DE69934690D1 - Gentransfermethoden - Google Patents

Gentransfermethoden

Info

Publication number
DE69934690D1
DE69934690D1 DE69934690T DE69934690T DE69934690D1 DE 69934690 D1 DE69934690 D1 DE 69934690D1 DE 69934690 T DE69934690 T DE 69934690T DE 69934690 T DE69934690 T DE 69934690T DE 69934690 D1 DE69934690 D1 DE 69934690D1
Authority
DE
Germany
Prior art keywords
target cells
binding
gene transfer
substance
retrovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69934690T
Other languages
English (en)
Other versions
DE69934690T2 (de
Inventor
Mitsuhiro Ueno
Hirofumi Yoshioka
Haruko Konishi
Kimikazu Hashino
Mio Morishita
Hideto Chono
Tsuyoshi Miyamura
Mutsumi Sano
Kiyozo Asada
Kei Fujinaga
Ikunoshin Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takara Bio Inc
Original Assignee
Takara Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc filed Critical Takara Bio Inc
Application granted granted Critical
Publication of DE69934690D1 publication Critical patent/DE69934690D1/de
Publication of DE69934690T2 publication Critical patent/DE69934690T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13045—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/10—Vectors comprising a non-peptidic targeting moiety
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/851—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from growth factors; from growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
DE69934690T 1998-07-01 1999-06-25 Gentransfermethoden Expired - Lifetime DE69934690T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP18624098 1998-07-01
JP18624098 1998-07-01
JP5691599 1999-03-04
JP5691599 1999-03-04
PCT/JP1999/003403 WO2000001836A1 (fr) 1998-07-01 1999-06-25 Procedes de transfert de genes

Publications (2)

Publication Number Publication Date
DE69934690D1 true DE69934690D1 (de) 2007-02-15
DE69934690T2 DE69934690T2 (de) 2007-11-15

Family

ID=26397921

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69939955T Expired - Lifetime DE69939955D1 (de) 1998-07-01 1999-06-25 Methoden für Gentransfer mit Retroviren
DE69934690T Expired - Lifetime DE69934690T2 (de) 1998-07-01 1999-06-25 Gentransfermethoden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69939955T Expired - Lifetime DE69939955D1 (de) 1998-07-01 1999-06-25 Methoden für Gentransfer mit Retroviren

Country Status (10)

Country Link
US (3) US6787359B1 (de)
EP (2) EP1094114B1 (de)
JP (1) JP3807937B2 (de)
KR (1) KR100608154B1 (de)
CN (1) CN1190496C (de)
AT (2) ATE350482T1 (de)
AU (1) AU4393899A (de)
DE (2) DE69939955D1 (de)
ES (2) ES2316675T3 (de)
WO (1) WO2000001836A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551843B1 (en) * 1999-01-29 2003-04-22 Immunivest Corporation Methods for enhancing binding interactions between members of specific binding pairs
KR100674140B1 (ko) * 1999-03-23 2007-01-26 다카라 바이오 가부시키가이샤 유전자 치료제
JP2005052001A (ja) * 2001-07-05 2005-03-03 Takara Bio Inc 遺伝子治療剤
WO2004079332A2 (en) * 2003-03-04 2004-09-16 National Institute Of Advanced Industrial Science And Technology Composition and method for increasing efficiency of introduction of target substance into cell
WO2005001090A1 (ja) * 2003-06-26 2005-01-06 National Institute Of Advanced Industrial Science And Technology 細胞の核酸導入効率を改善する方法および組成物
JPWO2005073385A1 (ja) * 2004-01-29 2008-01-10 独立行政法人産業技術総合研究所 遺伝子導入効率を上昇させるための組成物および方法
US9057056B2 (en) * 2004-09-29 2015-06-16 Takara Bio Inc. Method for producing retrovirus using human producer cells with increased N-acetylglucosaminyltransferase III activity
CN101115830B (zh) * 2005-02-07 2012-09-05 宝生物工程株式会社 逆转录病毒储存方法
WO2006134871A1 (ja) * 2005-06-15 2006-12-21 Takara Bio Inc. 脂肪細胞あるいは前駆脂肪細胞への遺伝子導入方法
JP5453629B2 (ja) 2006-08-23 2014-03-26 タカラバイオ株式会社 遠心用袋状容器を使用した遺伝子導入方法
AU2007294731B2 (en) 2006-09-13 2014-04-17 Abbvie Inc. Cell culture improvements
DK2295538T3 (en) * 2008-07-07 2015-12-21 Takara Bio Inc Process for producing a pluripotent stem cell
US20120142109A1 (en) 2009-08-25 2012-06-07 Yoshinori Katayama Method for producing t cell population under presence of retinoic acid
US9228206B2 (en) 2010-06-30 2016-01-05 Takara Bio Inc. Method for gene transfer
EP2589656B8 (de) * 2010-06-30 2016-07-13 Takara Bio Inc. Geneinsetzungsverfahren
WO2012046727A1 (ja) * 2010-10-05 2012-04-12 タカラバイオ株式会社 ウイルスベクターの製造方法
JP6053688B2 (ja) 2011-10-07 2016-12-27 国立大学法人三重大学 キメラ抗原受容体
EP2829606A4 (de) 2012-03-22 2016-02-24 Takara Bio Inc Verfahren zur herstellung von viralen vektoren
AU2016301195B2 (en) 2015-08-06 2022-09-01 Dana-Farber Cancer Institute, Inc. Targeted protein degradation to attenuate adoptive T-cell therapy associated adverse inflammatory responses
US11052111B2 (en) 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
WO2018045177A1 (en) 2016-09-01 2018-03-08 Chimera Bioengineering, Inc. Gold optimized car t-cells
US11524988B2 (en) * 2016-09-19 2022-12-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Artificial antigen presenting cells for genetic engineering of immune cells
US11311609B2 (en) 2017-02-08 2022-04-26 Dana-Farber Cancer Institute, Inc. Regulating chimeric antigen receptors
EP4043038A4 (de) 2019-10-11 2023-11-01 Takara Bio Inc. Sirna-expressionsvektor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9014294D0 (en) * 1990-06-27 1990-08-15 Medical Res Council Assay for cytotoxic t cells
JPH05252941A (ja) * 1991-08-12 1993-10-05 Sakai Enetsukusu Kk 動物細胞培養用担体
NL9101680A (nl) * 1991-10-04 1993-05-03 Tno Werkwijze voor het genetisch modificeren van beenmergcellen van primaten, alsmede daarbij bruikbare cellen die recombinante retrovirale vectoren produceren.
US5656456A (en) 1992-07-13 1997-08-12 Bionebraska, Inc. Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof
EP0672129A4 (de) * 1992-11-20 1997-06-11 Univ New Jersey Med Zelltyp spezifischer gentransfer mit hilfe von retroviralen vektoren welche antikörper-hülle fusionsproteine haben.
US6013628A (en) * 1994-02-28 2000-01-11 Regents Of The University Of Minnesota Method for treating conditions of the eye using polypeptides
US5686278A (en) 1994-03-25 1997-11-11 Indiana University Foundation Methods for enhanced retrovirus-mediated gene transfer
JPH08317785A (ja) * 1995-03-17 1996-12-03 Kanagawa Kagaku Gijutsu Akad 糖鎖の固定化法及びそれを用いた細胞培養基材
NZ311175A (en) 1995-07-03 1999-11-29 Koken Co Gene preparation comprising a gene incorporated into a biocompatible carrier which preferably contains collagen
JP3867160B2 (ja) * 1995-07-03 2007-01-10 大日本住友製薬株式会社 遺伝子製剤
CN1326999C (zh) 1995-09-29 2007-07-18 印地安纳大学研究及科技有限公司 使用含有病毒和细胞结合区域的分子增强病毒介导的dna转移的方法
JP3343357B2 (ja) * 1995-11-13 2002-11-11 寳酒造株式会社 レトロウイルスによる標的細胞への遺伝子導入方法
US6133030A (en) * 1997-05-14 2000-10-17 The General Hospital Corporation Co-cultivation of cells in a micropatterned configuration

Also Published As

Publication number Publication date
EP1094114A4 (de) 2002-10-30
EP1094114A1 (de) 2001-04-25
EP1362918B8 (de) 2009-08-05
AU4393899A (en) 2000-01-24
US20040058447A1 (en) 2004-03-25
US20080044903A1 (en) 2008-02-21
DE69939955D1 (de) 2009-01-02
KR100608154B1 (ko) 2006-08-04
ATE414780T1 (de) 2008-12-15
EP1362918B1 (de) 2008-11-19
DE69934690T2 (de) 2007-11-15
EP1094114B1 (de) 2007-01-03
EP1362918A1 (de) 2003-11-19
ES2316675T3 (es) 2009-04-16
JP3807937B2 (ja) 2006-08-09
KR20010071422A (ko) 2001-07-28
CN1190496C (zh) 2005-02-23
US6787359B1 (en) 2004-09-07
CN1314947A (zh) 2001-09-26
ATE350482T1 (de) 2007-01-15
WO2000001836A1 (fr) 2000-01-13
ES2277438T3 (es) 2007-07-01

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