DK0628569T3 - Triterpenderivater og endothelinreceptorantagonister indeholdende samme - Google Patents

Triterpenderivater og endothelinreceptorantagonister indeholdende samme

Info

Publication number
DK0628569T3
DK0628569T3 DK94304165.7T DK94304165T DK0628569T3 DK 0628569 T3 DK0628569 T3 DK 0628569T3 DK 94304165 T DK94304165 T DK 94304165T DK 0628569 T3 DK0628569 T3 DK 0628569T3
Authority
DK
Denmark
Prior art keywords
same
receptor antagonists
endothelin receptor
triterpene derivatives
hydrogen
Prior art date
Application number
DK94304165.7T
Other languages
Danish (da)
English (en)
Inventor
Toshiro Konoike
Yoshitaka Araki
Tetsuyoshi Hayashi
Kensuke Sakurai
Takehiko Tozyo
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of DK0628569T3 publication Critical patent/DK0628569T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK94304165.7T 1993-06-11 1994-06-09 Triterpenderivater og endothelinreceptorantagonister indeholdende samme DK0628569T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14041693 1993-06-11

Publications (1)

Publication Number Publication Date
DK0628569T3 true DK0628569T3 (da) 1996-09-30

Family

ID=15268217

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94304165.7T DK0628569T3 (da) 1993-06-11 1994-06-09 Triterpenderivater og endothelinreceptorantagonister indeholdende samme

Country Status (11)

Country Link
US (2) US5463107A (fr)
EP (2) EP0628569B1 (fr)
JP (1) JP2724114B2 (fr)
KR (1) KR100201015B1 (fr)
CN (2) CN1041938C (fr)
AT (2) ATE142640T1 (fr)
DE (2) DE69400506T2 (fr)
DK (1) DK0628569T3 (fr)
ES (2) ES2116663T3 (fr)
GR (1) GR3021952T3 (fr)
TW (1) TW272974B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2116663T3 (es) 1993-06-11 1998-07-16 Shionogi & Co Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.
EP0838223B1 (fr) * 1995-06-02 2003-07-23 Shionogi & Co., Ltd. Inhibiteur de l'oedeme cerebral
AU1319697A (en) * 1996-01-23 1997-08-20 Shionogi & Co., Ltd. Process for producing oleanolic acid analogs by culturing hairy root
JP2007217438A (ja) * 2001-07-17 2007-08-30 Shionogi & Co Ltd 注射用医薬製剤
TWI232102B (en) * 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
CA2480096A1 (fr) 2002-03-22 2003-10-02 Shionogi & Co., Ltd. Procede de production de derives de triterpenes
JPWO2004108163A1 (ja) * 2003-06-04 2006-07-20 塩野義製薬株式会社 低帯電性粉末の製造方法
TWI335335B (en) * 2004-03-24 2011-01-01 Shionogi & Co A novel crystal of a triterpene derivative
US8017793B2 (en) 2004-05-14 2011-09-13 Shionogi & Co., Ltd. Oxidation of alcohol with use of hydrogen peroxide and tungsten catalyst
JPWO2006077801A1 (ja) * 2005-01-18 2008-06-19 塩野義製薬株式会社 ミリセロン誘導体の製造方法
JPWO2007072845A1 (ja) * 2005-12-21 2009-05-28 塩野義製薬株式会社 虚血性脳卒中治療薬または治療方法
WO2007103727A2 (fr) * 2006-03-03 2007-09-13 Savipu Pharmaceuticals Dérivés de triterpènes pour le traitement de cancers et de maladies inflammatoires par inhibition de la nf-kb
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2115665T3 (es) 1991-01-29 1998-07-01 Shionogi & Co Derivado de triterpeno.
ES2116663T3 (es) 1993-06-11 1998-07-16 Shionogi & Co Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.

Also Published As

Publication number Publication date
EP0682009A2 (fr) 1995-11-15
EP0628569B1 (fr) 1996-09-11
DE69400506D1 (de) 1996-10-17
TW272974B (fr) 1996-03-21
CN1215725A (zh) 1999-05-05
KR100201015B1 (ko) 1999-06-15
EP0628569A1 (fr) 1994-12-14
ES2116663T3 (es) 1998-07-16
CN1041938C (zh) 1999-02-03
JP2724114B2 (ja) 1998-03-09
DE69400506T2 (de) 1997-02-13
ES2094622T3 (es) 1997-01-16
US5463107A (en) 1995-10-31
KR950000663A (ko) 1995-01-03
CN1070183C (zh) 2001-08-29
US5587505A (en) 1996-12-24
DE69410081T2 (de) 1998-10-08
EP0682009B1 (fr) 1998-05-06
EP0682009A3 (fr) 1997-02-05
CN1106368A (zh) 1995-08-09
DE69410081D1 (de) 1998-06-10
JPH0753484A (ja) 1995-02-28
GR3021952T3 (en) 1997-03-31
ATE142640T1 (de) 1996-09-15
ATE165811T1 (de) 1998-05-15

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