ES2062458T3 - Derivados del 1,2-benzisoxazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Derivados del 1,2-benzisoxazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2062458T3
ES2062458T3 ES90403145T ES90403145T ES2062458T3 ES 2062458 T3 ES2062458 T3 ES 2062458T3 ES 90403145 T ES90403145 T ES 90403145T ES 90403145 T ES90403145 T ES 90403145T ES 2062458 T3 ES2062458 T3 ES 2062458T3
Authority
ES
Spain
Prior art keywords
radical
formula
image
hydrogen atom
represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90403145T
Other languages
English (en)
Inventor
Jean Louis Peglion
Francis Colpaert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2062458T3 publication Critical patent/ES2062458T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPUESTOS DE FORMULA I: EN LA QUE RO ENTERO DE 0 A 5, N REPRESENTA UN NUMERO ENTERO DE 1 A 2, P ES IGUAL A 0, 1 O 2 TAN CADA UNO UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN RADICAL ALQUILO LINEAL O RAMIFICADO, UN RADICAL TRIFLUROMETILO, UN RADICAL ALCOXI, UN RADICAL ALQUILTIO O UN RADICAL HIDROXI. FURAN-2-ILO (PUDIENDO CADA UNO SER SUSTITUIDO EN EL CICLO BENCENICO), UN RADICAL 2, 3, 6, 7 TETRAHIDRO BENZO [1,2-B; 4,5B]DIFUNAN-2-ILO, UN RADICAL 4-OXO 4H-CROMEN-2-ILO (EVENTUALMENTE SUSTITUIDO EN EL CICLO BENZENICO), UN RADICAL BENZOCICLOBUTENILO DE FORMULA A O UN RADICAL INDANILO DE FORMULA B: (EN LAS QUE: R SUB 1 Y R SUB 2 IDENTICOS O DIFERENTES REPRESENTAN CADA UNO UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN RADICAL TRIFLUROMETILO, UN RADICAL ALQUILO, UN RADICAL ALCOXI, UN RADICAL HIDROXI, UN RADICAL HIDROXIALQUILO, UN RADICAL ALQUILTIO O FORMAN EN CONJUNTO UN RADICAL METILENODIOXI, UN RADICAL ETILENODIOXI Y R SUB 3 REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ALQUILO LINEAL O RAMIFICADO DE 1 A 6 ATOMOS DE CARBONO), O UN RADICAL DE FORMULA C: (EN LA QUE R SUB 4, R SUB 5, Y R SUB 6 IDENTICOS O DIFERENTES REPRESENTAN CADA UNO UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN RADICAL TRIFLUOROMETILO, UN RADICAL HIDROXI, UN RADICAL ALQUILO, UN RADICAL ALCOXI, UN RADICAL ALQUILTIO Y R SUB 7 REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL HIDROXI), SUS ISOMEROS OPTICOS Y SUS SALES DE ADICION CON UN ACIDO ORGANICO O MINERAL FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
ES90403145T 1989-11-07 1990-11-07 Derivados del 1,2-benzisoxazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2062458T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8914571A FR2654104B1 (fr) 1989-11-07 1989-11-07 Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2062458T3 true ES2062458T3 (es) 1994-12-16

Family

ID=9387148

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90403145T Expired - Lifetime ES2062458T3 (es) 1989-11-07 1990-11-07 Derivados del 1,2-benzisoxazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
US (2) US5100902A (es)
EP (1) EP0428437B1 (es)
JP (1) JPH0692403B2 (es)
AT (1) ATE110075T1 (es)
AU (1) AU631466B2 (es)
CA (1) CA2029372C (es)
DE (1) DE69011628T2 (es)
DK (1) DK0428437T3 (es)
ES (1) ES2062458T3 (es)
FR (1) FR2654104B1 (es)
IE (1) IE65004B1 (es)
NZ (1) NZ235892A (es)
OA (1) OA09468A (es)
PT (1) PT95808B (es)
ZA (1) ZA908884B (es)

Families Citing this family (41)

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US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5750542A (en) 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
DE69232907T2 (de) * 1991-03-28 2003-05-15 Eisai Co Ltd Neue heterocyclische/cyclische amine
EP0602242A4 (en) * 1991-08-22 1994-06-29 Yoshitomi Pharmaceutical Benzisoxazole compound and use thereof.
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
JPH07502268A (ja) * 1991-11-27 1995-03-09 ノボ　ノルディスク　アクティーゼルスカブ 化学化合物、それらの製法および使用
FR2694005B1 (fr) * 1992-07-21 1994-08-26 Adir Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
JP3462501B2 (ja) * 1992-11-23 2003-11-05 アベンティス・ファーマスーティカルズ・インコーポレイテツド 置換された３−（アミノアルキルアミノ）−１，２−ベンゾイソキサゾールおよび関連化合物
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
JP4782252B2 (ja) * 1994-01-10 2011-09-28 テバ ファーマシューティカル インダストリーズ リミテッド １−アミノインダン及びこれらの組成物
US5877218A (en) 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US6743808B1 (en) 1994-06-08 2004-06-01 H. Lundbeck A/S 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) tetrahydropyridines or piperazines
ZA954689B (en) 1994-06-08 1996-01-29 Lundbeck & Co As H 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines
IL117646A (en) * 1995-04-12 2000-06-01 Ferrer Int 7-¬3-¬4-(6-fluoro-1,2-benzisoxazole-3-YL)piperidin-1-YL¾propoxy¾3-alkyl-chromen-4-ones their preparation their uses and pharmaceutical compositions comprising them
ES2101646B1 (es) * 1995-04-12 1998-04-01 Ferrer Int Nuevo compuesto derivado del cromeno.
FR2735129B1 (fr) * 1995-06-07 1997-07-11 Adir Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL130528A (en) 1996-12-18 2004-12-15 Teva Pharma Aminoindan derivatives, pharmaceutical compositions comprising them and uses thereof
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
DE60008917T2 (de) * 1999-12-08 2005-03-10 Grelan Pharmaceutical Co., Ltd., Hamura Neue 1,8-naphtyridin-2(1h)-on-derivate
DE60112725T2 (de) * 2000-02-18 2006-06-01 Meiji Seika Kaisha Ltd. Phenoxyalkylaminderivate als agonisten des opioid-delta rezeptors
JP3772204B2 (ja) * 2000-06-05 2006-05-10 独立行政法人産業技術総合研究所 糖鎖誘導体及びその製造方法
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
WO2004009591A1 (en) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. A process for the preparation of antipsychotic risperidone
BRPI0416739A (pt) * 2003-12-08 2007-01-16 Warner Lambert Co derivados de indano substituìdo heterocìclico e compostos afins para o tratamento de esquizofrenia
JP4970290B2 (ja) * 2005-02-25 2012-07-04 ファイザー株式会社 ベンズイソキサゾール誘導体
PT1877390E (pt) 2005-04-26 2010-05-31 Hypnion Inc Compostos benzisoxazole-piridina e métodos para a sua utilização
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
BRPI0620659A2 (pt) * 2005-12-09 2017-10-31 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd método para a prevenção do aparecimento de sintomas de uma doença neurodegenerativa em um indivíduo predisposto à doença neurodegenerativa, método de redução de stress oxidante no cérebro de um indivíduo afligido com stress oxidante, método de tratamento de um indivíduo afligido com a degeneração cognitiva suave e composição farmacêutica
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
WO2007126041A1 (ja) 2006-04-28 2007-11-08 Eisai R & D Management Co., Ltd. ベンゾイソオキサゾール化合物
ATE544766T1 (de) 2009-07-13 2012-02-15 Krka Verfahren zur synthese von paliperidon
WO2012063269A2 (en) 2010-11-12 2012-05-18 Cadila Healthcare Limited Process for preparing iloperidone
JP2016000697A (ja) * 2012-10-02 2016-01-07 大日本住友製薬株式会社 ピリミジン誘導体
US10384995B2 (en) * 2016-08-12 2019-08-20 Bayer Cropscience Aktiengesellschaft Method for preparing substituted styrene derivatives
CN115057809B (zh) * 2022-07-15 2024-02-13 扬州市普林斯医药科技有限公司 一种4-(2,4-二氟苯甲酰基)-哌啶的制备方法

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US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4472193A (en) * 1982-07-06 1984-09-18 The Dow Chemical Company Naphthyridinyloxy(or thio)phenoxy propanoic acids, derivatives thereof and methods of herbicidal use
US4528376A (en) * 1982-08-11 1985-07-09 Hoechst-Roussel Pharmaceuticals Inc. 3-(4-Piperidyl)-1,2-benzisoxazoles
AU5529286A (en) * 1985-03-26 1986-10-02 Hayes, B.L. Shock absorbent moving platform
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JPH01199967A (ja) * 1987-10-26 1989-08-11 Sumitomo Pharmaceut Co Ltd 新規なイミド誘導体
WO1991008208A1 (en) * 1989-12-04 1991-06-13 Schering Corporation Heterocyclic substituted naphthyridinones and methods and compositions employing them

Also Published As

Publication number Publication date
AU631466B2 (en) 1992-11-26
IE903992A1 (en) 1991-05-08
CA2029372A1 (fr) 1991-05-08
JPH0692403B2 (ja) 1994-11-16
IE65004B1 (en) 1995-10-04
US5100902A (en) 1992-03-31
ATE110075T1 (de) 1994-09-15
DE69011628D1 (de) 1994-09-22
US5134147A (en) 1992-07-28
FR2654104A1 (fr) 1991-05-10
PT95808B (pt) 1997-11-28
EP0428437A1 (fr) 1991-05-22
OA09468A (fr) 1992-11-15
DK0428437T3 (da) 1995-01-02
ZA908884B (en) 1991-08-28
DE69011628T2 (de) 1995-03-30
FR2654104B1 (fr) 1992-01-03
CA2029372C (fr) 1998-01-06
AU6581990A (en) 1991-05-16
PT95808A (pt) 1991-09-13
JPH03188077A (ja) 1991-08-16
EP0428437B1 (fr) 1994-08-17
NZ235892A (en) 1992-08-26

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