DE69938548T2 - Pth2 rezeptor selektive verbindungen - Google Patents
Pth2 rezeptor selektive verbindungen Download PDFInfo
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- DE69938548T2 DE69938548T2 DE69938548T DE69938548T DE69938548T2 DE 69938548 T2 DE69938548 T2 DE 69938548T2 DE 69938548 T DE69938548 T DE 69938548T DE 69938548 T DE69938548 T DE 69938548T DE 69938548 T2 DE69938548 T2 DE 69938548T2
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- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001300 stimulation of adenylate cyclase Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- NUQJSUROPOMGCR-UHFFFAOYSA-N tert-butyl 2h-benzotriazole-4-carboxylate Chemical compound CC(C)(C)OC(=O)C1=CC=CC2=C1N=NN2 NUQJSUROPOMGCR-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72956 | 1987-07-15 | ||
| US7295698A | 1998-05-05 | 1998-05-05 | |
| PCT/US1999/009521 WO1999057139A2 (en) | 1998-05-05 | 1999-05-03 | Pth2 receptor selective compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69938548D1 DE69938548D1 (de) | 2008-05-29 |
| DE69938548T2 true DE69938548T2 (de) | 2009-06-18 |
Family
ID=22110801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69938548T Expired - Lifetime DE69938548T2 (de) | 1998-05-05 | 1999-05-03 | Pth2 rezeptor selektive verbindungen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7531621B1 (https=) |
| EP (1) | EP1075491B1 (https=) |
| JP (1) | JP4460157B2 (https=) |
| AT (1) | ATE392431T1 (https=) |
| AU (1) | AU3673699A (https=) |
| CA (1) | CA2327509A1 (https=) |
| DE (1) | DE69938548T2 (https=) |
| ES (1) | ES2302374T3 (https=) |
| HU (1) | HUP0300891A2 (https=) |
| NO (1) | NO20005556L (https=) |
| PL (1) | PL344645A1 (https=) |
| WO (1) | WO1999057139A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0962467A4 (en) | 1996-09-26 | 2002-10-30 | Chugai Pharmaceutical Co Ltd | Antibody against human parathormone related peptides |
| KR100508338B1 (ko) | 1997-05-15 | 2005-08-17 | 츄가이 세이야꾸 가부시키가이샤 | 악액질 치료제 |
| WO2001002011A1 (fr) * | 1999-07-02 | 2001-01-11 | Chugai Seiyaku Kabushiki Kaisha | REMEDES CONTRE LES MALADIES CAUSEES PAR PTH OU PTHrP |
| TWI255718B (en) | 1999-07-02 | 2006-06-01 | Chugai Pharmaceutical Co Ltd | Ameliorative agent for low vasopressin concentration |
| US8029793B2 (en) | 2000-04-28 | 2011-10-04 | Chugai Seiyaku Kabushiki Kaisha | Methods for inhibiting cell proliferation |
| US20030091973A1 (en) * | 2000-09-19 | 2003-05-15 | Horesovsky Gregory J. | Method of identifying osteoregenerative agents using differential gene expression |
| WO2004071396A2 (en) * | 2003-02-17 | 2004-08-26 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with parathyroid hormone receptor 2 (pthr2) |
| BRPI0719885B8 (pt) | 2006-10-13 | 2021-05-25 | Lilly Co Eli | peptídeos peguilados como moduladores de receptores de pth, seus usos, e composição. |
| CN104072606B (zh) | 2007-08-01 | 2017-09-22 | 总医院有限公司 | 利用g蛋白偶联受体和相关组合物的筛选方法 |
| MX358161B (es) | 2010-05-13 | 2018-08-06 | The General Hospital Corp Star | Analogos de hormona paratiroidea y usos para los mismos. |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001223A (en) * | 1987-05-26 | 1991-03-19 | Merck & Co., Inc. | Parathyroid hormone antagonists with enhanced metabolic properties |
| EP0293158A3 (en) | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroid hormone antagonists |
| US5527772A (en) | 1987-10-20 | 1996-06-18 | Holick; Michael F. | Regulation of cell proliferation and differentiation using peptides |
| DE68921665T2 (de) | 1988-05-09 | 1995-09-21 | Merck & Co Inc | Hemmer vom flüssigen kalziumerhöhenden Faktor. |
| US4968669A (en) | 1988-05-09 | 1990-11-06 | Merck & Co., Inc. | Parathyroid hormone antagonists |
| CA2040264A1 (en) | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| US5087562A (en) | 1990-04-25 | 1992-02-11 | Merck & Co., Inc. | Humoral hypercalcemic factor antagonists with modification at position 13 . . . |
| US5093233A (en) | 1990-04-25 | 1992-03-03 | Merck & Co., Inc. | Antagonists with position 13 modification |
| US5149779A (en) | 1990-07-26 | 1992-09-22 | Merck & Co., Inc. | Humoral hypercalcemic factor antagonists |
| JPH0532696A (ja) * | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| WO1992011286A1 (en) | 1990-12-21 | 1992-07-09 | Allelix Biopharmaceuticals Inc. | Oxidation resistant variants of parathyroid hormone |
| DE4203040A1 (de) | 1992-02-04 | 1993-08-05 | Boehringer Mannheim Gmbh | Neue parathormonfragmente, deren herstellung und diese enthaltende arzneimittel |
| US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| US5556940A (en) * | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| US5747456A (en) | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
| US5717062A (en) | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| US5969095A (en) | 1995-07-13 | 1999-10-19 | Biomeasure, Inc. | Analogs of parathyroid hormone |
| US5723577A (en) * | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| US5955574A (en) * | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
| JP3259011B2 (ja) * | 1995-08-02 | 2002-02-18 | ミヤチテクノス株式会社 | インバータ式抵抗溶接制御方法及び装置 |
| JP4142743B2 (ja) | 1996-07-31 | 2008-09-03 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモンに関連する新規ペプチド類似体 |
-
1999
- 1999-05-03 US US09/674,597 patent/US7531621B1/en not_active Expired - Fee Related
- 1999-05-03 HU HU0300891A patent/HUP0300891A2/hu unknown
- 1999-05-03 WO PCT/US1999/009521 patent/WO1999057139A2/en not_active Ceased
- 1999-05-03 ES ES99918938T patent/ES2302374T3/es not_active Expired - Lifetime
- 1999-05-03 CA CA002327509A patent/CA2327509A1/en not_active Abandoned
- 1999-05-03 DE DE69938548T patent/DE69938548T2/de not_active Expired - Lifetime
- 1999-05-03 EP EP99918938A patent/EP1075491B1/en not_active Expired - Lifetime
- 1999-05-03 AU AU36736/99A patent/AU3673699A/en not_active Abandoned
- 1999-05-03 PL PL99344645A patent/PL344645A1/xx not_active Application Discontinuation
- 1999-05-03 AT AT99918938T patent/ATE392431T1/de not_active IP Right Cessation
- 1999-05-03 JP JP2000547108A patent/JP4460157B2/ja not_active Expired - Fee Related
-
2000
- 2000-11-03 NO NO20005556A patent/NO20005556L/no not_active Application Discontinuation
-
2009
- 2009-03-27 US US12/413,303 patent/US20090226477A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090226477A1 (en) | 2009-09-10 |
| ES2302374T3 (es) | 2008-07-01 |
| JP2002513801A (ja) | 2002-05-14 |
| WO1999057139A3 (en) | 2000-02-03 |
| NO20005556L (no) | 2001-01-03 |
| DE69938548D1 (de) | 2008-05-29 |
| CA2327509A1 (en) | 1999-11-11 |
| EP1075491A2 (en) | 2001-02-14 |
| WO1999057139A2 (en) | 1999-11-11 |
| AU3673699A (en) | 1999-11-23 |
| HUP0300891A2 (hu) | 2003-07-28 |
| JP4460157B2 (ja) | 2010-05-12 |
| US7531621B1 (en) | 2009-05-12 |
| EP1075491B1 (en) | 2008-04-16 |
| NO20005556D0 (no) | 2000-11-03 |
| PL344645A1 (en) | 2001-11-19 |
| ATE392431T1 (de) | 2008-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BETH ISRAEL DEACONESS MEDICAL CENTER, INC., BO, US Owner name: IPSEN PHARMA S.A.S., BOULOGNE-BILLANCOURT, FR |