HUP0104071A2 - Az alfavbéta6-integrint gátló vegyületek - Google Patents
Az alfavbéta6-integrint gátló vegyületekInfo
- Publication number
- HUP0104071A2 HUP0104071A2 HU0104071A HUP0104071A HUP0104071A2 HU P0104071 A2 HUP0104071 A2 HU P0104071A2 HU 0104071 A HU0104071 A HU 0104071A HU P0104071 A HUP0104071 A HU P0104071A HU P0104071 A2 HUP0104071 A2 HU P0104071A2
- Authority
- HU
- Hungary
- Prior art keywords
- leu
- phg
- nle
- phe
- asp
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002682 anti-psoriatic effect Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 108010004788 integrin alphavbeta6 Proteins 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 108091006082 receptor inhibitors Proteins 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány újszerű peptideket ismertet, amelyek biológiai hatásukataz anb6-integrin ligandumaiként fejtik ki. Ezek a peptidek egy közösszerkezeti egységet tartalmaznak - ez az AspLeuXaaLeu, illetve előnyösformában ArgXaaAspLeuXaaXaaLeuArg, ahol Xaa jelentése tetszőlegesaminosavmaradék. A találmány szerinti peptidek az anb6-integrin-receptor hatásos gátlói, és ennek következtében különböző betegségekés patológiás állapotok kezelésére bevethetők; ilyen betegségekpéldául a trombózis, szívinfarktus, koszorúeres szívmegbetegedések,arterioszklerózis, daganatok, csontritkulás, fibrózisok, gyulladások,fertőzések, pszoriázisok; továbbá sebgyógyulási folyamatokbefolyásolására is felhasználhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19858587 | 1998-12-19 | ||
| PCT/EP1999/009842 WO2000037487A1 (de) | 1998-12-19 | 1999-12-11 | INHIBITOREN DES INTEGRINS αvβ¿6? |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0104071A2 true HUP0104071A2 (hu) | 2002-03-28 |
Family
ID=7891641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104071A HUP0104071A2 (hu) | 1998-12-19 | 1999-12-11 | Az alfavbéta6-integrint gátló vegyületek |
Country Status (7)
| Country | Link |
|---|---|
| KR (1) | KR20010101178A (hu) |
| AU (1) | AU770295B2 (hu) |
| HU (1) | HUP0104071A2 (hu) |
| ID (1) | ID29917A (hu) |
| PL (1) | PL348058A1 (hu) |
| RU (1) | RU2002124494A (hu) |
| SK (1) | SK8052001A3 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05008313A (es) * | 2003-02-06 | 2005-09-20 | Merck Patent Gmbh | Sulfonamidas peptidicas. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219515A (en) * | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
-
1999
- 1999-12-11 PL PL99348058A patent/PL348058A1/xx unknown
- 1999-12-11 HU HU0104071A patent/HUP0104071A2/hu unknown
- 1999-12-11 ID IDW00200101585A patent/ID29917A/id unknown
- 1999-12-11 AU AU19777/00A patent/AU770295B2/en not_active Ceased
- 1999-12-11 SK SK805-2001A patent/SK8052001A3/sk unknown
- 1999-12-11 RU RU2002124494/04A patent/RU2002124494A/ru not_active Application Discontinuation
- 1999-12-11 KR KR1020017007309A patent/KR20010101178A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU770295B2 (en) | 2004-02-19 |
| SK8052001A3 (en) | 2002-07-02 |
| AU1977700A (en) | 2000-07-12 |
| PL348058A1 (en) | 2002-05-06 |
| KR20010101178A (ko) | 2001-11-14 |
| RU2002124494A (ru) | 2004-01-10 |
| ID29917A (id) | 2001-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU729910B2 (en) | Serine protease inhibitors | |
| Krstenansky et al. | Antithrombin properties of C-terminus of hirudin using synthetic unsulfated Nα-acetyl-hirudin45–65 | |
| AU707094B2 (en) | Analogs of parathyroid hormone | |
| Shieh et al. | Amino acid sequence of a coagulant enzyme, flavoxobin, from Trimeresurus flavoviridis venom | |
| US5446130A (en) | Parathyroid hormone antagonists | |
| US5955574A (en) | Analogs of parathyroid hormone | |
| HUT58352A (en) | Process for producing new proteines | |
| UA35636C2 (uk) | Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавців | |
| AU5918594A (en) | Linear adhesion inhibitors | |
| IE913120A1 (en) | Enzyme inhibitors | |
| AU716716B2 (en) | Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases | |
| US4211693A (en) | Peptides with para-substituted phenylalanine | |
| CA2292846A1 (en) | Lh-rh peptide analogues, their uses and pharmaceutical compositions containing them | |
| ZA9394B (en) | A novel human kunitz-type inhibitor and variants thereof | |
| Magdolen et al. | Cyclo19, 31 [D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) | |
| NO941151L (no) | Lineære adhesjonsinhibitorer | |
| Kubiak et al. | In vitro metabolic degradation of a bovine growth hormone-releasing factor analog Leu27-bGRF (1-29) NH2 in bovine and porcine plasma. Correlation with plasma dipeptidylpeptidase activity. | |
| CA1321281C (en) | Humoral hypercalcemic factor antagonists | |
| EP0328090A2 (en) | LHRH analogs | |
| HUP0104071A2 (hu) | Az alfavbéta6-integrint gátló vegyületek | |
| Bovy et al. | A carboxy-terminus truncated analog of angiotensin II,[Sar1] angiotensin II-(1-7)-amide, provides an entry to a new class of angiotensin II antagonists | |
| HUP0003357A2 (hu) | Angiogén hatású ciklusos azapeptidek, ezeket hatóanyagként tartalmazó gyógyászati készítmények, eljárás ezek előállítására és alkalmazásuk | |
| Fujimoto et al. | Effects of caerulein-related peptides on cholecystokinin receptor bindings in brain and pancreas | |
| US5087562A (en) | Humoral hypercalcemic factor antagonists with modification at position 13 . . . | |
| EP1624885A2 (en) | Synthetic peptide analogs of arg-pro-pro-gly-phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 |