DE69900870T2 - Testkarte zur quantifizierung und zur nachweis von mikroorganismen - Google Patents
Testkarte zur quantifizierung und zur nachweis von mikroorganismenInfo
- Publication number
- DE69900870T2 DE69900870T2 DE69900870T DE69900870T DE69900870T2 DE 69900870 T2 DE69900870 T2 DE 69900870T2 DE 69900870 T DE69900870 T DE 69900870T DE 69900870 T DE69900870 T DE 69900870T DE 69900870 T2 DE69900870 T2 DE 69900870T2
- Authority
- DE
- Germany
- Prior art keywords
- card
- cavities
- analysis
- biological fluid
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 244000005700 microbiome Species 0.000 title claims description 38
- 238000012360 testing method Methods 0.000 title description 11
- 238000001514 detection method Methods 0.000 title description 3
- 238000011002 quantification Methods 0.000 title description 3
- 238000004458 analytical method Methods 0.000 claims abstract description 142
- 239000013060 biological fluid Substances 0.000 claims abstract description 57
- 238000002347 injection Methods 0.000 claims abstract description 33
- 239000007924 injection Substances 0.000 claims abstract description 33
- 238000000034 method Methods 0.000 claims abstract description 30
- 238000012546 transfer Methods 0.000 claims abstract description 13
- 239000000523 sample Substances 0.000 claims description 80
- 239000007788 liquid Substances 0.000 claims description 55
- 239000012472 biological sample Substances 0.000 claims description 33
- 239000012530 fluid Substances 0.000 claims description 24
- 238000009826 distribution Methods 0.000 claims description 23
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 102000039446 nucleic acids Human genes 0.000 claims description 7
- 108020004707 nucleic acids Proteins 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 3
- 238000010790 dilution Methods 0.000 description 16
- 239000012895 dilution Substances 0.000 description 16
- 239000002609 medium Substances 0.000 description 11
- 238000012512 characterization method Methods 0.000 description 9
- 238000011109 contamination Methods 0.000 description 9
- 239000011541 reaction mixture Substances 0.000 description 9
- 239000012620 biological material Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 239000002313 adhesive film Substances 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 238000003856 thermoforming Methods 0.000 description 4
- 238000011144 upstream manufacturing Methods 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 239000012470 diluted sample Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000005353 urine analysis Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9811053A FR2782729B1 (fr) | 1998-09-01 | 1998-09-01 | Carte de denombrement et de caracterisation de micro-organismes |
| PCT/FR1999/002082 WO2000012674A1 (fr) | 1998-09-01 | 1999-09-01 | Carte de denombrement et de caracterisation de micro-organismes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69900870D1 DE69900870D1 (de) | 2002-03-21 |
| DE69900870T2 true DE69900870T2 (de) | 2002-11-21 |
Family
ID=9530111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69900870T Expired - Lifetime DE69900870T2 (de) | 1998-09-01 | 1999-09-01 | Testkarte zur quantifizierung und zur nachweis von mikroorganismen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6458553B1 (fr) |
| EP (1) | EP1105457B1 (fr) |
| JP (1) | JP4578682B2 (fr) |
| AT (1) | ATE213017T1 (fr) |
| AU (1) | AU774508B2 (fr) |
| CA (1) | CA2343010C (fr) |
| DE (1) | DE69900870T2 (fr) |
| FR (1) | FR2782729B1 (fr) |
| WO (1) | WO2000012674A1 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10197480B2 (en) | 2012-11-07 | 2019-02-05 | Sandstone Diagnostics, Inc. | Methods and devices for processing samples and counting cells |
| US11471881B2 (en) | 2013-02-07 | 2022-10-18 | Laboratory Corporation Of America Holdings | Automated sample processing, fluid distribution, and sedimentation assay |
| US11714034B2 (en) | 2012-11-07 | 2023-08-01 | Laboratory Corporation Of America Holdings | Methods and devices for processing samples and counting cells |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2782729B1 (fr) * | 1998-09-01 | 2002-10-25 | Bio Merieux | Carte de denombrement et de caracterisation de micro-organismes |
| FR2827196A1 (fr) * | 2001-07-13 | 2003-01-17 | Bio Merieux | Recipient perfectionne facilitant son vidage complet |
| FR2833699B1 (fr) * | 2001-12-19 | 2004-05-28 | Bio Merieux | Procede de controle de la presence ou de l'absence ou de controle du remplissage d'un contenant et dispositif de mise en oeuvre du procede |
| FR2928656B1 (fr) | 2008-03-14 | 2011-08-26 | Biomerieux Sa | Procede de detection en temps reel de microorganismes dans un milieu de culture liquide par agglutination. |
| EP2373974A1 (fr) | 2008-12-19 | 2011-10-12 | 3M Innovative Properties Company | Système et procédé de concentration d'échantillons |
| EP2373975B1 (fr) | 2008-12-19 | 2020-04-01 | 3M Innovative Properties Company | Système et procédé de traitement d'échantillons |
| US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| US10196700B2 (en) * | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
| JP5766178B2 (ja) | 2009-03-24 | 2015-08-19 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ＳｌｉｐＣｈｉｐ装置および方法 |
| WO2011105884A2 (fr) * | 2010-02-22 | 2011-09-01 | Barrenechea Oar Jose Carlos | Appareil et procédé destinés à distribuer des échantillons liquides dans des petits volumes |
| FR2957608B1 (fr) * | 2010-03-19 | 2014-08-08 | Biomerieux Sa | Procede d'estimation du nombre de microorganismes dans un echantillon et dispositif pour mettre en œuvre ledit procede |
| WO2013003308A1 (fr) | 2011-06-30 | 2013-01-03 | 3M Innovative Properties Company | Systèmes et procédés de détection d'un analyte d'intérêt dans un échantillon au moyen de surfaces microstructurées |
| CN103620373B (zh) | 2011-06-30 | 2017-07-07 | 3M创新有限公司 | 利用过滤器和微结构化表面检测样品中所关注分析物的方法 |
| US9063121B2 (en) * | 2012-05-09 | 2015-06-23 | Stat-Diagnostica & Innovation, S.L. | Plurality of reaction chambers in a test cartridge |
| US10520521B2 (en) | 2014-06-30 | 2019-12-31 | Phc Holdings Corporation | Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system |
| JP6588908B2 (ja) | 2014-06-30 | 2019-10-09 | Ｐｈｃホールディングス株式会社 | 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム |
| US10539582B2 (en) | 2014-06-30 | 2020-01-21 | Phc Holdings Corporation | Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles |
| JP6548645B2 (ja) | 2014-06-30 | 2019-07-24 | Ｐｈｃホールディングス株式会社 | 試料分析用基板および試料分析装置 |
| US10539583B2 (en) | 2014-12-12 | 2020-01-21 | Phc Holdings Corporation | Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1598197A (fr) * | 1968-11-19 | 1970-07-06 | ||
| US4018652A (en) * | 1976-01-09 | 1977-04-19 | Mcdonnell Douglas Corporation | Process and apparatus for ascertaining the concentration of microorganism in a water specimen |
| US4077845A (en) * | 1977-04-20 | 1978-03-07 | Miles Laboratories, Inc. | Disposable inoculation device and process of using same |
| US4318994A (en) * | 1979-08-30 | 1982-03-09 | Mcdonnell Douglas Corporation | Enterobacteriaceae species biochemical test card |
| US4806316A (en) * | 1987-03-17 | 1989-02-21 | Becton, Dickinson And Company | Disposable device for use in chemical, immunochemical and microorganism analysis |
| US5149505A (en) * | 1989-07-18 | 1992-09-22 | Abbott Laboratories | Diagnostic testing device |
| US5254479A (en) * | 1991-12-19 | 1993-10-19 | Eastman Kodak Company | Methods for preventing air injection into a detection chamber supplied with injected liquid |
| US5518892A (en) | 1994-02-23 | 1996-05-21 | Idexx Laboratories, Inc. | Apparatus and method for quantification of biological material in a liquid sample |
| DE29500587U1 (de) * | 1995-01-17 | 1996-05-15 | Schreiber, Hans, Dr. Dr., 69469 Weinheim | Bausatz insbesondere zur Blutgruppenbestimmung |
| US5609828A (en) * | 1995-05-31 | 1997-03-11 | bio M erieux Vitek, Inc. | Sample card |
| US5700655A (en) | 1995-11-14 | 1997-12-23 | Idexx Laboratories, Inc. | Method for quantification of biological material in a sample |
| FR2782729B1 (fr) * | 1998-09-01 | 2002-10-25 | Bio Merieux | Carte de denombrement et de caracterisation de micro-organismes |
-
1998
- 1998-09-01 FR FR9811053A patent/FR2782729B1/fr not_active Expired - Fee Related
-
1999
- 1999-09-01 CA CA2343010A patent/CA2343010C/fr not_active Expired - Lifetime
- 1999-09-01 EP EP99940269A patent/EP1105457B1/fr not_active Expired - Lifetime
- 1999-09-01 JP JP2000567664A patent/JP4578682B2/ja not_active Expired - Lifetime
- 1999-09-01 AU AU54276/99A patent/AU774508B2/en not_active Expired
- 1999-09-01 DE DE69900870T patent/DE69900870T2/de not_active Expired - Lifetime
- 1999-09-01 AT AT99940269T patent/ATE213017T1/de not_active IP Right Cessation
- 1999-09-01 US US09/763,757 patent/US6458553B1/en not_active Expired - Lifetime
- 1999-09-01 WO PCT/FR1999/002082 patent/WO2000012674A1/fr active IP Right Grant
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10197480B2 (en) | 2012-11-07 | 2019-02-05 | Sandstone Diagnostics, Inc. | Methods and devices for processing samples and counting cells |
| US11714034B2 (en) | 2012-11-07 | 2023-08-01 | Laboratory Corporation Of America Holdings | Methods and devices for processing samples and counting cells |
| US11471881B2 (en) | 2013-02-07 | 2022-10-18 | Laboratory Corporation Of America Holdings | Automated sample processing, fluid distribution, and sedimentation assay |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000012674A1 (fr) | 2000-03-09 |
| JP4578682B2 (ja) | 2010-11-10 |
| FR2782729A1 (fr) | 2000-03-03 |
| AU774508B2 (en) | 2004-07-01 |
| DE69900870D1 (de) | 2002-03-21 |
| JP2002523083A (ja) | 2002-07-30 |
| EP1105457A1 (fr) | 2001-06-13 |
| AU5427699A (en) | 2000-03-21 |
| CA2343010C (fr) | 2010-06-08 |
| ATE213017T1 (de) | 2002-02-15 |
| EP1105457B1 (fr) | 2002-02-06 |
| CA2343010A1 (fr) | 2000-03-09 |
| FR2782729B1 (fr) | 2002-10-25 |
| US6458553B1 (en) | 2002-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: WITTE, WELLER & PARTNER, 70178 STUTTGART |