DK0528882T3 - DNA-amplifikationssystem til påvisning af genetiske sygdomme ved hjælp af termostabil ligase - Google Patents

DNA-amplifikationssystem til påvisning af genetiske sygdomme ved hjælp af termostabil ligase

Info

Publication number
DK0528882T3
DK0528882T3 DK91909119T DK91909119T DK0528882T3 DK 0528882 T3 DK0528882 T3 DK 0528882T3 DK 91909119 T DK91909119 T DK 91909119T DK 91909119 T DK91909119 T DK 91909119T DK 0528882 T3 DK0528882 T3 DK 0528882T3
Authority
DK
Denmark
Prior art keywords
detection
nucleic acid
amplification system
dna amplification
genetic diseases
Prior art date
Application number
DK91909119T
Other languages
Danish (da)
English (en)
Inventor
Francis Barany
John Zebala
Deborah A Nickerson
Robert J Kaiser Jr
Leroy Hood
Original Assignee
Cornell Res Foundation Inc
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc, California Inst Of Techn filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of DK0528882T3 publication Critical patent/DK0528882T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK91909119T 1990-05-03 1991-04-29 DNA-amplifikationssystem til påvisning af genetiske sygdomme ved hjælp af termostabil ligase DK0528882T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51844790A 1990-05-03 1990-05-03
PCT/US1991/002968 WO1991017239A1 (en) 1990-05-03 1991-04-29 A thermostable ligase mediated dna amplification system for the detection of genetic diseases

Publications (1)

Publication Number Publication Date
DK0528882T3 true DK0528882T3 (da) 2008-01-14

Family

ID=24063976

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91909119T DK0528882T3 (da) 1990-05-03 1991-04-29 DNA-amplifikationssystem til påvisning af genetiske sygdomme ved hjælp af termostabil ligase

Country Status (7)

Country Link
EP (2) EP1507000B1 (ja)
JP (3) JP3889807B2 (ja)
AT (2) ATE375392T1 (ja)
DE (2) DE69133582T2 (ja)
DK (1) DK0528882T3 (ja)
ES (1) ES2294777T3 (ja)
WO (1) WO1991017239A1 (ja)

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DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
DE4217134A1 (de) * 1992-05-23 1993-11-25 Boehringer Mannheim Gmbh Thermostabile Ligase aus Archaebakterien
US5700672A (en) * 1992-07-23 1997-12-23 Stratagene Purified thermostable pyrococcus furiousus DNA ligase
EP0654093B1 (en) * 1992-08-03 2001-01-03 Abbott Laboratories Detecting and amplifying target nucleic acids using exonucleolytic activity
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US5445933A (en) * 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
US5462854A (en) * 1993-04-19 1995-10-31 Beckman Instruments, Inc. Inverse linkage oligonucleotides for chemical and enzymatic processes
PL316611A1 (en) * 1994-04-04 1997-01-20 Ciba Corning Diagnostics Corp Hybrisdisation/ligation tests for determining specific sequences of nucleic acids
WO1996012824A2 (en) * 1994-10-21 1996-05-02 Abbott Laboratories Use of spermidine to relieve inhibition of ligase chain reaction in a clinical test sample
AU3943095A (en) * 1994-11-04 1996-05-31 Genis Hf. A gene from the bacterium rhodothermus marinus, coding for the amino acid sequence of dna-ligase, produced in escherichia coli or some other suitable host organism
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP1958955B1 (en) 1996-02-09 2013-09-04 Cornell Research Foundation, Inc. Spatially addressable oligonucleotide arrays and method of making the same
CA2255774C (en) 1996-05-29 2008-03-18 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
AU776810B2 (en) * 1996-07-19 2004-09-23 Cornell Research Foundation Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
US6312892B1 (en) * 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
DE69936147T2 (de) * 1998-10-30 2008-01-24 Cornell Research Foundation, Inc. High fidelity thermostabile ligase und ihre verwendung
US6949370B1 (en) 1998-10-30 2005-09-27 Cornell Research Foundation, Inc. High fidelity thermostable ligase and uses thereof
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
ATE237399T1 (de) 1999-09-29 2003-05-15 Tecan Trading Ag Thermocycler sowie hebeelement für mikrotiterplatte
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
WO2001079548A2 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US6719949B1 (en) 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US6942836B2 (en) 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US7309575B2 (en) * 2002-01-16 2007-12-18 The University Of North Carolina At Chapel Hill Protein purification and detection methods
US20040258563A1 (en) 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
US7364855B2 (en) 2004-04-30 2008-04-29 Applera Corporation Methods and kits for methylation detection
WO2006076017A2 (en) 2004-04-30 2006-07-20 Applera Corporation Methods and kits for identifying target nucleotides in mixed populations
US7709201B2 (en) 2004-08-24 2010-05-04 Cornell Research Foundation, Inc. Detection of nucleic acid differences using endonuclease cleavage/ligase resealing reactions and capillary electrophoresis or microarrays
CN101356285A (zh) 2005-08-16 2009-01-28 梅洛根有限责任公司 鉴定陨石色基因的方法
US7285388B1 (en) 2006-04-07 2007-10-23 Merlogen, Llc Methods for identification of alport syndrome
WO2009087686A2 (en) * 2008-01-04 2009-07-16 Premas Biotech Pvt.Ltd Nucleic acid based detection methods
WO2009087687A1 (en) * 2008-01-04 2009-07-16 Premas Biotech Pvt.Ltd Nucleic acid based detection process and uses thereof
JP6871160B2 (ja) 2014-10-08 2021-05-12 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 核酸の発現、スプライス変異体、転座、コピー数、またはメチル化変化を識別及び定量化するための方法

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US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
AU3539089A (en) * 1988-04-08 1989-11-03 Salk Institute For Biological Studies, The Ligase-based amplification method
US4879214A (en) * 1988-11-15 1989-11-07 E. I. Du Pont De Nemours And Company Differentiation of nucleic acid segments on the basis of nucleotide differences
AU627809B2 (en) * 1988-12-16 1992-09-03 Abbott Laboratories Isolating thermostable enzymes from engineered mesophiles

Also Published As

Publication number Publication date
JPH05508764A (ja) 1993-12-09
ATE375392T1 (de) 2007-10-15
ES2294777T3 (es) 2008-04-01
EP1507000B1 (en) 2010-03-03
WO1991017239A1 (en) 1991-11-14
DE69133582T2 (de) 2008-07-24
JP3889807B2 (ja) 2007-03-07
DE69133629D1 (de) 2010-04-15
EP0528882B1 (en) 2007-10-10
ATE459709T1 (de) 2010-03-15
JP2004089204A (ja) 2004-03-25
EP0528882A1 (en) 1993-03-03
JP2001269187A (ja) 2001-10-02
EP0528882A4 (en) 1993-09-08
EP1507000A2 (en) 2005-02-16
EP1507000A3 (en) 2006-03-29
DE69133582D1 (de) 2007-11-22

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