DE69325370T2 - Attenuierter respiratorischer synzytialvirus enthaltende impfstoff-zusammensetzungen - Google Patents
Attenuierter respiratorischer synzytialvirus enthaltende impfstoff-zusammensetzungenInfo
- Publication number
- DE69325370T2 DE69325370T2 DE69325370T DE69325370T DE69325370T2 DE 69325370 T2 DE69325370 T2 DE 69325370T2 DE 69325370 T DE69325370 T DE 69325370T DE 69325370 T DE69325370 T DE 69325370T DE 69325370 T2 DE69325370 T2 DE 69325370T2
- Authority
- DE
- Germany
- Prior art keywords
- attenuated
- virus
- respiratory syncytial
- syncytial virus
- vaccine compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Vertical, Hearth, Or Arc Furnaces (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87274692A | 1992-04-21 | 1992-04-21 | |
US3994593A | 1993-04-09 | 1993-04-09 | |
PCT/US1993/003670 WO1993021310A1 (en) | 1992-04-21 | 1993-04-20 | Attenuated respiratory syncytial virus vaccine compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69325370D1 DE69325370D1 (de) | 1999-07-22 |
DE69325370T2 true DE69325370T2 (de) | 1999-10-14 |
Family
ID=26716607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69325370T Expired - Fee Related DE69325370T2 (de) | 1992-04-21 | 1993-04-20 | Attenuierter respiratorischer synzytialvirus enthaltende impfstoff-zusammensetzungen |
Country Status (18)
Country | Link |
---|---|
US (3) | US5922326A (de) |
EP (1) | EP0640128B1 (de) |
JP (1) | JP3883202B2 (de) |
KR (1) | KR100257171B1 (de) |
AT (1) | ATE181359T1 (de) |
AU (1) | AU683840B2 (de) |
CA (1) | CA2118509C (de) |
DE (1) | DE69325370T2 (de) |
DK (1) | DK0640128T3 (de) |
ES (1) | ES2132233T3 (de) |
GR (1) | GR3031208T3 (de) |
HU (1) | HU220189B (de) |
IL (1) | IL105456A (de) |
MX (1) | MX9302278A (de) |
NZ (1) | NZ252857A (de) |
RU (1) | RU2139729C1 (de) |
UA (1) | UA41315C2 (de) |
WO (1) | WO1993021310A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
TW275632B (de) * | 1992-04-21 | 1996-05-11 | American Cyanamid Co | |
ATE164313T1 (de) | 1993-08-06 | 1998-04-15 | Connaught Lab | Inaktivierte respiratorische synzytial-virus- impfstoffe |
US7223410B1 (en) | 1994-08-05 | 2007-05-29 | Sanofi Pasteur Limited | Inactivated respiratory syncytial viral vaccines |
US5716821A (en) * | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
US5789229A (en) * | 1994-09-30 | 1998-08-04 | Uab Research Foundation | Stranded RNA virus particles |
US6019980A (en) * | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
US6083925A (en) | 1995-06-07 | 2000-07-04 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
US7846455B2 (en) | 1996-07-15 | 2010-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated chimeric respiratory syncytial virus |
US20050287540A1 (en) * | 1995-09-27 | 2005-12-29 | Murphy Brian R | Production of attenuated negative stranded RNA virus vaccines from cloned nucleotide sequences |
WO1997012032A1 (en) * | 1995-09-27 | 1997-04-03 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
US6689367B1 (en) | 1995-09-27 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
AU2438597A (en) * | 1996-04-04 | 1997-10-29 | Regents Of The University Of Michigan, The | Attenuated respiratory syncytial virus |
US6077514A (en) * | 1996-04-04 | 2000-06-20 | The Regents Of The University Of Michigan | Attenuated respiratory syncytial virus |
CA2260107A1 (en) * | 1996-07-12 | 1998-01-22 | The Regents Of The University Of Michigan | Two-step immunization procedure against the pyramyxoviridae family of viruses using attenuated viral strains and subunit protein preparation |
KR100894670B1 (ko) | 1996-07-15 | 2009-04-22 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 | 클론닝된 뉴클레오타이드 서열로부터 약독화된 호흡기 세포융합 바이러스 백신의 생산 |
US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
CN1232504A (zh) * | 1996-09-27 | 1999-10-20 | 美国氰胺公司 | 在单链负义病毒目病毒内引起减毒的3'基因组启动子区和聚合酶基因中的突变 |
US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
US6410023B1 (en) | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
FR2764903A1 (fr) * | 1997-06-23 | 1998-12-24 | Pasteur Institut | Detection des infections par des paramyxovirus (virus respiratoire syncitial et virus parainfluenza) utilisant des polynucleotides codant de la proteine l |
US7662397B2 (en) | 1997-07-15 | 2010-02-16 | The United States Of America As Represented By The Department Of Health And Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
US20040005542A1 (en) | 2001-06-22 | 2004-01-08 | Krempl Christine D | Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes |
US6482414B1 (en) | 1998-08-13 | 2002-11-19 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6579528B1 (en) | 1998-08-13 | 2003-06-17 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6177082B1 (en) | 1998-08-13 | 2001-01-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
AU4065500A (en) | 1999-04-13 | 2000-11-14 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
BR0013195A (pt) * | 1999-07-09 | 2002-07-23 | Government Of The Us Dept Of H | Produção de vacinas de virus sincicial respiratório quimérico humano-bovino, atenuado |
US7820182B2 (en) * | 1999-07-09 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions |
ATE350056T1 (de) | 2000-04-03 | 2007-01-15 | Univ Pittsburgh | Zusammensetzungen, die kälteangepasste pferdeinfluenzaviren enthaltende, für die behandlung von bestehende virusinfektionen des atmungssystems |
EP1441762A1 (de) * | 2001-09-28 | 2004-08-04 | University Of South Florida | Rsv genexpressions impstoff |
WO2003091401A2 (en) | 2002-04-26 | 2003-11-06 | Medimmune Vaccines, Inc. | Multi plasmid system for the production of influenza virus |
US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
AU2003295339B2 (en) * | 2002-09-27 | 2009-03-26 | Medimmune, Llc | Functional mutations in respiratory syncytial virus |
US7687240B2 (en) * | 2003-03-18 | 2010-03-30 | Wyeth Holdings Corporation | Process for increasing RSV surface glycoprotein yields using a mutant strain of RSV |
US7572904B2 (en) * | 2003-03-28 | 2009-08-11 | Medimmune, Llc | Nucleic acids encoding respiratory syncytial virus subgroup B strain 9320 |
WO2005018539A2 (en) * | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
AU2004299057B2 (en) * | 2003-12-17 | 2010-06-24 | Wyeth Llc | Methods for porducing storage stable viruses and immunogenic compositions thereof |
JP4771959B2 (ja) | 2003-12-23 | 2011-09-14 | メディミューン,エルエルシー | インフルエンザウイルス作製のための多重プラスミド系 |
EP1771552B1 (de) | 2004-05-25 | 2012-08-01 | MedImmune Vaccines, Inc. | Influenza-hämagglutinin- und neuraminidase-varianten |
WO2006098901A2 (en) | 2005-03-08 | 2006-09-21 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
EP2049662A4 (de) * | 2006-07-21 | 2009-12-30 | Medimmune Llc | Verfahren und zusammensetzungen zur erhöhung des replikationsvermögens eines influenza-virus |
KR101586968B1 (ko) * | 2006-08-09 | 2016-01-20 | 메디뮨 엘엘씨 | 인플루엔자 헤마글루티닌 및 뉴라미니다제 변이체 |
US8673613B2 (en) * | 2007-06-18 | 2014-03-18 | Medimmune, Llc | Influenza B viruses having alterations in the hemaglutinin polypeptide |
WO2009012155A2 (en) * | 2007-07-13 | 2009-01-22 | Medimmune, Llc | Preparation of negative-stranded rna viruses by electroporation |
CN102149405A (zh) | 2008-07-11 | 2011-08-10 | 米迪缪尼股份有限公司 | 流感血凝素和神经氨酸酶变体 |
MX2011008497A (es) | 2009-02-12 | 2011-12-16 | Us Gov Nat Inst Health | Variantes de hemaglutinina y neuraminidasa de influenza. |
GB201003630D0 (en) | 2010-03-04 | 2010-04-21 | Novartis Ag | Avian rotavirus |
CA2850962A1 (en) | 2011-10-07 | 2013-09-06 | Medimmune, Llc | Influenza hemagglutinin variants |
DK3511015T3 (da) * | 2012-04-13 | 2021-03-15 | Us Health | Genetisk stabil levende svækket respiratorisk syncytialvirusvaccine og fremstilling deraf |
EP3766516A1 (de) * | 2013-03-14 | 2021-01-20 | President and Fellows of Harvard College | Zusammensetzungen von nanopartikeln |
CN105189756B (zh) | 2013-03-14 | 2021-06-11 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
BR112018008708A2 (pt) | 2015-10-29 | 2018-11-06 | Univ Emory | rsv quimérico, composições imunogênicas e métodos de uso |
RU2746280C1 (ru) * | 2020-08-03 | 2021-04-12 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Штамм респираторно-синцитиального вируса RSV/Novosibirsk/66Hl/2018 для использования в диагностике респираторно-синцитиальной вирусной инфекции и исследования эффективности противовирусных препаратов in vitro |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4866034A (en) * | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
US4800078A (en) * | 1987-05-28 | 1989-01-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunotherapeutic method of treating respiratory disease by intranasal administration of Igb |
US5250298A (en) * | 1988-10-07 | 1993-10-05 | University Of Delaware | Live attenuated newcastle disease virus vaccines and preparation thereof |
-
1993
- 1993-04-19 IL IL10545693A patent/IL105456A/en not_active IP Right Cessation
- 1993-04-20 NZ NZ252857A patent/NZ252857A/en not_active IP Right Cessation
- 1993-04-20 AU AU42907/93A patent/AU683840B2/en not_active Ceased
- 1993-04-20 DK DK93912315T patent/DK0640128T3/da active
- 1993-04-20 AT AT93912315T patent/ATE181359T1/de not_active IP Right Cessation
- 1993-04-20 KR KR1019940703740A patent/KR100257171B1/ko not_active IP Right Cessation
- 1993-04-20 UA UA94105948A patent/UA41315C2/uk unknown
- 1993-04-20 WO PCT/US1993/003670 patent/WO1993021310A1/en active IP Right Grant
- 1993-04-20 EP EP93912315A patent/EP0640128B1/de not_active Expired - Lifetime
- 1993-04-20 HU HU9403023A patent/HU220189B/hu not_active IP Right Cessation
- 1993-04-20 MX MX9302278A patent/MX9302278A/es not_active IP Right Cessation
- 1993-04-20 ES ES93912315T patent/ES2132233T3/es not_active Expired - Lifetime
- 1993-04-20 JP JP51866393A patent/JP3883202B2/ja not_active Expired - Fee Related
- 1993-04-20 RU RU94045898A patent/RU2139729C1/ru not_active IP Right Cessation
- 1993-04-20 DE DE69325370T patent/DE69325370T2/de not_active Expired - Fee Related
- 1993-04-20 CA CA002118509A patent/CA2118509C/en not_active Expired - Fee Related
-
1994
- 1994-10-21 US US08/327,263 patent/US5922326A/en not_active Expired - Lifetime
-
1995
- 1995-05-30 US US08/453,304 patent/US6284254B1/en not_active Expired - Lifetime
- 1995-05-30 US US08/453,294 patent/US5882651A/en not_active Expired - Lifetime
-
1999
- 1999-09-15 GR GR990402303T patent/GR3031208T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69325370D1 (de) | 1999-07-22 |
UA41315C2 (uk) | 2001-09-17 |
KR950701382A (ko) | 1995-03-23 |
JP3883202B2 (ja) | 2007-02-21 |
AU683840B2 (en) | 1997-11-27 |
RU2139729C1 (ru) | 1999-10-20 |
GR3031208T3 (en) | 1999-12-31 |
JPH07505891A (ja) | 1995-06-29 |
ATE181359T1 (de) | 1999-07-15 |
CA2118509C (en) | 2009-05-19 |
NZ252857A (en) | 1997-06-24 |
US5882651A (en) | 1999-03-16 |
DK0640128T3 (da) | 1999-11-22 |
KR100257171B1 (ko) | 2000-05-15 |
WO1993021310A1 (en) | 1993-10-28 |
EP0640128B1 (de) | 1999-06-16 |
HU220189B (hu) | 2001-11-28 |
ES2132233T3 (es) | 1999-08-16 |
MX9302278A (es) | 1994-07-29 |
RU94045898A (ru) | 1996-09-20 |
US6284254B1 (en) | 2001-09-04 |
AU4290793A (en) | 1993-11-18 |
CA2118509A1 (en) | 1993-10-28 |
IL105456A (en) | 1996-12-05 |
US5922326A (en) | 1999-07-13 |
EP0640128A1 (de) | 1995-03-01 |
IL105456A0 (en) | 1993-08-18 |
HUT69992A (en) | 1995-09-28 |
HU9403023D0 (en) | 1994-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69325370D1 (de) | Attenuierter respiratorischer synzytialvirus enthaltende impfstoff-zusammensetzungen | |
MA22842A1 (fr) | Procede de preparation de compositions de vaccin. | |
CA2339089A1 (en) | Cold-adapted equine influenza viruses | |
BRPI9710363B1 (pt) | partìcula de vìrus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vìrus sincicial respiratório recombinante (rsv) infeccioso. | |
EE05633B1 (et) | Muundatud vaktsiiniaviirus Ankara (MVA), sellega nakatatud peremeesrakk ning seda sisaldav farmatseutiline kompositsioon, MVA valmistamine ja raviotstarbeline kasutamine | |
DK0869814T3 (da) | Stabilisatorer til levende vacciner | |
PL340659A1 (en) | Spheroides, method of obtaining them and pharmacological compositions | |
TW266228B (de) | ||
MD1838G2 (ro) | Derivaţi de 5,6-diclorbenzimidazol, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă de tratament sau de prevenire a infecţiei virotice herpetice | |
GB9306731D0 (en) | Vaccines | |
WO2001060849A3 (en) | Cold-adapted equine influenza viruses | |
ES2182914T3 (es) | Inmunopotenciacion inducida de quitosan. | |
WO2000057909A3 (en) | Attenuated dengue-2 virus vaccine | |
NZ505894A (en) | Methylenebisbenzaldehyde derivatives, methylidynetrisphenol derivative and pharmaceuticals thereof; useful for treating or preventing pneumovirus infection and associated diseases | |
ES8703526A1 (es) | Un procedimiento para producir un polipeptido no toxico | |
WO2000057908A3 (en) | Attenuated dengue-1 virus vaccine | |
WO2000057904A3 (en) | Attenuated dengue-3 virus vaccine | |
AU4930001A (en) | Cold-adapted equine influenza viruses | |
AU3439799A (en) | Immunization against and treatment for infection by (h.pylori) | |
WO2003049670A3 (en) | Adjuvant formulations for bacterial and virus vaccines and method of making same | |
ES2055610T3 (es) | Vacuna contra hrsv. | |
DK0579765T3 (da) | Fremgangsmåde og præparat til behandling af herpes-relaterede sygdomme | |
NO982854L (no) | Nitrogenoksyd (NO) syntetase-inhibitor for Õ behandle eller forebygge type II diabetes | |
NO980721L (no) | Vaksiner | |
MX9801664A (es) | Formas zwitterionicas de trovafloxacina, procedimiento para su preparacion, composiciones que las contienen y uso de las mismas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J. |
|
8339 | Ceased/non-payment of the annual fee |