DK0608759T3 - Piperazinderivater - Google Patents
PiperazinderivaterInfo
- Publication number
- DK0608759T3 DK0608759T3 DK94100709T DK94100709T DK0608759T3 DK 0608759 T3 DK0608759 T3 DK 0608759T3 DK 94100709 T DK94100709 T DK 94100709T DK 94100709 T DK94100709 T DK 94100709T DK 0608759 T3 DK0608759 T3 DK 0608759T3
- Authority
- DK
- Denmark
- Prior art keywords
- chr
- fibrinogen
- piperazine
- cmh2m
- thromboses
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 108010012088 Fibrinogen Receptors Proteins 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4302485A DE4302485A1 (de) | 1993-01-29 | 1993-01-29 | Piperazinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0608759T3 true DK0608759T3 (da) | 2001-12-03 |
Family
ID=6479203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94100709T DK0608759T3 (da) | 1993-01-29 | 1994-01-19 | Piperazinderivater |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5908843A (fr) |
| EP (1) | EP0608759B1 (fr) |
| JP (1) | JPH06271549A (fr) |
| KR (1) | KR100312539B1 (fr) |
| CN (1) | CN1056141C (fr) |
| AT (1) | ATE204570T1 (fr) |
| AU (1) | AU670649B2 (fr) |
| CA (1) | CA2114361A1 (fr) |
| CZ (1) | CZ288122B6 (fr) |
| DE (2) | DE4302485A1 (fr) |
| DK (1) | DK0608759T3 (fr) |
| ES (1) | ES2162825T3 (fr) |
| GR (1) | GR3036838T3 (fr) |
| HU (1) | HU222013B1 (fr) |
| NO (1) | NO312550B1 (fr) |
| PL (1) | PL172716B1 (fr) |
| PT (1) | PT608759E (fr) |
| RU (1) | RU2154639C2 (fr) |
| SK (1) | SK281842B6 (fr) |
| UA (1) | UA34429C2 (fr) |
| ZA (1) | ZA94615B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9602294D0 (en) * | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
| CZ298089B6 (cs) * | 1996-07-25 | 2007-06-20 | Biogen Idec Ma Inc. | Inhibitory bunecné adheze, zpusob jejich prípravya farmaceutické prostredky s jejich obsahem |
| KR20000029984A (ko) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| EP0966460A1 (fr) | 1997-02-13 | 1999-12-29 | Zeneca Limited | Composes heterocycliques utilises comme inhibiteurs de l'oxydo-squalene cyclase |
| JP2001511799A (ja) | 1997-02-13 | 2001-08-14 | ゼネカ・リミテッド | オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物 |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| FR2781220B1 (fr) * | 1998-07-17 | 2000-10-13 | Lafon Labor | Piperazinones substituees en beta |
| FR2781221B1 (fr) * | 1998-07-17 | 2000-10-13 | Lafon Labor | Piperazinones substituees en alpha |
| DE19835950A1 (de) * | 1998-08-08 | 2000-02-10 | Merck Patent Gmbh | Piperazinonderivate |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| US6713472B1 (en) | 1999-07-26 | 2004-03-30 | Santen Pharmaceutical Co., Ltd. | Thiazine or pyrazine derivatives |
| US7122580B2 (en) * | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| AU2004244982A1 (en) * | 2003-06-02 | 2004-12-16 | Georgetown University | Anti-HIV benzamide compounds |
| US20060194814A1 (en) * | 2003-06-02 | 2006-08-31 | Vassilios Papadopoulos | Benzamide compounds |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| WO2005014534A1 (fr) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Composes aryle et heteroaryle, compositions, et methodes d'utilisation |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| AU2006275568A1 (en) * | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| SG11202106506WA (en) | 2018-12-19 | 2021-07-29 | Celgene Corp | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
| AU2019403207A1 (en) | 2018-12-19 | 2021-07-15 | Celgene Corporation | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3711335A1 (de) * | 1987-04-03 | 1988-10-20 | Merck Patent Gmbh | Aminosaeurederivate |
| US5053393A (en) * | 1988-07-20 | 1991-10-01 | Monsanto Company | Novel platelet-aggregation inhibitor |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| DE4007869A1 (de) * | 1990-03-13 | 1991-09-19 | Merck Patent Gmbh | Aminosaeurederivate |
| IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
| AU646966B2 (en) * | 1991-08-23 | 1994-03-10 | Takeda Chemical Industries Ltd. | 2-piperazinone compounds, their production and use |
| JP3719612B2 (ja) * | 1993-06-14 | 2005-11-24 | 塩野義製薬株式会社 | ヘテロ環を含有する尿素誘導体 |
-
1993
- 1993-01-29 DE DE4302485A patent/DE4302485A1/de not_active Withdrawn
- 1993-11-30 UA UA93003858A patent/UA34429C2/uk unknown
-
1994
- 1994-01-18 JP JP6003451A patent/JPH06271549A/ja active Pending
- 1994-01-19 DE DE59409833T patent/DE59409833D1/de not_active Expired - Fee Related
- 1994-01-19 DK DK94100709T patent/DK0608759T3/da active
- 1994-01-19 EP EP94100709A patent/EP0608759B1/fr not_active Expired - Lifetime
- 1994-01-19 PT PT94100709T patent/PT608759E/pt unknown
- 1994-01-19 AT AT94100709T patent/ATE204570T1/de not_active IP Right Cessation
- 1994-01-19 ES ES94100709T patent/ES2162825T3/es not_active Expired - Lifetime
- 1994-01-20 SK SK68-94A patent/SK281842B6/sk unknown
- 1994-01-25 CZ CZ1994163A patent/CZ288122B6/cs unknown
- 1994-01-25 AU AU54702/94A patent/AU670649B2/en not_active Ceased
- 1994-01-25 CN CN94101127A patent/CN1056141C/zh not_active Expired - Fee Related
- 1994-01-27 CA CA002114361A patent/CA2114361A1/fr not_active Abandoned
- 1994-01-28 ZA ZA94615A patent/ZA94615B/xx unknown
- 1994-01-28 NO NO19940308A patent/NO312550B1/no not_active IP Right Cessation
- 1994-01-28 HU HU9400249A patent/HU222013B1/hu not_active IP Right Cessation
- 1994-01-28 KR KR1019940001512A patent/KR100312539B1/ko not_active IP Right Cessation
- 1994-01-28 PL PL94302069A patent/PL172716B1/pl unknown
- 1994-01-28 RU RU94002323/04A patent/RU2154639C2/ru not_active IP Right Cessation
- 1994-01-31 US US08/189,385 patent/US5908843A/en not_active Expired - Fee Related
-
2001
- 2001-10-09 GR GR20010401700T patent/GR3036838T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2162825T3 (es) | 2002-01-16 |
| CZ16394A3 (en) | 1994-08-17 |
| AU5470294A (en) | 1994-08-04 |
| KR100312539B1 (ko) | 2002-02-19 |
| SK281842B6 (sk) | 2001-08-06 |
| DE59409833D1 (de) | 2001-09-27 |
| UA34429C2 (uk) | 2001-03-15 |
| HUT70042A (en) | 1995-09-28 |
| ZA94615B (en) | 1994-09-13 |
| DE4302485A1 (de) | 1994-08-04 |
| EP0608759A2 (fr) | 1994-08-03 |
| KR940018372A (ko) | 1994-08-16 |
| CA2114361A1 (fr) | 1994-07-30 |
| PT608759E (pt) | 2002-02-28 |
| NO940308D0 (no) | 1994-01-28 |
| JPH06271549A (ja) | 1994-09-27 |
| AU670649B2 (en) | 1996-07-25 |
| SK6894A3 (en) | 1994-08-10 |
| ATE204570T1 (de) | 2001-09-15 |
| EP0608759B1 (fr) | 2001-08-22 |
| HU9400249D0 (en) | 1994-05-30 |
| HU222013B1 (hu) | 2003-03-28 |
| NO312550B1 (no) | 2002-05-27 |
| EP0608759A3 (fr) | 1994-10-05 |
| GR3036838T3 (en) | 2002-01-31 |
| PL172716B1 (pl) | 1997-11-28 |
| PL302069A1 (en) | 1994-08-08 |
| RU2154639C2 (ru) | 2000-08-20 |
| CN1056141C (zh) | 2000-09-06 |
| US5908843A (en) | 1999-06-01 |
| CZ288122B6 (cs) | 2001-04-11 |
| NO940308L (no) | 1994-08-01 |
| CN1099759A (zh) | 1995-03-08 |
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