DE69942307D1 - N-terminal veränderte glp-1 abkömmlinge - Google Patents
N-terminal veränderte glp-1 abkömmlingeInfo
- Publication number
- DE69942307D1 DE69942307D1 DE69942307T DE69942307T DE69942307D1 DE 69942307 D1 DE69942307 D1 DE 69942307D1 DE 69942307 T DE69942307 T DE 69942307T DE 69942307 T DE69942307 T DE 69942307T DE 69942307 D1 DE69942307 D1 DE 69942307D1
- Authority
- DE
- Germany
- Prior art keywords
- glp
- derivatives
- abömmlinge
- insulin dependent
- terminal changed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK26898 | 1998-02-27 | ||
DK26398 | 1998-02-27 | ||
DK50898 | 1998-04-08 | ||
PCT/DK1999/000085 WO1999043707A1 (en) | 1998-02-27 | 1999-02-25 | N-terminally modified glp-1 derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69942307D1 true DE69942307D1 (de) | 2010-06-10 |
Family
ID=27220551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69942307T Expired - Lifetime DE69942307D1 (de) | 1998-02-27 | 1999-02-25 | N-terminal veränderte glp-1 abkömmlinge |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1062240B1 (de) |
JP (1) | JP2002506792A (de) |
AT (1) | ATE466028T1 (de) |
AU (1) | AU2610899A (de) |
DE (1) | DE69942307D1 (de) |
WO (1) | WO1999043707A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1932535A3 (de) | 1998-07-31 | 2008-10-29 | Novo Nordisk A/S | Anregung der Beta-Zellbildung |
EP1076066A1 (de) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptide zur Senkung des Blutglukosespiegels |
US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
EP1634605A3 (de) | 2000-03-08 | 2006-10-11 | Novo Nordisk A/S | Behandlung von Dyslipämie bei einem Patienten mit Typ 2 Diabetes |
KR20030009389A (ko) * | 2000-03-14 | 2003-01-29 | 브루카드 괴케 | 유문동-유문-십이지장 운동성에 대한 글루카곤 유사펩티드-1 (7-36)의 효과 |
JP2004509079A (ja) * | 2000-08-02 | 2004-03-25 | セラテクノロジーズ・インコーポレーテッド | 効力が増大した修飾生体ペプチド |
EP1346722B1 (de) | 2000-12-01 | 2008-12-10 | Takeda Pharmaceutical Company Limited | Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz |
CA2434237C (en) * | 2000-12-07 | 2012-05-15 | Eli Lilly And Company | Glp-1 fusion proteins |
WO2003002136A2 (en) | 2001-06-28 | 2003-01-09 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
MXPA04001525A (es) * | 2001-08-23 | 2004-05-31 | Lilly Co Eli | Analogos de peptido -1 similar al glucagon. |
EP1432430A4 (de) * | 2001-08-28 | 2006-05-10 | Lilly Co Eli | Vormischungen von glp-1 und basalinsulin |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
DE60230818D1 (de) | 2001-09-24 | 2009-02-26 | Imp Innovations Ltd | Pyy3-36 zur zur reduzierung oder vorbeugung von fettleibigkeit |
JP2005508360A (ja) * | 2001-10-19 | 2005-03-31 | イーライ・リリー・アンド・カンパニー | Glp−1およびインスリンの二相混合物 |
CA2468700A1 (en) | 2002-01-08 | 2003-07-17 | Eli Lilly And Company | Extended glucagon-like peptide-1 analogs |
AU2003201998C1 (en) | 2002-01-10 | 2012-10-25 | Imperial Innovations Limited | Modification of feeding behavior |
JP2006501820A (ja) * | 2002-09-06 | 2006-01-19 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 修飾glp−1受容体アゴニストおよびそれらの薬理学的使用法 |
AU2003271452A1 (en) | 2002-09-25 | 2004-04-19 | Theratechnologies Inc. | Modified glp-1 peptides with increased biological potency |
GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
WO2004067548A2 (en) * | 2003-01-31 | 2004-08-12 | Theratechnologies Inc. | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
EP1626981A4 (de) * | 2003-03-04 | 2006-11-22 | Biorexis Pharmaceutical Corp | Dipeptidylpeptidase-geschützte proteine |
CN102174102A (zh) | 2003-05-15 | 2011-09-07 | 塔夫茨大学信托人 | 肽和多肽药物的稳定类似物 |
WO2004105790A1 (en) | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
ES2380437T3 (es) | 2003-06-03 | 2012-05-11 | Novo Nordisk A/S | Composiciones farmacéuticas de péptido GLP-1 estabilizadas |
CA2539253A1 (en) * | 2003-09-19 | 2005-03-31 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
CN100444898C (zh) * | 2003-09-19 | 2008-12-24 | 诺沃挪第克公司 | 治疗肽的清蛋白结合型衍生物 |
EP1667724A2 (de) * | 2003-09-19 | 2006-06-14 | Novo Nordisk A/S | Albumin bindende derivate von therapeutischen peptiden |
MXPA06005581A (es) | 2003-11-20 | 2006-08-11 | Novo Nordisk As | Formulaciones de peptidos que contienen propilenglicol que son optimas para la produccion y uso en dispositivos de inyeccion. |
JP4865565B2 (ja) | 2003-12-09 | 2012-02-01 | ノヴォ ノルディスク アー/エス | Glp−1アゴニストを用いた食物選択の制御 |
EP2210900A3 (de) * | 2003-12-16 | 2010-08-11 | Ipsen Pharma | GlLP-1-Analoga |
EP1758575A1 (de) | 2004-06-11 | 2007-03-07 | Novo Nordisk A/S | Bekämpfung von arzneimittel-induzierter fettleibigkeit unter verwendung von glp-1-agonisten |
ES2442223T3 (es) | 2004-08-31 | 2014-02-10 | Novo Nordisk A/S | Uso de tris(hidroximetil) aminometano para la estabilización de péptidos, polipéptidos y proteínas |
WO2006051110A2 (en) | 2004-11-12 | 2006-05-18 | Novo Nordisk A/S | Stable formulations of insulinoptropic peptides |
KR20070120112A (ko) | 2005-03-18 | 2007-12-21 | 노보 노르디스크 에이/에스 | 연장형 glp-1 화합물 |
TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
JP2008539735A (ja) * | 2005-05-06 | 2008-11-20 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | グルカゴン様ペプチド1(glp−1)受容体アンタゴニストおよびそれらの薬理学的使用方法 |
WO2007075534A2 (en) * | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Polymer conjugates of glp-1 |
CA2658654A1 (en) | 2006-07-24 | 2008-01-31 | Biorexis Pharmaceutical Corporation | Exendin fusion proteins |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
KR20110122100A (ko) | 2009-01-22 | 2011-11-09 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 안정한 성장 호르몬 화합물 |
EP2461831B1 (de) | 2009-08-06 | 2018-11-21 | Novo Nordisk Health Care AG | Wachstumshormone mit verlängerter in-vivo-wirksamkeit |
DK2513140T3 (en) * | 2009-12-16 | 2016-01-18 | Novo Nordisk As | Double-acylated GLP-1 derivatives |
JP5980689B2 (ja) | 2010-01-22 | 2016-08-31 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
CN102834109B (zh) | 2010-01-22 | 2016-01-20 | 诺沃—诺迪斯克保健股份有限公司 | 稳定的生长激素化合物 |
EP2555791B1 (de) | 2010-04-09 | 2017-11-01 | Sinai Health System | Verfahren zur behandlung von erkrankungen des magen-darm-trakts mittels eines glp-1-agonisten |
SG184988A1 (en) | 2010-04-27 | 2012-11-29 | Zealand Pharma As | Peptide conjugates of glp-1 receptor agonists and gastrin and their use |
KR20130093470A (ko) | 2010-04-30 | 2013-08-22 | 가부시키가이샤산와카가쿠켄큐쇼 | 생리활성 물질 등의 생체 내 안정성 향상을 위한 펩티드 및 생체 내 안정성이 향상된 생리활성 물질 |
WO2012054822A1 (en) | 2010-10-22 | 2012-04-26 | Nektar Therapeutics | Pharmacologically active polymer-glp-1 conjugates |
DK3326620T3 (da) | 2010-12-16 | 2020-05-25 | Novo Nordisk As | Faste sammensætninger omfattende en glp-1-agonist og et salt af n-(8-(2- hydroxybenzoyl)amino)caprylsyre |
MX355361B (es) | 2011-04-12 | 2018-04-17 | Novo Nordisk As | Derivados de peptido 1 tipo glucagon (glp-1) doblemente acilados. |
BR112014010780A2 (pt) | 2011-11-03 | 2017-04-25 | Zealand Pharma As | conjugados do peptídeo agonista do receptor glp-1-gastrina |
AU2013234496B2 (en) | 2012-03-22 | 2017-07-27 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
EP4331667A2 (de) | 2012-03-22 | 2024-03-06 | Novo Nordisk A/S | Zusammensetzungen mit einem abgabemittel und herstellung davon |
HUE042757T2 (hu) | 2012-03-22 | 2019-07-29 | Novo Nordisk As | Szállító szert tartalmazó készítmények és elõállításuk |
ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
US20150157619A1 (en) | 2012-07-10 | 2015-06-11 | Takeda Pharmaceutical Company Limited | Pharmaceutical preparation for injection |
NZ704043A (en) | 2012-07-23 | 2017-07-28 | Zealand Pharma As | Glucagon analogues |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
US20150273069A1 (en) | 2012-10-17 | 2015-10-01 | Novo Nordisk A/S | Fatty acid acylated amino acids for oral peptide delivery |
JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
PL3057984T3 (pl) | 2013-10-17 | 2018-12-31 | Zealand Pharma A/S | Acylowane analogi glukagonu |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
MX369770B (es) | 2013-11-06 | 2019-11-21 | Zealand Pharma As | Compuestos agonistas triples de glucagón-glp-1-gip. |
EP3065767B1 (de) | 2013-11-06 | 2020-12-30 | Zealand Pharma A/S | Zweifach-gip-glp-1-agonistenverbindung und verfahren |
EP3006045B3 (de) | 2014-10-07 | 2021-03-17 | Cyprumed GmbH | Pharmazeutische Formulierungen zur oralen Verabreichung von Peptid- oder Proteinarzneimitteln |
CA2965732A1 (en) | 2014-10-29 | 2016-05-06 | Zealand Pharma A/S | Gip agonist compounds and methods |
JP6989385B2 (ja) | 2015-04-16 | 2022-01-05 | ジーランド ファーマ アクティーゼルスカブ | アシル化グルカゴン類似体 |
CA2997343A1 (en) | 2015-10-07 | 2017-04-13 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
WO2018065634A1 (en) | 2016-10-07 | 2018-04-12 | Cyprumed Gmbh | Pharmaceutical compositions for the nasal delivery of peptide or protein drugs |
JP6563614B1 (ja) | 2016-12-09 | 2019-08-21 | ジーランド・ファーマ・ア/エス | アシル化glp−1/glp−2二重アゴニスト |
TWI783890B (zh) | 2017-08-24 | 2022-11-11 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
IL275778B2 (en) | 2018-02-02 | 2023-12-01 | Novo Nordisk As | Solid compounds that make up glp-1 agonist n-8-2-hydroxybenzoyl salt |
BR112020019148A2 (pt) * | 2018-03-23 | 2021-01-26 | Carmot Therapeutics, Inc. | moduladores de receptores acoplados à proteína g |
KR20200141469A (ko) | 2018-04-05 | 2020-12-18 | 썬 파마슈티칼 인더스트리스 리미티드 | 신규한 glp-1 유사체 |
US20210087250A1 (en) | 2018-04-06 | 2021-03-25 | Cyprumed Gmbh | Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
KR20220143037A (ko) | 2020-02-18 | 2022-10-24 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 이의 용도 |
JP2023524695A (ja) | 2020-04-29 | 2023-06-13 | ノヴォ ノルディスク アー/エス | Glp-1作動薬およびヒスチジンを含む固形組成物 |
CN116419750A (zh) | 2020-09-07 | 2023-07-11 | 西普鲁梅有限公司 | 改进的glp-1受体激动剂的药物制剂 |
KR20230083294A (ko) | 2020-09-30 | 2023-06-09 | 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 | 폴리펩타이드 접합체 및 사용 방법 |
WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341320C (en) | 1986-05-05 | 2001-11-20 | Joel Habener | Insulinotropic hormone |
US5614492A (en) * | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
NZ222907A (en) | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
ATE193541T1 (de) | 1989-03-20 | 2000-06-15 | Gen Hospital Corp | Insulinotropes hormon |
US5545618A (en) * | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
CA2073856C (en) | 1990-01-24 | 2002-12-03 | Douglas I. Buckley | Glp-1 analogs useful for diabetes treatment |
DK36492D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Praeparat |
DK36392D0 (da) * | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
GB9409496D0 (en) * | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
US5869602A (en) * | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
CZ297338B6 (cs) * | 1996-03-01 | 2006-11-15 | Novo Nordisk A/S | Peptid potlacující chut k jídlu, farmaceutický prostredek jej obsahující a jeho pouzití |
DE69737479T4 (de) | 1996-08-30 | 2010-05-06 | Novo Nordisk A/S | Glp-1 derivate |
-
1999
- 1999-02-25 AT AT99906078T patent/ATE466028T1/de not_active IP Right Cessation
- 1999-02-25 AU AU26108/99A patent/AU2610899A/en not_active Abandoned
- 1999-02-25 DE DE69942307T patent/DE69942307D1/de not_active Expired - Lifetime
- 1999-02-25 WO PCT/DK1999/000085 patent/WO1999043707A1/en active Application Filing
- 1999-02-25 EP EP99906078A patent/EP1062240B1/de not_active Expired - Lifetime
- 1999-02-25 JP JP2000533457A patent/JP2002506792A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2610899A (en) | 1999-09-15 |
EP1062240B1 (de) | 2010-04-28 |
ATE466028T1 (de) | 2010-05-15 |
JP2002506792A (ja) | 2002-03-05 |
EP1062240A1 (de) | 2000-12-27 |
WO1999043707A1 (en) | 1999-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69942307D1 (de) | N-terminal veränderte glp-1 abkömmlinge | |
WO1999043705A8 (en) | N-terminally truncated glp-1 derivatives | |
DE68929217D1 (en) | Insulinotropes hormon | |
Adelhorst et al. | Structure-activity studies of glucagon-like peptide-1. | |
PH12021550154A1 (en) | Gip/glp1 co-agonist compounds. | |
WO2006121860A3 (en) | Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use | |
NO992557L (no) | Bruk av GLP-1-analoger og derivater administrert perifert i regulering av fedme | |
DE69327309T2 (de) | Verwendung eines peptids | |
PE47096A1 (es) | Analogo, composicion y uso del peptido insulinotropico similar al glucagon | |
DK0699686T3 (da) | Biologisk aktive fragmenter af glukagon-lignende insulinotropisk peptid | |
EP2070946A3 (de) | Erfindung betreffend GLP-1 und Exendin | |
EA199900169A1 (ru) | Применение глюкагоноподобного пептида-1 (glp-1) или его аналогов для устранения катаболических изменений после оперативного вмешательства | |
NO20063436L (no) | Intranasal administrasjon av glukose-regulerende peptider | |
BR0116024A (pt) | Proteìna de fusão heteróloga e uso da mesma | |
EA200100289A1 (ru) | Способ введения инсулинотропных пептидов | |
BR9607647A (pt) | Derivado de insulina e composição farmacêutica e processo para o tratamento de diabetes em um paciente em necessidade deste tratamento | |
WO2003082898A2 (en) | Novel analogues of glucose-dependent insulinotropic polypeptide | |
JP2004509079A5 (de) | ||
DE60110054D1 (en) | Cardioprotektive phosphonate | |
MX2022009149A (es) | Compuestos coagonistas de gip/glp1. | |
TW200716156A (en) | Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonists and their pharmacological methods of use | |
Kühn-Wache et al. | Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance | |
Hinke et al. | Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP) | |
PE108199A1 (es) | Composicion farmaceutica de tiazolidindiona y sulfonilurea | |
Hinke et al. | [Ser2]-and [Ser (p) 2] incretin analogs: Comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |