MX9302278A - Composiciones de vacuna de virus sincicial. - Google Patents
Composiciones de vacuna de virus sincicial.Info
- Publication number
- MX9302278A MX9302278A MX9302278A MX9302278A MX9302278A MX 9302278 A MX9302278 A MX 9302278A MX 9302278 A MX9302278 A MX 9302278A MX 9302278 A MX9302278 A MX 9302278A MX 9302278 A MX9302278 A MX 9302278A
- Authority
- MX
- Mexico
- Prior art keywords
- attenuated
- virus
- rsv
- compositions
- respiratory syncytial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Vertical, Hearth, Or Arc Furnaces (AREA)
Abstract
La presente invención proporción composiciones de vacuna del virus sincicial respiratorio atenuado (RSV). Más particularmente, el virus atenuado puede ser un derivado del RSV, el cual ha sido atenuado incompletamente por el pasaje en frío o introducción de mutaciones, las cuales producen un virus que tiene un fenotipo sensible a la temperatura (ts) o un fenotipo adaptado al frío (ca). La invención también proporciona métodos para estimular al sistema inmune de un individuo, para inducir la protección contra el virus sincicial respiratorio por la administración de RSV atenuado. La invención también proporciona cultivos puros de virus RSV atenuado, en el que el virus ha sido atenuado más completamente por otra derivación de los mutantes ts o cp atenuados incompletamente, identificados en lo anterior.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87274692A | 1992-04-21 | 1992-04-21 | |
US3994593A | 1993-04-09 | 1993-04-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9302278A true MX9302278A (es) | 1994-07-29 |
Family
ID=26716607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9302278A MX9302278A (es) | 1992-04-21 | 1993-04-20 | Composiciones de vacuna de virus sincicial. |
Country Status (18)
Country | Link |
---|---|
US (3) | US5922326A (es) |
EP (1) | EP0640128B1 (es) |
JP (1) | JP3883202B2 (es) |
KR (1) | KR100257171B1 (es) |
AT (1) | ATE181359T1 (es) |
AU (1) | AU683840B2 (es) |
CA (1) | CA2118509C (es) |
DE (1) | DE69325370T2 (es) |
DK (1) | DK0640128T3 (es) |
ES (1) | ES2132233T3 (es) |
GR (1) | GR3031208T3 (es) |
HU (1) | HU220189B (es) |
IL (1) | IL105456A (es) |
MX (1) | MX9302278A (es) |
NZ (1) | NZ252857A (es) |
RU (1) | RU2139729C1 (es) |
UA (1) | UA41315C2 (es) |
WO (1) | WO1993021310A1 (es) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
TW275632B (es) * | 1992-04-21 | 1996-05-11 | American Cyanamid Co | |
DE69409243T2 (de) | 1993-08-06 | 1998-08-06 | Connaught Lab | Inaktivierte respiratorische synzytial-virus-impfstoffe |
US7223410B1 (en) | 1994-08-05 | 2007-05-29 | Sanofi Pasteur Limited | Inactivated respiratory syncytial viral vaccines |
WO1996010400A1 (en) * | 1994-09-30 | 1996-04-11 | The Uab Research Foundation | Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses |
US5716821A (en) * | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
US6083925A (en) | 1995-06-07 | 2000-07-04 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
US6019980A (en) * | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
US7846455B2 (en) | 1996-07-15 | 2010-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated chimeric respiratory syncytial virus |
US20050287540A1 (en) * | 1995-09-27 | 2005-12-29 | Murphy Brian R | Production of attenuated negative stranded RNA virus vaccines from cloned nucleotide sequences |
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
JPH11512609A (ja) | 1995-09-27 | 1999-11-02 | アメリカ合衆国 | クローン化されたヌクレオチド配列からの感染性RSウイルス(respiratory syncytial virus)の生産 |
US6689367B1 (en) | 1995-09-27 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
AU2438597A (en) * | 1996-04-04 | 1997-10-29 | Regents Of The University Of Michigan, The | Attenuated respiratory syncytial virus |
US6077514A (en) * | 1996-04-04 | 2000-06-20 | The Regents Of The University Of Michigan | Attenuated respiratory syncytial virus |
ATE234631T1 (de) * | 1996-07-12 | 2003-04-15 | Aventis Pasteur | Immunisierungsverfahren in zwei schritten gegen pyramyxoviridae-viren unter verwendung abgeschwächter viraler stämme und preparation von proteinuntereinheiten |
US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
EP2112220A3 (en) * | 1996-07-15 | 2010-01-06 | The Government of the United States of America, as represented by The Department of Health and Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
AU4427897A (en) * | 1996-09-27 | 1998-04-17 | American Cyanamid Company | 3' genomic promoter region and polymerase gene mutations responsible for att enuation in viruses of the order designated mononegavirales |
US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US6410023B1 (en) | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
FR2764903A1 (fr) * | 1997-06-23 | 1998-12-24 | Pasteur Institut | Detection des infections par des paramyxovirus (virus respiratoire syncitial et virus parainfluenza) utilisant des polynucleotides codant de la proteine l |
US20040005542A1 (en) | 2001-06-22 | 2004-01-08 | Krempl Christine D | Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes |
US7662397B2 (en) | 1997-07-15 | 2010-02-16 | The United States Of America As Represented By The Department Of Health And Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
US6177082B1 (en) | 1998-08-13 | 2001-01-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6482414B1 (en) | 1998-08-13 | 2002-11-19 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6579528B1 (en) | 1998-08-13 | 2003-06-17 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
WO2000061611A2 (en) | 1999-04-13 | 2000-10-19 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
US7820182B2 (en) * | 1999-07-09 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions |
EP1287152B1 (en) | 1999-07-09 | 2008-12-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Human-bovine chimeric respiratory syncytial virus vaccines |
CA2403979A1 (en) | 2000-04-03 | 2001-10-11 | The University Of Pittsburgh Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
KR20040071678A (ko) * | 2001-09-28 | 2004-08-12 | 유니버시티 오브 사우스 플로리다 | Rsv 유전자 발현 백신 |
WO2003091401A2 (en) | 2002-04-26 | 2003-11-06 | Medimmune Vaccines, Inc. | Multi plasmid system for the production of influenza virus |
US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
EP1572108A4 (en) * | 2002-09-27 | 2008-09-17 | Medimmune Vaccines Inc | FUNCTIONAL MUTATIONS OF RSV (RESPIRATORY SYNCYTIAL VIRUS) |
CA2518924C (en) * | 2003-03-18 | 2016-06-07 | Wyeth Holdings Corporation | Process for increasing rsv surface glycoprotein yields using a mutant strain of rsv |
ATE469170T1 (de) * | 2003-03-28 | 2010-06-15 | Medimmune Llc | Zusammensetzungen und verfahren mit dem respiratory syncytial virus untergruppe b stamm 9320 |
WO2005018539A2 (en) | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
WO2005058356A2 (en) * | 2003-12-17 | 2005-06-30 | Wyeth | Methods for porducing storage stable viruses and immunogenic compositions thereof |
ES2345492T3 (es) | 2003-12-23 | 2010-09-24 | Medimmune, Llc | Sistema multiplasmido para la produccion del virus de la gripe. |
WO2005116260A2 (en) * | 2004-05-25 | 2005-12-08 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
EP2441471B1 (en) | 2005-03-08 | 2014-10-08 | MedImmune, LLC | Reassortant influenza viruses |
EP2049662A4 (en) * | 2006-07-21 | 2009-12-30 | Medimmune Llc | METHODS AND COMPOSITIONS FOR INCREASING REPLICATION CAPACITY OF A FLU VIRUS |
CA2659267C (en) * | 2006-08-09 | 2016-12-13 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
JP5666905B2 (ja) * | 2007-06-18 | 2015-02-12 | メディミューン,エルエルシー | ヘマグルチニンポリペプチド中に変化を有するインフルエンザbウイルス |
EP2069485A4 (en) * | 2007-07-13 | 2011-05-25 | Medimmune Llc | PREPARATION OF NEGATIVE STRAND RNA VIRUSES BY ELECTROPORATION |
SG192501A1 (en) | 2008-07-11 | 2013-08-30 | Medimmune Llc | Influenza hemagglutinin and neuraminidase variants |
WO2010093537A2 (en) * | 2009-02-12 | 2010-08-19 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
GB201003630D0 (en) | 2010-03-04 | 2010-04-21 | Novartis Ag | Avian rotavirus |
SG11201401137TA (en) | 2011-10-07 | 2014-07-30 | Medimmune Llc | Influenza hemagglutinin variants |
EP3875112A1 (en) | 2012-04-13 | 2021-09-08 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Genetically stable live attenuated respiratory syncytial virus vaccine and its production |
CN105189756B (zh) | 2013-03-14 | 2021-06-11 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
CA2902560A1 (en) * | 2013-03-14 | 2014-09-25 | President And Fellows Of Harvard College | Nanoparticle-based compositions |
US11235050B2 (en) | 2015-10-29 | 2022-02-01 | Emory University | Chimeric RSV, immunogenic compositions, and methods of use |
RU2746280C1 (ru) * | 2020-08-03 | 2021-04-12 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Штамм респираторно-синцитиального вируса RSV/Novosibirsk/66Hl/2018 для использования в диагностике респираторно-синцитиальной вирусной инфекции и исследования эффективности противовирусных препаратов in vitro |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4866034A (en) * | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
US4800078A (en) * | 1987-05-28 | 1989-01-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunotherapeutic method of treating respiratory disease by intranasal administration of Igb |
US5250298A (en) * | 1988-10-07 | 1993-10-05 | University Of Delaware | Live attenuated newcastle disease virus vaccines and preparation thereof |
-
1993
- 1993-04-19 IL IL10545693A patent/IL105456A/en not_active IP Right Cessation
- 1993-04-20 KR KR1019940703740A patent/KR100257171B1/ko not_active IP Right Cessation
- 1993-04-20 DE DE69325370T patent/DE69325370T2/de not_active Expired - Fee Related
- 1993-04-20 HU HU9403023A patent/HU220189B/hu not_active IP Right Cessation
- 1993-04-20 WO PCT/US1993/003670 patent/WO1993021310A1/en active IP Right Grant
- 1993-04-20 JP JP51866393A patent/JP3883202B2/ja not_active Expired - Fee Related
- 1993-04-20 AU AU42907/93A patent/AU683840B2/en not_active Ceased
- 1993-04-20 EP EP93912315A patent/EP0640128B1/en not_active Expired - Lifetime
- 1993-04-20 CA CA002118509A patent/CA2118509C/en not_active Expired - Fee Related
- 1993-04-20 UA UA94105948A patent/UA41315C2/uk unknown
- 1993-04-20 ES ES93912315T patent/ES2132233T3/es not_active Expired - Lifetime
- 1993-04-20 NZ NZ252857A patent/NZ252857A/en not_active IP Right Cessation
- 1993-04-20 MX MX9302278A patent/MX9302278A/es not_active IP Right Cessation
- 1993-04-20 AT AT93912315T patent/ATE181359T1/de not_active IP Right Cessation
- 1993-04-20 DK DK93912315T patent/DK0640128T3/da active
- 1993-04-20 RU RU94045898A patent/RU2139729C1/ru not_active IP Right Cessation
-
1994
- 1994-10-21 US US08/327,263 patent/US5922326A/en not_active Expired - Lifetime
-
1995
- 1995-05-30 US US08/453,304 patent/US6284254B1/en not_active Expired - Lifetime
- 1995-05-30 US US08/453,294 patent/US5882651A/en not_active Expired - Lifetime
-
1999
- 1999-09-15 GR GR990402303T patent/GR3031208T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH07505891A (ja) | 1995-06-29 |
UA41315C2 (uk) | 2001-09-17 |
KR100257171B1 (ko) | 2000-05-15 |
EP0640128B1 (en) | 1999-06-16 |
RU2139729C1 (ru) | 1999-10-20 |
CA2118509A1 (en) | 1993-10-28 |
AU4290793A (en) | 1993-11-18 |
US5882651A (en) | 1999-03-16 |
HUT69992A (en) | 1995-09-28 |
KR950701382A (ko) | 1995-03-23 |
US5922326A (en) | 1999-07-13 |
EP0640128A1 (en) | 1995-03-01 |
DE69325370T2 (de) | 1999-10-14 |
DK0640128T3 (da) | 1999-11-22 |
WO1993021310A1 (en) | 1993-10-28 |
IL105456A0 (en) | 1993-08-18 |
ATE181359T1 (de) | 1999-07-15 |
DE69325370D1 (de) | 1999-07-22 |
NZ252857A (en) | 1997-06-24 |
GR3031208T3 (en) | 1999-12-31 |
HU220189B (hu) | 2001-11-28 |
IL105456A (en) | 1996-12-05 |
US6284254B1 (en) | 2001-09-04 |
HU9403023D0 (en) | 1994-12-28 |
RU94045898A (ru) | 1996-09-20 |
ES2132233T3 (es) | 1999-08-16 |
JP3883202B2 (ja) | 2007-02-21 |
AU683840B2 (en) | 1997-11-27 |
CA2118509C (en) | 2009-05-19 |
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