JP2002523424A - 新規な抗糖尿病ペプチド - Google Patents
新規な抗糖尿病ペプチドInfo
- Publication number
- JP2002523424A JP2002523424A JP2000566301A JP2000566301A JP2002523424A JP 2002523424 A JP2002523424 A JP 2002523424A JP 2000566301 A JP2000566301 A JP 2000566301A JP 2000566301 A JP2000566301 A JP 2000566301A JP 2002523424 A JP2002523424 A JP 2002523424A
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- compound according
- seq
- ala
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000003472 antidiabetic agent Substances 0.000 title 1
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- 238000000034 method Methods 0.000 claims abstract description 31
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 24
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims abstract description 13
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 239000003937 drug carrier Substances 0.000 claims abstract description 3
- 230000005176 gastrointestinal motility Effects 0.000 claims abstract 3
- 150000001413 amino acids Chemical group 0.000 claims description 70
- 230000030136 gastric emptying Effects 0.000 claims description 18
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- YSZNURNVYFUEHC-BQBZGAKWSA-N Lys-Ser Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CO)C(O)=O YSZNURNVYFUEHC-BQBZGAKWSA-N 0.000 claims description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/138,056 | 1998-08-21 | ||
| US09/138,056 US6087334A (en) | 1998-08-21 | 1998-08-21 | Anti-diabetic peptides |
| PCT/US1999/017918 WO2000011029A2 (en) | 1998-08-21 | 1999-08-09 | Novel anti-diabetic peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002523424A true JP2002523424A (ja) | 2002-07-30 |
| JP2002523424A5 JP2002523424A5 (https=) | 2006-09-07 |
Family
ID=22480238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000566301A Pending JP2002523424A (ja) | 1998-08-21 | 1999-08-09 | 新規な抗糖尿病ペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6087334A (https=) |
| EP (1) | EP1104438B1 (https=) |
| JP (1) | JP2002523424A (https=) |
| AT (1) | ATE354590T1 (https=) |
| AU (1) | AU766545B2 (https=) |
| CA (1) | CA2337971C (https=) |
| DE (1) | DE69935229T2 (https=) |
| ES (1) | ES2283127T3 (https=) |
| WO (1) | WO2000011029A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012520262A (ja) * | 2009-03-12 | 2012-09-06 | ノルディック・ビオサイエンス・エー／エス | 糖尿病およびメタボリックシンドロームの治療 |
| JP2017530108A (ja) * | 2014-09-04 | 2017-10-12 | ノヴォ ノルディスク アー／エス | 新規のアミリン及びカルシトニン受容体アゴニスト |
| JP2018515471A (ja) * | 2015-04-28 | 2018-06-14 | ケアジェン カンパニー, リミテッドCaregen Co., Ltd. | 抗肥満及び抗糖尿作用を有するペプチド及びその用途 |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143718A (en) | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| AU2001293557A1 (en) * | 2000-09-19 | 2002-04-02 | University Of Toronto | New inhibitors of iapp fibril formation and uses thereof |
| NZ534557A (en) * | 2002-01-08 | 2007-10-26 | Amylin Pharmaceuticals Inc | Use of amylin or amylin agonists in the manufacture of a medicament for use in the treatment of dyslipidemia, wherein the medicament reduces post-prandial triglyceride levels |
| US6923175B2 (en) | 2002-03-20 | 2005-08-02 | Mannkind Corporation | Inhalation apparatus |
| US20080260838A1 (en) * | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| RU2385878C2 (ru) * | 2004-02-11 | 2010-04-10 | Амилин Фармасьютикалз, Инк. | Пептид, обладающий свойствами амилина (варианты), и его применение (варианты) |
| US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| WO2006045603A1 (en) * | 2004-10-26 | 2006-05-04 | Lonza Ag | S-alkyl-sulphenyl protection groups in solid-phase synthesis |
| US7759312B2 (en) * | 2005-03-11 | 2010-07-20 | Endo Pharmaceuticals Solutions Inc. | Delivery of dry formulations of octreotide |
| EP2455072A1 (en) * | 2005-03-11 | 2012-05-23 | Endo Pharmaceuticals Solutions Inc. | Controlled release formulations of octreotide |
| EP2258382A3 (en) | 2005-03-31 | 2014-05-14 | Amylin Pharmaceuticals, LLC | Amylin and amylin agonists for treating psychiatric diseases and disorders |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
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| US20090181890A1 (en) * | 2006-03-31 | 2009-07-16 | Amylin Pharmaceuticals , Inc. | Amylin and Amylin Agonists for Treating Psychiatric Diseases and Disorders |
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- 1999-08-09 CA CA2337971A patent/CA2337971C/en not_active Expired - Fee Related
- 1999-08-09 ES ES99939073T patent/ES2283127T3/es not_active Expired - Lifetime
- 1999-08-09 AU AU53430/99A patent/AU766545B2/en not_active Ceased
- 1999-08-09 WO PCT/US1999/017918 patent/WO2000011029A2/en not_active Ceased
- 1999-08-09 EP EP99939073A patent/EP1104438B1/en not_active Expired - Lifetime
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| JPS6463594A (en) * | 1987-04-27 | 1989-03-09 | Amylin Corp | Peptides |
| JPH0196137A (ja) * | 1987-08-26 | 1989-04-14 | Amylin Corp | 真性糖尿病の治療 |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012520262A (ja) * | 2009-03-12 | 2012-09-06 | ノルディック・ビオサイエンス・エー／エス | 糖尿病およびメタボリックシンドロームの治療 |
| JP2017530108A (ja) * | 2014-09-04 | 2017-10-12 | ノヴォ ノルディスク アー／エス | 新規のアミリン及びカルシトニン受容体アゴニスト |
| JP2018515471A (ja) * | 2015-04-28 | 2018-06-14 | ケアジェン カンパニー, リミテッドCaregen Co., Ltd. | 抗肥満及び抗糖尿作用を有するペプチド及びその用途 |
| US10351597B2 (en) | 2015-04-28 | 2019-07-16 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
| JP2020007372A (ja) * | 2015-04-28 | 2020-01-16 | ケアジェン カンパニー, リミテッドCaregen Co., Ltd. | 抗肥満及び抗糖尿作用を有するペプチド及びその用途 |
| JP2020007371A (ja) * | 2015-04-28 | 2020-01-16 | ケアジェン カンパニー, リミテッドCaregen Co., Ltd. | 抗肥満及び抗糖尿作用を有するペプチド及びその用途 |
| JP2020007373A (ja) * | 2015-04-28 | 2020-01-16 | ケアジェン カンパニー, リミテッドCaregen Co., Ltd. | 抗肥満及び抗糖尿作用を有するペプチド及びその用途 |
| US10626145B2 (en) | 2015-04-28 | 2020-04-21 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
| US10738081B2 (en) | 2015-04-28 | 2020-08-11 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
| US11186611B2 (en) | 2015-04-28 | 2021-11-30 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69935229T2 (de) | 2007-11-08 |
| HK1038025A1 (en) | 2002-03-01 |
| EP1104438B1 (en) | 2007-02-21 |
| CA2337971C (en) | 2011-04-26 |
| WO2000011029A3 (en) | 2000-06-22 |
| AU766545B2 (en) | 2003-10-16 |
| AU5343099A (en) | 2000-03-14 |
| DE69935229D1 (de) | 2007-04-05 |
| ATE354590T1 (de) | 2007-03-15 |
| US6087334A (en) | 2000-07-11 |
| WO2000011029A2 (en) | 2000-03-02 |
| EP1104438A2 (en) | 2001-06-06 |
| CA2337971A1 (en) | 2000-03-02 |
| ES2283127T3 (es) | 2007-10-16 |
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