DE69919143T2 - Nukleinsäure hybridisierung-testverfahren in lösung - Google Patents

Nukleinsäure hybridisierung-testverfahren in lösung Download PDF

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Publication number
DE69919143T2
DE69919143T2 DE69919143T DE69919143T DE69919143T2 DE 69919143 T2 DE69919143 T2 DE 69919143T2 DE 69919143 T DE69919143 T DE 69919143T DE 69919143 T DE69919143 T DE 69919143T DE 69919143 T2 DE69919143 T2 DE 69919143T2
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DE
Germany
Prior art keywords
label
capture
waveguide
target polynucleotide
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69919143T
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German (de)
English (en)
Other versions
DE69919143D1 (de
Inventor
Andreas Abel
Joseph James BECK
Markus Ehrat
Peter Oroszlan
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Novartis AG
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Novartis AG
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Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE69919143D1 publication Critical patent/DE69919143D1/de
Application granted granted Critical
Publication of DE69919143T2 publication Critical patent/DE69919143T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69919143T 1998-03-19 1999-03-17 Nukleinsäure hybridisierung-testverfahren in lösung Expired - Lifetime DE69919143T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9805935 1998-03-19
GBGB9805935.5A GB9805935D0 (en) 1998-03-19 1998-03-19 Organic compounds
PCT/EP1999/001782 WO1999047705A1 (en) 1998-03-19 1999-03-17 Detection method

Publications (2)

Publication Number Publication Date
DE69919143D1 DE69919143D1 (de) 2004-09-09
DE69919143T2 true DE69919143T2 (de) 2005-08-11

Family

ID=10828909

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919143T Expired - Lifetime DE69919143T2 (de) 1998-03-19 1999-03-17 Nukleinsäure hybridisierung-testverfahren in lösung

Country Status (8)

Country Link
US (1) US20060188873A1 (enExample)
EP (1) EP1064406B1 (enExample)
JP (1) JP2002506984A (enExample)
AT (1) ATE272721T1 (enExample)
AU (1) AU3414599A (enExample)
DE (1) DE69919143T2 (enExample)
GB (1) GB9805935D0 (enExample)
WO (1) WO1999047705A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001262178A1 (en) * 2000-04-14 2001-10-30 Zeptosens Ag Grid-waveguide structure for reinforcing an excitation field and use thereof
US20030138208A1 (en) * 2000-05-06 2003-07-24 Michael Pawlak Grating optical waveguide structure for multi-analyte determinations and the use thereof
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
GB0106949D0 (en) * 2001-03-20 2001-05-09 Norchip As Detection of mycobacteria
JP3448654B2 (ja) 2001-11-22 2003-09-22 北陸先端科学技術大学院大学長 バイオチップ、バイオチップアレイ、及びそれらを用いたスクリーニング方法
JP2005519593A (ja) 2002-01-18 2005-07-07 ユニバーシティ オブ ユタ リサーチ ファウンデーション 平面導波路を使用する1塩基多型の検出法
GB0507835D0 (en) * 2005-04-18 2005-05-25 Solexa Ltd Method and device for nucleic acid sequencing using a planar wave guide
WO2007037282A1 (ja) * 2005-09-27 2007-04-05 Eisai R & D Management Co., Ltd. 微小粒子に自己集合体を形成させる方法及び標的分析物の検出方法
KR20100025328A (ko) * 2008-08-27 2010-03-09 삼성전자주식회사 이중가닥 영역과 말단 단일가닥 영역을 포함하는 이중가닥 핵산 프로브가 고정된 마이크로어레이를 제조하는 방법
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8331751B2 (en) 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8300993B2 (en) 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US9109793B2 (en) * 2009-07-20 2015-08-18 Crayola, Llc Illuminated display unit
WO2012037369A1 (en) 2010-09-15 2012-03-22 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
WO2013129457A1 (ja) 2012-02-27 2013-09-06 東レ株式会社 核酸の検出方法
EP3908826A4 (en) * 2019-01-08 2022-10-19 Akoya Biosciences, Inc. FLEXIBLE DETECTION SYSTEMS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
GB9119735D0 (en) * 1991-09-16 1991-10-30 Secr Defence Gene probe biosensor method
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
EP1890130A3 (en) * 1995-05-12 2008-02-27 Novartis AG Sensor platform for the parallel detection of a plurality of analytes using evanescently excited luminescenes
AU4040097A (en) * 1996-07-12 1998-02-09 Tm Technologies, Inc. Signal amplification method
US5832165A (en) * 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays

Also Published As

Publication number Publication date
EP1064406B1 (en) 2004-08-04
JP2002506984A (ja) 2002-03-05
DE69919143D1 (de) 2004-09-09
WO1999047705A1 (en) 1999-09-23
ATE272721T1 (de) 2004-08-15
EP1064406A1 (en) 2001-01-03
AU3414599A (en) 1999-10-11
GB9805935D0 (en) 1998-05-13
US20060188873A1 (en) 2006-08-24

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Legal Events

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8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

8328 Change in the person/name/address of the agent

Representative=s name: LUETJENS, H., DIPL.-CHEM. DR. RER. NAT., PAT.-ANW.