DK0632053T3 - Cykliske adhæsionsinhibitorer - Google Patents

Cykliske adhæsionsinhibitorer

Info

Publication number
DK0632053T3
DK0632053T3 DK94104396T DK94104396T DK0632053T3 DK 0632053 T3 DK0632053 T3 DK 0632053T3 DK 94104396 T DK94104396 T DK 94104396T DK 94104396 T DK94104396 T DK 94104396T DK 0632053 T3 DK0632053 T3 DK 0632053T3
Authority
DK
Denmark
Prior art keywords
lys
alanine
asp
atoms
prodn
Prior art date
Application number
DK94104396T
Other languages
Danish (da)
English (en)
Inventor
Guenter Dr Hoelzemann
Brunhilde Dr Felding-Habermann
Friedrich Dr Rippmann
Beate Diefenbach
Horst Prof Dr Kessler
Roland Haubner
Jochen Wermuth
Alfred Dr Jonczyk
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6484433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0632053(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0632053T3 publication Critical patent/DK0632053T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
DK94104396T 1993-04-01 1994-03-21 Cykliske adhæsionsinhibitorer DK0632053T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4310643A DE4310643A1 (de) 1993-04-01 1993-04-01 Cyclische Adhäsionsinhibitoren

Publications (1)

Publication Number Publication Date
DK0632053T3 true DK0632053T3 (da) 2000-03-13

Family

ID=6484433

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94104396T DK0632053T3 (da) 1993-04-01 1994-03-21 Cykliske adhæsionsinhibitorer

Country Status (20)

Country Link
US (2) US5849692A (zh)
EP (1) EP0632053B1 (zh)
JP (1) JP3694332B2 (zh)
KR (1) KR100304201B1 (zh)
CN (1) CN1056851C (zh)
AT (1) ATE184288T1 (zh)
AU (1) AU684489B2 (zh)
CA (1) CA2120303C (zh)
CZ (1) CZ286768B6 (zh)
DE (2) DE4310643A1 (zh)
DK (1) DK0632053T3 (zh)
ES (1) ES2138632T3 (zh)
GR (1) GR3032074T3 (zh)
HU (1) HUT69726A (zh)
NO (1) NO313756B1 (zh)
PL (1) PL178791B1 (zh)
RU (1) RU2130030C1 (zh)
SK (1) SK281828B6 (zh)
TW (1) TW343198B (zh)
UA (1) UA34436C2 (zh)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753230A (en) 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
DE4415310A1 (de) * 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptide
US7053041B1 (en) * 1996-05-31 2006-05-30 The Scripps Research Institute Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
DE19534016A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Biotinderivate
DE19534177A1 (de) * 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19538741A1 (de) * 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptidderivate
DE19613933A1 (de) * 1996-04-06 1997-10-09 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
RU2194528C2 (ru) 1996-05-31 2002-12-20 Дзе Скриппс Рисерч Инститьют Способы и композиции, используемые для ингибирования ангиогенеза
DE19736772A1 (de) * 1997-08-23 1999-02-25 Merck Patent Gmbh Cyclopeptidderivate
CA2356929A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combonation therapy in the treatment of neoplasia
UA71608C2 (en) 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
DE19933173A1 (de) 1999-07-15 2001-01-18 Merck Patent Gmbh Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶
US6359015B1 (en) 2000-02-28 2002-03-19 The United States Of America As Represented By The Department Of Veterans Affairs Method for antagonizing inhibition effects of alcohol on cell adhesion
US6624187B1 (en) * 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
DE10040105A1 (de) 2000-08-17 2002-02-28 Merck Patent Gmbh Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften
FR2814744B1 (fr) * 2000-10-04 2002-11-29 Commissariat Energie Atomique Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese
US20020168360A1 (en) * 2001-03-02 2002-11-14 Christine Dingivan Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphanubeta3 antagonists in combination with other prophylactic or therapeutic agents
US7879267B2 (en) * 2001-08-02 2011-02-01 J&J Vision Care, Inc. Method for coating articles by mold transfer
CA2478239A1 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
AU2003213682C1 (en) * 2002-03-04 2008-06-12 Medimmune, Inc. Methods of preventing or treating disorders by administering an integrin alphavbeta3 antagonist in combination with an HMG-CoA reductase inhibitor or a bisphosphonate
EP2270049A3 (en) 2002-04-12 2011-03-09 Medimmune, Inc. Recombinant anti-interleukin-9-antibody
GB0217017D0 (en) * 2002-07-23 2002-08-28 Bioacta Ltd Peptide 2
ITRM20020402A1 (it) * 2002-07-29 2004-01-29 Sigma Tau Ind Farmaceuti Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.
US6977272B2 (en) * 2002-10-16 2005-12-20 President And Fellows Of Harvard College Method for antagonizing inhibition effects of alcohol on cell adhesion
US20040176272A1 (en) * 2003-01-30 2004-09-09 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
WO2004091510A2 (en) * 2003-04-11 2004-10-28 Medimmune, Inc. Recombinant il-9 antibodies and uses thereof
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
ITRM20040239A1 (it) * 2004-05-13 2004-08-13 Sigma Tau Ind Farmaceuti Derivati ciclopeptidici ad attivita' antintegrine.
AU2005299355A1 (en) 2004-10-27 2006-05-04 Medimmune, Llc Modulation of antibody specificity by tailoring the affinity to cognate antigens
EP2043603A4 (en) 2006-07-11 2010-10-27 Arubor Corp PREVENTION AND THERAPY OF RHINOSINUSITIS WITH PROINFLAMMATORY CYTOKINHERMERS
HUE048024T2 (hu) 2006-08-10 2020-05-28 Roy C Levitt Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
RU2500685C2 (ru) 2006-11-10 2013-12-10 Кара Терапеутикс, Инк Синтетические пептидные амиды
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US20110027209A1 (en) 2008-04-08 2011-02-03 Merck Patent Gesellschaft Compositions Containing Cyclic Peptides And Methods Of Use
WO2010046900A2 (en) 2008-10-23 2010-04-29 Steba Biotech N.V. Rgd-containing peptidomimetics and uses thereof
CN101906141B (zh) * 2009-06-02 2013-04-17 首都医科大学 一类肽链与双脂肪醇链的偶联物及其制备方法和应用
CN101906144B (zh) * 2009-06-03 2013-06-19 首都医科大学 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
RU2626002C1 (ru) 2016-10-24 2017-07-21 Общество С Ограниченной Ответственностью "Айвикс" Новая группа пептидов для лечения женской сексуальной дисфункции
RU2655763C2 (ru) * 2016-10-24 2018-05-29 Общество С Ограниченной Ответственностью "Айвикс" Фармацевтическая композиция и способ лечения женских сексуальных дисфункций
US10494403B2 (en) 2018-03-06 2019-12-03 Ciphore Biomed Technology Limited Company Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472305A (en) * 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
JPH04264097A (ja) * 1991-02-16 1992-09-18 Asahi Glass Co Ltd ペプチド誘導体およびその用途
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
UA43823C2 (uk) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis

Also Published As

Publication number Publication date
EP0632053A3 (de) 1995-02-15
CN1099760A (zh) 1995-03-08
NO941152D0 (no) 1994-03-29
US6169072B1 (en) 2001-01-02
SK281828B6 (sk) 2001-08-06
HUT69726A (en) 1995-09-28
ES2138632T3 (es) 2000-01-16
JPH06329698A (ja) 1994-11-29
GR3032074T3 (en) 2000-03-31
CA2120303C (en) 2007-05-01
SK38394A3 (en) 1995-02-08
JP3694332B2 (ja) 2005-09-14
PL178791B1 (pl) 2000-06-30
CA2120303A1 (en) 1994-10-02
RU2130030C1 (ru) 1999-05-10
US5849692A (en) 1998-12-15
AU5918594A (en) 1994-10-06
TW343198B (en) 1998-10-21
NO941152L (no) 1994-10-03
HU9400937D0 (en) 1994-06-28
EP0632053B1 (de) 1999-09-08
DE4310643A1 (de) 1994-10-06
CZ286768B6 (en) 2000-07-12
EP0632053A2 (de) 1995-01-04
NO313756B1 (no) 2002-11-25
DE59408715D1 (de) 1999-10-14
AU684489B2 (en) 1997-12-18
UA34436C2 (uk) 2001-03-15
CN1056851C (zh) 2000-09-27
KR100304201B1 (ko) 2001-11-30
ATE184288T1 (de) 1999-09-15
CZ70494A3 (en) 1995-01-18

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