DE69927790D1 - Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen - Google Patents

Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen

Info

Publication number
DE69927790D1
DE69927790D1 DE69927790T DE69927790T DE69927790D1 DE 69927790 D1 DE69927790 D1 DE 69927790D1 DE 69927790 T DE69927790 T DE 69927790T DE 69927790 T DE69927790 T DE 69927790T DE 69927790 D1 DE69927790 D1 DE 69927790D1
Authority
DE
Germany
Prior art keywords
epothilones
synthesis
intermediate products
analogical
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69927790T
Other languages
English (en)
Other versions
DE69927790T2 (de
Inventor
J Danishefsky
Aaron Balog
Peter Bertinato
Dai-Shi Su
Ting-Chau Memorial Sloan- Chou
Dongfang Meng
Ted Kamenecka
J Sorensen
Scott Kuduk
Christina Harris
Xiu-Guo Zhang
Joseph R Bertino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research filed Critical Sloan Kettering Institute for Cancer Research
Application granted granted Critical
Publication of DE69927790D1 publication Critical patent/DE69927790D1/de
Publication of DE69927790T2 publication Critical patent/DE69927790T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
DE69927790T 1998-02-25 1999-02-24 Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen Expired - Lifetime DE69927790T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US92319P 1997-05-02
US7594798P 1998-02-25 1998-02-25
US75947P 1998-02-25
US9231998P 1998-07-09 1998-07-09
US9773398P 1998-08-24 1998-08-24
US97733P 1998-08-24
PCT/US1999/004008 WO1999043653A1 (en) 1998-02-25 1999-02-24 Synthesis of epothilones, intermediates thereto and analogues therof

Publications (2)

Publication Number Publication Date
DE69927790D1 true DE69927790D1 (de) 2006-03-02
DE69927790T2 DE69927790T2 (de) 2006-07-20

Family

ID=27372770

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69927790T Expired - Lifetime DE69927790T2 (de) 1998-02-25 1999-02-24 Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen

Country Status (10)

Country Link
EP (1) EP1058679B1 (de)
JP (1) JP2002504540A (de)
AT (1) ATE307123T1 (de)
AU (1) AU758526B2 (de)
CA (1) CA2322157C (de)
DE (1) DE69927790T2 (de)
IL (2) IL138113A0 (de)
MX (1) MXPA00008365A (de)
NZ (1) NZ506742A (de)
WO (1) WO1999043653A1 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
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CA2322157A1 (en) 1999-09-02
DE69927790T2 (de) 2006-07-20
AU758526B2 (en) 2003-03-20
MXPA00008365A (es) 2002-11-07
NZ506742A (en) 2003-09-26
AU2785899A (en) 1999-09-15
EP1058679A1 (de) 2000-12-13
CA2322157C (en) 2012-05-29
JP2002504540A (ja) 2002-02-12
IL138113A0 (en) 2001-10-31
IL138113A (en) 2007-02-11
ATE307123T1 (de) 2005-11-15
WO1999043653A1 (en) 1999-09-02

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