DK0610138T3 - Fremgangsmåde til fremstilling af 6 alpha,9 alpha-difluorsteroider samt mellemprodukter dertil - Google Patents

Fremgangsmåde til fremstilling af 6 alpha,9 alpha-difluorsteroider samt mellemprodukter dertil

Info

Publication number
DK0610138T3
DK0610138T3 DK94400227.8T DK94400227T DK0610138T3 DK 0610138 T3 DK0610138 T3 DK 0610138T3 DK 94400227 T DK94400227 T DK 94400227T DK 0610138 T3 DK0610138 T3 DK 0610138T3
Authority
DK
Denmark
Prior art keywords
alpha
preparation
intermediates therefor
steroids
difluoro
Prior art date
Application number
DK94400227.8T
Other languages
Danish (da)
English (en)
Inventor
Philippe Mackiewicz
Jean-Yves Godard
Christian Richard
Denis Prat
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of DK0610138T3 publication Critical patent/DK0610138T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94400227.8T 1993-02-05 1994-02-03 Fremgangsmåde til fremstilling af 6 alpha,9 alpha-difluorsteroider samt mellemprodukter dertil DK0610138T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301275A FR2701262B1 (fr) 1993-02-05 1993-02-05 Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.

Publications (1)

Publication Number Publication Date
DK0610138T3 true DK0610138T3 (da) 1996-10-07

Family

ID=9443760

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94400227.8T DK0610138T3 (da) 1993-02-05 1994-02-03 Fremgangsmåde til fremstilling af 6 alpha,9 alpha-difluorsteroider samt mellemprodukter dertil

Country Status (18)

Country Link
US (2) US5478957A (ja)
EP (1) EP0610138B1 (ja)
JP (1) JP3346873B2 (ja)
KR (1) KR100312269B1 (ja)
CN (1) CN1070499C (ja)
AT (1) ATE140925T1 (ja)
AU (1) AU671695B2 (ja)
CA (1) CA2115015C (ja)
DE (1) DE69400343T2 (ja)
DK (1) DK0610138T3 (ja)
ES (1) ES2091100T3 (ja)
FR (1) FR2701262B1 (ja)
GR (1) GR3020750T3 (ja)
HU (1) HU214717B (ja)
MX (1) MX9400910A (ja)
RU (1) RU2127739C1 (ja)
TW (1) TW243452B (ja)
ZA (1) ZA94778B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
KR100245651B1 (ko) * 1996-09-21 2000-02-15 윤종용 반도체 웨이퍼 보트의 이송장치
US6410760B1 (en) 1999-10-13 2002-06-25 Pharmacia & Upjohn Company Process to prepare androst-4-en-17-carboxylic acid
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.
PT102628B (pt) 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
ES2184628B1 (es) * 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
CN1596241A (zh) * 2001-11-29 2005-03-16 塔罗制药美国公司 6α－氟皮质甾类的制备方法
ITMI20020676A1 (it) * 2002-03-29 2003-09-29 Farmabios S R L Ora Farmabios Processo di preparazione di 6(alfa)-fluro steroidi
CA2509366C (en) * 2002-12-09 2008-04-15 Sicor Inc. Process for the preparation of pregnanes
FR2854402B1 (fr) * 2003-04-29 2008-07-04 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947409A (en) * 1958-06-19 1976-03-30 Merck & Co., Inc. 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof
US3014938A (en) * 1959-09-07 1961-12-26 Syntex Sa Preparation of 16, 21-diacetate derivative of cyclopentanophenanthrene compounds
US3546215A (en) * 1967-10-18 1970-12-08 Syntex Corp 6-gem-difluoro steroids
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US3828080A (en) * 1972-01-20 1974-08-06 Glaxo Lab Ltd Androstane-17beta-carboxylic acids and processes for the preparation thereof
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
US4198404A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 6 Alpha, 6 beta-difluoro-etianic acid derivatives
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
US4607028A (en) * 1983-08-18 1986-08-19 Ciba-Geigy Corporation Novel carboxylic acid esters
WO1991003459A1 (en) * 1989-08-30 1991-03-21 Whitby Research, Inc. Substituted 2-aminotetralins useful as dopaminergics
JPH05507912A (ja) * 1990-06-11 1993-11-11 アルコン・ラボラトリーズ，インコーポレイテッド 血管形成を阻害するステロイド

Also Published As

Publication number Publication date
CN1099758A (zh) 1995-03-08
FR2701262B1 (fr) 1995-03-24
AU671695B2 (en) 1996-09-05
ES2091100T3 (es) 1996-10-16
TW243452B (ja) 1995-03-21
US5478957A (en) 1995-12-26
ATE140925T1 (de) 1996-08-15
FR2701262A1 (fr) 1994-08-12
HU9400323D0 (en) 1994-05-30
CA2115015A1 (fr) 1994-08-06
MX9400910A (es) 1994-08-31
EP0610138A1 (fr) 1994-08-10
KR940019721A (ko) 1994-09-14
JP3346873B2 (ja) 2002-11-18
HUT67405A (en) 1995-04-28
KR100312269B1 (ko) 2002-05-13
US5556965A (en) 1996-09-17
HU214717B (hu) 1998-05-28
CN1070499C (zh) 2001-09-05
EP0610138B1 (fr) 1996-07-31
DE69400343T2 (de) 1997-01-16
CA2115015C (fr) 2004-01-27
ZA94778B (en) 1995-02-06
JPH06279485A (ja) 1994-10-04
AU5489294A (en) 1994-08-11
RU2127739C1 (ru) 1999-03-20
GR3020750T3 (en) 1996-11-30
DE69400343D1 (de) 1996-09-05

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