DK0487602T3 - 5-(1-aminocyclohexyl)-2(1H)-pyridinon og relaterede forbindelser - Google Patents

5-(1-aminocyclohexyl)-2(1H)-pyridinon og relaterede forbindelser

Info

Publication number
DK0487602T3
DK0487602T3 DK90912876.1T DK90912876T DK0487602T3 DK 0487602 T3 DK0487602 T3 DK 0487602T3 DK 90912876 T DK90912876 T DK 90912876T DK 0487602 T3 DK0487602 T3 DK 0487602T3
Authority
DK
Denmark
Prior art keywords
image
loweralkyl
hydrogen
pyridinone
aminocyclohexyl
Prior art date
Application number
DK90912876.1T
Other languages
Danish (da)
English (en)
Inventor
Richard Charles Effland
David Marc Fink
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0487602T3 publication Critical patent/DK0487602T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK90912876.1T 1989-08-16 1990-08-16 5-(1-aminocyclohexyl)-2(1H)-pyridinon og relaterede forbindelser DK0487602T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/394,448 US4978663A (en) 1989-08-16 1989-08-16 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility

Publications (1)

Publication Number Publication Date
DK0487602T3 true DK0487602T3 (da) 1998-02-09

Family

ID=23558997

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90912876.1T DK0487602T3 (da) 1989-08-16 1990-08-16 5-(1-aminocyclohexyl)-2(1H)-pyridinon og relaterede forbindelser

Country Status (14)

Country Link
US (1) US4978663A (ko)
EP (1) EP0487602B1 (ko)
JP (3) JP2557568B2 (ko)
KR (1) KR927003532A (ko)
AT (1) ATE155458T1 (ko)
AU (1) AU652126B2 (ko)
CA (2) CA2063594C (ko)
DE (1) DE69031075T2 (ko)
DK (1) DK0487602T3 (ko)
ES (1) ES2109239T3 (ko)
FI (1) FI920637A0 (ko)
HU (2) HUT67589A (ko)
NO (1) NO920600L (ko)
WO (1) WO1991002721A1 (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW473479B (en) * 1997-12-19 2002-01-21 Takeda Chemical Industries Ltd Phosphonocephem derivatives, their production and use
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
JP5133416B2 (ja) * 2007-09-14 2013-01-30 オルソー−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド． １’，３’−二置換−４−フェニル−３，４，５，６−テトラヒドロ−２ｈ，１’ｈ−［１，４’］ビピリジニル−２’−オン
EP2205565B1 (en) * 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
ATE516272T1 (de) 2007-09-14 2011-07-15 Ortho Mcneil Janssen Pharm 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one
EP2220083B1 (en) * 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
CA2738849C (en) 2008-10-16 2016-06-28 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
CN102232074B (zh) 2008-11-28 2014-12-03 奥梅-杨森制药有限公司 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
MY161325A (en) 2009-05-12 2017-04-14 Janssen Pharmaceuticals Inc 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
ES2409006T3 (es) 2009-05-12 2013-06-24 Janssen Pharmaceuticals Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
CA2815002C (en) 2010-11-08 2019-10-22 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
BR112016016390B1 (pt) 2014-01-21 2023-04-11 Janssen Pharmaceutica Nv Produto compreendendo modulador alostérico positivo do receptor glutamatérgico metabotrópico do subtipo 2 e ligante da proteína de vesícula sináptica 2a
ES2860298T3 (es) 2014-01-21 2021-10-04 Janssen Pharmaceutica Nv Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
CN112409267A (zh) * 2019-08-22 2021-02-26 江苏阿尔法药业有限公司 一种索菲布韦中间体的制备方法
CN112409266A (zh) * 2019-08-22 2021-02-26 江苏阿尔法药业有限公司 一种索菲布韦中间体及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA903224A (en) * 1972-06-20 F. Czaja Robert Process for the production of pyridones
GB851577A (en) * 1958-03-06 1960-10-19 Parke Davis & Co Pyridine compounds and methods for producing the same
US3655897A (en) * 1971-01-25 1972-04-11 Merck & Co Inc Anti-inflammatory agents
JPS61165372A (ja) * 1985-01-17 1986-07-26 Daicel Chem Ind Ltd ５−ハロピリジン−３−カルボキサミド化合物
DE3823991A1 (de) * 1988-07-15 1990-02-15 Basf Ag Heterocyclisch substituierte (alpha)-aryl-acrylsaeureester und fungizide, die diese verbindungen enthalten

Also Published As

Publication number Publication date
ES2109239T3 (es) 1998-01-16
JPH09100287A (ja) 1997-04-15
HU9200461D0 (en) 1992-05-28
KR927003532A (ko) 1992-12-18
EP0487602A4 (en) 1993-03-17
NO920600D0 (no) 1992-02-14
JPH09100288A (ja) 1997-04-15
AU652126B2 (en) 1994-08-18
ATE155458T1 (de) 1997-08-15
WO1991002721A1 (en) 1991-03-07
AU6284290A (en) 1991-04-03
EP0487602B1 (en) 1997-07-16
CA2063594C (en) 2002-07-16
JP2708736B2 (ja) 1998-02-04
US4978663A (en) 1990-12-18
JPH04507421A (ja) 1992-12-24
CA2063594A1 (en) 1991-02-17
HUT67589A (en) 1995-04-28
JP2708737B2 (ja) 1998-02-04
DE69031075D1 (de) 1997-08-21
CA2332188A1 (en) 1991-02-17
NO920600L (no) 1992-04-14
DE69031075T2 (de) 1998-02-26
FI920637A0 (fi) 1992-02-14
EP0487602A1 (en) 1992-06-03
JP2557568B2 (ja) 1996-11-27
CA2332188C (en) 2007-01-23

Similar Documents

Publication Publication Date Title
DK0487602T3 (da) 5-(1-aminocyclohexyl)-2(1H)-pyridinon og relaterede forbindelser
DK0461079T3 (da) Substituerede phthalider og heterocykliske phthalider
SE7907121L (sv) Ftalimidinderivat
DK0405425T3 (da) Heteroarylamino- og heteroaryloxypyridinaminer og beslægtede forbindelser, en fremgangsmåde til deres fremstilling og deres
DK0450812T3 (da) Antihypercholesterolemika
FR2459235B1 (ko)
DK490486D0 (da) Sammensaetning til behandling af atherosclerose, tromboser og/eller perifere karsygdomme
BR1100534A (pt) Carbamatos substituìdos de 1-(piridilamino substituìdo) -1h-indol-5-ila
ES2022342B3 (es) Hidrazinas n-(opcinalmente sustituidas)-n'-sustituidas-n, n'-disustituidas, insecticidas.
ATE76405T1 (de) 2-trifluormethyl-benzimidazole.
NO874872D0 (no) Kondenderte heterocykliske tetrahydroaminokinolinoler og beslektede forbindelser samt fremgangsmaate for fremstilling derav.
HUT42277A (en) Herbicides containing as active subtance derivatives of new 1-aryl-4-nitro-pirasole and process for production of the active substances
NO913140L (no) 1-(pyridinylalkyl)-1h-indoler, indoliner og beslektede analoger.
NO911998L (no) Pyrido(3,4-b)(pyrrolo(1,2-e)(1,4,5)oksadiazepin og beslektede analoger og fremgangsmaate for fremstilling derav.
NO902556L (no) 4,5,5a,6-tetrahydro-3h-isoksazol(5,4,3-kl)akridinderivater og fremgangsmaate for fremstilling derav.
DK0485716T3 (da) Fremgangsmåde til fremstilling af insekticide, nematicide og acaricide 4-substituerede 5-(trifluormethyl)pyrrol-3-carbonitril-forbindelser