NO941151L - Lineære adhesjonsinhibitorer - Google Patents
Lineære adhesjonsinhibitorerInfo
- Publication number
- NO941151L NO941151L NO941151A NO941151A NO941151L NO 941151 L NO941151 L NO 941151L NO 941151 A NO941151 A NO 941151A NO 941151 A NO941151 A NO 941151A NO 941151 L NO941151 L NO 941151L
- Authority
- NO
- Norway
- Prior art keywords
- gly
- asn
- lys
- asp
- leu
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FBKUOPULLUJMOC-UHFFFAOYSA-N 2-[[2-(9h-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid Chemical compound C1=CC=C2C(COC(=O)NCC(=O)NCC(=O)O)C3=CC=CC=C3C2=C1 FBKUOPULLUJMOC-UHFFFAOYSA-N 0.000 abstract 1
- SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical group C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
- XWOBNBRUDDUEEY-UWVGGRQHSA-N Leu-His Chemical group CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CNC=N1 XWOBNBRUDDUEEY-UWVGGRQHSA-N 0.000 abstract 1
- LCPYQJIKPJDLLB-UWVGGRQHSA-N Leu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CC(C)C LCPYQJIKPJDLLB-UWVGGRQHSA-N 0.000 abstract 1
- DTERQYGMUDWYAZ-UHFFFAOYSA-N N-acetyl-N-thioacetyl-Lysine Natural products CC(=O)NCCCCC(N)C(O)=O DTERQYGMUDWYAZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000267 glycino group Chemical group [H]N([*])C([H])([H])C(=O)O[H] 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 108010091798 leucylleucine Proteins 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Lineære peptider med formel I. hvor X er H, acyl med 1-10 C-atomer, H-Asn, H-Val-Asn, H-Asp-Val-Asn, Fmoc-Gly-Gly, H-Lys-Gly-Gly, H-Lys-Pro, H-Tyr-Gly-Gly, H-Cys-Gly-Gly, H-Cys(Trt)-Gly-Gly, H-Cys-Gly-Gly-Thr-Asp-Val-Asn eller H-Thr-Asp-Val-Asn; A, B og C uav-hengig av hverandre mangler eller er en aminosyrerest valgt fra en gruppe be-stående av Ala, Arg, Asn, Asp, Asp(OR), Cys, Gin, Glu, Gly, His, Ile, Leu, Lys, Lys(Ac), Lys(AcNH), Lys(AcSH), Met, Orn, Phe, 4-Hal-Phe, Pro, Ser, Thr, Trp, Tyr eller Val, idet de nevnte aminosyrerester også kan være derivati-sert; E er Gly, His eller Leu-His; G mangler eller er Asp eller Asn; L mangler eller er Gly, Ile, Leu eller Leu-Leu; Z er NHeller 0H; Hal er F, Cl, Br eller I; og Ac er alkanoyl med 1-10 C-atomer; samt fysiologisk aksep-table salter derav. Forbindelsene virker som integrininhibitorer og kan særlig anvendes til profylakse og be-handling av sykdommer i blodomløpet og til tumorterapi.remstillingen av forbindelsene er beskrevet.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4310632A DE4310632A1 (de) | 1993-04-01 | 1993-04-01 | Lineare Adhäsionsinhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO941151D0 NO941151D0 (no) | 1994-03-29 |
| NO941151L true NO941151L (no) | 1994-10-03 |
Family
ID=6484423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941151A NO941151L (no) | 1993-04-01 | 1994-03-29 | Lineære adhesjonsinhibitorer |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0618225A1 (no) |
| JP (1) | JPH06321988A (no) |
| CN (1) | CN1099040A (no) |
| AU (1) | AU5798494A (no) |
| CA (1) | CA2120302A1 (no) |
| CZ (1) | CZ70394A3 (no) |
| DE (1) | DE4310632A1 (no) |
| HU (1) | HU9400932D0 (no) |
| NO (1) | NO941151L (no) |
| SK (1) | SK38494A3 (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770565A (en) * | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
| US5874562A (en) * | 1995-06-07 | 1999-02-23 | Progenitor, Inc. | Nucleic acid encoding developmentally-regulated endothelial cell locus-1 |
| US6100423A (en) * | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
| ATE203234T1 (de) | 1995-08-30 | 2001-08-15 | Searle & Co | Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten |
| AU721034B2 (en) | 1996-02-15 | 2000-06-22 | Biosense, Inc. | Catheter based surgery |
| US6443974B1 (en) | 1996-07-28 | 2002-09-03 | Biosense, Inc. | Electromagnetic cardiac biostimulation |
| ES2255155T3 (es) | 1998-02-05 | 2006-06-16 | Biosense Webster, Inc. | Dispositivo para la administracion intracardiaca de farmacos. |
| CZ20012320A3 (cs) | 1998-12-23 | 2002-10-16 | G. D. Searle & Co. | Léčivo s obsahem inhibitoru cyklooxygenázy-2 a jednoho nebo více antineoplastických činidel pro kombinační terapii při léčení neoplasie |
| JP2004501166A (ja) | 2000-06-16 | 2004-01-15 | ハーキュリーズ・インコーポレーテッド | 化学修飾ペプチド、組成物、並びに製造方法および使用 |
| GB0323378D0 (en) | 2003-10-07 | 2003-11-05 | Univ Leicester | Therapeutic agent |
| DE602005023429D1 (de) | 2004-10-19 | 2010-10-21 | Lonza Ag | Verfahren zur festphasen-peptidsynthese |
| EP2190450A2 (en) * | 2007-09-11 | 2010-06-02 | Mondobiotech Laboratories AG | Use of melanin concentrating hormone and met-enkephalin as therapeutic agents |
| EP2197471A2 (en) * | 2007-09-11 | 2010-06-23 | Mondobiotech Laboratories AG | Use of the peptides maippkknqdk (cow kappa casein 106-116) and/or ygfqna (serorphin) as therapeutic agents |
| CN106279362B (zh) * | 2015-06-23 | 2019-07-12 | 首都医科大学 | Arg-Leu-Val-Cys-Val，其合成，药理活性和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049659A (en) * | 1988-02-09 | 1991-09-17 | Dana Farber Cancer Institute | Proteins which induce immunological effector cell activation and chemattraction |
| US5196511A (en) * | 1989-12-01 | 1993-03-23 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
-
1993
- 1993-04-01 DE DE4310632A patent/DE4310632A1/de not_active Withdrawn
-
1994
- 1994-03-21 EP EP94104395A patent/EP0618225A1/de not_active Withdrawn
- 1994-03-23 AU AU57984/94A patent/AU5798494A/en not_active Abandoned
- 1994-03-25 CZ CZ94703A patent/CZ70394A3/cs unknown
- 1994-03-29 NO NO941151A patent/NO941151L/no unknown
- 1994-03-30 CA CA002120302A patent/CA2120302A1/en not_active Abandoned
- 1994-03-30 CN CN94104073A patent/CN1099040A/zh active Pending
- 1994-03-31 HU HU9400932A patent/HU9400932D0/hu unknown
- 1994-03-31 JP JP6096828A patent/JPH06321988A/ja active Pending
- 1994-03-31 SK SK384-94A patent/SK38494A3/sk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ70394A3 (en) | 1994-12-15 |
| SK38494A3 (en) | 1995-02-08 |
| EP0618225A1 (de) | 1994-10-05 |
| JPH06321988A (ja) | 1994-11-22 |
| NO941151D0 (no) | 1994-03-29 |
| AU5798494A (en) | 1994-10-06 |
| CN1099040A (zh) | 1995-02-22 |
| DE4310632A1 (de) | 1994-10-06 |
| HU9400932D0 (en) | 1994-06-28 |
| CA2120302A1 (en) | 1994-10-02 |
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