ES8701784A1 - Un procedimiento para preparar un peptido ciclico con acti- vidad antagonista de vasopresina - Google Patents

Un procedimiento para preparar un peptido ciclico con acti- vidad antagonista de vasopresina

Info

Publication number
ES8701784A1
ES8701784A1 ES549077A ES549077A ES8701784A1 ES 8701784 A1 ES8701784 A1 ES 8701784A1 ES 549077 A ES549077 A ES 549077A ES 549077 A ES549077 A ES 549077A ES 8701784 A1 ES8701784 A1 ES 8701784A1
Authority
ES
Spain
Prior art keywords
alk
phe
tyr
gly
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549077A
Other languages
English (en)
Other versions
ES549077A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES8701784A1 publication Critical patent/ES8701784A1/es
Publication of ES549077A0 publication Critical patent/ES549077A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UN PEPTIDO CICLICO CON ACTIVIDAD ANTAGONISTA DE VASOPRESINA DE FORMULA (I), EN LA QUE P, X, Y, Z Y A SON OPCIONALMENTE DIVERSOS AMINOACIDOS Y R ES H O METILO. COMPRENDE CICLAR UN COMPUESTO OPCIONALMENTE PROTEGIDO DE FORMULA (II), EN LA QUE X, P, R, Y, Z Y A SON LOS ANTES INDICADOS, PERO Z ES UN ENLACE SENCILLO O UN OH TERMINAL Y Q1 Y Q2 SON H O UN GRUPO DESPLAZABLE, Y DESPUES SEPARAR LOS GRUPOS PROTECTORES, HACER REACCIONAR DICHOS COMPUESTOS CYS(OH)6 O Z(OH)7, CON UN DIPEPTIDO Z-A, O UN AMINOACIDO DE A O Z EN FORMA PROTEGIDA O EN FORMA AMIDA, O FORMAR UNA SAL FARMACEUTICAMENTE ACEPTABLE O UN PROFARMACO DEL MISMO. APLICABLE EN FARMACOS VASODILATADORES SELECTIVOS.
ES549077A 1984-11-21 1985-11-20 Un procedimiento para preparar un peptido ciclico con acti- vidad antagonista de vasopresina Expired ES8701784A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/673,828 US4599324A (en) 1984-11-21 1984-11-21 V1-vasopressin antagonists

Publications (2)

Publication Number Publication Date
ES8701784A1 true ES8701784A1 (es) 1986-12-01
ES549077A0 ES549077A0 (es) 1986-12-01

Family

ID=24704273

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549077A Expired ES8701784A1 (es) 1984-11-21 1985-11-20 Un procedimiento para preparar un peptido ciclico con acti- vidad antagonista de vasopresina

Country Status (10)

Country Link
US (1) US4599324A (es)
EP (1) EP0182626A3 (es)
JP (1) JPS61137898A (es)
AU (1) AU588004B2 (es)
CA (1) CA1249399A (es)
DK (1) DK528885A (es)
ES (1) ES8701784A1 (es)
GR (1) GR852780B (es)
PT (1) PT81510B (es)
ZA (1) ZA858891B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684622A (en) * 1984-11-21 1987-08-04 Smithkline Beckman Corporation Compositions and methods for producing vasodilation and antioxytocic activity
US4687758A (en) * 1985-11-19 1987-08-18 Smithkline Beckman Corporation Des-proline-N-methylarginine vasopressins
PT84342B (pt) * 1986-02-25 1989-09-14 Smithkline Beecham Corp Processo de preparacao de compostos de vasopressina
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
EP0412508B1 (de) * 1989-08-07 1995-07-05 Ceskoslovenska Akademie Ved Vasopressin-Analoga,ihre Herstellung und ihre pharmazeutische Verwendung
US5225528A (en) * 1990-02-27 1993-07-06 Merck & Co., Inc. Cyclic hexapeptide oxytocin antagonists
SE9002384D0 (sv) * 1990-07-09 1990-07-09 Ferring Ab Derivat av baklobshormoner
US20030103983A1 (en) * 2002-05-09 2003-06-05 Pressler Milton Lethan Ace inhibitor-vasopressin antagonist combinations
FR2819809B1 (fr) * 2001-01-23 2003-05-16 Commissariat Energie Atomique Peptides presentant un affinite pour la proteine virale gp120, et utilisation de ces peptides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1246055A (en) * 1980-03-24 1988-12-06 Joseph H. Cort N-.omega.-substituted hormonogens of vasopressin and its synthetic analogs
US4491577A (en) * 1981-11-16 1985-01-01 The Medical College Of Ohio Antagonists of the antidiuretic action of arginine vasopressin
ATE20072T1 (de) * 1982-12-21 1986-06-15 Ferring Ab Vasotocinderivate.
US4469679A (en) * 1983-02-16 1984-09-04 Smithkline Beckman Corporation Octapeptide vasopressin antagonists
CA1238314A (en) * 1983-09-22 1988-06-21 James F. Callahan Process for preparing basic heptapeptide vasopressin antagonists
US4481194A (en) * 1984-03-07 1984-11-06 Smithkline Beckman Corporation Des-proline-des-glycine vasopressin antagonists
US4481193A (en) * 1984-03-07 1984-11-06 Smithkline Beckman Corporation Des-proline vasopressin antagonists
US4623716A (en) * 1984-11-01 1986-11-18 Usv Pharmaceutical Corp. Process for the preparation and purification of peptides

Also Published As

Publication number Publication date
AU588004B2 (en) 1989-09-07
EP0182626A2 (en) 1986-05-28
DK528885D0 (da) 1985-11-15
PT81510B (en) 1987-09-18
JPS61137898A (ja) 1986-06-25
AU4990085A (en) 1986-05-29
EP0182626A3 (en) 1988-10-05
US4599324A (en) 1986-07-08
DK528885A (da) 1986-05-22
PT81510A (en) 1985-12-01
ZA858891B (en) 1986-10-29
CA1249399A (en) 1989-01-24
ES549077A0 (es) 1986-12-01
GR852780B (es) 1986-03-14

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