DE69933147T2 - Sustiuierte cyclische verbindungen, verfahren zu ihrer herstellung sowie sie enthaltende pharmazeutische zusammesetzungen - Google Patents

Sustiuierte cyclische verbindungen, verfahren zu ihrer herstellung sowie sie enthaltende pharmazeutische zusammesetzungen Download PDF

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DE69933147T2
DE69933147T2 DE69933147T DE69933147T DE69933147T2 DE 69933147 T2 DE69933147 T2 DE 69933147T2 DE 69933147 T DE69933147 T DE 69933147T DE 69933147 T DE69933147 T DE 69933147T DE 69933147 T2 DE69933147 T2 DE 69933147T2
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ethyl
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DE69933147D1 (de
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Daniel Lesieur
Frederique Klupsch
Gerald Guillaumet
Marie-Claude Viaud
Michel Langlois
Caroline Bennejean
Pierre Renard
Philippe Delagrange
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Les Laboratoires Servier SAS
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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO274596A0 (en) * 1996-10-04 1996-10-31 Armstrong, Stuart Maxwell Method for the treatment of neurological or neuropsychiatric disorders
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6569879B2 (en) * 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
FR2814165B1 (fr) * 2000-09-15 2002-11-22 Adir Nouveaux derives biphenyles substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ526622A (en) * 2000-12-11 2006-07-28 Amgen Sf Llc CXCR3 antagonists
US6794379B2 (en) * 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
FR2853649B1 (fr) * 2003-04-09 2006-07-14 Servier Lab Nouveaux derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2857011B1 (fr) * 2003-07-04 2005-09-16 Servier Lab Nouveaux derives du benzothiophene 2-thiosubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
CA2566196A1 (en) * 2004-05-05 2005-11-10 F. Hoffmann-La Roche Ag Arylsulfonyl benzodioxanes useful for modulating the 5-ht6 receptor, the 5-ht2a receptor or both
WO2006019497A2 (en) * 2004-06-17 2006-02-23 Neurocrine Biosciences, Inc. Sleep-inducing compounds and methods related thereto
US7375102B2 (en) * 2004-06-28 2008-05-20 Amgen Sf, Llc Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
US7271271B2 (en) * 2004-06-28 2007-09-18 Amgen Sf, Llc Imidazolo-related compounds, compositions and methods for their use
US7939538B2 (en) 2004-06-28 2011-05-10 Amgen Inc. Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
SI1831159T1 (sl) * 2004-12-21 2010-04-30 Hoffmann La Roche Derivati tetralina in indana ter njune uporabe
BRPI0515835A (pt) 2004-12-21 2008-08-12 Hoffmann La Roche derivados de tetralina e de indano e seus usos
ES2306275T3 (es) * 2004-12-21 2008-11-01 F. Hoffmann-La Roche Ag Derivados de cromano y sus usos como ligandos dde receptores 5-ht.
RU2388748C2 (ru) * 2004-12-21 2010-05-10 Ф. Хоффманн-Ля Рош Аг Производные тетралина и индана и их применения в качестве антагонистов 5-нт
CA2591810A1 (en) 2004-12-21 2006-06-29 F.Hoffmann-La Roche Ag Chroman derivatives and uses thereof in the treatment of cns disorders
CA2628173A1 (en) * 2005-11-03 2007-05-10 F. Hoffmann-La Roche Ag Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors
WO2007067257A2 (en) 2005-12-02 2007-06-14 Vanderbilt University Broad-emission nanocrystals and methods of making and using same
CN101379060B (zh) * 2006-02-10 2012-05-23 转化技术制药公司 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法
MX2008015511A (es) 2006-06-20 2008-12-18 Hoffmann La Roche Derivados de arilsulfonilnaftaleno y usos de los mismos.
BRPI0713736A2 (pt) * 2006-06-20 2014-11-18 Hoffmann La Roche Derivados de tetralina e indano e emprego destes
AU2007263075A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonamidyl tetralin derivatives and uses thereof
WO2009045385A1 (en) * 2007-10-04 2009-04-09 Merck & Co., Inc. N-hydroxy-naphthalene dicarboxamide and n-hydroxy-biphenyl-dicarboxamide compounds as histone deacetylase inhibitors
EP2163551B1 (en) 2008-09-08 2011-11-16 Cadila Pharmaceuticals Ltd. An improved process for the preparation of nebivolol hydrochloride
CN101481321B (zh) * 2009-02-27 2012-04-18 上海医药工业研究院 阿戈美拉汀卤化氢复合物及其制备方法
AU2015210833B2 (en) 2014-02-03 2019-01-03 Vitae Pharmaceuticals, Llc Dihydropyrrolopyridine inhibitors of ROR-gamma
CN104292125B (zh) * 2014-08-14 2016-06-01 广东东阳光药业有限公司 萘衍生物及其在药物上的应用
JP6564029B2 (ja) 2014-10-14 2019-08-21 ヴァイティー ファーマシューティカルズ,エルエルシー Ror−ガンマのジヒドロピロロピリジン阻害剤
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3247357A4 (en) 2015-01-20 2018-07-11 Xoc Pharmaceuticals, Inc Isoergoline compounds and uses thereof
MX2017009405A (es) * 2015-01-20 2018-01-18 Xoc Pharmaceuticals Inc Compuestos de tipo ergolina y usos de estos.
DK3331876T3 (da) 2015-08-05 2021-01-11 Vitae Pharmaceuticals Llc Modulators of ror-gamma
MA53943A (fr) 2015-11-20 2021-08-25 Vitae Pharmaceuticals Llc Modulateurs de ror-gamma
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ROR-γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2018223065A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN115650976A (zh) 2017-07-24 2023-01-31 生命医药有限责任公司 RORγ的抑制剂
CN108156986A (zh) * 2018-01-04 2018-06-15 山东农业大学 外源褪黑素对苹果矮化自根砧木幼苗臭氧胁迫缓解效应的应用
US20240300939A1 (en) 2021-06-14 2024-09-12 Scorpion Therapeutics, Inc. Urea derivatives which can be used to treat cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
FR2680507B1 (fr) * 1991-08-23 1993-10-08 Adir Cie Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2689124A1 (fr) * 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2705095B1 (fr) * 1993-05-12 1995-06-23 Adir Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
US5350748A (en) * 1993-08-18 1994-09-27 Warner-Lambert Company 3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion
FR2713636B1 (fr) * 1993-12-07 1996-01-05 Adir Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
AU3399895A (en) * 1994-09-12 1996-03-29 Takeda Chemical Industries Ltd. Benzocycloalkene compounds, their production and use
JP3908798B2 (ja) * 1994-09-12 2007-04-25 武田薬品工業株式会社 ベンゾシクロアルケン類、その製造法および剤
JPH08268987A (ja) * 1995-02-24 1996-10-15 Bristol Myers Squibb Co テトラリニル−,及びインダニル−エチルアミド誘導体
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
FR2734815B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2734814B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CZ292443B6 (cs) * 1995-12-05 2003-09-17 Darwin Discovery Limited Benzofuransulfonamid, farmaceutický prostředek jej obsahující a jeho použití
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR101012391B1 (ko) 2008-11-11 2011-02-09 엘지전자 주식회사 무선 통신 시스템에 있어서, 하향링크로 서브프레임 지정 정보를 전송하는 방법

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NZ507692A (en) 2002-06-28
FR2778662A1 (fr) 1999-11-19
ES2255261T3 (es) 2006-06-16
DE69933149T2 (de) 2006-12-21
DE69933147D1 (de) 2006-10-19
PL344048A1 (en) 2001-09-24
CN1300277A (zh) 2001-06-20
ZA200006528B (en) 2001-11-14
US6872851B1 (en) 2005-03-29
HUP0101813A3 (en) 2002-10-28
PL195613B1 (pl) 2007-10-31
ES2255260T3 (es) 2006-06-16
US7183318B2 (en) 2007-02-27
HUP0101800A2 (en) 2001-10-28
CN1304400A (zh) 2001-07-18
JP2002514620A (ja) 2002-05-21
EP1077928B1 (fr) 2005-12-07
BR9911783A (pt) 2002-12-31
DK1077928T3 (da) 2006-04-18
US20050059729A1 (en) 2005-03-17
NO20005714L (no) 2000-11-13
CA2331877C (fr) 2006-02-28
US20050124682A1 (en) 2005-06-09
JP2002514619A (ja) 2002-05-21
DK1077927T3 (da) 2006-04-18
EP1077927A1 (fr) 2001-02-28
US7115752B2 (en) 2006-10-03
NO20005714D0 (no) 2000-11-13
ZA200006529B (en) 2001-05-22
NZ507691A (en) 2002-05-31
PL344012A1 (en) 2001-09-24
AU3610499A (en) 1999-11-29
NO20005715D0 (no) 2000-11-13
AU748567B2 (en) 2002-06-06
AU3610399A (en) 1999-11-29
CA2331870C (fr) 2007-05-08
ATE312073T1 (de) 2005-12-15
AU747301B2 (en) 2002-05-16
EP1077927B1 (fr) 2005-12-07
WO1999058496A1 (fr) 1999-11-18
FR2778662B1 (fr) 2000-06-16
HUP0101800A3 (en) 2002-12-28
US20040002491A1 (en) 2004-01-01
US6605632B1 (en) 2003-08-12
CA2331870A1 (fr) 1999-11-18
BR9911771A (pt) 2001-10-02
DE69933149D1 (de) 2006-10-19
EP1077928A1 (fr) 2001-02-28
WO1999058495A1 (fr) 1999-11-18
HUP0101813A2 (hu) 2001-11-28
NO20005715L (no) 2000-11-13
US7126012B2 (en) 2006-10-24
CA2331877A1 (fr) 1999-11-18
ATE312072T1 (de) 2005-12-15

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