DK0492350T3 - Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA - Google Patents
Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABAInfo
- Publication number
- DK0492350T3 DK0492350T3 DK91121554.9T DK91121554T DK0492350T3 DK 0492350 T3 DK0492350 T3 DK 0492350T3 DK 91121554 T DK91121554 T DK 91121554T DK 0492350 T3 DK0492350 T3 DK 0492350T3
- Authority
- DK
- Denmark
- Prior art keywords
- gaba
- vinyl
- allenyl
- preparation
- directed
- Prior art date
Links
- 229960003692 gamma aminobutyric acid Drugs 0.000 title abstract 3
- OYVDXEVJHXWJAE-RXMQYKEDSA-N (5s)-5-ethenylpyrrolidin-2-one Chemical compound C=C[C@@H]1CCC(=O)N1 OYVDXEVJHXWJAE-RXMQYKEDSA-N 0.000 abstract 1
- -1 1,5-disubstituted-pyrrolidinone Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62873890A | 1990-12-17 | 1990-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0492350T3 true DK0492350T3 (da) | 1998-01-26 |
Family
ID=24520094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91121554.9T DK0492350T3 (da) | 1990-12-17 | 1991-12-16 | Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0492350B1 (de) |
| JP (1) | JP3143877B2 (de) |
| KR (1) | KR920012021A (de) |
| AT (1) | ATE159246T1 (de) |
| AU (2) | AU644919B2 (de) |
| CA (1) | CA2057699C (de) |
| DE (1) | DE69127960T2 (de) |
| DK (1) | DK0492350T3 (de) |
| ES (1) | ES2110974T3 (de) |
| GR (1) | GR3025831T3 (de) |
| HU (1) | HU218793B (de) |
| IE (1) | IE914371A1 (de) |
| IL (1) | IL100360A (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL100360A (en) * | 1990-12-17 | 1998-08-16 | Merrell Dow Pharma | HISTORY OF PYROLIDINONE USED AS SUBSTANCE (S) -Vinyl and Alanyl GABA |
| WO1995000470A1 (en) * | 1993-06-23 | 1995-01-05 | Merrell Pharmaceuticals Inc. | Novel processes for preparing (s)-4-amino-hepta-5,6-dienoic acid and intermediates thereof |
| ITMI991330A1 (it) * | 1999-06-15 | 2000-12-15 | Isagro Spa | Processo per la preparazione di fungicidi otticamente attivi costituiti da n-acil derivati del metil n-(2,6-dimetilfenil)-d-alaninato |
| CN110713440B (zh) * | 2018-07-11 | 2022-01-25 | 武汉武药科技有限公司 | 一种氨己烯酸的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960927A (en) * | 1975-03-18 | 1976-06-01 | Richardson-Merrell Inc. | Olefinic derivatives of amino acids |
| US3959356A (en) * | 1975-03-18 | 1976-05-25 | Richardson-Merrell Inc. | Acetylene derivatives of amino acids |
| GB2120244B (en) * | 1982-05-17 | 1985-05-01 | Merrell Toraude & Co | Aminoalkadiene derivative |
| GB2133002B (en) * | 1982-12-30 | 1986-01-29 | Merrell Toraude & Co | Process for preparing 4-amino-5-hexenoic acid |
| NO842759L (no) * | 1983-07-07 | 1985-01-08 | Syntex Inc | Fremgangsmaate ved fremstilling av nye, terapeutisk virksomme gamma-allenyl-gamma-aminosmoersyrer |
| US4912232A (en) * | 1983-10-14 | 1990-03-27 | Dow Chemical Company | Preparation of N-hydrocarbylcarbonyl-5-(1-hydrocarbylcarbonyloxy)hydrocarbyl-pyrrolidin-2-one |
| US4873336A (en) * | 1988-03-28 | 1989-10-10 | Gaf Corporation | Process for the preparation of N-vinyl lactams |
| IE61631B1 (en) * | 1988-05-20 | 1994-11-16 | Zambon Spa | Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them |
| IL100360A (en) * | 1990-12-17 | 1998-08-16 | Merrell Dow Pharma | HISTORY OF PYROLIDINONE USED AS SUBSTANCE (S) -Vinyl and Alanyl GABA |
-
1991
- 1991-12-12 IL IL10036091A patent/IL100360A/en not_active IP Right Cessation
- 1991-12-12 AU AU89635/91A patent/AU644919B2/en not_active Expired
- 1991-12-16 CA CA002057699A patent/CA2057699C/en not_active Expired - Lifetime
- 1991-12-16 ES ES91121554T patent/ES2110974T3/es not_active Expired - Lifetime
- 1991-12-16 HU HU969/91A patent/HU218793B/hu unknown
- 1991-12-16 DE DE69127960T patent/DE69127960T2/de not_active Expired - Lifetime
- 1991-12-16 EP EP91121554A patent/EP0492350B1/de not_active Expired - Lifetime
- 1991-12-16 IE IE437191A patent/IE914371A1/en not_active IP Right Cessation
- 1991-12-16 DK DK91121554.9T patent/DK0492350T3/da active
- 1991-12-16 AT AT91121554T patent/ATE159246T1/de not_active IP Right Cessation
- 1991-12-17 KR KR1019910023189A patent/KR920012021A/ko not_active Application Discontinuation
- 1991-12-17 JP JP03352847A patent/JP3143877B2/ja not_active Expired - Lifetime
-
1994
- 1994-01-21 AU AU53900/94A patent/AU658538B2/en not_active Expired
-
1998
- 1998-01-07 GR GR980400006T patent/GR3025831T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3025831T3 (en) | 1998-04-30 |
| KR920012021A (ko) | 1992-07-25 |
| CA2057699A1 (en) | 1992-06-18 |
| IE914371A1 (en) | 1992-06-17 |
| AU8963591A (en) | 1992-06-18 |
| HU913969D0 (en) | 1992-02-28 |
| IL100360A (en) | 1998-08-16 |
| EP0492350A1 (de) | 1992-07-01 |
| EP0492350B1 (de) | 1997-10-15 |
| IL100360A0 (en) | 1992-09-06 |
| JP3143877B2 (ja) | 2001-03-07 |
| DE69127960T2 (de) | 1998-03-05 |
| DE69127960D1 (de) | 1997-11-20 |
| ES2110974T3 (es) | 1998-03-01 |
| HUT63829A (en) | 1993-10-28 |
| AU644919B2 (en) | 1993-12-23 |
| AU5390094A (en) | 1994-03-17 |
| CA2057699C (en) | 2002-10-29 |
| AU658538B2 (en) | 1995-04-13 |
| JPH04334364A (ja) | 1992-11-20 |
| HU218793B (hu) | 2000-12-28 |
| ATE159246T1 (de) | 1997-11-15 |
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