DK0600965T3 - Primere til matrixafhængige, enzymatiske nukleinsyresynteser - Google Patents

Primere til matrixafhængige, enzymatiske nukleinsyresynteser

Info

Publication number
DK0600965T3
DK0600965T3 DK92917597T DK92917597T DK0600965T3 DK 0600965 T3 DK0600965 T3 DK 0600965T3 DK 92917597 T DK92917597 T DK 92917597T DK 92917597 T DK92917597 T DK 92917597T DK 0600965 T3 DK0600965 T3 DK 0600965T3
Authority
DK
Denmark
Prior art keywords
pct
nucleic acid
primers
enzymatic nucleic
dependent
Prior art date
Application number
DK92917597T
Other languages
Danish (da)
English (en)
Inventor
Hartmut Seliger
Wojciech T Markiewicz
Gabriele Griger
Rudi Risch
Margit Klotz
Original Assignee
Boehringer Mannheim Gmbh
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh, Roche Diagnostics Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of DK0600965T3 publication Critical patent/DK0600965T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK92917597T 1991-08-28 1992-08-22 Primere til matrixafhængige, enzymatiske nukleinsyresynteser DK0600965T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4128480 1991-08-28
PCT/EP1992/001932 WO1993005060A1 (de) 1991-08-28 1992-08-22 Funktionalisierte trägermaterialien für gleichzeitige synthese und direktmarkierung von oligonukleotiden als primer für matrizenabhängige enzymatische nukleinsäuresynthesen

Publications (1)

Publication Number Publication Date
DK0600965T3 true DK0600965T3 (da) 1998-09-23

Family

ID=6439283

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92917597T DK0600965T3 (da) 1991-08-28 1992-08-22 Primere til matrixafhængige, enzymatiske nukleinsyresynteser

Country Status (10)

Country Link
US (1) US5574141A (ko)
EP (1) EP0600965B1 (ko)
JP (1) JP2562862B2 (ko)
KR (1) KR0123559B1 (ko)
AT (1) ATE163308T1 (ko)
CA (1) CA2113478C (ko)
DE (2) DE4227882A1 (ko)
DK (1) DK0600965T3 (ko)
ES (1) ES2116342T3 (ko)
WO (1) WO1993005060A1 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4418691A1 (de) * 1994-05-28 1996-02-22 Boehringer Mannheim Gmbh 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
CA2279669A1 (en) * 1995-12-15 1997-06-16 Enzo Therapeutics, Inc. Property effecting and/or property exhibiting constructs for the expression of non-native nucleic acid processing components for therapeutic and diagnostic uses
US6291164B1 (en) 1996-11-22 2001-09-18 Invitrogen Corporation Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
US6235483B1 (en) * 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
JP4128453B2 (ja) * 2001-03-19 2008-07-30 プレジデント アンド フェロウズ オブ ハーバード カレッジ 新規分子機能の進化
WO2002103008A2 (en) 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
EP1540013B1 (en) * 2002-08-19 2015-07-08 The President and Fellows of Harvard College Evolving new molecular function
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
SG10201408401RA (en) 2009-09-16 2015-01-29 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
CN102782134B (zh) 2009-12-29 2017-11-24 库尔纳公司 通过抑制核呼吸因子1(nrf1)的天然反义转录物而治疗nrf1相关疾病
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
EP2655414B1 (en) 2010-12-23 2018-08-29 Roche Diagniostics GmbH Bispecific binding agent
JP6046049B2 (ja) 2010-12-23 2016-12-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二価結合剤による翻訳後修飾されたポリペプチドの検出
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
EP2812357B1 (en) 2012-02-10 2020-11-04 F.Hoffmann-La Roche Ag Single-chain antibodies and other heteromultimers
MX354862B (es) 2012-06-27 2018-03-23 Hoffmann La Roche Método para la producción de entidades dirigidas altamente selectivas hechas a la medida y biespecíficas que contienen dos entidades de unión diferentes.
CA2871882A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
WO2014021938A1 (en) * 2012-08-02 2014-02-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for nucleic acid synthesis using oligo-templated polymerization
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU666183A1 (ru) * 1977-06-15 1979-06-05 Новосибирский институт органической химии СО АН СССР Способ получени активных производных динуклеотидов
FR2519005B1 (fr) * 1981-12-29 1985-10-25 Pasteur Institut Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn
DK171161B1 (da) * 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
US4762779A (en) * 1985-06-13 1988-08-09 Amgen Inc. Compositions and methods for functionalizing nucleic acids
SU1318600A1 (ru) * 1985-10-09 1987-06-23 Всесоюзный Научно-Исследовательский Институт Молекулярной Биологии Способ твердофазного синтеза олигонуклеотидов
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
SU1439108A1 (ru) * 1986-05-11 1988-11-23 Всесоюзный Научно-Исследовательский Институт Молекулярной Биологии Способ получени носителей дл твердофазного синтеза олигонуклеотидов
DE3801987A1 (de) * 1988-01-23 1989-07-27 Boehringer Mannheim Gmbh Traeger zur chemischen oder/und enzymatischen umsetzung von nukleinsaeuren oder nukleinsaeurefragmenten an festphasen
US5082934A (en) * 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US5141813A (en) * 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5403709A (en) * 1992-10-06 1995-04-04 Hybridon, Inc. Method for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages

Also Published As

Publication number Publication date
KR0123559B1 (ko) 1997-11-28
DE4227882A1 (de) 1993-04-01
US5574141A (en) 1996-11-12
EP0600965B1 (de) 1998-02-18
JPH06506700A (ja) 1994-07-28
JP2562862B2 (ja) 1996-12-11
ATE163308T1 (de) 1998-03-15
CA2113478C (en) 2001-06-12
CA2113478A1 (en) 1993-03-18
EP0600965A1 (de) 1994-06-15
ES2116342T3 (es) 1998-07-16
DE59209203D1 (de) 1998-03-26
WO1993005060A1 (de) 1993-03-18

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