DE69940216D1 - Verfahren und vorrichtung zur anwendung in der tandemmassenspektrometrie - Google Patents

Verfahren und vorrichtung zur anwendung in der tandemmassenspektrometrie

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Publication number
DE69940216D1
DE69940216D1 DE69940216T DE69940216T DE69940216D1 DE 69940216 D1 DE69940216 D1 DE 69940216D1 DE 69940216 T DE69940216 T DE 69940216T DE 69940216 T DE69940216 T DE 69940216T DE 69940216 D1 DE69940216 D1 DE 69940216D1
Authority
DE
Germany
Prior art keywords
ions
mass
gas
ion trap
charge ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940216T
Other languages
English (en)
Inventor
Donald Douglas
Jennifer Campbell
Bruce A Collings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Application granted granted Critical
Publication of DE69940216D1 publication Critical patent/DE69940216D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205Device types
    • H01J49/422Two-dimensional RF ion traps
    • H01J49/4225Multipole linear ion traps, e.g. quadrupoles, hexapoles
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
DE69940216T 1998-12-02 1999-11-30 Verfahren und vorrichtung zur anwendung in der tandemmassenspektrometrie Expired - Lifetime DE69940216D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002255188A CA2255188C (en) 1998-12-02 1998-12-02 Method and apparatus for multiple stages of mass spectrometry
PCT/CA1999/001142 WO2000033350A2 (en) 1998-12-02 1999-11-30 Method and apparatus for multiple stages of mass spectrometry

Publications (1)

Publication Number Publication Date
DE69940216D1 true DE69940216D1 (de) 2009-02-12

Family

ID=4163071

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940216T Expired - Lifetime DE69940216D1 (de) 1998-12-02 1999-11-30 Verfahren und vorrichtung zur anwendung in der tandemmassenspektrometrie

Country Status (6)

Country Link
US (1) US6833544B1 (de)
EP (1) EP1135790B1 (de)
AT (1) ATE419643T1 (de)
CA (1) CA2255188C (de)
DE (1) DE69940216D1 (de)
WO (1) WO2000033350A2 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545268B1 (en) * 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
US7060972B2 (en) 2000-07-21 2006-06-13 Mds Inc. Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
US6720554B2 (en) * 2000-07-21 2004-04-13 Mds Inc. Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
CA2431809C (en) 2000-12-14 2013-07-02 Mds Inc., Doing Business As Mds Sciex Apparatus and method for msnth in a tandem mass spectrometer system
GB2388248B (en) 2001-11-22 2004-03-24 Micromass Ltd Mass spectrometer
WO2003056604A1 (en) 2001-12-21 2003-07-10 Mds Inc., Doing Business As Mds Sciex Use of notched broadband waveforms in a linear ion trap
US7049580B2 (en) 2002-04-05 2006-05-23 Mds Inc. Fragmentation of ions by resonant excitation in a high order multipole field, low pressure ion trap
US20030189168A1 (en) * 2002-04-05 2003-10-09 Frank Londry Fragmentation of ions by resonant excitation in a low pressure ion trap
EP1502280B1 (de) 2002-04-29 2013-09-04 MDS Inc., doing business as MDS Sciex Breite ionenfragmentierungsabdeckung zur massenspektrometrie mittels kollisionsenergieänderung
US6872939B2 (en) 2002-05-17 2005-03-29 Micromass Uk Limited Mass spectrometer
GB2389704B (en) * 2002-05-17 2004-06-02 * Micromass Limited Mass Spectrometer
US6982417B2 (en) * 2003-10-09 2006-01-03 Siemens Energy & Automation, Inc. Method and apparatus for detecting low-mass ions
JP4223937B2 (ja) * 2003-12-16 2009-02-12 株式会社日立ハイテクノロジーズ 質量分析装置
WO2005106921A1 (en) 2004-05-05 2005-11-10 Mds Inc. Doing Business Through Its Mds Sciex Division Ion guide for mass spectrometer
US20060208187A1 (en) * 2005-03-18 2006-09-21 Alex Mordehai Apparatus and method for improved sensitivity and duty cycle
JP2008542729A (ja) 2005-06-03 2008-11-27 エムディーエス インコーポレイテッド ドゥーイング ビジネス スルー イッツ エムディーエス サイエックス ディヴィジョン 再帰的な質量分析に関するデータのコレクションのためのシステムおよび方法
US7166836B1 (en) 2005-09-07 2007-01-23 Agilent Technologies, Inc. Ion beam focusing device
US7312442B2 (en) * 2005-09-13 2007-12-25 Agilent Technologies, Inc Enhanced gradient multipole collision cell for higher duty cycle
US7557343B2 (en) 2005-09-13 2009-07-07 Agilent Technologies, Inc. Segmented rod multipole as ion processing cell
US7541575B2 (en) 2006-01-11 2009-06-02 Mds Inc. Fragmenting ions in mass spectrometry
DE102006016896B4 (de) * 2006-04-11 2009-06-10 Bruker Daltonik Gmbh Orthogonal-Flugzeitmassenspektrometer geringer Massendiskriminierung
US7633060B2 (en) 2007-04-24 2009-12-15 Thermo Finnigan Llc Separation and axial ejection of ions based on m/z ratio
US8030612B2 (en) 2007-11-09 2011-10-04 Dh Technologies Development Pte. Ltd. High resolution excitation/isolation of ions in a low pressure linear ion trap
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
CA2711707C (en) * 2008-01-31 2017-08-22 Dh Technologies Development Pte. Ltd. Methods for fragmenting ions in a linear ion trap
CA2711781C (en) * 2008-01-31 2016-09-06 Dh Technologies Development Pte. Ltd. Method of operating a linear ion trap to provide low pressure short time high amplitude excitation
JP5912253B2 (ja) * 2008-01-31 2016-04-27 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド パルス圧力による低圧短時間高振幅励起を提供するための線形イオントラップの動作方法
DE102008023693A1 (de) * 2008-05-15 2009-11-19 Bruker Daltonik Gmbh 3D-Ionenfalle als Fragmentierungszelle
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
GB0900973D0 (en) 2009-01-21 2009-03-04 Micromass Ltd Method and apparatus for performing MS^N
WO2011091023A1 (en) * 2010-01-20 2011-07-28 Waters Technologies Corporation Techniques for efficient fragmentation of peptides
GB2519490A (en) * 2012-09-07 2015-04-22 Waters Technologies Corp Techniques for performing mass spectrometry
US9343277B2 (en) * 2012-12-20 2016-05-17 Dh Technologies Development Pte. Ltd. Parsing events during MS3 experiments
JP2016507151A (ja) * 2013-02-18 2016-03-07 マイクロマス ユーケー リミテッド 自動排出イオントラップを用いた質量分析器における、気相反応の改善された効率および精密制御
CA2900739C (en) * 2013-02-18 2019-08-27 Micromass Uk Limited Device allowing improved reaction monitoring of gas phase reactions in mass spectrometers using an auto ejection ion trap
US9824871B2 (en) 2013-03-15 2017-11-21 Thermo Finnigan Llc Hybrid mass spectrometer and methods of operating a mass spectrometer
CN112420478B (zh) 2013-04-23 2024-05-10 莱克公司 具有高吞吐量的多反射质谱仪
JP6377740B2 (ja) * 2013-11-07 2018-08-22 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 向上した選別性のためのms3を通したフロー
US9312111B2 (en) * 2014-04-02 2016-04-12 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for sub-micrometer elemental image analysis by mass spectrometry
DE102015117635B4 (de) * 2015-10-16 2018-01-11 Bruker Daltonik Gmbh Strukturaufklärung von intakten schweren Molekülen und Molekülkomplexen in Massenspektrometern
GB2544484B (en) * 2015-11-17 2019-01-30 Thermo Fisher Scient Bremen Gmbh Addition of reactive species to ICP source in a mass spectrometer
CN106169411B (zh) * 2016-07-13 2018-03-27 中国计量科学研究院 新型串并联质谱装置系统及其参数调节方法和使用方法
GB201613988D0 (en) 2016-08-16 2016-09-28 Micromass Uk Ltd And Leco Corp Mass analyser having extended flight path
GB2567794B (en) 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
GB2563571B (en) * 2017-05-26 2023-05-24 Micromass Ltd Time of flight mass analyser with spatial focussing
WO2019030473A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov FIELDS FOR SMART REFLECTIVE TOF SM
WO2019030472A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov IONIC MIRROR FOR MULTI-REFLECTION MASS SPECTROMETERS
WO2019030477A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov ACCELERATOR FOR MASS SPECTROMETERS WITH MULTIPASSES
US11081332B2 (en) 2017-08-06 2021-08-03 Micromass Uk Limited Ion guide within pulsed converters
WO2019030475A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov MASS SPECTROMETER WITH MULTIPASSAGE
EP3662503A1 (de) 2017-08-06 2020-06-10 Micromass UK Limited Ioneninjektion in ein massenspektrometer mit mehreren durchgängen
US11295944B2 (en) 2017-08-06 2022-04-05 Micromass Uk Limited Printed circuit ion mirror with compensation
US10541125B2 (en) * 2017-12-20 2020-01-21 Shimadzu Corporation Ion analyzer
GB201806507D0 (en) 2018-04-20 2018-06-06 Verenchikov Anatoly Gridless ion mirrors with smooth fields
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201807605D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
US10665441B2 (en) * 2018-08-08 2020-05-26 Thermo Finnigan Llc Methods and apparatus for improved tandem mass spectrometry duty cycle
GB201901411D0 (en) 2019-02-01 2019-03-20 Micromass Ltd Electrode assembly for mass spectrometer
CN112071737B (zh) * 2020-03-20 2024-04-16 昆山聂尔精密仪器有限公司 一种离子激发和离子选择信号的生成方法和装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755670A (en) 1986-10-01 1988-07-05 Finnigan Corporation Fourtier transform quadrupole mass spectrometer and method
US5179278A (en) 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
US6011259A (en) * 1995-08-10 2000-01-04 Analytica Of Branford, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSN analysis
US5420425A (en) 1994-05-27 1995-05-30 Finnigan Corporation Ion trap mass spectrometer system and method
EP0843887A1 (de) 1995-08-11 1998-05-27 Mds Health Group Limited Spektrometer mit axialfeld
US6093929A (en) * 1997-05-16 2000-07-25 Mds Inc. High pressure MS/MS system
WO1999030350A1 (en) 1997-12-05 1999-06-17 University Of British Columbia Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap
US6504148B1 (en) * 1999-05-27 2003-01-07 Mds Inc. Quadrupole mass spectrometer with ION traps to enhance sensitivity
JP2003507874A (ja) * 1999-08-26 2003-02-25 ユニバーシティ オブ ニュー ハンプシャー 多段型の質量分析計

Also Published As

Publication number Publication date
US6833544B1 (en) 2004-12-21
CA2255188C (en) 2008-11-18
ATE419643T1 (de) 2009-01-15
EP1135790B1 (de) 2008-12-31
WO2000033350A2 (en) 2000-06-08
EP1135790A2 (de) 2001-09-26
WO2000033350A3 (en) 2000-10-26
CA2255188A1 (en) 2000-06-02

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