DE841940T1 - Isolierung und/oder konservierung von dentritischen zellenfür die immuntherapie von prostatakrebs - Google Patents
Isolierung und/oder konservierung von dentritischen zellenfür die immuntherapie von prostatakrebsInfo
- Publication number
- DE841940T1 DE841940T1 DE0841940T DE96927268T DE841940T1 DE 841940 T1 DE841940 T1 DE 841940T1 DE 0841940 T DE0841940 T DE 0841940T DE 96927268 T DE96927268 T DE 96927268T DE 841940 T1 DE841940 T1 DE 841940T1
- Authority
- DE
- Germany
- Prior art keywords
- seq
- prostate cancer
- cells
- use according
- prostate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010060862 Prostate cancer Diseases 0.000 title claims 28
- 208000000236 Prostatic Neoplasms Diseases 0.000 title claims 28
- 238000009169 immunotherapy Methods 0.000 title 1
- 238000009413 insulation Methods 0.000 title 1
- 238000004321 preservation Methods 0.000 title 1
- 210000004443 dendritic cell Anatomy 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 8
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 8
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 6
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 239000006166 lysate Substances 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 5
- 208000023958 prostate neoplasm Diseases 0.000 claims 5
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 210000005259 peripheral blood Anatomy 0.000 claims 4
- 239000011886 peripheral blood Substances 0.000 claims 4
- 102000015728 Mucins Human genes 0.000 claims 3
- 108010063954 Mucins Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 210000002307 prostate Anatomy 0.000 claims 3
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 230000005907 cancer growth Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 210000001541 thymus gland Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229940126587 biotherapeutics Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001195—Prostate specific membrane antigen [PSMA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
- A61K40/4276—Prostate specific membrane antigen [PSMA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/58—Prostate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/509,254 US5788963A (en) | 1995-07-31 | 1995-07-31 | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| PCT/US1996/012389 WO1997004802A1 (en) | 1995-07-31 | 1996-07-29 | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE841940T1 true DE841940T1 (de) | 2001-08-23 |
Family
ID=24025874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0841940T Pending DE841940T1 (de) | 1995-07-31 | 1996-07-29 | Isolierung und/oder konservierung von dentritischen zellenfür die immuntherapie von prostatakrebs |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5788963A (https=) |
| EP (2) | EP2377548A3 (https=) |
| JP (1) | JP4267692B2 (https=) |
| AU (1) | AU723607B2 (https=) |
| CA (1) | CA2228176C (https=) |
| DE (1) | DE841940T1 (https=) |
| IL (1) | IL123079A0 (https=) |
| NZ (1) | NZ315441A (https=) |
| WO (1) | WO1997004802A1 (https=) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7252829B1 (en) | 1998-06-17 | 2007-08-07 | Idm Pharma, Inc. | HLA binding peptides and their uses |
| US20020168374A1 (en) * | 1992-08-07 | 2002-11-14 | Ralph T. Kubo | Hla binding peptides and their uses |
| US20040110283A1 (en) * | 1997-02-27 | 2004-06-10 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Induction of tumor and viral immunity using antigen presenting cell co-culture products and fusion products |
| US20050170503A1 (en) * | 1997-02-27 | 2005-08-04 | University Of Pittsburgh | In vitro induction of antigen-specific T-cells using dendritic cell-tumor cell or dendritic cell-viral cell derived immunogens |
| US7282198B2 (en) * | 1997-03-19 | 2007-10-16 | The University Of Arkansas For Medical Sciences | Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme |
| WO1999024554A2 (en) | 1997-11-12 | 1999-05-20 | University Of Pittsburgh | Isolation, characterization, and identification of dendritic like cells and methods of using same |
| AU3305699A (en) * | 1998-02-26 | 1999-09-15 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
| AU3102599A (en) * | 1998-03-20 | 1999-10-11 | Genzyme Corporation | Compositions and methods for the frozen storage of dendritic cells |
| US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
| EP1068296B1 (en) | 1998-03-31 | 2011-08-10 | Geron Corporation | Compositions for eliciting an immune response to a telomerase antigen |
| EP1078060B1 (en) * | 1998-05-11 | 2007-01-10 | E.P. Prof. Dr. Rieber | Antibodies to dendritic cells and human dendritic cell populations and uses thereof |
| US7351546B2 (en) * | 1998-09-22 | 2008-04-01 | Becton, Dickinson And Company | Flow cytometric, whole blood dendritic cell immune function assay |
| US6495333B1 (en) | 1998-09-22 | 2002-12-17 | Becton Dickinson And Company | Flow cytometric, whole blood dendritic cell immune function assay |
| US6387888B1 (en) | 1998-09-30 | 2002-05-14 | American Foundation For Biological Research, Inc. | Immunotherapy of cancer through expression of truncated tumor or tumor-associated antigen |
| CA2345277C (en) | 1998-10-20 | 2011-05-24 | Salvatore Albani | Methods for isolation, quantification, characterization and modulation of antigen-specific t cells |
| US6787154B2 (en) * | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
| US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
| GB9827103D0 (en) * | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
| GB9827104D0 (en) * | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
| CA2367692A1 (en) * | 1999-03-15 | 2000-09-21 | Introgen Therapeutics, Inc. | Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses |
| DE60044125D1 (de) | 1999-04-14 | 2010-05-20 | Novartis Vaccines & Diagnostic | Zusammensetzungen und verfahren zur auslösung einer immunantwort auf basis alphavirus-vektoren-systeme |
| US7713739B1 (en) * | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| US7015205B1 (en) | 1999-10-18 | 2006-03-21 | St. Vincent's Hospital And Medical Center Of New York | Melanoma vaccine and methods of making and using same |
| KR100363587B1 (ko) * | 1999-11-12 | 2002-12-06 | 이시우 | 대식세포와 종양세포의 융합에 의한 항종양 세포성 치료제 |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| CN1454215B (zh) * | 1999-11-15 | 2013-01-02 | 米勒腾尼生物技术有限公司 | 树突状细胞特异的抗原结合片段、组合物及其使用方法、被其识别的抗原及由其获得的细胞 |
| AU1811801A (en) * | 1999-12-03 | 2001-06-12 | Dendreon Corporation | Cryopreservation of antigen-loaded dendritic cells and their precursors in serum-free media |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US20030027246A1 (en) * | 2000-03-31 | 2003-02-06 | Artur Pedyczak | Immunogenic peptides derived from prostate-specific membrane antigen (PSMA) and uses thereof |
| CA2408547A1 (en) * | 2000-05-11 | 2001-11-15 | Altarex Corp. | Therapeutic method and composition utilizing antigen-antibody complexation and presentation by dendritic cells |
| US20030175247A1 (en) * | 2000-05-12 | 2003-09-18 | Michael Salgaller | Method to increase class I presentation of exogenous antigens by human dendritic cells |
| DE10041515A1 (de) * | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| CA2460014A1 (en) * | 2000-09-21 | 2002-03-28 | The Regents Of The University Of California | Spas-1 cancer antigen |
| US20070031372A1 (en) * | 2004-08-05 | 2007-02-08 | Hadden John W | Vaccine immunotherapy for immune suppressed patients |
| US20070154399A1 (en) * | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
| AU2002232560A1 (en) | 2000-10-27 | 2002-05-06 | Immuno-Rx, Inc | Vaccine immunotherapy for immune suppressed patients |
| US20070025958A1 (en) * | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
| DE10112851C1 (de) | 2001-03-16 | 2002-10-10 | Gsf Forschungszentrum Umwelt | Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen |
| WO2003008537A2 (en) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
| US20030082806A1 (en) * | 2001-04-27 | 2003-05-01 | Xcyte Therapies, Inc. | Maturation of antigen-presenting cells using activated T cells |
| CA2459713C (en) | 2001-09-06 | 2015-08-18 | Northwest Biotherapeutics, Inc. | Compositions and methods for priming monocytic dendritic cells and t cells for th-1 response |
| WO2003033520A2 (en) * | 2001-09-24 | 2003-04-24 | University Of Pittburgh Of The Commonwealth System Of Higher Education | Anticancer vaccine and diganostic methods and reagents |
| US20050215472A1 (en) * | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| JP5355839B2 (ja) * | 2001-10-23 | 2013-11-27 | ピーエスエムエー デベロプメント カンパニー, エル.エル.シー. | Psma抗体およびタンパク質マルチマー |
| AU2002349543A1 (en) * | 2001-12-10 | 2003-06-23 | Kyogo Itoh | Tumor antigens |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| SI1509244T1 (sl) * | 2002-06-06 | 2011-11-30 | Immunicum An | Nov postopek in spojina za izdelavo celične alogenične vakcine |
| CN1713951B (zh) | 2002-06-19 | 2010-05-26 | 西北生物治疗药物公司 | 切向流过滤设备和白细胞富集方法 |
| US20040022813A1 (en) * | 2002-08-05 | 2004-02-05 | Jean-Claude Bystryn | Shed antigen vaccine with dendritic cells adjuvant |
| JP2004196770A (ja) * | 2002-10-24 | 2004-07-15 | Effector Cell Institute Inc | 樹状細胞前駆体の血中レベル上昇剤 |
| KR100522526B1 (ko) * | 2002-11-28 | 2005-10-19 | 주식회사 바이넥스 | 면역 치료용 수지상 세포의 제조방법 |
| CN102600461B (zh) * | 2002-12-06 | 2017-07-14 | 西北生物治疗药物公司 | 给予体外部分成熟的树突细胞治疗肿瘤 |
| US20040202663A1 (en) * | 2003-01-28 | 2004-10-14 | Shanghai Sunway Biotech Co., Ltd. | Therapy for primary and metastatic cancers |
| WO2004075855A2 (en) * | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
| RU2364625C2 (ru) | 2003-02-27 | 2009-08-20 | Норсуэст Байотерапьютикс, Инк. | Генерирование дендритных клеток из моноцитарных предшественников дендритных клеток с помощью gm-csf в отсутствие дополнительных цитокинов |
| EP1670513B1 (en) * | 2003-10-06 | 2013-01-23 | Cedars-Sinai Medical Center | Cox-2 inhibitors and dendritic cells for use in the treatment of cancer. |
| JP5015601B2 (ja) * | 2003-10-21 | 2012-08-29 | セダーズ−シナイ メディカル センター | 中枢神経系の癌を含む癌の処置のための系および方法 |
| DE602005022728D1 (de) * | 2004-08-19 | 2010-09-16 | Univ Cardiff | Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie |
| CN100591761C (zh) * | 2004-08-19 | 2010-02-24 | 加的夫大学学院咨询有限公司 | 呈递抗原的人γδT细胞的制备和在免疫治疗中的用途 |
| WO2006023598A2 (en) * | 2004-08-19 | 2006-03-02 | University Of Maryland, Baltimore | Prostate-specific antigen-derived mhc class ii-restricted peptides and their use in vaccines to treat or prevent prostate cancer |
| WO2007044033A2 (en) * | 2004-12-07 | 2007-04-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Therapeutic and diagnostic cloned mhc-unrestricted receptor specific for the muc1 tumor associated antigen |
| US8420078B2 (en) * | 2005-03-10 | 2013-04-16 | Yeda Research And Development Co. Ltd. | Methods and immunogenic cell preparations for treating antigen-associated diseases |
| CA2504279A1 (en) * | 2005-04-15 | 2006-10-15 | University Of Saskatchewan | Materials and method of modulating the immune response using t helper-antigen presenting cells |
| EP1888105A2 (en) * | 2005-05-12 | 2008-02-20 | Introgen Therapeutics, Inc. | P53 vaccines for the treatment of cancers |
| SG162817A1 (en) | 2005-06-17 | 2010-07-29 | Mannkind Corp | Methods and compositions.to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
| US8338173B2 (en) * | 2005-08-11 | 2012-12-25 | University College Cardiff Consultants Limited | Preparation of antigen-presenting human γδ T cells and use in immunotherapy |
| KR20220113543A (ko) | 2005-12-08 | 2022-08-12 | 노쓰웨스트 바이오써라퓨틱스, 인크. | 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법 |
| WO2007137300A2 (en) | 2006-05-23 | 2007-11-29 | Bellicum Pharmaceuticals, Inc. | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| CA2700573C (en) | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| CA2700436C (en) | 2006-09-28 | 2017-04-18 | John S. Yu | Cancer vaccines and vaccination methods |
| US8097242B2 (en) * | 2006-10-05 | 2012-01-17 | The Board Of Trustees Of The University Of Arkansas | Target CA125 peptides for cancer immunotherapy |
| JP5563472B2 (ja) | 2007-11-28 | 2014-07-30 | アイ アール エックス セーラピューティクス, インコーポレイテッド | 免疫学的効果を増大させる方法 |
| US20110189093A1 (en) * | 2008-04-14 | 2011-08-04 | Proscan Rx Pharma | Prostate specific membrane antigen antibodies and antigen binding fragments |
| US8748170B2 (en) | 2008-07-25 | 2014-06-10 | University of Pittsburgh—of the Commonwealth System of Higher Education | Polypeptides derived from cyclin B1 and uses thereof |
| PL2328923T3 (pl) | 2008-09-02 | 2016-06-30 | Cedars Sinai Medical Center | Epitopy CD133 |
| EP2326350B1 (en) | 2008-09-08 | 2013-09-04 | Psma Development Company, L.L.C. | Compounds for killing psma-expressing, taxane-resistant cancer cells |
| DK2352756T3 (da) | 2008-11-24 | 2012-12-03 | Helmholtz Zentrum Muenchen | Højaffin T-cellereceptor og anvendelse af denne |
| EP2427485B1 (en) * | 2009-05-07 | 2016-12-07 | ImmunoCellular Therapeutics, Ltd. | Cd133 epitopes |
| CA3017298C (en) | 2009-05-15 | 2021-09-28 | Irx Therapeutics, Inc. | Compositions comprising primary cell-derived biologics for enhancing immune responses in patients |
| ES2667476T3 (es) | 2009-12-08 | 2018-05-11 | Irx Therapeutics, Inc. | Método para invertir la supresión inmunitaria de células de Langerhans |
| US20110251128A1 (en) * | 2010-02-26 | 2011-10-13 | The Board Of Regents Of The University Of Texas System | THYMOSIN Beta4 PEPTIDES PROMOTE TISSUE REGENERATION |
| US9629357B2 (en) * | 2013-02-01 | 2017-04-25 | Primegen Biotech Llc | Cryopreservation of cells and tissue for clinical application |
| ES2662333T3 (es) | 2013-02-14 | 2018-04-06 | Immunocellular Therapeutics Ltd. | Vacunas contra el cáncer y métodos de vacunación |
| US10320290B2 (en) * | 2013-08-09 | 2019-06-11 | Microsemi Corporation | Voltage regulator with switching and low dropout modes |
| DK3277325T3 (da) | 2015-04-03 | 2021-01-18 | H Lee Moffitt Cancer Ct & Res | Kombinationsimmunterapi for cancer |
| KR102873947B1 (ko) | 2015-05-07 | 2025-10-22 | 베이롤 칼리지 오브 메드신 | 수지상 세포 면역요법 |
| US10801041B2 (en) | 2015-11-18 | 2020-10-13 | Orbis Health Solutions, Llc | T7 alpha viral vector system |
| US11020465B2 (en) | 2016-03-04 | 2021-06-01 | The Trustees Of Columbia University In The City Of New York | Development of dual whole cell-based vaccine against pancreatic cancer |
| WO2017181163A2 (en) | 2016-04-16 | 2017-10-19 | Oncocyte Corporation | Methods and compositions for detection and diagnosis of breast cancer |
| JP2021533759A (ja) * | 2018-08-10 | 2021-12-09 | ユーティレックス カンパニー リミテッド | 癌抗原特異的cd8+t細胞を調製および凍結保存するための方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| US5004681B1 (en) * | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5162504A (en) * | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
| US20030072751A1 (en) * | 1990-03-14 | 2003-04-17 | Heribert Bohlen | Idiotypic vaccination against b cell lymphoma |
| US5227471A (en) * | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
| AU4678993A (en) * | 1992-07-16 | 1994-02-14 | Board Of Trustees Of The Leland Stanford Junior University | Methods for using dendritic cells to activate t cells |
| EP0692973A1 (en) * | 1993-03-15 | 1996-01-24 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Peptide coated dendritic cells as immunogens |
| PT765386E (pt) * | 1994-06-14 | 2015-02-06 | Univ Leland Stanford Junior | Processos para a activação in vivo de células t, através de células dendríticas pulsadas com antigénio |
-
1995
- 1995-07-31 US US08/509,254 patent/US5788963A/en not_active Expired - Lifetime
-
1996
- 1996-07-29 IL IL12307996A patent/IL123079A0/xx not_active IP Right Cessation
- 1996-07-29 CA CA2228176A patent/CA2228176C/en not_active Expired - Lifetime
- 1996-07-29 EP EP10183831A patent/EP2377548A3/en not_active Withdrawn
- 1996-07-29 DE DE0841940T patent/DE841940T1/de active Pending
- 1996-07-29 NZ NZ315441A patent/NZ315441A/xx unknown
- 1996-07-29 EP EP96927268A patent/EP0841940A4/en not_active Withdrawn
- 1996-07-29 AU AU67146/96A patent/AU723607B2/en not_active Expired
- 1996-07-29 JP JP50782397A patent/JP4267692B2/ja not_active Expired - Lifetime
- 1996-07-29 WO PCT/US1996/012389 patent/WO1997004802A1/en not_active Ceased
-
2012
- 2012-06-14 US US13/523,828 patent/US20130017600A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997004802A1 (en) | 1997-02-13 |
| US20130017600A1 (en) | 2013-01-17 |
| CA2228176C (en) | 2015-05-26 |
| JP2001520633A (ja) | 2001-10-30 |
| AU6714696A (en) | 1997-02-26 |
| AU723607B2 (en) | 2000-08-31 |
| US5788963A (en) | 1998-08-04 |
| MX9800821A (es) | 1998-10-31 |
| EP0841940A4 (en) | 2005-01-05 |
| JP4267692B2 (ja) | 2009-05-27 |
| EP2377548A3 (en) | 2012-10-10 |
| IL123079A0 (en) | 1998-09-24 |
| CA2228176A1 (en) | 1997-02-13 |
| EP2377548A2 (en) | 2011-10-19 |
| EP0841940A1 (en) | 1998-05-20 |
| NZ315441A (en) | 1999-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE841940T1 (de) | Isolierung und/oder konservierung von dentritischen zellenfür die immuntherapie von prostatakrebs | |
| DE69334186T2 (de) | Vom MAGE-3-Gen en abgeleitetes und von HLA-A1 präsentiertes, isoliertes Nonapeptid und dessen Anwendungen | |
| DE60030450T2 (de) | Von MUC-1 abgeleitete Peptide | |
| DE69929533T2 (de) | Immunotherapeutische methoden mit verwendung von wt-1 and gata-1 epitopen | |
| DE69937294T2 (de) | Von cyclophilin b abstammende tumorantigen-peptide | |
| CA2440303C (en) | Wt1 modified peptide | |
| DE69520959T2 (de) | Isolierte von tumor abstossenden vorläufer antigen mage-2 abgeleitete peptide und deren verwendung | |
| Nakata et al. | Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo. | |
| DE69519748T2 (de) | Aus den vorstufen des mage tumor-abstossungsantigen abstammende einzelne peptede, die hla-a2 moleküle komplexieren | |
| Lee et al. | Heterogeneity of human γδ T cells and their role in cancer immunity | |
| DE3781204T2 (de) | Verfahren zur herstellung von lymphokinaktivierten toetenden zellen. | |
| WO2003102023A1 (de) | An mhc-moleküle bindende tumor-assoziierte peptide | |
| Mosier et al. | Cellular deficit in thymectomized mice | |
| Zivkovic et al. | Oxidative burst and anticancer activities of rat neutrophils | |
| ATE17858T1 (de) | Angiotropine aus leukozyten und entzuendeten geweben: eine neue klasse von natuerlichen chemotropischen und mitogenen proteinen fuer die spezifische induktion des gesteuerten wachstums von blutgefaessen, fuer neue gefaessbildung von geweben und fuer die morphogenese von blutgefaessverzweigungen; verfahren zu ihrer biotechnischen herstellung und pharmazeutische zusammensetzungen. | |
| DE102005041616A1 (de) | Melanom-assoziierte MHC Klasse I assoziierte Oligopeptide und deren Verwendungen | |
| Watanabe et al. | The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7 | |
| DE69721485T2 (de) | Durch hla-b44 moleküle präsentierte tumor-abstossungsantigene und ihre verwendungen | |
| Kuge et al. | Interleukin‐12 augments the generation of autologous tumor‐reactive CD8+ cytotoxic T lymphocytes from tumor‐infiltrating lymphocytes | |
| DE60130634T2 (de) | Identifizierung von antigenen peptiden durch zytotoxische t-lymphozyten aktiviert von dendritischen zellhybriden | |
| AT400444B (de) | Verfahren zur herstellung von oncostatin m | |
| DE69828791T2 (de) | Das antigen ha-1 | |
| DE69825395T2 (de) | Medikament, behandlungsmethode, prophylaktikum und prophylaxe gegen immunologische erkrankungen von hunden und katzen | |
| DE69821919T2 (de) | Fischprotein, dessen gen, reagenzien zur induktion von apoptose, und antikrebsmittel | |
| WO1999044629A2 (de) | Verwendung von cd137 zur förderung der proliferation peripherer monocyten |