DK0532341T3 - Biologisk fremgangsmåde til fremstilling af 7-ADCA - Google Patents
Biologisk fremgangsmåde til fremstilling af 7-ADCAInfo
- Publication number
- DK0532341T3 DK0532341T3 DK92308286T DK92308286T DK0532341T3 DK 0532341 T3 DK0532341 T3 DK 0532341T3 DK 92308286 T DK92308286 T DK 92308286T DK 92308286 T DK92308286 T DK 92308286T DK 0532341 T3 DK0532341 T3 DK 0532341T3
- Authority
- DK
- Denmark
- Prior art keywords
- adipoyl
- adca
- strain
- activity
- apa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium
- Y10S435/935—Penicillium chrysogenum
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75787991A | 1991-09-11 | 1991-09-11 | |
| US07/933,469 US5318896A (en) | 1991-09-11 | 1992-08-28 | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0532341T3 true DK0532341T3 (da) | 1999-07-19 |
Family
ID=27116462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92308286T DK0532341T3 (da) | 1991-09-11 | 1992-09-11 | Biologisk fremgangsmåde til fremstilling af 7-ADCA |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5318896A (da) |
| EP (2) | EP0843013A3 (da) |
| JP (2) | JP3027847B2 (da) |
| KR (2) | KR0132440B1 (da) |
| CN (2) | CN1066488C (da) |
| AT (1) | ATE173017T1 (da) |
| AU (1) | AU657787B2 (da) |
| BG (1) | BG62177B1 (da) |
| CA (1) | CA2077921C (da) |
| CZ (1) | CZ287357B6 (da) |
| DE (1) | DE69227494T2 (da) |
| DK (1) | DK0532341T3 (da) |
| ES (1) | ES2126588T3 (da) |
| FI (1) | FI108148B (da) |
| HU (1) | HU217171B (da) |
| IL (1) | IL103076A (da) |
| MX (1) | MX9205175A (da) |
| NO (1) | NO316742B1 (da) |
| NZ (1) | NZ244236A (da) |
| RO (1) | RO115886B1 (da) |
| RU (1) | RU2178808C2 (da) |
| SK (1) | SK282387B6 (da) |
| TW (1) | TW270149B (da) |
| UA (1) | UA41292C2 (da) |
| WO (1) | WO1993005158A1 (da) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6709859B1 (en) * | 1986-01-31 | 2004-03-23 | Beecham Group P.L.C. | Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression |
| EP0233715B1 (en) * | 1986-01-31 | 1994-05-25 | BEECHAM GROUP plc | Isolation and expression of genes involved in the biosynthesis of beta-lactams |
| KR100227711B1 (ko) * | 1991-10-15 | 1999-12-01 | 한스 발터 라벤 | 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정 |
| ATE234926T1 (de) * | 1993-07-30 | 2003-04-15 | Dsm Nv | Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca |
| PL180799B1 (pl) * | 1993-07-30 | 2001-04-30 | Gist Brocades Bv | Sposób wydajnego wytwarzania 7-ADCA poprzez 2-(karboksyetylotio)acetylo-7-ADCA i 3-(karboksymetylotio)-propionylo-7-ADCA |
| US5731165A (en) * | 1995-06-02 | 1998-03-24 | Gist-Brocades, B.V. | Process for the production of 7-ADCA via expandase activity on penicillin G |
| EP0863989A2 (en) * | 1995-11-27 | 1998-09-16 | Gist-Brocades B.V. | Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g |
| AU2508897A (en) * | 1996-04-04 | 1997-10-29 | Gist-Brocades B.V. | An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof |
| US6320069B1 (en) | 1996-07-02 | 2001-11-20 | Toray Industries, Inc. | Production of optically active ketone |
| AU4201897A (en) | 1996-07-16 | 1998-02-09 | Gist-Brocades B.V. | Novel process for the preparation of cephalosporins using (acremonium chrysogenum) |
| JP4217277B2 (ja) * | 1997-02-20 | 2009-01-28 | コニンクリーケ デーエスエム ナムローゼ フェンノートシャップ | 化学的に明確な培地を用いた工業的規模での有用化合物の発酵生産 |
| ES2237840T3 (es) | 1997-04-22 | 2005-08-01 | Dsm Ip Assets B.V. | Proceso mejorado para la produccion fermentativa de cefalosporina. |
| AU7648798A (en) * | 1997-04-22 | 1998-11-13 | Gist-Brocades B.V. | A method for controlling the solubility of a beta-lactam nucleus |
| US6518039B2 (en) * | 1997-04-22 | 2003-02-11 | Dsm N.V. | Process for the fermentative production of deacylated cephalosporins |
| BR9804858A (pt) * | 1997-04-22 | 1999-08-24 | Gist Brocades Bv | M-todo de prepara-Æo de antibiÄtico b-lactam |
| PT915988E (pt) * | 1997-04-22 | 2003-06-30 | Dsm Nv | Processo para a producao fermentativa de cefalosporinas desaciladas |
| WO1999033994A1 (en) * | 1997-12-24 | 1999-07-08 | Isis Innovation Limited | Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure |
| JP2002509933A (ja) * | 1998-03-27 | 2002-04-02 | デーエスエム・ナムローゼ・フェンノートシャップ | セファロスポリンの発酵製造の新規な方法 |
| US6383773B2 (en) * | 1998-04-23 | 2002-05-07 | Massachusetts Institute Of Technology | Penicillin conversion |
| WO1999060102A2 (en) | 1998-05-19 | 1999-11-25 | Dsm N.V. | Improved in vivo production of cephalosporins |
| ES2165276B1 (es) * | 1999-06-18 | 2003-03-01 | Antibioticos Sau | Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc) |
| PL206316B1 (pl) | 2000-05-13 | 2010-07-30 | Smithkline Beecham Plcsmithkline Beecham Plc | Sposób wytwarzania klawulanianu potasu |
| ES2571865T3 (es) | 2005-12-28 | 2016-05-27 | Dsm Sinochem Pharm Nl Bv | Acilasas de beta-lactama de tipo II mutantes |
| EP1987041B1 (en) * | 2006-02-23 | 2013-05-22 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Improved cephalosporin production |
| EP2123772A1 (en) | 2008-04-29 | 2009-11-25 | DSM IP Assets B.V. | Beta-lactam antibiotic producing strains |
| CN102131917A (zh) * | 2008-08-05 | 2011-07-20 | 帝斯曼知识产权资产管理有限公司 | 生产己二酰基-7-adca的菌株 |
| CN102119213A (zh) * | 2008-08-05 | 2011-07-06 | 帝斯曼知识产权资产管理有限公司 | 生产己二酰基-7-adca的菌株 |
| WO2010015627A2 (en) | 2008-08-05 | 2010-02-11 | Dsm Ip Assets B.V. | Adipoyl-7-adca producing strains |
| WO2010115838A1 (en) | 2009-04-03 | 2010-10-14 | Dsm Ip Assets B.V. | Fermentation process |
| WO2011161004A1 (en) | 2010-06-22 | 2011-12-29 | Dsm Ip Assets B.V. | Air bubble fermentation process |
| CN103108879B (zh) | 2010-09-07 | 2016-08-17 | 中化帝斯曼制药有限公司荷兰公司 | 用于生产头孢菌素类的方法 |
| BR112013022521B1 (pt) | 2011-03-03 | 2019-05-07 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | PROCESSO PARA A DEGRADAÇÃO DE UM COMPOSTO ß-LACTÂMICO E USO DE SULFITO NA DEGRADAÇÃO DE UM COMPOSTO ß-LACTÂMICO |
| WO2015091455A1 (en) | 2013-12-17 | 2015-06-25 | Dpx Holdings B.V. | Bioreactor |
| CN113699209B (zh) * | 2021-08-30 | 2023-05-02 | 浙江昂利康制药股份有限公司 | 一种7-adca回收方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1270852A (fr) * | 1960-09-20 | 1961-09-01 | Bayer Ag | Procédé d'acylation enzymatique d'acide 6-aminopénicillanique |
| EP0233715B1 (en) * | 1986-01-31 | 1994-05-25 | BEECHAM GROUP plc | Isolation and expression of genes involved in the biosynthesis of beta-lactams |
| HUT43644A (en) * | 1986-11-17 | 1987-11-30 | Univ Oxford | Process for producing 3-substituted-cephalosporines |
| DE3881531D1 (de) * | 1987-01-17 | 1993-07-15 | Hoechst Ag | Verwendung von gamma-glutamyl-transpeptidase. |
| US5070020A (en) * | 1988-05-09 | 1991-12-03 | Eli Lilly And Company | Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase |
| US5108918A (en) * | 1988-08-11 | 1992-04-28 | Gist-Brocades | Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites |
| IL95766A (en) * | 1989-09-27 | 1996-12-05 | Lilly Co Eli | Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity |
| KR0171897B1 (ko) * | 1989-12-27 | 1999-02-01 | 후지사와 도모끼찌로 | 7-아미노세펨 화합물 또는 그 염류의 제조 방법 |
| KR100227711B1 (ko) * | 1991-10-15 | 1999-12-01 | 한스 발터 라벤 | 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정 |
-
1992
- 1992-08-28 US US07/933,469 patent/US5318896A/en not_active Expired - Lifetime
- 1992-09-07 NZ NZ244236A patent/NZ244236A/en not_active IP Right Cessation
- 1992-09-07 IL IL10307692A patent/IL103076A/en not_active IP Right Cessation
- 1992-09-10 MX MX9205175A patent/MX9205175A/es unknown
- 1992-09-10 CA CA002077921A patent/CA2077921C/en not_active Expired - Fee Related
- 1992-09-10 CN CN92112278A patent/CN1066488C/zh not_active Expired - Lifetime
- 1992-09-11 KR KR1019940700777A patent/KR0132440B1/ko active
- 1992-09-11 KR KR1019940700777A patent/KR940702544A/ko not_active IP Right Cessation
- 1992-09-11 JP JP5505516A patent/JP3027847B2/ja not_active Expired - Fee Related
- 1992-09-11 AU AU23542/92A patent/AU657787B2/en not_active Ceased
- 1992-09-11 EP EP97203374A patent/EP0843013A3/en not_active Withdrawn
- 1992-09-11 DE DE69227494T patent/DE69227494T2/de not_active Expired - Fee Related
- 1992-09-11 WO PCT/US1992/007711 patent/WO1993005158A1/en active IP Right Grant
- 1992-09-11 AT AT92308286T patent/ATE173017T1/de not_active IP Right Cessation
- 1992-09-11 EP EP92308286A patent/EP0532341B1/en not_active Expired - Lifetime
- 1992-09-11 CZ CZ1994532A patent/CZ287357B6/cs not_active IP Right Cessation
- 1992-09-11 UA UA94005434A patent/UA41292C2/uk unknown
- 1992-09-11 HU HU9400715A patent/HU217171B/hu not_active IP Right Cessation
- 1992-09-11 RO RO94-00380A patent/RO115886B1/ro unknown
- 1992-09-11 SK SK288-94A patent/SK282387B6/sk unknown
- 1992-09-11 ES ES92308286T patent/ES2126588T3/es not_active Expired - Lifetime
- 1992-09-11 RU RU94017674/13A patent/RU2178808C2/ru not_active IP Right Cessation
- 1992-09-11 DK DK92308286T patent/DK0532341T3/da active
- 1992-09-19 TW TW081107399A patent/TW270149B/zh active
-
1994
- 1994-03-09 BG BG98643A patent/BG62177B1/bg unknown
- 1994-03-10 NO NO19940848A patent/NO316742B1/no unknown
- 1994-03-10 FI FI941135A patent/FI108148B/fi active
-
1999
- 1999-08-26 JP JP11239731A patent/JP3072101B2/ja not_active Expired - Fee Related
-
2000
- 2000-08-31 CN CN00126889A patent/CN1332247A/zh active Pending
Also Published As
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