DK0478729T3 - Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil - Google Patents

Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil

Info

Publication number
DK0478729T3
DK0478729T3 DK91906948.4T DK91906948T DK0478729T3 DK 0478729 T3 DK0478729 T3 DK 0478729T3 DK 91906948 T DK91906948 T DK 91906948T DK 0478729 T3 DK0478729 T3 DK 0478729T3
Authority
DK
Denmark
Prior art keywords
derivatives
dkp
novel intermediates
diketopiperazine
aspartame
Prior art date
Application number
DK91906948.4T
Other languages
Danish (da)
English (en)
Inventor
John B Hill
Tse-Lok Ho
Mark R Johnson
Russell Klix
Gayle Webber
Robert A Erickson
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Application granted granted Critical
Publication of DK0478729T3 publication Critical patent/DK0478729T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91906948.4T 1990-03-15 1991-03-12 Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil DK0478729T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49824390A 1990-03-15 1990-03-15
US60665690A 1990-10-31 1990-10-31
US65878491A 1991-02-26 1991-02-26
US66480691A 1991-03-08 1991-03-08

Publications (1)

Publication Number Publication Date
DK0478729T3 true DK0478729T3 (da) 1996-09-16

Family

ID=27504394

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91906948.4T DK0478729T3 (da) 1990-03-15 1991-03-12 Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil

Country Status (16)

Country Link
EP (1) EP0478729B1 (cs)
CN (1) CN1057835A (cs)
AT (1) ATE141613T1 (cs)
AU (1) AU628257B2 (cs)
CA (1) CA2060515A1 (cs)
CS (1) CS70091A2 (cs)
DE (1) DE69121502T2 (cs)
DK (1) DK0478729T3 (cs)
ES (1) ES2091324T3 (cs)
GR (1) GR3020839T3 (cs)
HU (1) HUT60712A (cs)
IE (1) IE910896A1 (cs)
NO (1) NO920193L (cs)
NZ (1) NZ237469A (cs)
PT (1) PT97049B (cs)
WO (1) WO1991014378A1 (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04234374A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc ジケトピペラジン誘導体の製造方法
JPH04234375A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物及びその製造法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en) 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
AU2001279313B2 (en) 2000-08-04 2007-03-01 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US6967202B2 (en) 2000-08-04 2005-11-22 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
DK1571970T3 (da) 2002-10-02 2011-11-28 Dmi Biosciences Inc Diagnose og monitorering af sygdomme
NZ576931A (en) 2003-05-15 2010-12-24 Dmi Biosciences Inc Treatment of T-cell mediated diseases
US8217047B2 (en) 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
CN104958752B (zh) 2011-10-10 2019-01-18 安皮奥制药股份有限公司 退行性关节病的治疗
CA2846464A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
AU2012328605B9 (en) 2011-10-28 2017-08-03 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
MX2015010937A (es) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas.
WO2016028790A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
HK1246669A1 (zh) 2015-06-22 2018-09-14 Ampio Pharmaceuticals, Inc. 人血清白蛋白低分子量组分在疾病治疗中的应用
EP3560345B1 (en) * 2016-12-21 2023-08-09 Suntory Holdings Limited Food and beverages containing cyclo(aspartyl-glycine), glucose, and maltose
WO2024075813A1 (ja) * 2022-10-07 2024-04-11 学校法人中部大学 ジケトピペラジン化合物を用いるポリペプチド合成

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038106A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Aktivatoren fuer Perverbindungen
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) * 1985-06-04 1994-06-22 味の素株式会社 β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids

Also Published As

Publication number Publication date
NO920193D0 (no) 1992-01-15
PT97049B (pt) 1998-07-31
WO1991014378A1 (en) 1991-10-03
ES2091324T3 (es) 1996-11-01
ATE141613T1 (de) 1996-09-15
PT97049A (pt) 1991-12-31
AU628257B2 (en) 1992-09-10
NZ237469A (en) 1993-08-26
AU7564891A (en) 1991-10-21
EP0478729A4 (en) 1993-06-16
HUT60712A (en) 1992-10-28
CA2060515A1 (en) 1991-09-16
DE69121502D1 (de) 1996-09-26
EP0478729B1 (en) 1996-08-21
EP0478729A1 (en) 1992-04-08
IE910896A1 (en) 1991-09-25
CN1057835A (zh) 1992-01-15
NO920193L (no) 1992-01-15
GR3020839T3 (en) 1996-11-30
DE69121502T2 (de) 1997-01-16
CS70091A2 (en) 1991-10-15

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