DK0428437T3 - 1,2-benzisoxazolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem - Google Patents
1,2-benzisoxazolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder demInfo
- Publication number
- DK0428437T3 DK0428437T3 DK90403145.7T DK90403145T DK0428437T3 DK 0428437 T3 DK0428437 T3 DK 0428437T3 DK 90403145 T DK90403145 T DK 90403145T DK 0428437 T3 DK0428437 T3 DK 0428437T3
- Authority
- DK
- Denmark
- Prior art keywords
- radical
- formula
- image
- hydrogen atom
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8914571A FR2654104B1 (fr) | 1989-11-07 | 1989-11-07 | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0428437T3 true DK0428437T3 (da) | 1995-01-02 |
Family
ID=9387148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90403145.7T DK0428437T3 (da) | 1989-11-07 | 1990-11-07 | 1,2-benzisoxazolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem |
Country Status (15)
Country | Link |
---|---|
US (2) | US5100902A (de) |
EP (1) | EP0428437B1 (de) |
JP (1) | JPH0692403B2 (de) |
AT (1) | ATE110075T1 (de) |
AU (1) | AU631466B2 (de) |
CA (1) | CA2029372C (de) |
DE (1) | DE69011628T2 (de) |
DK (1) | DK0428437T3 (de) |
ES (1) | ES2062458T3 (de) |
FR (1) | FR2654104B1 (de) |
IE (1) | IE65004B1 (de) |
NZ (1) | NZ235892A (de) |
OA (1) | OA09468A (de) |
PT (1) | PT95808B (de) |
ZA (1) | ZA908884B (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
ES2188584T3 (es) * | 1991-03-28 | 2003-07-01 | Eisai Co Ltd | Derivados heterociclicos de amina. |
US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
EP0602242A4 (en) * | 1991-08-22 | 1994-06-29 | Yoshitomi Pharmaceutical | Benzisoxazole compound and use thereof. |
WO1993010742A2 (en) * | 1991-11-27 | 1993-06-10 | Novo Nordisk A/S | Chemical compounds, their preparation and use |
US5378714A (en) * | 1991-11-27 | 1995-01-03 | Novo Nordisk A/S | Antipsychotic piperidine derivatives |
FR2694005B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
DE69332691T2 (de) * | 1992-11-23 | 2003-12-18 | Aventis Pharma Inc | Substituierte 3-(aminoalkylamino)-1,2-benzisoxazole und verwandte verbindungen |
US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
DK60593D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
DK60793D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
CA2180841C (en) * | 1994-01-10 | 2007-03-27 | Sasson Cohen | 1-aminoindan derivatives and compositions thereof |
US5914349A (en) | 1994-01-10 | 1999-06-22 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
US6743808B1 (en) | 1994-06-08 | 2004-06-01 | H. Lundbeck A/S | 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) tetrahydropyridines or piperazines |
IL114026A (en) | 1994-06-08 | 1999-06-20 | Lundbeck & Co As H | 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzo thiophenemethyl) piperidines tetrahydropyridines or piperazines and pharmaceutical compositions containing them |
ES2101646B1 (es) * | 1995-04-12 | 1998-04-01 | Ferrer Int | Nuevo compuesto derivado del cromeno. |
IL117646A (en) * | 1995-04-12 | 2000-06-01 | Ferrer Int | 7-¬3-¬4-(6-fluoro-1,2-benzisoxazole-3-YL)piperidin-1-YL¾propoxy¾3-alkyl-chromen-4-ones their preparation their uses and pharmaceutical compositions comprising them |
FR2735129B1 (fr) * | 1995-06-07 | 1997-07-11 | Adir | Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE69738275T2 (de) | 1996-12-18 | 2008-08-28 | Teva Pharmaceutical Industries Ltd. | Aminoindanderivate |
ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
ES2144355B1 (es) * | 1997-12-30 | 2001-01-01 | Ferrer Int | Compuestos derivados del cromeno. |
US6737547B1 (en) | 1998-12-31 | 2004-05-18 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using N-acyl-1H-aminoindenes |
WO2001042244A1 (fr) * | 1999-12-08 | 2001-06-14 | Grelan Pharmaceutical Co., Ltd. | Nouveaux derives 1,8-naphtyridin-2(1h)-one |
EP1256575B1 (de) * | 2000-02-18 | 2005-08-17 | Meiji Seika Kaisha Ltd. | Phenoxyalkylaminderivate als agonisten des opioid-delta rezeptors |
JP3772204B2 (ja) * | 2000-06-05 | 2006-05-10 | 独立行政法人産業技術総合研究所 | 糖鎖誘導体及びその製造方法 |
GB0102841D0 (en) * | 2001-02-05 | 2001-03-21 | Novartis Ag | Organic compounds |
US7355042B2 (en) * | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
WO2004009591A1 (en) * | 2002-07-22 | 2004-01-29 | Aurobindo Pharma Ltd. | A process for the preparation of antipsychotic risperidone |
JP2007513197A (ja) * | 2003-12-08 | 2007-05-24 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 統合失調症の治療のための複素環式置換インダン誘導体および関連化合物 |
ES2523459T3 (es) * | 2005-02-25 | 2014-11-26 | Raqualia Pharma Inc | Derivados de benzisoxazol |
DE602006012650D1 (de) | 2005-04-26 | 2010-04-15 | Hypnion Inc | Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung |
DE102005026194A1 (de) * | 2005-06-06 | 2006-12-07 | Grünenthal GmbH | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
BRPI0620659A2 (pt) * | 2005-12-09 | 2017-10-31 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | método para a prevenção do aparecimento de sintomas de uma doença neurodegenerativa em um indivíduo predisposto à doença neurodegenerativa, método de redução de stress oxidante no cérebro de um indivíduo afligido com stress oxidante, método de tratamento de um indivíduo afligido com a degeneração cognitiva suave e composição farmacêutica |
TW200744576A (en) * | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
JPWO2007126041A1 (ja) | 2006-04-28 | 2009-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ベンゾイソオキサゾール化合物 |
SI2275423T1 (sl) | 2009-07-13 | 2012-06-29 | Krka D.D., Novo Mesto | Postopek za sintezo paliperidona |
WO2012063269A2 (en) | 2010-11-12 | 2012-05-18 | Cadila Healthcare Limited | Process for preparing iloperidone |
JP2016000697A (ja) * | 2012-10-02 | 2016-01-07 | 大日本住友製薬株式会社 | ピリミジン誘導体 |
CN109641822B (zh) * | 2016-08-12 | 2022-03-11 | 拜耳作物科学股份公司 | 制备取代苯乙烯衍生物的方法 |
CN115057809B (zh) * | 2022-07-15 | 2024-02-13 | 扬州市普林斯医药科技有限公司 | 一种4-(2,4-二氟苯甲酰基)-哌啶的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
US4472193A (en) * | 1982-07-06 | 1984-09-18 | The Dow Chemical Company | Naphthyridinyloxy(or thio)phenoxy propanoic acids, derivatives thereof and methods of herbicidal use |
US4528376A (en) * | 1982-08-11 | 1985-07-09 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(4-Piperidyl)-1,2-benzisoxazoles |
AU5529286A (en) * | 1985-03-26 | 1986-10-02 | Hayes, B.L. | Shock absorbent moving platform |
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
JPH01199967A (ja) * | 1987-10-26 | 1989-08-11 | Sumitomo Pharmaceut Co Ltd | 新規なイミド誘導体 |
AU6960391A (en) * | 1989-12-04 | 1991-06-26 | Schering Corporation | Heterocyclic substituted naphthyridinones and methods and compositions employing them |
-
1989
- 1989-11-07 FR FR8914571A patent/FR2654104B1/fr not_active Expired - Lifetime
-
1990
- 1990-10-26 US US07/604,789 patent/US5100902A/en not_active Expired - Fee Related
- 1990-10-30 NZ NZ235892A patent/NZ235892A/xx unknown
- 1990-11-06 ZA ZA908884A patent/ZA908884B/xx unknown
- 1990-11-06 AU AU65819/90A patent/AU631466B2/en not_active Ceased
- 1990-11-06 CA CA002029372A patent/CA2029372C/fr not_active Expired - Fee Related
- 1990-11-06 IE IE399290A patent/IE65004B1/en not_active IP Right Cessation
- 1990-11-06 PT PT95808A patent/PT95808B/pt not_active IP Right Cessation
- 1990-11-07 JP JP2302284A patent/JPH0692403B2/ja not_active Expired - Lifetime
- 1990-11-07 EP EP90403145A patent/EP0428437B1/de not_active Expired - Lifetime
- 1990-11-07 ES ES90403145T patent/ES2062458T3/es not_active Expired - Lifetime
- 1990-11-07 DE DE69011628T patent/DE69011628T2/de not_active Expired - Fee Related
- 1990-11-07 AT AT90403145T patent/ATE110075T1/de not_active IP Right Cessation
- 1990-11-07 DK DK90403145.7T patent/DK0428437T3/da active
- 1990-11-07 OA OA59885A patent/OA09468A/xx unknown
-
1991
- 1991-10-21 US US07/779,828 patent/US5134147A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2654104B1 (fr) | 1992-01-03 |
US5134147A (en) | 1992-07-28 |
FR2654104A1 (fr) | 1991-05-10 |
CA2029372A1 (fr) | 1991-05-08 |
JPH03188077A (ja) | 1991-08-16 |
DE69011628T2 (de) | 1995-03-30 |
ATE110075T1 (de) | 1994-09-15 |
IE903992A1 (en) | 1991-05-08 |
NZ235892A (en) | 1992-08-26 |
IE65004B1 (en) | 1995-10-04 |
CA2029372C (fr) | 1998-01-06 |
EP0428437B1 (de) | 1994-08-17 |
PT95808B (pt) | 1997-11-28 |
ES2062458T3 (es) | 1994-12-16 |
ZA908884B (en) | 1991-08-28 |
EP0428437A1 (de) | 1991-05-22 |
DE69011628D1 (de) | 1994-09-22 |
PT95808A (pt) | 1991-09-13 |
AU6581990A (en) | 1991-05-16 |
OA09468A (fr) | 1992-11-15 |
US5100902A (en) | 1992-03-31 |
JPH0692403B2 (ja) | 1994-11-16 |
AU631466B2 (en) | 1992-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0428437T3 (da) | 1,2-benzisoxazolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
ES2083569T3 (es) | Nuevos derivados de ariletenileno y procedimiento para su preparacion. | |
DK0562956T3 (da) | Hidtil ukendte naphthylalkylaminer, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
DK1546134T3 (da) | Piperazinsubstituerede arylbenzodiazepiner | |
ATE266664T1 (de) | Pyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
YU47002B (sh) | N-imidazolini i n-imidazolilmetilni derivati supstituisanih bicikličnih jedinjenja i postupak za njihovo dobijanje | |
DK0379412T3 (da) | Derivater af 1,8-benzonaphthyridin, fremstilling af disse forbindelser og midler, som indeholder forbindelserne | |
ES2052181T3 (es) | Derivados de 2-oxo-1-oxa-8-azaespiro(4,5)decano, procesos para su preparacion y composiciones farmaceuticas de los mismos. | |
SE9001269L (sv) | 2-substituerade n,n'-ditrimetoxbensoylpiperaziner, en framstaellningsmetod foer dessa samt terapeutiska kompositioner som innehaaller dem | |
NO171362C (no) | Analogifremgangsmaate for fremstilling av nye aralkylaminforbindelser og deres salter | |
DE69823411D1 (de) | 2-Aminoidan Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen | |
DK0463944T3 (da) | Hidtil ukendte acylbenzoxazolinoner, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
DE69702955D1 (de) | Bis-Imide Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitung | |
DK614989D0 (da) | Indolderivater, fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem | |
NO903512L (no) | Nye 1-oxa-2-oxo-8-azaspiro(4,5)decanderivater, farmasoeytiske preparater som inneholder dem og fremgangsmaate for fremstilling av dem. | |
ES2054234T3 (es) | Un procedimiento para la preparacion de derivados indol. | |
ES2192827T3 (es) | Derivados de 8h-(2,3-b)-pirrolicin-8-ona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
ATE49207T1 (de) | 3-iminopyridazinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
DK0412015T3 (da) | Hidtil ukendte N-(23-vincristinoyl)- og N-(5-noranhydro-23-vinblastinoyl)-1-aminomethylphosphon- syrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
ATE218574T1 (de) | Bis pyrido(4,3-b)carbazolverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
TH37483A (th) | อนุพันธ์ 5-เมโรอิลแนพธาลีน |