DK0508756T3 - Stabiliseret vitamin D-præparat - Google Patents
Stabiliseret vitamin D-præparatInfo
- Publication number
- DK0508756T3 DK0508756T3 DK92303129.8T DK92303129T DK0508756T3 DK 0508756 T3 DK0508756 T3 DK 0508756T3 DK 92303129 T DK92303129 T DK 92303129T DK 0508756 T3 DK0508756 T3 DK 0508756T3
- Authority
- DK
- Denmark
- Prior art keywords
- active compound
- pharmaceutical composition
- heat
- vitamin
- preparation
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title abstract 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 3
- 235000019166 vitamin D Nutrition 0.000 title abstract 3
- 239000011710 vitamin D Substances 0.000 title abstract 3
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 3
- 229940046008 vitamin d Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000002845 discoloration Methods 0.000 abstract 1
- 229960002061 ergocalciferol Drugs 0.000 abstract 1
- 239000007970 homogeneous dispersion Substances 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 235000001892 vitamin D2 Nutrition 0.000 abstract 1
- 239000011653 vitamin D2 Substances 0.000 abstract 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7621091 | 1991-04-09 | ||
| JP1909992 | 1992-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0508756T3 true DK0508756T3 (da) | 1997-03-24 |
Family
ID=26355908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92303129.8T DK0508756T3 (da) | 1991-04-09 | 1992-04-08 | Stabiliseret vitamin D-præparat |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5487900A (https=) |
| EP (1) | EP0508756B1 (https=) |
| JP (1) | JPH05279260A (https=) |
| KR (1) | KR100231633B1 (https=) |
| AT (1) | ATE144424T1 (https=) |
| AU (1) | AU649802B2 (https=) |
| CA (1) | CA2065603C (https=) |
| DE (1) | DE69214704T2 (https=) |
| DK (1) | DK0508756T3 (https=) |
| ES (1) | ES2094290T3 (https=) |
| GR (1) | GR3021892T3 (https=) |
| IE (1) | IE75709B1 (https=) |
| NZ (1) | NZ242271A (https=) |
| TW (1) | TW212761B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19701264A1 (de) * | 1997-01-16 | 1998-07-23 | Kief Lizenz Verwertungsgesells | Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische |
| AU7895601A (en) * | 2000-07-18 | 2002-01-30 | Bone Care Int Inc | Stabilized 1alpha-hydroxy vitamin d |
| AU8252101A (en) * | 2000-08-30 | 2002-03-13 | Chugai Pharmaceutical Co Ltd | Oct preparations |
| JP2005515996A (ja) * | 2001-12-03 | 2005-06-02 | ノバセア インコーポレイティッド | 活性型ビタミンｄ化合物を含む薬学的組成物 |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
| CA2624897C (en) * | 2005-10-12 | 2017-02-14 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
| ES2593047T3 (es) | 2006-02-03 | 2016-12-05 | Opko Renal, Llc | Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3 |
| ES2670029T3 (es) | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
| US11752158B2 (en) | 2007-04-25 | 2023-09-12 | Eirgen Pharma Ltd. | Method of treating vitamin D insufficiency and deficiency |
| KR20190028822A (ko) | 2007-04-25 | 2019-03-19 | 사이토크로마 인코포레이티드 | 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| HUE073014T2 (hu) | 2007-04-25 | 2025-12-28 | Opko Renal Llc | Eljárás a másodlagos hyperparathyreoidismus biztonságos és hatékony kezelésére és megelõzésére krónikus vesebetegség esetén |
| US8592401B2 (en) | 2007-04-25 | 2013-11-26 | Proventiv Therapeutics, Llc | Methods and compounds for vitamin D therapy |
| EP2281058B1 (en) | 2008-04-02 | 2016-06-29 | Opko Ireland Global Holdings, Ltd. | Methods, compositions, uses, and kits useful for vitamin d deficiency and related disorders |
| WO2011123476A1 (en) | 2010-03-29 | 2011-10-06 | Cytochroma Inc. | Methods and compositions for reducing parathyroid levels |
| CA2698160C (en) * | 2010-03-30 | 2017-07-25 | Alphora Research Inc. | Stabilized doxercalciferol and process for manufacturing the same |
| EP2468265A3 (en) * | 2010-12-04 | 2013-01-02 | DEEF Pharmaceutical Industries Co. | Homogeneous preparations containing vitamin D |
| KR101847947B1 (ko) * | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| JP7032322B2 (ja) | 2016-03-28 | 2022-03-08 | オプコ アイルランド グローバル ホールディングス リミテッド | ビタミンｄ治療法 |
| JP7085105B2 (ja) * | 2016-11-10 | 2022-06-16 | 日産化学株式会社 | ビタミンｄ３誘導体の製剤 |
| JP7603000B2 (ja) * | 2018-08-31 | 2024-12-19 | オプコ アイルランド グローバル ホールディングス リミテッド | ビタミンｄ小児用剤形、製造方法および使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンｄ↓３類組成物 |
| JPS6217A (ja) * | 1985-02-14 | 1987-01-06 | Chugai Pharmaceut Co Ltd | 安定な活性型ビタミンｄ３類製剤 |
| DE3612212A1 (de) * | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| JP2525478B2 (ja) * | 1989-03-01 | 1996-08-21 | 帝人株式会社 | 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤 |
| JPH04198129A (ja) * | 1990-11-28 | 1992-07-17 | Sumitomo Pharmaceut Co Ltd | 活性型ビタミンｄ↓３類含有組成物 |
-
1992
- 1992-04-08 DE DE69214704T patent/DE69214704T2/de not_active Expired - Lifetime
- 1992-04-08 IE IE921126A patent/IE75709B1/en not_active IP Right Cessation
- 1992-04-08 CA CA002065603A patent/CA2065603C/en not_active Expired - Lifetime
- 1992-04-08 EP EP92303129A patent/EP0508756B1/en not_active Expired - Lifetime
- 1992-04-08 TW TW081102667A patent/TW212761B/zh active
- 1992-04-08 ES ES92303129T patent/ES2094290T3/es not_active Expired - Lifetime
- 1992-04-08 NZ NZ242271A patent/NZ242271A/en not_active IP Right Cessation
- 1992-04-08 AT AT92303129T patent/ATE144424T1/de not_active IP Right Cessation
- 1992-04-08 DK DK92303129.8T patent/DK0508756T3/da active
- 1992-04-09 AU AU14804/92A patent/AU649802B2/en not_active Ceased
- 1992-04-09 JP JP4088666A patent/JPH05279260A/ja not_active Withdrawn
- 1992-04-09 KR KR1019920005930A patent/KR100231633B1/ko not_active Expired - Fee Related
-
1994
- 1994-02-07 US US08/193,650 patent/US5487900A/en not_active Expired - Lifetime
-
1996
- 1996-12-04 GR GR960403313T patent/GR3021892T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69214704D1 (de) | 1996-11-28 |
| US5487900A (en) | 1996-01-30 |
| AU649802B2 (en) | 1994-06-02 |
| GR3021892T3 (en) | 1997-03-31 |
| TW212761B (https=) | 1993-09-11 |
| DE69214704T2 (de) | 1997-04-17 |
| EP0508756A1 (en) | 1992-10-14 |
| CA2065603C (en) | 2007-04-03 |
| IE75709B1 (en) | 1997-09-10 |
| AU1480492A (en) | 1992-10-15 |
| ATE144424T1 (de) | 1996-11-15 |
| KR920019346A (ko) | 1992-11-19 |
| NZ242271A (en) | 1993-10-26 |
| KR100231633B1 (ko) | 1999-11-15 |
| IE921126A1 (en) | 1992-10-21 |
| JPH05279260A (ja) | 1993-10-26 |
| ES2094290T3 (es) | 1997-01-16 |
| CA2065603A1 (en) | 1992-10-10 |
| EP0508756B1 (en) | 1996-10-23 |
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