DK0484573T3 - Physostigmin-beslægtede 4- og 6-carbamater, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler - Google Patents
Physostigmin-beslægtede 4- og 6-carbamater, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidlerInfo
- Publication number
- DK0484573T3 DK0484573T3 DK90121267.0T DK90121267T DK0484573T3 DK 0484573 T3 DK0484573 T3 DK 0484573T3 DK 90121267 T DK90121267 T DK 90121267T DK 0484573 T3 DK0484573 T3 DK 0484573T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- loweralkyl
- hydrogen
- physostigmine
- carbamates
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 title 1
- 229960001697 physostigmine Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- -1 loweralkyl Chemical group 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/413,901 US4914102A (en) | 1989-09-28 | 1989-09-28 | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
US07/431,103 US5081117A (en) | 1989-09-28 | 1989-11-03 | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0484573T3 true DK0484573T3 (da) | 1996-07-22 |
Family
ID=40149690
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90118376.4T DK0420140T3 (da) | 1989-09-28 | 1990-09-25 | N-Aminocarbamater beslægtede med physostigmin, en fremgangsmåde til deres fremstilling og deres anvedelse som lægemidler |
DK90121267.0T DK0484573T3 (da) | 1989-09-28 | 1990-11-07 | Physostigmin-beslægtede 4- og 6-carbamater, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90118376.4T DK0420140T3 (da) | 1989-09-28 | 1990-09-25 | N-Aminocarbamater beslægtede med physostigmin, en fremgangsmåde til deres fremstilling og deres anvedelse som lægemidler |
Country Status (21)
Country | Link |
---|---|
US (2) | US4914102A (da) |
EP (2) | EP0420140B1 (da) |
JP (2) | JPH0723377B2 (da) |
KR (1) | KR100189665B1 (da) |
AT (2) | ATE156825T1 (da) |
AU (3) | AU639943B2 (da) |
CA (2) | CA2026381A1 (da) |
CZ (1) | CZ279604B6 (da) |
DE (2) | DE69031259T2 (da) |
DK (2) | DK0420140T3 (da) |
ES (2) | ES2104572T3 (da) |
FI (2) | FI93961C (da) |
GR (2) | GR3019468T3 (da) |
HU (1) | HU206355B (da) |
IE (1) | IE72153B1 (da) |
IL (2) | IL95807A (da) |
NO (2) | NO174469B (da) |
NZ (2) | NZ235460A (da) |
PL (1) | PL287618A1 (da) |
PT (2) | PT95449B (da) |
ZA (2) | ZA907725B (da) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
DE69020989T2 (de) * | 1989-09-19 | 1996-02-08 | Hoechst Roussel Pharma | Verfahren zur Racematspaltung von 5-alkoxy-substituierten (+/-)-1,3-dimethyloxindolylethylaminen. |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
US5077289A (en) * | 1989-11-30 | 1991-12-31 | Hoechst Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
SG52631A1 (en) * | 1990-01-22 | 1998-09-28 | Hoechst Roussel Pharma | Process for the enantioselection sznthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine |
MC2287A1 (fr) * | 1990-06-27 | 1993-07-14 | Hoechst Roussel Pharma | Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole |
US5171750A (en) * | 1991-09-26 | 1992-12-15 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted phenserines as specific inhibitors of acetylcholinesterase |
JP3708957B2 (ja) * | 1991-09-26 | 2005-10-19 | アメリカ合衆国 | (−)−エゼロリン、(−)−n1−ノルエゼロリンおよび(−)−n1−ベンジルノルエゼロリンの置換フェンゼリンおよびフェニルカルバミン酸塩:特異的アセチルコリンエステラーゼ阻害薬としての使用 |
US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
IT1253007B (it) * | 1991-12-31 | 1995-07-10 | Aesculapius Farma Srl | Derivati dell'eserolina ad attivita' anticolinesterasica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
US5302721A (en) * | 1992-07-21 | 1994-04-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of preparation of physostigmine carbamate derivatives from eseretholes |
FI933264A (fi) * | 1992-07-21 | 1994-01-22 | Hoechst Roussel Pharma | Foerfarande foer framstaellning av fysostigminkarbamatderivat fraon fysostigmin |
US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
ES2685923T3 (es) * | 2002-06-14 | 2018-10-15 | Toyama Chemical Co., Ltd. | Composición medicinal para mejorar la función cerebral |
US7897639B2 (en) * | 2003-10-21 | 2011-03-01 | Colucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
US20050222123A1 (en) | 2004-01-27 | 2005-10-06 | North Shore-Long Island Jewish Research Institute | Cholinesterase inhibitors for treating inflammation |
US20050182044A1 (en) * | 2004-02-17 | 2005-08-18 | Bruinsma Gosse B. | Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate |
CA2508585A1 (en) * | 2004-06-01 | 2005-12-01 | Axonyx, Inc. | Transdermal delivery system for treatment of cognitive disorders |
EP1604686A1 (en) * | 2004-06-08 | 2005-12-14 | Axonyx, Inc. | Use of phenserine and a HMG CoA reductase inhibitor for delaying Alzheimer's disease progression |
WO2006060082A1 (en) * | 2004-10-22 | 2006-06-08 | THE GOVERNMENT OF THE U.S.A. as represented by THE SEC., DEPT. OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH | Tricyclic compounds, preparation thereof and use thereof as cholinesterase activity inhibitors |
EA037187B1 (ru) | 2010-02-09 | 2021-02-17 | Дзе Джонс Хопкинс Юниверсити | Способ и композиция для лечения когнитивного расстройства |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
MX362886B (es) | 2012-12-13 | 2019-02-22 | H Lundbeck As | Composición sinérgica que comprende vortioxetina y donepezilo para incrementar los niveles de acetilcolina en el cerebro, y el uso de la misma en el tratamiento de una disfunción cognitiva. |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3897451A (en) * | 1973-04-27 | 1975-07-29 | Univ Ohio State Res Found | Synthesis of oxindoles from anilines and intermediates therein |
IT1109003B (it) * | 1977-09-20 | 1985-12-16 | Univ Firenze | Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo |
IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
US4741107A (en) * | 1987-07-31 | 1988-05-03 | Circle Jeffrey L | Artwork aid adapted for facilitating placement of lettering along arc of a circle |
US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
DE69020989T2 (de) * | 1989-09-19 | 1996-02-08 | Hoechst Roussel Pharma | Verfahren zur Racematspaltung von 5-alkoxy-substituierten (+/-)-1,3-dimethyloxindolylethylaminen. |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
US5077289A (en) * | 1989-11-30 | 1991-12-31 | Hoechst Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
SG52631A1 (en) * | 1990-01-22 | 1998-09-28 | Hoechst Roussel Pharma | Process for the enantioselection sznthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine |
-
1989
- 1989-09-28 US US07/413,901 patent/US4914102A/en not_active Expired - Fee Related
- 1989-11-03 US US07/431,103 patent/US5081117A/en not_active Expired - Fee Related
-
1990
- 1990-09-25 ES ES90118376T patent/ES2104572T3/es not_active Expired - Lifetime
- 1990-09-25 DE DE69031259T patent/DE69031259T2/de not_active Expired - Fee Related
- 1990-09-25 AT AT90118376T patent/ATE156825T1/de not_active IP Right Cessation
- 1990-09-25 DK DK90118376.4T patent/DK0420140T3/da active
- 1990-09-25 EP EP90118376A patent/EP0420140B1/en not_active Expired - Lifetime
- 1990-09-26 IL IL9580790A patent/IL95807A/en not_active IP Right Cessation
- 1990-09-26 NZ NZ235460A patent/NZ235460A/xx unknown
- 1990-09-26 FI FI904730A patent/FI93961C/fi not_active IP Right Cessation
- 1990-09-27 NO NO904209A patent/NO174469B/no not_active IP Right Cessation
- 1990-09-27 CA CA002026381A patent/CA2026381A1/en not_active Abandoned
- 1990-09-27 PT PT95449A patent/PT95449B/pt not_active IP Right Cessation
- 1990-09-27 ZA ZA907725A patent/ZA907725B/xx unknown
- 1990-09-27 JP JP2255477A patent/JPH0723377B2/ja not_active Expired - Lifetime
- 1990-09-27 AU AU63227/90A patent/AU639943B2/en not_active Ceased
- 1990-11-01 FI FI905418A patent/FI92701C/fi not_active IP Right Cessation
- 1990-11-01 NZ NZ235921A patent/NZ235921A/en unknown
- 1990-11-01 KR KR1019900017657A patent/KR100189665B1/ko not_active IP Right Cessation
- 1990-11-01 IL IL9620990A patent/IL96209A/en not_active IP Right Cessation
- 1990-11-02 AU AU65712/90A patent/AU635575B2/en not_active Ceased
- 1990-11-02 PL PL28761890A patent/PL287618A1/xx unknown
- 1990-11-02 JP JP2295595A patent/JPH0780885B2/ja not_active Expired - Fee Related
- 1990-11-02 HU HU906999A patent/HU206355B/hu not_active IP Right Cessation
- 1990-11-02 NO NO904783A patent/NO175980C/no not_active IP Right Cessation
- 1990-11-02 PT PT95772A patent/PT95772B/pt not_active IP Right Cessation
- 1990-11-02 ZA ZA908800A patent/ZA908800B/xx unknown
- 1990-11-02 CZ CS905407A patent/CZ279604B6/cs not_active IP Right Cessation
- 1990-11-02 IE IE396590A patent/IE72153B1/en not_active IP Right Cessation
- 1990-11-02 CA CA002029265A patent/CA2029265C/en not_active Expired - Fee Related
- 1990-11-07 ES ES90121267T patent/ES2085309T3/es not_active Expired - Lifetime
- 1990-11-07 DE DE69025941T patent/DE69025941T2/de not_active Expired - Fee Related
- 1990-11-07 EP EP90121267A patent/EP0484573B1/en not_active Expired - Lifetime
- 1990-11-07 DK DK90121267.0T patent/DK0484573T3/da active
- 1990-11-07 AT AT90121267T patent/ATE135355T1/de not_active IP Right Cessation
-
1993
- 1993-01-27 AU AU32046/93A patent/AU646986B2/en not_active Ceased
-
1996
- 1996-03-29 GR GR960400847T patent/GR3019468T3/el unknown
-
1997
- 1997-10-14 GR GR970402666T patent/GR3025021T3/el unknown
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