ES2149959T3 - Compuestos de 1-arilindol sustituidos en la posicion 3. - Google Patents

Compuestos de 1-arilindol sustituidos en la posicion 3.

Info

Publication number
ES2149959T3
ES2149959T3 ES95903771T ES95903771T ES2149959T3 ES 2149959 T3 ES2149959 T3 ES 2149959T3 ES 95903771 T ES95903771 T ES 95903771T ES 95903771 T ES95903771 T ES 95903771T ES 2149959 T3 ES2149959 T3 ES 2149959T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
group
alkenyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903771T
Other languages
English (en)
Inventor
Kim Andersen
Jens Kristian Perregaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2149959T3 publication Critical patent/ES2149959T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE 1 - ARILINDOL 3 - SUSTITUIDOS QUE TIENEN LA FORMULA GENERAL (I) EN LA QUE AR ES UN GRUPO DE ARILO OPCIONALMENTE SUSTITUIDO; X REPRESENTA UN ENLACE, UN GRUPO DE HIDROCARBURO DIVALENTE O METILENOXIDO O - TIOXO; R1-R2 SON HIDROGENO O SUSTITUYENTES; R5 ES HIDROGENO, HIDROXIDO, ALCOXIDO, HALOGENO, TRIFLUORMETILO, ALQUILO O ALQUENILO; R6 Y R7 SON HIDROGENO, ALQUILO O ALQUENILO; R8 ES ALQUILO O ALQUENILO O REPRESENTA UN GRUPO DE LA FORMULA (I) O (IB); EN DONDE: W ES O O S; U ES N O CH; Z ES (CH{SUB, 2}){SUB, M}, 1,2 - FENILENO; CH=CH, COCH{SUB, 2} O CSCH{SUB, 2}-; V ES O, S, CH{SUB, 2}, O NR10, EN DONDE R10 ES HIDROGENO O ALQUILO; U{SUB, 1} ES O, S, CH{SUB, 2} O NR11, EN DONDE R11 ES COMO R10; Y V{SUB, 1} ES NR12R13, OR14, SR15 O CR16R17R18, EN DONDE CADA R12-R18 ES COMO LOS SUSTITUYENTES DE R10; R9 ES HIDROGENO O ALQUILO; O R9 ESTA UNIDA A R7 PARA FORMAR UN ANILLO; O R8 Y R9 FORMAN JUNTAS UN ANILLO DE MORFOLINILO O PIPERIDINILO, ESTE ULTIMO OPCIONALMENTE SUSTITUIDO PORALQUILO O UN GRUPO DE LA FORMULA (1A) O (1B), UN GRUPO DE CARBAMOILO, LOS COMPUESTOS MUESTRAN ACTIVIDAD ANTISEROTONERGICA CENTRAL Y POSIBLEMENTE TAMBIEN ACTIVIDAD ANTIDOPAMINERGICA Y SON, DE ESTA FORMA, UTILES PARA EL TRATAMIENTO DE DESORDENES DEL SISTEMA NERVIOSO CENTRAL (SNC). LOS COMPUESTOS SE PREPARAN POR METODOS CONOCIDOS "PER SE".
ES95903771T 1993-12-16 1994-12-15 Compuestos de 1-arilindol sustituidos en la posicion 3. Expired - Lifetime ES2149959T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK931395A DK139593D0 (da) 1993-12-16 1993-12-16 Compounds

Publications (1)

Publication Number Publication Date
ES2149959T3 true ES2149959T3 (es) 2000-11-16

Family

ID=8104386

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903771T Expired - Lifetime ES2149959T3 (es) 1993-12-16 1994-12-15 Compuestos de 1-arilindol sustituidos en la posicion 3.

Country Status (25)

Country Link
US (1) US5789404A (es)
EP (2) EP0734384B1 (es)
JP (1) JPH09506595A (es)
KR (1) KR100363484B1 (es)
CN (1) CN1080261C (es)
AT (1) ATE195313T1 (es)
AU (1) AU682915B2 (es)
CA (1) CA2179179A1 (es)
CZ (1) CZ285028B6 (es)
DE (1) DE69425510T2 (es)
DK (2) DK139593D0 (es)
ES (1) ES2149959T3 (es)
FI (1) FI962496A (es)
GR (1) GR3034744T3 (es)
HK (1) HK1013815A1 (es)
HU (1) HU223318B1 (es)
IL (1) IL111989A (es)
NO (1) NO306671B1 (es)
NZ (1) NZ277483A (es)
PL (1) PL181253B1 (es)
PT (1) PT734384E (es)
RU (1) RU2139287C1 (es)
SK (1) SK283451B6 (es)
WO (1) WO1995016684A1 (es)
ZA (1) ZA949918B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3162695A (en) * 1994-08-03 1996-03-04 Asta Medica Aktiengesellschaft Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
MY125942A (en) * 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
JP5682051B2 (ja) 2006-05-18 2015-03-11 ファーマサイクリックス，インク． 細胞内キナーゼ阻害剤

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1220628A (en) * 1968-07-20 1971-01-27 Pfizer Ltd N-phenyl indole derivatives and pharmaceutical compositions thereof
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
DE1911893A1 (de) * 1969-03-08 1970-09-24 Thiemann Gmbh Chem Pharm Fabri Verfahren zur Herstellung von N-(Halogen-aryl)-2-methyl-5-alkoxy-indol-3-essigsaeuren
BE795457A (fr) * 1972-02-16 1973-08-16 Clin Midy Amines indoliques, leur preparation et leur application en therapeutiques
FR2242091A1 (en) * 1973-09-04 1975-03-28 Delalande Sa 1-Phenyl-2-methyl-3-aminomethyl-5-methoxy indole derivs - with e.g. analgesic, antidepressive and anti-arrhythmic props
US4558048A (en) * 1984-04-06 1985-12-10 Pfizer Inc. Method of treating diarrhoea using indole compounds
DE3430284A1 (de) * 1984-08-17 1986-02-27 Troponwerke GmbH & Co KG, 5000 Köln Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung
DK152090D0 (da) * 1990-06-22 1990-06-22 Lundbaek A S H Piperidylsubstituerede indolderivater
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
DK36391D0 (da) * 1991-03-01 1991-03-01 Lundbeck & Co As H Anvendelse af piperidylsubstituerede indolderivater til behandling af stofmisbrug
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2705346B1 (fr) * 1993-05-18 1995-08-11 Union Pharma Scient Appl Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques .
US5504101A (en) * 1994-05-06 1996-04-02 Allelix Biopharmaceuticals, Inc. 5-HT-1D receptor ligands

Also Published As

Publication number Publication date
ZA949918B (en) 1995-08-23
SK75896A3 (en) 1996-11-06
EP0734384A1 (en) 1996-10-02
IL111989A0 (en) 1995-03-15
WO1995016684A1 (en) 1995-06-22
KR100363484B1 (ko) 2003-02-05
JPH09506595A (ja) 1997-06-30
HU223318B1 (hu) 2004-05-28
AU1272195A (en) 1995-07-03
DK139593D0 (da) 1993-12-16
DE69425510D1 (de) 2000-09-14
GR3034744T3 (en) 2001-02-28
US5789404A (en) 1998-08-04
NO306671B1 (no) 1999-12-06
ATE195313T1 (de) 2000-08-15
NO962505D0 (no) 1996-06-13
CZ172796A3 (en) 1996-11-13
DK0734384T3 (da) 2001-01-02
NO962505L (no) 1996-08-12
HK1013815A1 (en) 1999-09-10
AU682915B2 (en) 1997-10-23
PT734384E (pt) 2000-12-29
CZ285028B6 (cs) 1999-05-12
PL181253B1 (pl) 2001-06-29
EP0939077A3 (en) 2003-11-19
IL111989A (en) 2000-10-31
SK283451B6 (sk) 2003-08-05
HUT76276A (en) 1997-07-28
NZ277483A (en) 1998-05-27
CN1080261C (zh) 2002-03-06
EP0939077A2 (en) 1999-09-01
FI962496A0 (fi) 1996-06-14
CA2179179A1 (en) 1995-06-22
EP0734384B1 (en) 2000-08-09
RU2139287C1 (ru) 1999-10-10
CN1142824A (zh) 1997-02-12
HU9601640D0 (en) 1996-08-28
DE69425510T2 (de) 2001-04-19
FI962496A (fi) 1996-06-14
PL315027A1 (en) 1996-09-30
KR960706492A (ko) 1996-12-09

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