EP0917592A4 - Abgeschwaechter rsv - Google Patents

Abgeschwaechter rsv

Info

Publication number
EP0917592A4
EP0917592A4 EP97920111A EP97920111A EP0917592A4 EP 0917592 A4 EP0917592 A4 EP 0917592A4 EP 97920111 A EP97920111 A EP 97920111A EP 97920111 A EP97920111 A EP 97920111A EP 0917592 A4 EP0917592 A4 EP 0917592A4
Authority
EP
European Patent Office
Prior art keywords
respiratory syncytial
syncytial virus
attenuated respiratory
attenuated
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97920111A
Other languages
English (en)
French (fr)
Other versions
EP0917592A1 (de
Inventor
Hunein F Maassab
M Louise Herlocher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Publication of EP0917592A1 publication Critical patent/EP0917592A1/de
Publication of EP0917592A4 publication Critical patent/EP0917592A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561—Methods of inactivation or attenuation
    • C12N2760/18564—Methods of inactivation or attenuation by serial passage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP97920111A 1996-04-04 1997-04-03 Abgeschwaechter rsv Withdrawn EP0917592A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1484896P 1996-04-04 1996-04-04
US14848P 1996-04-04
PCT/US1997/005588 WO1997038138A1 (en) 1996-04-04 1997-04-03 Attenuated respiratory syncytial virus

Publications (2)

Publication Number Publication Date
EP0917592A1 EP0917592A1 (de) 1999-05-26
EP0917592A4 true EP0917592A4 (de) 2002-04-24

Family

ID=21768115

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97920111A Withdrawn EP0917592A4 (de) 1996-04-04 1997-04-03 Abgeschwaechter rsv

Country Status (4)

Country Link
EP (1) EP0917592A4 (de)
AU (1) AU2438597A (de)
CA (1) CA2250883A1 (de)
WO (1) WO1997038138A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077514A (en) * 1996-04-04 2000-06-20 The Regents Of The University Of Michigan Attenuated respiratory syncytial virus
JP2001517448A (ja) * 1997-09-19 2001-10-09 アメリカン・サイアナミド・カンパニー 弱毒化呼吸合胞体ウイルス
EP1112350A2 (de) 1998-09-01 2001-07-04 St. Louis University Temperaturempfindlicher und erkältungs-adaptierter menschlicher parainfluenzavirus-typ 2 (hpiv-2) und darauf basierende impfstoffe
CA2742086A1 (en) 2008-11-05 2010-05-14 Merck Sharp & Dohme Corp. Live, attenuated respiratory syncytial virus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122167A (en) * 1977-02-09 1978-10-24 Merck & Co., Inc. Respiratory synctial vaccine
EP0567100A1 (de) * 1992-04-21 1993-10-27 American Cyanamid Company Mutantes respiratorisches Synzytialvirus (RSV), dieses enthaltende Impfstoffe und Verfahren zur Verwendung
WO1993021310A1 (en) * 1992-04-21 1993-10-28 American Home Products Corporation Attenuated respiratory syncytial virus vaccine compositions
WO1998002180A1 (en) * 1996-07-12 1998-01-22 Connaught Laboratories Limited Two-step immunization procedure against the pyramyxoviridae family of viruses using attenuated viral strains and subunit protein preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149650A (en) * 1986-01-14 1992-09-22 University Of North Carolina At Chapel Hill Vaccines for human respiratory virus
US5223254A (en) * 1987-09-29 1993-06-29 Praxis Biologics, Inc. Respiratory syncytial virus: vaccines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122167A (en) * 1977-02-09 1978-10-24 Merck & Co., Inc. Respiratory synctial vaccine
EP0567100A1 (de) * 1992-04-21 1993-10-27 American Cyanamid Company Mutantes respiratorisches Synzytialvirus (RSV), dieses enthaltende Impfstoffe und Verfahren zur Verwendung
WO1993021310A1 (en) * 1992-04-21 1993-10-28 American Home Products Corporation Attenuated respiratory syncytial virus vaccine compositions
WO1998002180A1 (en) * 1996-07-12 1998-01-22 Connaught Laboratories Limited Two-step immunization procedure against the pyramyxoviridae family of viruses using attenuated viral strains and subunit protein preparation

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CONNORS MARK ET AL: "A cold-passaged attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes.", VIROLOGY, vol. 208, no. 2, 1995, pages 478 - 484, XP002047454, ISSN: 0042-6822 *
CROWE J E ET AL: "A COMPARISON IN CHIMPANZEES OF THE IMMUNOGENICITY AND EFFICACY OF LIVE ATTENUATED RESPIRATORY SYNCYTIAL VIRUS (RSV) TEMPERATURE-SENSITIVE MUTANT VACCINES AND VACCINIA VIRUS RECOMBINANTS THAT EXPRESS THE SURFACE GLYCOPROTEINS OF RSV", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 11, no. 14, 1993, pages 1395 - 1404, XP002910146, ISSN: 0264-410X *
CROWE J E: "CURRENT APPROACHES TO THE DEVELOPMENT OF VACCINES AGAINST DISEASE CAUSED BY RESPIRATORY SYNCYTIAL VIRUS (RSV) AND PARAINFLUENZA VIRUS(PIV)", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 13, no. 4, 1995, pages 415 - 421, XP002028713, ISSN: 0264-410X *
CROWE JAMES E JR ET AL: "A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees.", VACCINE, vol. 12, no. 9, 1994, pages 783 - 790, XP001021054, ISSN: 0264-410X *
EWASYSHYN M ET AL: "PROSPECTS FOR IMMUNIZATION AGAINST RESPIRATORY SYNCYTIAL VIRUS", VACCINE RESEARCH, MARY ANN LIEBERT, INC., PUBLISHERS, US, vol. 2, no. 4, 1993, pages 263 - 272, XP002044888 *
HERLOCHER M L ET AL: "Immunological properties of plaque purified strains of live attenuated respiratory syncytial virus ( RSV ) for human vaccine.", VACCINE, (1999 JAN) 17 (2) 172-81., XP004139973 *
HSU K-H L ET AL: "Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 13, no. 5, 1995, pages 509 - 515, XP004057727, ISSN: 0264-410X *
MAASSAB H F ET AL: "DEVELOPMENT AND CHARACTERIZATION OF COLD-ADAPTED VIRUSES FOR USE AS LIVE VIRUS VACCINES", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 3, 1 December 1985 (1985-12-01), pages 355 - 369, XP002910149, ISSN: 0264-410X *
MURPHY B R ET AL: "AN UPDATE ON APPROACHES TO THE DEVELOPMENT OF RESPIRATORY SYNCYTIAL VIRUS (RSV) AND PARAINFLUENZA VIRUS TYPE 3 (PIV3) VACCINES", VIRUS RESEARCH, AMSTERDAM, NL, vol. 32, 1994, pages 13 - 36, XP002910147, ISSN: 0168-1702 *
See also references of WO9738138A1 *
STOKES A ET AL: "The complete nucleotide sequence of two cold-adapted, temperature-sensitive attenuated mutant vaccine viruses (cp12 and cp45) derived from the JS strain of human parainfluenza virus type 3 (PIV3).", VIRUS RESEARCH, (1993 OCT) 30 (1) 43-52., XP002051711 *
WRIGHT P F ET AL: "ADMINISTRATION OF A HIGHLY ATTENUATED, LIVE RESPIEATORY SYNCYTIAL VIRUS VACCINE TO ADULTS AND CHILDREN", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 37, no. 1, 1 July 1982 (1982-07-01), pages 397 - 400, XP002910148, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
AU2438597A (en) 1997-10-29
CA2250883A1 (en) 1997-10-16
EP0917592A1 (de) 1999-05-26
WO1997038138A1 (en) 1997-10-16

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