DE69917258D1 - Methode und vorrichtung zum elektrochemischen immunoassay mehrerer analyten - Google Patents

Methode und vorrichtung zum elektrochemischen immunoassay mehrerer analyten

Info

Publication number
DE69917258D1
DE69917258D1 DE69917258T DE69917258T DE69917258D1 DE 69917258 D1 DE69917258 D1 DE 69917258D1 DE 69917258 T DE69917258 T DE 69917258T DE 69917258 T DE69917258 T DE 69917258T DE 69917258 D1 DE69917258 D1 DE 69917258D1
Authority
DE
Germany
Prior art keywords
liquid sample
redox reversible
redox
reversible species
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69917258T
Other languages
English (en)
Other versions
DE69917258T2 (de
Inventor
B Buck
D Deng
R Diebold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Operations Inc
Original Assignee
Roche Diagnostics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Corp filed Critical Roche Diagnostics Corp
Publication of DE69917258D1 publication Critical patent/DE69917258D1/de
Application granted granted Critical
Publication of DE69917258T2 publication Critical patent/DE69917258T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/002—Osmium compounds
    • C07F15/0026—Osmium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
DE69917258T 1998-06-01 1999-05-28 Methode und vorrichtung zum elektrochemischen immunoassay mehrerer analyten Expired - Lifetime DE69917258T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8757698P 1998-06-01 1998-06-01
US87576P 1998-06-01
PCT/US1999/011850 WO1999063346A1 (en) 1998-06-01 1999-05-28 Method and device for electrochemical immunoassay of multiple analytes

Publications (2)

Publication Number Publication Date
DE69917258D1 true DE69917258D1 (de) 2004-06-17
DE69917258T2 DE69917258T2 (de) 2005-07-14

Family

ID=22205995

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69902265T Expired - Lifetime DE69902265T2 (de) 1998-06-01 1999-05-28 Redox-reversible imidazol-osmiumkomplex-konjugate
DE69917258T Expired - Lifetime DE69917258T2 (de) 1998-06-01 1999-05-28 Methode und vorrichtung zum elektrochemischen immunoassay mehrerer analyten
DE69902662T Expired - Lifetime DE69902662T2 (de) 1998-06-01 1999-05-28 Redox-reversibele bipyridyl-osmiumkomplex-konjugate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69902265T Expired - Lifetime DE69902265T2 (de) 1998-06-01 1999-05-28 Redox-reversible imidazol-osmiumkomplex-konjugate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69902662T Expired - Lifetime DE69902662T2 (de) 1998-06-01 1999-05-28 Redox-reversibele bipyridyl-osmiumkomplex-konjugate

Country Status (8)

Country Link
US (5) US6352824B1 (de)
EP (3) EP1084132B1 (de)
AT (3) ATE221076T1 (de)
AU (3) AU4217899A (de)
CA (3) CA2333875C (de)
DE (3) DE69902265T2 (de)
ES (3) ES2179660T3 (de)
WO (3) WO1999062918A1 (de)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6294281B1 (en) 1998-06-17 2001-09-25 Therasense, Inc. Biological fuel cell and method
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US8268143B2 (en) * 1999-11-15 2012-09-18 Abbott Diabetes Care Inc. Oxygen-effect free analyte sensor
US8444834B2 (en) 1999-11-15 2013-05-21 Abbott Diabetes Care Inc. Redox polymers for use in analyte monitoring
DK1230249T3 (da) * 1999-11-15 2004-08-30 Therasense Inc Overgangsmetalkomplekser med bidentatligand, der har en imidazolring
WO2001075149A2 (de) * 2000-03-30 2001-10-11 Infineon Technologies Ag Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor
DE10015816A1 (de) * 2000-03-30 2001-10-18 Infineon Technologies Ag Biosensorchip
WO2001083674A1 (en) * 2000-05-03 2001-11-08 Gau Jen Jr Biological identification system with integrated sensor chip
CA2733852A1 (en) * 2000-07-14 2002-01-24 Lifescan, Inc. Electrochemical method for measuring chemical reaction rates
DE60125544T2 (de) * 2000-07-14 2007-10-04 Lifescan, Inc., Milpitas Elektrochemisches verfahren zur messung chemischer reaktionsraten
CA2421217A1 (en) * 2000-09-20 2003-03-03 Yuko Seino Reaction detecting method, immunoreaction detecting method and device
GB0026276D0 (en) * 2000-10-27 2000-12-13 Univ Ulster Method for chlorine plasma modification of silver electrodes
AU2002232518A1 (en) * 2000-11-13 2002-05-21 Sigma-Aldrich Co. Improved assay and reagents or immunological determination of analyte concentration
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6576102B1 (en) 2001-03-23 2003-06-10 Virotek, L.L.C. Electrochemical sensor and method thereof
US6572745B2 (en) 2001-03-23 2003-06-03 Virotek, L.L.C. Electrochemical sensor and method thereof
US6676816B2 (en) * 2001-05-11 2004-01-13 Therasense, Inc. Transition metal complexes with (pyridyl)imidazole ligands and sensors using said complexes
US8226814B2 (en) * 2001-05-11 2012-07-24 Abbott Diabetes Care Inc. Transition metal complexes with pyridyl-imidazole ligands
US8070934B2 (en) 2001-05-11 2011-12-06 Abbott Diabetes Care Inc. Transition metal complexes with (pyridyl)imidazole ligands
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
US7005273B2 (en) * 2001-05-16 2006-02-28 Therasense, Inc. Method for the determination of glycated hemoglobin
US20020179457A1 (en) * 2001-05-18 2002-12-05 Adam Heller Electrochemical method for high-throughput screening of minute quantities of candidate compounds
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
EP1404234B1 (de) 2001-06-12 2011-02-09 Pelikan Technologies Inc. Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
JP4272051B2 (ja) 2001-06-12 2009-06-03 ペリカン テクノロジーズ インコーポレイテッド 血液試料採取装置及び方法
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US6562581B2 (en) * 2001-08-31 2003-05-13 Portascience Method for quantitative determination of glycated hemoglobin
US6861224B2 (en) * 2001-11-02 2005-03-01 Fujitsu Limited Protein detecting device
AU2003210438A1 (en) * 2002-01-04 2003-07-24 Board Of Regents, The University Of Texas System Droplet-based microfluidic oligonucleotide synthesis engine
AU2003214625A1 (en) * 2002-04-08 2003-10-27 Yeda Research And Development Co. Ltd. Histone conjugates and uses thereof
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7368190B2 (en) * 2002-05-02 2008-05-06 Abbott Diabetes Care Inc. Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods
US7560239B2 (en) * 2002-06-04 2009-07-14 Lin-Zhi International Inc. Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
EP1560930A4 (de) * 2002-11-15 2007-05-16 Applera Corp NUKLEINSûURESEQUENZNACHWEIS
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
DE502004003698D1 (de) * 2003-05-13 2007-06-14 Siemens Ag Schaltkreisanordnung zur potentialkonstanthaltung an einem biosensor und zur digitalisierung des messstroms
ES2347248T3 (es) 2003-05-30 2010-10-27 Pelikan Technologies Inc. Procedimiento y aparato para la inyeccion de fluido.
DK1633235T3 (da) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparat til udtagelse af legemsvæskeprøver og detektering af analyt
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
WO2005012900A1 (en) * 2003-06-20 2005-02-10 Roche Diagnostics Gmbh Biosensor with multiple electrical functionalities
CA2530297C (en) 2003-06-20 2011-04-12 F. Hoffmann-La Roche Ag Reagent stripe for test strip
ES2392170T3 (es) 2003-07-01 2012-12-05 F. Hoffmann-La Roche Ag Sistema de biosensor de afinidad electroquímica y métodos de utilización
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
WO2005065192A2 (en) 2003-12-29 2005-07-21 The Trustees Of Columbia University In The City Of New York Photolabile compounds
EP1706026B1 (de) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Verfahren und vorrichtung zur verbesserung der fluidströmung und der probennahme
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
GB2409902B (en) * 2004-01-08 2006-04-19 Schlumberger Holdings Electro-chemical sensor
US8758593B2 (en) * 2004-01-08 2014-06-24 Schlumberger Technology Corporation Electrochemical sensor
US7510849B2 (en) * 2004-01-29 2009-03-31 Glucolight Corporation OCT based method for diagnosis and therapy
US8696880B2 (en) * 2004-02-06 2014-04-15 Bayer Healthcare Llc Oxidizable species as an internal reference for biosensors and method of use
EP1751546A2 (de) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
US8268145B2 (en) 2004-05-21 2012-09-18 Agamatrix, Inc. Electrochemical cell and method of making an electrochemical cell
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US7511142B2 (en) * 2004-07-28 2009-03-31 Agency For Science, Technology And Research Mediator-modified redox biomolecules for use in electrochemical determination of analyte
US8036727B2 (en) 2004-08-11 2011-10-11 Glt Acquisition Corp. Methods for noninvasively measuring analyte levels in a subject
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
US20060054274A1 (en) * 2004-09-16 2006-03-16 Yaw-Huei Tsai Method for manufacturing optical filter
US7709149B2 (en) * 2004-09-24 2010-05-04 Lg Chem, Ltd. Composite precursor for aluminum-containing lithium transition metal oxide and process for preparation of the same
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JP2008537903A (ja) 2005-04-13 2008-10-02 グルコライト・コーポレーシヨン Ｏｃｔが基になった血糖モニターのデータ処理および較正方法
EP1813937A1 (de) * 2006-01-25 2007-08-01 Roche Diagnostics GmbH Elektrochemisches Biosensor-Analysesystem
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US7909983B2 (en) * 2006-05-04 2011-03-22 Nipro Diagnostics, Inc. System and methods for automatically recognizing a control solution
WO2008007277A2 (en) * 2006-06-27 2008-01-17 Agamatrix, Inc. Detection of analytes in a dual-mediator electrochemical test strip
US7699973B2 (en) * 2006-06-30 2010-04-20 Abbott Diabetes Care Inc. Rapid analyte measurement assay
CA2667012A1 (en) * 2006-10-26 2008-05-02 Abbott Laboratories Immunoassay of analytes in samples containing endogenous anti-analyte antibodies
US20080305512A1 (en) * 2006-10-26 2008-12-11 Mattingly Phillip G Assay for cardiac troponin autoantibodies
US7776605B2 (en) 2006-10-26 2010-08-17 Abbott Laboratories Assay for cardiac troponin autoantibodies
US8079955B2 (en) * 2006-11-28 2011-12-20 Isense Corporation Method and apparatus for managing glucose control
US7914999B2 (en) 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
WO2008083259A1 (en) * 2006-12-29 2008-07-10 Applera Corporation Systems and methods for detecting nucleic acids
EP2118657B1 (de) 2006-12-29 2014-05-21 Abbott Laboratories Nichtdenaturierendes lysereagens zur verwendung mit einem capture-in-solution-immunoassay
US8709709B2 (en) 2007-05-18 2014-04-29 Luoxis Diagnostics, Inc. Measurement and uses of oxidative status
JP5330381B2 (ja) 2007-05-18 2013-10-30 インスティチュート フォー モレキュラー メディスン インコーポレイテッド 酸化還元電位（ｏｒｐ）を測定及び使用する方法
WO2008148025A1 (en) 2007-05-23 2008-12-04 Arizona Board Of Regents For And On Behalf Of Arizona State University Systems and methods for integrated electrochemical and electrical detection
US8197650B2 (en) 2007-06-07 2012-06-12 Sensor Innovations, Inc. Silicon electrochemical sensors
KR20150013343A (ko) * 2007-07-23 2015-02-04 아가매트릭스, 인코포레이티드 전기화학적 테스트 스트립
US8571617B2 (en) 2008-03-04 2013-10-29 Glt Acquisition Corp. Flowometry in optical coherence tomography for analyte level estimation
US8008037B2 (en) 2008-03-27 2011-08-30 Roche Diagnostics Operations, Inc. Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
US8492158B2 (en) * 2008-03-31 2013-07-23 Applied Biosystems, Llc Electrochemical labels derived from siderophores
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
EP2357199A4 (de) * 2008-12-11 2013-02-20 Sekisui Medical Co Ltd ANTIKÖRPER GEGEN N-TERMINUS DER ß-KETTE VON HÄMOGLOBIN
US9341633B2 (en) * 2008-12-11 2016-05-17 Sekisui Medical Co., Ltd. Method for pre-treating sample containing glycated hemoglobin
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US20100213057A1 (en) 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
WO2010142037A1 (en) * 2009-06-08 2010-12-16 The University Of Western Ontario An electrochemical method and apparatus of identifying the presence of a target
US8652788B2 (en) * 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
US8835120B2 (en) * 2009-12-02 2014-09-16 Abbott Laboratories Assay for cardiac troponin-T (cTnT)
US20110136141A1 (en) * 2009-12-03 2011-06-09 Abbott Laboratories Peptide reagents and method for inhibiting autoantibody antigen binding
US8183002B2 (en) * 2009-12-03 2012-05-22 Abbott Laboratories Autoantibody enhanced immunoassays and kits
CN103069277B (zh) * 2010-03-31 2016-03-30 积水医疗株式会社 利用免疫色谱法的测定法、免疫色谱测试条和用于免疫色谱法的测定试剂盒
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
EP2649191B1 (de) * 2010-12-09 2021-06-16 Abbott Diabetes Care, Inc. Analytsensoren mit einer sensoroberfläche mit kleinen erfassungspunkten
WO2012083258A2 (en) 2010-12-16 2012-06-21 Sensor Innovations, Inc. Electrochemical sensors
CN103299181B (zh) 2011-02-28 2015-04-08 卢奥克西斯诊断股份有限公司 用于测量氧化还原电位的方法及设备
CN105388287A (zh) 2011-03-11 2016-03-09 内布拉斯加大学董事委员会 冠状动脉疾病的生物标志物
DE102011108885A1 (de) * 2011-07-28 2013-01-31 Forschungszentrum Jülich GmbH Elektrodenanordnung und Verfahren zum Betreiben der Elektrodenanordnung
AU2012304199B2 (en) * 2011-09-01 2015-10-01 Newsouth Innovations Pty Limited Electrochemical affinity sensor
AU2012304200A1 (en) * 2011-09-01 2013-05-02 Newsouth Innovations Pty Limited Electrochemical competition sensor
KR20150013146A (ko) 2012-04-19 2015-02-04 로익스 다이어그노스틱스, 아이엔씨. 다층겔
IN2015DN01707A (de) 2012-10-23 2015-05-22 Luoxis Diagnostics Inc
US9458488B2 (en) * 2013-03-15 2016-10-04 Nanomix, Inc. Point of care sensor systems
CN103205135B (zh) * 2013-04-25 2015-10-28 大连理工大学 光敏染料锇配合物及其制备方法、癌变早期dna氧化损伤快速检测试剂盒及检测方法
US10006881B2 (en) * 2013-06-03 2018-06-26 Life Safety Distribution Ag Microelectrodes for electrochemical gas detectors
KR20160134796A (ko) * 2014-03-20 2016-11-23 바이오 래드 래버러토리스 인코오포레이티드 당화 단백질 분석
US11009479B2 (en) 2014-05-27 2021-05-18 Case Western Reserve University Systems and methods for the detection of HbA1c
JP6576170B2 (ja) * 2015-09-02 2019-09-18 旭化成ファーマ株式会社 くし型電極を用いた糖化タンパク質の測定方法
US20210102913A1 (en) * 2017-03-29 2021-04-08 Case Western Reserve University Compositions and methods of detecting 17 beta-estradiol
CN108061777B (zh) * 2017-11-27 2020-05-08 浙江公正检验中心有限公司 减肥类保健食品中34种非法添加药物残留量的检测方法
US11697807B2 (en) 2019-09-30 2023-07-11 Case Western Reserve University Electrochemical biosensor
CN115215953B (zh) * 2022-07-15 2023-10-24 江西司托迈医疗科技有限公司 自组装氧化还原聚合物、传感器及其制备方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2058839B (en) 1979-09-08 1983-02-16 Engelhard Min & Chem Photo electrochemical processes
US4323536A (en) 1980-02-06 1982-04-06 Eastman Kodak Company Multi-analyte test device
US4293310A (en) 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
EP0078636B2 (de) 1981-10-23 1997-04-02 MediSense, Inc. Sensor für Bestandteile einer Flüssigkeitsmischung
US4478744A (en) * 1982-01-25 1984-10-23 Sherwood Medical Company Method of obtaining antibodies
DE3221339A1 (de) 1982-06-05 1983-12-08 Basf Ag, 6700 Ludwigshafen Verfahren zur elektrochemischen hydrierung von nicotinamidadenin-dinucleotid
CA1219040A (en) 1983-05-05 1987-03-10 Elliot V. Plotkin Measurement of enzyme-catalysed reactions
CA1220818A (en) 1983-05-05 1987-04-21 Hugh A.O. Hill Assay techniques utilising specific binding agents
CA1226036A (en) 1983-05-05 1987-08-25 Irving J. Higgins Analytical equipment and sensor electrodes therefor
GB8328520D0 (en) 1983-10-25 1983-11-23 Serono Diagnostics Ltd Methods of assay
GB8402058D0 (en) 1984-01-26 1984-02-29 Serono Diagnostics Ltd Methods of assay
US5141868A (en) 1984-06-13 1992-08-25 Internationale Octrooi Maatschappij "Octropa" Bv Device for use in chemical test procedures
GB8417301D0 (en) 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
GB8432069D0 (en) 1984-12-19 1985-01-30 Iq Bio Ltd Apparatus for immunoassay
GB8504522D0 (en) 1985-02-21 1985-03-27 Genetics Int Inc Electrochemistry of mediators
JPS63500024A (ja) 1985-06-12 1988-01-07 ボ−ゲル，フア−デイナンド　リンカ−ン 傾斜帆ヨット
US4830959A (en) 1985-11-11 1989-05-16 Medisense, Inc. Electrochemical enzymic assay procedures
US4963245A (en) 1986-05-02 1990-10-16 Ciba Corning Diagnostics Corp. Unitary multiple electrode sensor
US4900405A (en) 1987-07-15 1990-02-13 Sri International Surface type microelectronic gas and vapor sensor
US4832814A (en) 1987-12-28 1989-05-23 E. I. Du Pont De Nemours And Company Electrofusion cell and method of making the same
JP2638877B2 (ja) 1988-02-10 1997-08-06 日本電気株式会社 免疫化学的測定法
WO1989009397A1 (en) 1988-03-31 1989-10-05 Matsushita Electric Industrial Co., Ltd. Biosensor and process for its production
US4954414A (en) 1988-11-08 1990-09-04 The Mead Corporation Photosensitive composition containing a transition metal coordination complex cation and a borate anion and photosensitive materials employing the same
US5312762A (en) 1989-03-13 1994-05-17 Guiseppi Elie Anthony Method of measuring an analyte by measuring electrical resistance of a polymer film reacting with the analyte
US5198367A (en) 1989-06-09 1993-03-30 Masuo Aizawa Homogeneous amperometric immunoassay
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
EP0429076B1 (de) 1989-11-24 1996-01-31 Matsushita Electric Industrial Co., Ltd. Verfahren zur Herstellung eines Biosensors
WO1991009139A1 (en) 1989-12-15 1991-06-27 Boehringer Mannheim Corporation Redox mediator reagent and biosensor
US4999632A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corporation Analog to digital conversion with noise reduction
US5243516A (en) 1989-12-15 1993-09-07 Boehringer Mannheim Corporation Biosensing instrument and method
WO1991016630A1 (en) 1990-04-12 1991-10-31 Optical Systems Development Partners Device and method for electroimmunoassay
FR2673183B1 (fr) 1991-02-21 1996-09-27 Asulab Sa Complexes mono, bis ou tris (2,2'-bipyridine substituee) d'un metal choisi parmi le fer, le ruthenium, l'osmium ou le vanadium et leurs procedes de preparation .
FR2673289B1 (fr) 1991-02-21 1994-06-17 Asulab Sa Capteur de mesure de la quantite d'un composant en solution.
US5192415A (en) 1991-03-04 1993-03-09 Matsushita Electric Industrial Co., Ltd. Biosensor utilizing enzyme and a method for producing the same
US5264103A (en) 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
FR2692357A1 (fr) * 1992-06-12 1993-12-17 Centre Nat Rech Scient Antigène marqué par un système redox, procédé de dosage immunologique avec détection électrochimique et kit de dosage.
GB9225354D0 (en) * 1992-12-04 1993-01-27 Univ Manchester Immunoassay
JPH07508537A (ja) * 1993-04-21 1995-09-21 イーストマン コダック カンパニー イオン感受性化合物
DE4318519C2 (de) * 1993-06-03 1996-11-28 Fraunhofer Ges Forschung Elektrochemischer Sensor
US5352351A (en) 1993-06-08 1994-10-04 Boehringer Mannheim Corporation Biosensing meter with fail/safe procedures to prevent erroneous indications
US5405511A (en) 1993-06-08 1995-04-11 Boehringer Mannheim Corporation Biosensing meter with ambient temperature estimation method and system
US5366609A (en) 1993-06-08 1994-11-22 Boehringer Mannheim Corporation Biosensing meter with pluggable memory key
EP0702789B8 (de) 1993-06-08 2006-06-14 Roche Diagnostics Operations, Inc. Biomesser zur feststellung korrekter elektrodenkopplung und zur unterscheidung zwischen probe- und referenzstreifen
US5427912A (en) 1993-08-27 1995-06-27 Boehringer Mannheim Corporation Electrochemical enzymatic complementation immunoassay
US5437772A (en) 1993-11-01 1995-08-01 The Electrosynthesis Co., Inc. Portable lead detector
DE4344646A1 (de) 1993-12-24 1995-06-29 Frieder Prof Dr Scheller Vorrichtung für einen kompetitiven Immuno-Assay zur Bestimmung von Haptenen
US5589326A (en) * 1993-12-30 1996-12-31 Boehringer Mannheim Corporation Osmium-containing redox mediator
US5643721A (en) * 1994-02-09 1997-07-01 Abbott Laboratories Bioreagent immobilization medium
US5710009A (en) * 1994-02-17 1998-01-20 Serex, Inc. Receptor:release ligand (reland) complexes and release assays using said reland and methods and kits based thereon
US5437999A (en) 1994-02-22 1995-08-01 Boehringer Mannheim Corporation Electrochemical sensor
JP3027306B2 (ja) 1994-06-02 2000-04-04 松下電器産業株式会社 バイオセンサおよびその製造方法
AU6476696A (en) * 1995-06-07 1996-12-30 Igen, Inc. Simultaneous assay method using lanthanide chelates as the l uminophore for multiple labels
US5701373A (en) 1995-10-12 1997-12-23 Sdl, Inc. Method for improving the coupling efficiency of elliptical light beams into optical waveguides
DE19608493A1 (de) 1996-03-05 1997-09-11 Basf Ag Edelmetallfreie Katalysatorzusammensetzung zur Erzeugung von Wasserstoffperoxid
AU2530997A (en) * 1996-03-06 1997-09-22 Igen International, Inc. Ecl labels having improved nsb properties
DE19610115C2 (de) 1996-03-14 2000-11-23 Fraunhofer Ges Forschung Detektion von Molekülen und Molekülkomplexen
US5958791A (en) * 1996-09-27 1999-09-28 Innovative Biotechnologies, Inc. Interdigitated electrode arrays for liposome-enhanced immunoassay and test device
US6054039A (en) * 1997-08-18 2000-04-25 Shieh; Paul Determination of glycoprotein and glycosylated hemoglobin in blood
US6174734B1 (en) * 1997-10-24 2001-01-16 Abbott Laboratories Measurement of glycated hemoglobin

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