YU47002B - N-imidazolini i n-imidazolilmetilni derivati supstituisanih bicikličnih jedinjenja i postupak za njihovo dobijanje - Google Patents

N-imidazolini i n-imidazolilmetilni derivati supstituisanih bicikličnih jedinjenja i postupak za njihovo dobijanje

Info

Publication number
YU47002B
YU47002B YU192989A YU192989A YU47002B YU 47002 B YU47002 B YU 47002B YU 192989 A YU192989 A YU 192989A YU 192989 A YU192989 A YU 192989A YU 47002 B YU47002 B YU 47002B
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
substituted bicyclic
imidazolines
obtaining
bicyclic compounds
Prior art date
Application number
YU192989A
Other languages
English (en)
Other versions
YU192989A (en
Inventor
G. Carganico
P. Cozzi
A. Pillan
P. Salvati
Original Assignee
Farmitalia Carlo Erba S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888823488A external-priority patent/GB8823488D0/en
Priority claimed from GB898901095A external-priority patent/GB8901095D0/en
Priority claimed from GB898917201A external-priority patent/GB8917201D0/en
Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.
Publication of YU192989A publication Critical patent/YU192989A/xx
Publication of YU47002B publication Critical patent/YU47002B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

N-imidazolilni i N-im-idazolilmetilni derivati supstituisanih bicikličnih jedinjenja formule (I) ili njihove farmaceutski prihvatljive soli formule (I) u kojoj je A grupa CR3 ili CHR3, gde je R3 vodonik ili C1-C6 alkil ili grupa C=CR4R5, gde je svaki od R4 i R5 nezavisno vodonik ili C1-C5alkil; Z je -CH2-, -O- ili -S-; n je 0 ili 1; svaki od R i R1 je nezavisno vodonik ili C1-C6alkil; R2 je -COCH2OH, -CH2OR', -COOR', -CONR'R" ili -CH=CH-COOR', gde je svaki od R' i R" nezavisno vodonik ili C1-C6alkil; a) kada je n=0, tada je Z -CH2- ili -O-; kada je n=1, tada je Z -CH2-, -O- ili -S-; b) kada je A CR3 ili CHR3, gde je R3vodonik, tada je n=1; i c) kada je istovremeno A CHR3, gde je R3vodonik, Z je -CH2-, n je 1 i R2-COOR', gde je R' definisano kao gore, tada je bar jedan od R1 različit od vodonika. Prijava sadrži 1 nezavisan i 3 zavisna zahteva.
YU192989A 1988-10-06 1989-10-04 N-imidazolini i n-imidazolilmetilni derivati supstituisanih bicikličnih jedinjenja i postupak za njihovo dobijanje YU47002B (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888823488A GB8823488D0 (en) 1988-10-06 1988-10-06 N-imidazolyl-& n-imidazolylmethyl-derivatives of substituted bicyclic compounds
GB898901095A GB8901095D0 (en) 1989-01-18 1989-01-18 N imidazolymethyl derivatives of bicyclic compounds and process for their preparation
GB898917201A GB8917201D0 (en) 1989-07-27 1989-07-27 N-imidazolyl-and n-imidazolylmethyl-derivatives of exo-alkylidene substituted bicyclic compounds

Publications (2)

Publication Number Publication Date
YU192989A YU192989A (en) 1991-02-28
YU47002B true YU47002B (sh) 1994-11-15

Family

ID=27264115

Family Applications (1)

Application Number Title Priority Date Filing Date
YU192989A YU47002B (sh) 1988-10-06 1989-10-04 N-imidazolini i n-imidazolilmetilni derivati supstituisanih bicikličnih jedinjenja i postupak za njihovo dobijanje

Country Status (18)

Country Link
US (1) US5204364A (sh)
EP (2) EP0389613A1 (sh)
JP (1) JPH03501859A (sh)
KR (1) KR900701760A (sh)
AU (1) AU620647B2 (sh)
DE (1) DE68901441D1 (sh)
DK (1) DK137590A (sh)
ES (1) ES2033062T3 (sh)
FI (1) FI902774A0 (sh)
GR (1) GR3004983T3 (sh)
HU (1) HU208123B (sh)
IE (1) IE893204L (sh)
IL (1) IL91542A0 (sh)
MY (1) MY106401A (sh)
NZ (1) NZ230629A (sh)
PT (1) PT91913B (sh)
WO (1) WO1990003970A1 (sh)
YU (1) YU47002B (sh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8705174D0 (en) * 1987-03-05 1987-04-08 Ici Plc Heterocyclic compounds
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
WO1992000294A1 (fr) * 1990-06-22 1992-01-09 Taisho Pharmaceutical Co., Ltd. Derive de naphtothiopyranone
GB9025848D0 (en) * 1990-11-28 1991-01-09 Erba Carlo Spa Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation
GB9101375D0 (en) * 1991-01-22 1991-03-06 Erba Carlo Spa N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohepht(b)indole
GB9102862D0 (en) * 1991-02-11 1991-03-27 Erba Carlo Spa N-imidazolyl derivatives of substituted or alkoxymino tetrahydronaphthalenes and chromans
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9200689D0 (en) * 1992-01-14 1992-03-11 Rhone Poulenc Agriculture New compositions of matter
GB9509888D0 (en) * 1995-05-16 1995-07-12 Pharmacia Spa Terpenoidic derivatives useful as antitumour agents
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
JPH11106381A (ja) * 1997-09-30 1999-04-20 Ss Pharmaceut Co Ltd クロメン誘導体及びその塩並びにこれを含有する医薬
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
CN101578272A (zh) * 2006-12-18 2009-11-11 诺瓦提斯公司 1-取代的咪唑衍生物和它们作为醛固酮合酶抑制剂的用途

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DE2244761A1 (de) * 1972-09-09 1974-03-14 Schering Ag Indan- und tetralinderivate
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
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US4172141A (en) * 1976-03-17 1979-10-23 Syntex (U.S.A.) Inc. N-(naphthylethyl)imidazole derivatives
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EP0000950B1 (en) * 1977-08-26 1984-02-01 The Wellcome Foundation Limited Imidazole derivatives and salts thereof and their synthesis
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4218461A (en) * 1979-08-15 1980-08-19 E. R. Squibb & Sons, Inc. 2,3-Dihydro-2-[(1H-imidazol-1-yl)-methylene]-1H-inden-1-ones
US4500540A (en) * 1979-12-26 1985-02-19 Hoffmann-La Roche Inc. Thromboxane synthase inhibitors as insulin lowering agents and antionbesity agents
GB2071655B (en) * 1980-03-04 1983-06-22 Erba Farmitalia N-amidazolyl derivatives of1-chroman and process for their preparation
IL62122A0 (en) * 1980-03-04 1981-03-31 Erba Farmitalia N-imidazolyl derivatives of 1-chroman,their preparation and pharmaceutical compositions containing them
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Also Published As

Publication number Publication date
IE893204L (en) 1990-04-06
EP0363789B1 (en) 1992-05-06
FI902774A0 (fi) 1990-06-04
US5204364A (en) 1993-04-20
EP0389613A1 (en) 1990-10-03
JPH03501859A (ja) 1991-04-25
WO1990003970A1 (en) 1990-04-19
IL91542A0 (en) 1990-04-29
AU620647B2 (en) 1992-02-20
YU192989A (en) 1991-02-28
MY106401A (en) 1995-05-30
DE68901441D1 (de) 1992-06-11
HU208123B (en) 1993-08-30
DK137590A (da) 1990-08-06
HUT58705A (en) 1992-03-30
KR900701760A (ko) 1990-12-04
ES2033062T3 (es) 1993-03-01
DK137590D0 (da) 1990-06-01
PT91913A (pt) 1990-04-30
GR3004983T3 (sh) 1993-04-28
PT91913B (pt) 1995-05-31
EP0363789A1 (en) 1990-04-18
NZ230629A (en) 1990-12-21
AU4344689A (en) 1990-05-01

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