DE69909077T2 - Membranfiltration - Google Patents
Membranfiltration Download PDFInfo
- Publication number
- DE69909077T2 DE69909077T2 DE69909077T DE69909077T DE69909077T2 DE 69909077 T2 DE69909077 T2 DE 69909077T2 DE 69909077 T DE69909077 T DE 69909077T DE 69909077 T DE69909077 T DE 69909077T DE 69909077 T2 DE69909077 T2 DE 69909077T2
- Authority
- DE
- Germany
- Prior art keywords
- broth
- membrane
- transmembrane pressure
- filtration
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000005374 membrane filtration Methods 0.000 title description 8
- 238000000034 method Methods 0.000 claims abstract description 55
- 239000012528 membrane Substances 0.000 claims abstract description 42
- 238000001914 filtration Methods 0.000 claims abstract description 34
- 238000000855 fermentation Methods 0.000 claims abstract description 32
- 230000004151 fermentation Effects 0.000 claims abstract description 32
- 239000000919 ceramic Substances 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 3
- 239000000047 product Substances 0.000 claims description 35
- 239000012466 permeate Substances 0.000 claims description 20
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000009295 crossflow filtration Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 229940056360 penicillin g Drugs 0.000 claims description 5
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- MIFYHUACUWQUKT-UHFFFAOYSA-N Isopenicillin N Natural products OC(=O)C1C(C)(C)SC2C(NC(=O)CCCC(N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-UHFFFAOYSA-N 0.000 claims description 3
- 229930195708 Penicillin V Natural products 0.000 claims description 3
- 230000002924 anti-infective effect Effects 0.000 claims description 3
- MIFYHUACUWQUKT-QSKNDCFUSA-N isopenicillin n Chemical compound OC(=O)[C@@H]1C(C)(C)S[C@H]2[C@H](NC(=O)CCC[C@H](N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-QSKNDCFUSA-N 0.000 claims description 3
- 229910044991 metal oxide Inorganic materials 0.000 claims description 3
- 150000004706 metal oxides Chemical class 0.000 claims description 3
- 229940056367 penicillin v Drugs 0.000 claims description 3
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 claims description 3
- CSGFFYNMTALICU-ZWNOBZJWSA-N adipyl-7-aminodesacetoxycephalosporanic acid Natural products CC1=C(N2[C@H](SC1)[C@H](NC(=O)CCCCC(O)=O)C2=O)C(O)=O CSGFFYNMTALICU-ZWNOBZJWSA-N 0.000 claims description 2
- 229960003276 erythromycin Drugs 0.000 claims description 2
- 229960000988 nystatin Drugs 0.000 claims description 2
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 abstract description 6
- 235000010633 broth Nutrition 0.000 description 39
- 239000012465 retentate Substances 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 150000003952 β-lactams Chemical class 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 238000000108 ultra-filtration Methods 0.000 description 4
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000010924 continuous production Methods 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000011026 diafiltration Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 3
- 229940049954 penicillin Drugs 0.000 description 3
- 238000003672 processing method Methods 0.000 description 3
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 description 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 description 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 description 2
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000019371 penicillin G benzathine Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 description 1
- 229960005361 cefaclor Drugs 0.000 description 1
- 229940106164 cephalexin Drugs 0.000 description 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 229960003324 clavulanic acid Drugs 0.000 description 1
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940082150 encore Drugs 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- -1 α-aluminum oxide Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Glass Compositions (AREA)
- Polarising Elements (AREA)
- External Artificial Organs (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201209 | 1998-04-14 | ||
| EP98201209 | 1998-04-14 | ||
| PCT/EP1999/002645 WO1999053015A1 (en) | 1998-04-14 | 1999-04-14 | Membrane filtration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69909077D1 DE69909077D1 (de) | 2003-07-31 |
| DE69909077T2 true DE69909077T2 (de) | 2004-05-06 |
Family
ID=8233599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69909077T Expired - Fee Related DE69909077T2 (de) | 1998-04-14 | 1999-04-14 | Membranfiltration |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6515115B1 (https=) |
| EP (1) | EP1071744B1 (https=) |
| JP (1) | JP2002511243A (https=) |
| KR (1) | KR100594482B1 (https=) |
| CN (1) | CN1223670C (https=) |
| AT (1) | ATE243739T1 (https=) |
| AU (1) | AU3709199A (https=) |
| BR (1) | BR9909584A (https=) |
| DE (1) | DE69909077T2 (https=) |
| ES (1) | ES2201708T3 (https=) |
| ID (1) | ID26894A (https=) |
| PL (1) | PL188119B1 (https=) |
| PT (1) | PT1071744E (https=) |
| RU (1) | RU2247773C2 (https=) |
| SI (1) | SI1071744T1 (https=) |
| WO (1) | WO1999053015A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002219127A1 (en) | 2000-11-22 | 2002-06-03 | Biochemie Gesellschaft M.B.H. | Process for the production of ceftifur sodium salt |
| US7247210B2 (en) * | 2004-02-23 | 2007-07-24 | Ecolab Inc. | Methods for treating CIP equipment and equipment for treating CIP equipment |
| US7220358B2 (en) * | 2004-02-23 | 2007-05-22 | Ecolab Inc. | Methods for treating membranes and separation facilities and membrane treatment composition |
| US7392811B2 (en) * | 2004-02-23 | 2008-07-01 | Ecolab Inc. | Delivery head for multiple phase treatment composition, vessel including a delivery head, and method for treating a vessel interior surface |
| DK1988170T3 (da) | 2006-02-24 | 2019-07-22 | Toray Industries | Fremgangsmåde til fremstilling af et kemisk produkt og indretning til kontinuerlig fermentering |
| CN101117306B (zh) * | 2007-07-20 | 2011-01-19 | 三达膜科技（厦门）有限公司 | 一种1,3-丙二醇发酵液的除杂和脱盐方法 |
| DE102007054885A1 (de) * | 2007-11-15 | 2009-05-20 | Evonik Degussa Gmbh | Verfahren zur Fraktionierung oxidischer Nanopartikel durch Querstrom-Membranfiltration |
| CN102311912B (zh) * | 2010-07-06 | 2013-07-31 | 光明乳业股份有限公司 | 乳酸菌发酵剂的制备工艺及其专用设备 |
| CN102154408B (zh) * | 2011-01-13 | 2013-06-05 | 天津市工业微生物研究所 | 小核菌硬葡聚糖在线发酵提取方法及系统 |
| CN106511281A (zh) * | 2016-09-30 | 2017-03-22 | 华北制药河北华民药业有限责任公司 | 一种注射用头孢孟多酯钠粉针制剂的制备方法 |
| JP7539831B2 (ja) * | 2018-04-27 | 2024-08-26 | 株式会社カネカ | 補酵素ｑ１０の製造方法 |
| CN211111802U (zh) * | 2018-11-24 | 2020-07-28 | 江苏久吾高科技股份有限公司 | 一种抗生素发酵液的提纯装置 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE277088C (https=) | ||||
| JPH0734749B2 (ja) | 1988-02-03 | 1995-04-19 | 日本碍子株式会社 | エリスリトールの製造方法 |
| US4897465A (en) | 1988-10-12 | 1990-01-30 | Abbott Laboratories | Enrichment and concentration of proteins by ultrafiltration |
| US5273659A (en) * | 1991-07-08 | 1993-12-28 | Millipore Corporation | Process of recovering a solid component from a solid composition by clarification and extraction |
| DE4127648C1 (https=) * | 1991-08-21 | 1993-01-14 | Hoechst Ag, 6230 Frankfurt, De | |
| RU2090598C1 (ru) * | 1992-03-18 | 1997-09-20 | Гаврилюк Дмитрий викторович | Способ производства полусухих и полусладких вин |
| RU2031123C1 (ru) * | 1992-06-08 | 1995-03-20 | Барбот Владимир Сергеевич | Способ получения диоксиацетона |
| US5503750A (en) * | 1993-10-04 | 1996-04-02 | Russo, Jr.; Lawrence J. | Membrane-based process for the recovery of lactic acid by fermentation of carbohydrate substrates containing sugars |
| US5716526A (en) | 1994-01-14 | 1998-02-10 | The Liposome Company, Inc. | Method of separating materials from liposomes or lipid complexes |
| US5468847A (en) * | 1994-03-10 | 1995-11-21 | Minnesota Mining And Manufacturing Company | Method of isolating and purifying a biomacromolecule |
| US5616595A (en) * | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
-
1999
- 1999-04-14 ID IDW20001945A patent/ID26894A/id unknown
- 1999-04-14 KR KR1020007011382A patent/KR100594482B1/ko not_active Expired - Fee Related
- 1999-04-14 RU RU2000128651/13A patent/RU2247773C2/ru not_active IP Right Cessation
- 1999-04-14 AT AT99919252T patent/ATE243739T1/de not_active IP Right Cessation
- 1999-04-14 ES ES99919252T patent/ES2201708T3/es not_active Expired - Lifetime
- 1999-04-14 SI SI9930381T patent/SI1071744T1/xx unknown
- 1999-04-14 PL PL99343401A patent/PL188119B1/pl unknown
- 1999-04-14 DE DE69909077T patent/DE69909077T2/de not_active Expired - Fee Related
- 1999-04-14 CN CNB998050490A patent/CN1223670C/zh not_active Expired - Fee Related
- 1999-04-14 AU AU37091/99A patent/AU3709199A/en not_active Abandoned
- 1999-04-14 EP EP99919252A patent/EP1071744B1/en not_active Expired - Lifetime
- 1999-04-14 US US09/647,371 patent/US6515115B1/en not_active Expired - Fee Related
- 1999-04-14 PT PT99919252T patent/PT1071744E/pt unknown
- 1999-04-14 WO PCT/EP1999/002645 patent/WO1999053015A1/en not_active Ceased
- 1999-04-14 JP JP2000543563A patent/JP2002511243A/ja active Pending
- 1999-04-14 BR BR9909584-0A patent/BR9909584A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9909584A (pt) | 2000-12-19 |
| PL343401A1 (en) | 2001-08-13 |
| KR100594482B1 (ko) | 2006-07-03 |
| SI1071744T1 (en) | 2003-12-31 |
| PL188119B1 (pl) | 2004-12-31 |
| ID26894A (id) | 2001-02-15 |
| EP1071744B1 (en) | 2003-06-25 |
| PT1071744E (pt) | 2003-11-28 |
| WO1999053015A1 (en) | 1999-10-21 |
| JP2002511243A (ja) | 2002-04-16 |
| EP1071744A1 (en) | 2001-01-31 |
| CN1297475A (zh) | 2001-05-30 |
| ATE243739T1 (de) | 2003-07-15 |
| ES2201708T3 (es) | 2004-03-16 |
| KR20010042679A (ko) | 2001-05-25 |
| DE69909077D1 (de) | 2003-07-31 |
| RU2247773C2 (ru) | 2005-03-10 |
| AU3709199A (en) | 1999-11-01 |
| US6515115B1 (en) | 2003-02-04 |
| CN1223670C (zh) | 2005-10-19 |
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