DE69935229T2 - Neue antidiabetische peptide - Google Patents
Neue antidiabetische peptide Download PDFInfo
- Publication number
- DE69935229T2 DE69935229T2 DE69935229T DE69935229T DE69935229T2 DE 69935229 T2 DE69935229 T2 DE 69935229T2 DE 69935229 T DE69935229 T DE 69935229T DE 69935229 T DE69935229 T DE 69935229T DE 69935229 T2 DE69935229 T2 DE 69935229T2
- Authority
- DE
- Germany
- Prior art keywords
- xaa
- seq
- compound according
- solvent
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 108090000765 processed proteins & peptides Proteins 0.000 title description 248
- 102000004196 processed proteins & peptides Human genes 0.000 title description 64
- 239000003472 antidiabetic agent Substances 0.000 title description 2
- 230000003178 anti-diabetic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 127
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims abstract description 69
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims abstract description 69
- 230000000694 effects Effects 0.000 claims abstract description 29
- 239000000556 agonist Substances 0.000 claims abstract description 28
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
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- JWBLQDDHSDGEGR-DRZSPHRISA-N Phe-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 JWBLQDDHSDGEGR-DRZSPHRISA-N 0.000 claims description 3
- PYOHODCEOHCZBM-RYUDHWBXSA-N Phe-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 PYOHODCEOHCZBM-RYUDHWBXSA-N 0.000 claims description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/138,056 US6087334A (en) | 1998-08-21 | 1998-08-21 | Anti-diabetic peptides |
| PCT/US1999/017918 WO2000011029A2 (en) | 1998-08-21 | 1999-08-09 | Novel anti-diabetic peptides |
| US138056 | 2001-07-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69935229D1 DE69935229D1 (de) | 2007-04-05 |
| DE69935229T2 true DE69935229T2 (de) | 2007-11-08 |
Family
ID=22480238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69935229T Expired - Lifetime DE69935229T2 (de) | 1998-08-21 | 1999-08-09 | Neue antidiabetische peptide |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6087334A (https=) |
| EP (1) | EP1104438B1 (https=) |
| JP (1) | JP2002523424A (https=) |
| AT (1) | ATE354590T1 (https=) |
| AU (1) | AU766545B2 (https=) |
| CA (1) | CA2337971C (https=) |
| DE (1) | DE69935229T2 (https=) |
| ES (1) | ES2283127T3 (https=) |
| WO (1) | WO2000011029A2 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143718A (en) | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| CA2422911A1 (en) * | 2000-09-19 | 2002-03-28 | Paul Fraser | New inhibitors of iapp fibril formation and uses thereof |
| ATE412421T1 (de) * | 2002-01-08 | 2008-11-15 | Amylin Pharmaceuticals Inc | Verwendung von amylin, amylinanaloga und amylin derivaten zur behandlung von dyslipidämie und hypertriglyceridämie |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| US20080260838A1 (en) * | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| ATE471340T1 (de) * | 2004-02-11 | 2010-07-15 | Amylin Pharmaceuticals Inc | Peptide der amylin familie, verfahren zu deren herstellung und verwendung |
| US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| TW200637872A (en) * | 2004-10-26 | 2006-11-01 | Lonza Ag | Thiol group protection and cyclization in solid-phase peptide synthesis |
| US7759312B2 (en) * | 2005-03-11 | 2010-07-20 | Endo Pharmaceuticals Solutions Inc. | Delivery of dry formulations of octreotide |
| CN101193626A (zh) * | 2005-03-11 | 2008-06-04 | 益德威士医药股份有限公司 | 奥曲肽的受控释放制剂 |
| CN102343084A (zh) | 2005-03-31 | 2012-02-08 | 安米林药品公司 | 用于治疗精神病和精神障碍的胰淀素和胰淀素激动剂 |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB8720115D0 (en) * | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
| GB8709871D0 (en) * | 1987-04-27 | 1987-06-03 | Turner R C | Peptides |
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| CA2120131A1 (en) * | 1991-09-27 | 1994-05-11 | Robert A. Murgita | Expression and purification of cloned human alpha-fetoprotein |
| JPH07509008A (ja) * | 1993-05-12 | 1995-10-05 | ユニバーシティ・オブ・シンシナティ | アミリン・アンタゴニストおよびアゴニスト |
| US5625032A (en) * | 1993-07-21 | 1997-04-29 | Amylin Pharmaceuticals, Inc. | Selective amylin antagonist peptides and uses therefor |
| US6143718A (en) * | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
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1998
- 1998-08-21 US US09/138,056 patent/US6087334A/en not_active Expired - Lifetime
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1999
- 1999-08-09 AU AU53430/99A patent/AU766545B2/en not_active Ceased
- 1999-08-09 JP JP2000566301A patent/JP2002523424A/ja active Pending
- 1999-08-09 EP EP99939073A patent/EP1104438B1/en not_active Expired - Lifetime
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- 1999-08-09 AT AT99939073T patent/ATE354590T1/de not_active IP Right Cessation
- 1999-08-09 WO PCT/US1999/017918 patent/WO2000011029A2/en not_active Ceased
- 1999-08-09 DE DE69935229T patent/DE69935229T2/de not_active Expired - Lifetime
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| CA2337971A1 (en) | 2000-03-02 |
| EP1104438A2 (en) | 2001-06-06 |
| US6087334A (en) | 2000-07-11 |
| JP2002523424A (ja) | 2002-07-30 |
| CA2337971C (en) | 2011-04-26 |
| WO2000011029A2 (en) | 2000-03-02 |
| DE69935229D1 (de) | 2007-04-05 |
| ATE354590T1 (de) | 2007-03-15 |
| WO2000011029A3 (en) | 2000-06-22 |
| EP1104438B1 (en) | 2007-02-21 |
| AU5343099A (en) | 2000-03-14 |
| AU766545B2 (en) | 2003-10-16 |
| ES2283127T3 (es) | 2007-10-16 |
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