WO2004050857A3 - Splice variant of human sodium iii channel (hnaiii18) - Google Patents

Splice variant of human sodium iii channel (hnaiii18) Download PDF

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Publication number
WO2004050857A3
WO2004050857A3 PCT/US2003/038796 US0338796W WO2004050857A3 WO 2004050857 A3 WO2004050857 A3 WO 2004050857A3 US 0338796 W US0338796 W US 0338796W WO 2004050857 A3 WO2004050857 A3 WO 2004050857A3
Authority
WO
WIPO (PCT)
Prior art keywords
hnaiii18
splice variant
human sodium
channel
iii channel
Prior art date
Application number
PCT/US2003/038796
Other languages
French (fr)
Other versions
WO2004050857A2 (en
Inventor
Anja Kammesheidt
Dianne Hodges
Original Assignee
Euro Celtique Sa
Anja Kammesheidt
Dianne Hodges
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa, Anja Kammesheidt, Dianne Hodges filed Critical Euro Celtique Sa
Priority to AU2003297693A priority Critical patent/AU2003297693A1/en
Publication of WO2004050857A2 publication Critical patent/WO2004050857A2/en
Publication of WO2004050857A3 publication Critical patent/WO2004050857A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Described herein is a splice variant of the human NaIII channel α subunit, designated hNaIII18. Also described are nucleotide and amino acid sequence for hNaIII18, oligonucleotide primers and probes for hNaIII18, hNaIII18 regulatory sequences, hNaIII18-specific antibodies, methods of detecting hNaIII18 proteins or nucleic acids, and methods of screening for modulators of hNaIII18 expression or activity.
PCT/US2003/038796 2002-12-04 2003-12-04 Splice variant of human sodium iii channel (hnaiii18) WO2004050857A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003297693A AU2003297693A1 (en) 2002-12-04 2003-12-04 Splice variant of human sodium iii channel (hnaiii18)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43179402P 2002-12-04 2002-12-04
US60/431,794 2002-12-04

Publications (2)

Publication Number Publication Date
WO2004050857A2 WO2004050857A2 (en) 2004-06-17
WO2004050857A3 true WO2004050857A3 (en) 2005-03-17

Family

ID=32469613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038796 WO2004050857A2 (en) 2002-12-04 2003-12-04 Splice variant of human sodium iii channel (hnaiii18)

Country Status (2)

Country Link
AU (1) AU2003297693A1 (en)
WO (1) WO2004050857A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004299822A1 (en) * 2003-12-12 2005-06-30 Wyeth Novel sodium channel
US7531523B2 (en) 2005-02-17 2009-05-12 Vertex Pharmaceuticals Incorporated Sodium channel protein type III alpha-subunit splice variant
KR20130095772A (en) 2010-10-05 2013-08-28 퍼듀 퍼머 엘피 Quinazoline compounds as sodium channel blockers
US9388137B2 (en) 2011-10-31 2016-07-12 Purdue Pharma L.P. Quaternized amines as sodium channel blockers
US9181185B2 (en) 2011-10-31 2015-11-10 Purdue Pharma L.P. Heteroaryl compounds as sodium channel blockers
WO2013072758A1 (en) 2011-11-15 2013-05-23 Purdue Pharma L.P. Pyrimidine diol amides as sodium channel blockers
EP2968307A4 (en) 2013-03-15 2017-01-04 Purdue Pharma LP Carboxamide derivatives and use thereof
WO2015031036A1 (en) 2013-08-26 2015-03-05 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
US9340504B2 (en) 2013-11-21 2016-05-17 Purdue Pharma L.P. Pyridine and piperidine derivatives as novel sodium channel blockers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110672A (en) * 1994-11-02 2000-08-29 Research Foundation Of State University Of New York, The Suny At Stony Brook Peripheral nervous system specific sodium channels, DNA encoding therefor, crystallization, X-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110672A (en) * 1994-11-02 2000-08-29 Research Foundation Of State University Of New York, The Suny At Stony Brook Peripheral nervous system specific sodium channels, DNA encoding therefor, crystallization, X-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof

Also Published As

Publication number Publication date
AU2003297693A1 (en) 2004-06-23
AU2003297693A8 (en) 2004-06-23
WO2004050857A2 (en) 2004-06-17

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