RU2002121247A - Электрохимический способ анализа коагуляции и устройство для его осуществления - Google Patents

Электрохимический способ анализа коагуляции и устройство для его осуществления Download PDF

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RU2002121247A
RU2002121247A RU2002121247/14A RU2002121247A RU2002121247A RU 2002121247 A RU2002121247 A RU 2002121247A RU 2002121247/14 A RU2002121247/14 A RU 2002121247/14A RU 2002121247 A RU2002121247 A RU 2002121247A RU 2002121247 A RU2002121247 A RU 2002121247A
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change
viscosity
sample
certain distance
electrochemical
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RU2002121247/14A
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Тимоти Дж ОХАРА (US)
Тимоти Дж ОХАРА
Мари ТЕОДОРЧИК (US)
Мария ТЕОДОРЧИК
Роберт Джастис ШАРТЛ (US)
Роберт Джастис ШАРТЛ
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Лайфскен, Инк. (Us)
Лайфскен, Инк.
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/307—Disposable laminated or multilayered electrodes

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  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
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  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
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  • Urology & Nephrology (AREA)
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  • Food Science & Technology (AREA)
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  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
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  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (12)

1. Способ определения изменения вязкости пробы жидкости, заключающийся в том, что вводят пробу в электрохимическую ячейку, содержащую расположенные на определенном расстоянии друг против друга рабочий электрод и электрод сравнения, прикладывают электрический потенциал к реакционной ячейке для создания установившегося значения тока между расположенными на определенном расстоянии друг против друга рабочим электродом и электродом сравнения, определяют изменение установившегося значения тока для определения изменения вязкости пробы жидкости.
2. Способ по п.1, отличающийся тем, что изменение установившегося тока представляет собой понижение величины установившегося тока.
3. Способ по любому из пп.1 и 2, отличающийся тем, что изменение вязкости представляет собой ее увеличение.
4. Способ по любому из пп.1-3, отличающийся тем, что в качестве пробы жидкости используют пробу физиологической субстанции.
5. Способ по п.4, отличающийся тем, что пробой физиологической субстанции является кровь.
6. Способ по п.5, отличающийся тем, что определяют протромбиновое время (ПВ) упомянутой крови.
7. Способ по любому из предыдущих пп.1-6, отличающийся тем, что используют электрохимическую индикаторную полоску по любому из пп.8-10.
8. Электрохимическая индикаторная полоска, содержащая электрохимическую ячейку, включающую расположенные на определенном расстоянии друг против друга рабочий электрод и электрод сравнения, смесь реагентов, содержащую окислительно-восстановительную пару, катализатор коагуляции.
9. Индикаторная полоска по п.8, отличающаяся тем, что катализатор коагуляции содержит тромбопласин.
10. Индикаторная полоска по п.9, отличающийся тем, что окислительно-восстановительная пара содержит феррицианид и ферроцианид.
11. Измерительный прибор для определения изменения вязкости пробы жидкости, содержащий средство для приложения электрического потенциала к электрохимической ячейке, состоящей из расположенных на определенном расстоянии друг против друга рабочего электрода и электрода сравнения, и содержащей пробу жидкости, средство для измерения тока между расположенными на определенном расстоянии друг против друга электродами, средство для определения изменения измеренного тока в ячейке, средство для отнесения изменения измеренного тока в ячейке с изменением вязкости пробы жидкости.
12. Комплект для определения коагуляции в пробе крови, содержащий, по меньшей мере, одну электрохимическую индикаторную полоску по любому из пп.8-10, по меньшей мере, одно средство для калибрования и средство для взятия пробы.
RU2002121247/14A 2000-12-13 2001-12-06 Электрохимический способ анализа коагуляции и устройство для его осуществления RU2002121247A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/736,788 2000-12-13
US09/736,788 US6620310B1 (en) 2000-12-13 2000-12-13 Electrochemical coagulation assay and device

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RU2002121247A true RU2002121247A (ru) 2004-01-27

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US (2) US6620310B1 (ru)
EP (1) EP1402255A2 (ru)
JP (1) JP2004515784A (ru)
KR (1) KR20020086524A (ru)
CN (1) CN1429340A (ru)
AR (1) AR031803A1 (ru)
AU (2) AU3952602A (ru)
CA (1) CA2399811A1 (ru)
CZ (1) CZ20022733A3 (ru)
IL (1) IL151157A0 (ru)
MX (1) MXPA02007833A (ru)
PL (1) PL363112A1 (ru)
RU (1) RU2002121247A (ru)
WO (1) WO2002048707A2 (ru)

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