DE74909T1 - Zusammensetzungen mit gehalt an 5-hydroxytryptophan, verfahren zu ihrer herstellung und sie enthaltende arzneimittel. - Google Patents
Zusammensetzungen mit gehalt an 5-hydroxytryptophan, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.Info
- Publication number
- DE74909T1 DE74909T1 DE198282401683T DE82401683T DE74909T1 DE 74909 T1 DE74909 T1 DE 74909T1 DE 198282401683 T DE198282401683 T DE 198282401683T DE 82401683 T DE82401683 T DE 82401683T DE 74909 T1 DE74909 T1 DE 74909T1
- Authority
- DE
- Germany
- Prior art keywords
- htp
- inosine
- complex
- temperature
- purine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 title claims 10
- 238000000034 method Methods 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title claims 2
- 229940126601 medicinal product Drugs 0.000 title 1
- LDCYZAJDBXYCGN-UHFFFAOYSA-N oxitriptan Natural products C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 6
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 5
- 229930010555 Inosine Natural products 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229960003786 inosine Drugs 0.000 claims 5
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 4
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 3
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 claims 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 2
- 230000006340 racemization Effects 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 1
- 229960003459 allopurinol Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 claims 1
- 239000003456 ion exchange resin Substances 0.000 claims 1
- 229920003303 ion-exchange polymer Polymers 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 239000012452 mother liquor Substances 0.000 claims 1
- 239000002547 new drug Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229960005010 orotic acid Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003212 purines Chemical class 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 229940076279 serotonin Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8117492A FR2512672A1 (fr) | 1981-09-16 | 1981-09-16 | Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant |
| FR8213980A FR2531713A2 (fr) | 1981-09-16 | 1982-08-11 | Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE74909T1 true DE74909T1 (de) | 1984-09-13 |
Family
ID=26222544
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE198282401683T Pending DE74909T1 (de) | 1981-09-16 | 1982-09-16 | Zusammensetzungen mit gehalt an 5-hydroxytryptophan, verfahren zu ihrer herstellung und sie enthaltende arzneimittel. |
| DE8282401683T Expired DE3264433D1 (en) | 1981-09-16 | 1982-09-16 | Compositions on the basis of 5-hydroxy-tryptophane, manufacturing process and medicaments containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8282401683T Expired DE3264433D1 (en) | 1981-09-16 | 1982-09-16 | Compositions on the basis of 5-hydroxy-tryptophane, manufacturing process and medicaments containing them |
Country Status (8)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1171321B (it) * | 1981-06-22 | 1987-06-10 | Malesci Sas | Composizioni farmaceutiche antibroncospastiche idrosolubili costituite da sali della teofillina con aminoacidi basici |
| US4639465A (en) * | 1985-08-30 | 1987-01-27 | Commonwealth Medical Corporation Of America | Method and composition for relieving pain |
| US4650789A (en) * | 1985-10-15 | 1987-03-17 | Commonwealth Medical Corporation Of America | Method and composition for increasing production of serotonin |
| DK0628311T3 (da) * | 1992-07-08 | 2002-07-22 | Kyowa Hakko Kogyo Kk | Xanthinderivater som antidepressive midler |
| US5939076A (en) * | 1997-11-12 | 1999-08-17 | Allocca Techical, Inc. | Composition and method for treating or alleviating migraine headaches |
| SE9802555D0 (sv) * | 1998-07-16 | 1998-07-16 | A & Science Invest Ab | New pharmaceutical preparation and method |
| US20020045580A1 (en) * | 1999-11-24 | 2002-04-18 | Sacks Meir S. | Compositions for raising uric acid levels and methods of using same |
| US6068846A (en) * | 1998-08-05 | 2000-05-30 | Melaleuca, Incorporated | Methods and materials for treating depression and mood disorder |
| US20040254202A1 (en) * | 2003-06-13 | 2004-12-16 | The Procter & Gamble Company | Method of promoting sleep using topical administration of vasoactive agents |
| WO2009123978A1 (en) * | 2008-03-31 | 2009-10-08 | The Trustees Of Columbia University In The City Of New York | Methods of diagnosing, preventing and treating bone mass diseases |
| WO2012076916A1 (en) | 2010-12-09 | 2012-06-14 | Brainet Discovery Srl | Therapeutic association of 5 - hydroxy - tryptophan and caffeine for the treatment of the symptom of parkinson's disease, daytime sleepiness |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1601066A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1966-06-18 | 1970-08-10 | ||
| ES360566A1 (es) * | 1968-11-22 | 1970-10-16 | Made Labor Sa | Un metodo de obtencion de alfa-cetoglutarato de piridoxina y sus derivados. |
| ES376906A1 (es) * | 1970-02-25 | 1973-02-01 | Made Labor Sa | Un metodo de obtencion de alfa-cetoglutarato de piridoxina y 5-hidroxitriptofano. |
| GB1535778A (en) * | 1976-12-06 | 1978-12-13 | Mac Sweeney D | Compounds useful in treatment of unipolar depression |
| DE2841170A1 (de) * | 1978-09-21 | 1980-04-03 | Pharmazeutische Praeparate Apo | Hypnotikum |
| FR2499076A1 (fr) * | 1981-02-02 | 1982-08-06 | Panmedica Laboratoires | Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant |
-
1982
- 1982-08-11 FR FR8213980A patent/FR2531713A2/fr active Granted
- 1982-09-14 ES ES515709A patent/ES515709A0/es active Granted
- 1982-09-15 CA CA000411517A patent/CA1219582A/en not_active Expired
- 1982-09-15 GR GR69287A patent/GR77003B/el unknown
- 1982-09-16 US US06/418,599 patent/US4472387A/en not_active Expired - Lifetime
- 1982-09-16 DE DE198282401683T patent/DE74909T1/de active Pending
- 1982-09-16 DE DE8282401683T patent/DE3264433D1/de not_active Expired
- 1982-09-16 EP EP82401683A patent/EP0074909B1/fr not_active Expired
- 1982-09-16 AU AU88474/82A patent/AU557715B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0074909A1 (fr) | 1983-03-23 |
| ES8306439A1 (es) | 1983-06-01 |
| AU557715B2 (en) | 1987-01-08 |
| EP0074909B1 (fr) | 1985-06-26 |
| FR2531713B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-01-11 |
| GR77003B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-09-04 |
| DE3264433D1 (en) | 1985-08-01 |
| FR2531713A2 (fr) | 1984-02-17 |
| US4472387A (en) | 1984-09-18 |
| ES515709A0 (es) | 1983-06-01 |
| CA1219582A (en) | 1987-03-24 |
| AU8847482A (en) | 1983-03-24 |
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