) 1999-07-13
RU2139729C1 (ru) 1999-10-20
US5882651A (en) 1999-03-16
ATE181359T1 (de) 1999-07-15
DE69325370D1 (de) 1999-07-22
IL105456A (en) 1996-12-05
KR100257171B1 (ko) 2000-05-15
KR950701382A (ko) 1995-03-23
UA41315C2 (uk) 2001-09-17
HUT69992A (en) 1995-09-28
HU220189B (hu) 2001-11-28

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